請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/41306
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 江俊斌(CHUN-PIN CHIANG) | |
dc.contributor.author | Chia-Jung Lin | en |
dc.contributor.author | 林佳蓉 | zh_TW |
dc.date.accessioned | 2021-06-15T00:15:33Z | - |
dc.date.available | 2009-09-15 | |
dc.date.copyright | 2009-09-15 | |
dc.date.issued | 2009 | |
dc.date.submitted | 2009-06-16 | |
dc.identifier.citation | Achen, M. G., McColl, B. K., Stacker, S. A. Focus on lymphangiogenesis in tumor metastasis. Cancer Cell 2005; 7(2): 121-7.
Adachi, Y., Nakamura, H., Kitamura, Y., Taniguchi, Y., Araki, K., Shomori, K., Horie, Y., Kurozawa, Y., Ito, H., Hayashi, K. Lymphatic vessel density in pulmonary adenocarcinoma immunohistochemically evaluated with anti-podoplanin or anti-D2-40 antibody is correlated with lymphatic invasion or lymph node metastases. Pathol Int 2007; 57(4): 171-7. Al-Rawi, M. A., Mansel, R. E., Jiang, W. G. Lymphangiogenesis and its role in cancer. Histol Histopathol 2005; 20(1): 283-98. Alitalo, K. and Carmeliet, P. Molecular mechanisms of lymphangiogenesis in health and disease. Cancer Cell 2002; 1(3): 219-27. Andrews, N. A., Jones, A. S., Helliwell, T. R., Kinsella, A. R. Expression of the E-cadherin-catenin cell adhesion complex in primary squamous cell carcinomas of the head and neck and their nodal metastases. Br J Cancer 1997; 75(10): 1474-80. Bailey, D., Marks, A, Stratis, M., Baumal, R. Immunohistochemical staining of germ cell tumors and intratubular malignant germ cells of the testis using antibody to placental alkaline phosphatase and a monoclonal anti-seminoma antibody. Mod Pathol 1991; 4(2): 167-71. Barnes L., Eveson J. W., Reichart P., Sidransky D. World Health Organization Classificatoin of Tumours. Pathology & Genetics of Head and Neck Tumours. IARC Press: Lyon 2005. Beasley, N. J., Prevo, R., Banerji, S., Leek, R. D., Moore, J., van Trappen, P., Cox, G., Harris, A. L., Jackson, D. G. Intratumoral lymphangiogenesis and lymph node metastasis in head and neck cancer. Cancer Res 2002; 62(5): 1315-20. Birner, P., Obermair, A., Schindl, M., Kowalski, H., Breitenecker, G., Oberhuber, G. Selective immunohistochemical staining of blood and lymphatic vessels reveals independent prognostic influence of blood and lymphatic vessel invasion in early-stage cervical cancer. Clin Cancer Res 2001; 7(1): 93-7. Braun, M., Flucke, U., Debald, M., Walgenbach-Bruenagel, G., Walgenbach, K. J., Holler, T., Polcher, M., Wolfgarten, M., Sauerwald, A., Keyver-Paik, M., Kuhr, M., Buttner, R., Kuhn, W. Detection of lymphovascular invasion in early breast cancer by D2-40 (podoplanin): a clinically useful predictor for axillary lymph node metastases. Breast Cancer Res Treat 2008; 112(3): 503-11. Breiteneder-Geleff, S., Matsui, K., Soleiman, A., Meraner, P., Poczewski, H., Kalt, R., Schaffner, G., Kerjaschki, D. Podoplanin, novel 43-kd membrane protein of glomerular epithelial cells, is down-regulated in puromycin nephrosis. Am J Pathol 1997; 151(4): 1141-52. Breiteneder-Geleff, S., Soleiman, A., Kowalski, H., Horvat, R., Amann, G., Kriehuber, E., Diem, K., Weninger, W., Tschachler, E., Alitalo, K., Kerjaschki, D. Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium. Am J Pathol 1999; 154(2): 385-94. Cancer registry annual report in Taiwan area, 2006. Department of Health, The Executive Yuan, Taiwan, 2007. Cano, A., Perez-Moreno, M. A., Rodrigo, I., Locascio, A., Blanco, M. J., del Barrio, M. G., Portillo, F., Nieto, M. A. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2000; 2(2): 76-83. Chow, V., Yuen, A. P., Lam, K. Y., Tsao, G. S., Ho, W. K., Wei, W. I. A comparative study of the clinicopathological significance of E-cadherin and catenins (alpha, beta, gamma) expression in the surgical management of oral tongue carcinoma. J Cancer Res Clin Oncol 2001; 127(1): 59-63. Cuenca, A., Cheng, F., Wang, H., Brayer, J., Horna, P., Gu, L., Bien, H., Borrello, I. M., Levitsky, H. I., Sotomayor, E. M. Extra-lymphatic solid tumor growth is not immunologically ignored and results in early induction of antigen-specific T-cell anergy: dominant role of cross-tolerance to tumor antigens. Cancer Res 2003; 63(24): 9007-15. Debelenko, L. V., Perez-Atayde, A. R., Mulliken, J. B., Liang, M. G., Archibald, T. H., Kozakewich, H. P. D2-40 immunohistochemical analysis of pediatric vascular tumors reveals positivity in kaposiform hemangioendothelioma. Mod Pathol 2005; 18(11): 1454-60. Dumoff, K. L., Chu, C., Xu, X., Pasha, T., Zhang, P. J., Acs, G. Low D2-40 immunoreactivity correlates with lymphatic invasion and nodal metastasis in early-stage squamous cell carcinoma of the uterine cervix. Mod Pathol 2005; 18(1): 97-104. Franchi, A., Gallo, O., Massi, D., Baroni, G., Santucci, M. Tumor lymphangiogenesis in head and neck squamous cell carcinoma: a morphometric study with clinical correlations. Cancer 2004; 101(5): 973-8. Franchi, A., Massi, D., Santucci, M., Masini, E., Degl'Innocenti, D. R., Magnelli, L., Fanti, E., Naldini, A., Ardinghi, C., Carraro, F., Gallo, O. Inducible nitric oxide synthase activity correlates with lymphangiogenesis and vascular endothelial growth factor-C expression in head and neck squamous cell carcinoma. J Pathol 2006; 208(3): 439-45. Franke, F. E., Steger, K., Marks, A., Kutzner, H., Mentzel, T. Hobnail hemangiomas (targetoid hemosiderotic hemangiomas) are true lymphangiomas. J Cutan Pathol 2004; 31(5): 362-7. Friedl, P. and Wolf, K. Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer 2003; 3(5): 362-74. Frixen, U. H., Behrens, J., Sachs, M., Eberle, G., Voss, B., Warda, A., Lochner, D., Birchmeier, W. E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol 1991; 113(1): 173-85. Gamallo, C., Palacios, J., Suarez, A., Pizarro, A., Navarro, P., Quintanilla, M., Cano, A. Correlation of E-cadherin expression with differentiation grade and histological type in breast carcinoma. Am J Pathol 1993; 142(4): 987-93. Gandarillas, A., Scholl, F. G., Benito, N., Gamallo, C., Quintanilla, M. Induction of PA2.26, a cell-surface antigen expressed by active fibroblasts, in mouse epidermal keratinocytes during carcinogenesis. Mol Carcinog 1997; 20(1): 10-8. Gombos, Z., Xu, X., Chu, C. S., Zhang, P. J., Acs, G. Peritumoral lymphatic vessel density and vascular endothelial growth factor C expression in early-stage squamous cell carcinoma of the uterine cervix. Clin Cancer Res 2005; 11(23): 8364-71. Greenburg, G. and Hay, E. D. Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells. J Cell Biol 1982; 95(1): 333-9. Grunert, S., Jechlinger, M., Beug, H. Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis. Nat Rev Mol Cell Biol 2003; 4(8): 657-65. Guarino, M. Epithelial-to-mesenchymal change of differentiation. From embryogenetic mechanism to pathological patterns. Histol Histopathol 1995; 10(1): 171-84. Guarino, M., Micheli, P., Pallotti, F., Giordano, F. Pathological relevance of epithelial and mesenchymal phenotype plasticity. Pathol Res Pract 1999; 195(6): 379-89. Guarino, M., Rubino, B., Ballabio, G. The role of epithelial-mesenchymal transition in cancer pathology. Pathology 2007; 39(3): 305-18. He, Y., Rajantie, I., Pajusola, K., Jeltsch, M., Holopainen, T., Yla-Herttuala, S., Harding, T., Jooss, K., Takahashi, T., Alitalo, K. Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. Cancer Res 2005; 65(11): 4739-46. Hirakawa, S., Kodama, S., Kunstfeld, R., Kajiya, K., Brown, L. F., Detmar, M. VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis. J Exp Med 2005; 201(7): 1089-99. Horiguchi, A., Ito, K., Sumitomo, M., Kimura, F., Asano, T., Hayakawa, M. Intratumoral lymphatics and lymphatic invasion are associated with tumor aggressiveness and poor prognosis in renal cell carcinoma. Urology 2008; 71(5): 928-32. Hughes, S. C. and Fehon, R. G. Understanding ERM proteins--the awesome power of genetics finally brought to bear. Curr Opin Cell Biol 2007; 19(1): 51-6. Hulpiau, P. and van Roy, F. Molecular evolution of the cadherin superfamily. Int J Biochem Cell Biol 2009; 41(2): 349-69. Hung, K. F., Chang, C. S., Liu, C. J., Lui, M. T., Cheng, C. Y., Kao, S. Y. Differential expression of E-cadherin in metastatic lesions comparing to primary oral squamous cell carcinoma. J Oral Pathol Med 2006; 35(10): 589-94. Imai, T., Horiuchi, A., Shiozawa, T., Osada, R., Kikuchi, N., Ohira, S., Oka, K., Konishi, I. Elevated expression of E-cadherin and alpha-, beta-, and gamma-catenins in metastatic lesions compared with primary epithelial ovarian carcinomas. Hum Pathol 2004; 35(12): 1469-76. Inoue, M., Ogawa, H., Miyata, M., Shiozaki, H., Tanizawa, O. Expression of E-cadherin in normal, benign, and malignant tissues of female genital organs. Am J Clin Pathol 1992; 98(1): 76-80. Ito, T., Ishii, G., Nagai, K., Nagano, T., Kojika, M., Murata, Y., Atsumi, N., Nishiwaki, Y., Miyazaki, E., Kumamoto, T., Ochiai, A. Low podoplanin expression of tumor cells predicts poor prognosis in pathological stage IB squamous cell carcinoma of the lung, tissue microarray analysis of 136 patients using 24 antibodies. Lung Cancer 2009; 63(3): 418-24. Jain, R. K. and Fenton, B. T. Intratumoral lymphatic vessels: a case of mistaken identity or malfunction? J Natl Cancer Inst 2002; 94(6): 417-21. Jeng, J. H., Chen, S. Y., Liao, C. H., Tung, Y. Y., Lin, B. R., Hahn, L. J., Chang, M. C. Modulation of platelet aggregation by areca nut and betel leaf ingredients: roles of reactive oxygen species and cyclooxygenase. Free Radic Biol Med 2002; 32(9): 860-71. Ji, R. C. Lymphatic endothelial cells, lymphangiogenesis, and extracellular matrix. Lymphat Res Biol 2006; 4(2): 83-100. Ji, R. C. Lymphatic endothelial cells, tumor lymphangiogenesis and metastasis: New insights into intratumoral and peritumoral lymphatics. Cancer Metastasis Rev 2006; 25(4): 677-94. Jussila, L. and Alitalo, K. Vascular growth factors and lymphangiogenesis. Physiol Rev 2002; 82(3): 673-700. Kahn, H. J., Bailey, D., Marks, A. Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas. Mod Pathol 2002; 15(4): 434-40. Kato, Y., Fujita, N., Kunita, A., Sato, S., Kaneko, M., Osawa, M., Tsuruo, T. Molecular identification of Aggrus/T1alpha as a platelet aggregation-inducing factor expressed in colorectal tumors. J Biol Chem 2003; 278(51): 51599-605. Kawaguchi, H., El-Naggar, A. K., Papadimitrakopoulou, V., Ren, H., Fan, Y. H., Feng, L., Lee, J. J., Kim, E., Hong, W. K., Lippman, S. M., Mao, L. Podoplanin: a novel marker for oral cancer risk in patients with oral premalignancy. J Clin Oncol 2008; 26(3): 354-60. Kimura, N. and Kimura, I. Podoplanin as a marker for mesothelioma. Pathol Int 2005; 55(2): 83-6. Ko, Y. C., Huang, Y. L., Lee, C. H., Chen, M. J., Lin, L. M., Tsai, C.C. Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan. J Oral Pathol Med 1995; 24: 450-3. Kotani, M., Tajima, Y., Osanai, T., Irie, A., Iwatsuki, K., Kanai-Azuma, M., Imada, M., Kato, H., Shitara, H., Kubo, H., Sakuraba, H. Complementary DNA cloning and characterization of RANDAM-2, a type I membrane molecule specifically expressed on glutamatergic neuronal cells in the mouse cerebrum. J Neurosci Res 2003; 73(5): 603-13. Kowalski, P. J., Rubin, M. A., Kleer, C. G. E-cadherin expression in primary carcinomas of the breast and its distant metastases. Breast Cancer Res 2003; 5(6): R217-22. Kunita, A., Kashima, T. G., Morishita, Y., Fukayama, M., Kato, Y., Tsuruo, T., Fujita, N. The platelet aggregation-inducing factor aggrus/podoplanin promotes pulmonary metastasis. Am J Pathol 2007; 170(4): 1337-47. Kwan H.W. A statistical study on oral carcinomas in Taiwan with emphasis on the relationship with betel nut chewing: a preliminary report. J Formos Med Assoc 1976; 75: 497-505. Kyzas, P. A., Geleff, S., Batistatou, A., Agnantis, N. J., Stefanou, D. Evidence for lymphangiogenesis and its prognostic implications in head and neck squamous cell carcinoma. J Pathol 2005; 206(2): 170-7. Mahomed, F., Altini, M., Meer, S. Altered E-cadherin/beta-catenin expression in oral squamous carcinoma with and without nodal metastasis. Oral Dis 2007; 13(4): 386-92. Mareel, M. and Leroy, A. Clinical, cellular, and molecular aspects of cancer invasion. Physiol Rev 2003; 83(2): 337-76. Martin-Villar, E., Megias, D., Castel, S., Yurrita, M. M., Vilaro, S., Quintanilla, M. Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition. J Cell Sci 2006; 119(Pt 21): 4541-53. Martin-Villar, E., Scholl, F. G., Gamallo, C., Yurrita, M. M., Munoz-Guerra, M., Cruces, J., Quintanilla, M. Characterization of human PA2.26 antigen (T1alpha-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas. Int J Cancer 2005; 113(6): 899-910. Mattijssen, V., Peters, H. M., Schalkwijk, L., Manni, J. J., van 't Hof-Grootenboer, B., de Mulder, P. H., Ruiter, D. J. E-cadherin expression in head and neck squamous-cell carcinoma is associated with clinical outcome. Int J Cancer 1993; 55(4): 580-5. Maula, S. M., Luukkaa, M., Grenman, R., Jackson, D., Jalkanen, S.Ristamaki, R. Intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinomas of the head and neck region. Cancer Res 2003; 63(8): 1920-6. Mehta, P. Potential role of platelets in the pathogenesis of tumor metastasis. Blood 1984; 63(1): 55-63. Miyahara, M., Tanuma, J., Sugihara, K., Semba, I. Tumor lymphangiogenesis correlates with lymph node metastasis and clinicopathologic parameters in oral squamous cell carcinoma. Cancer 2007; 110(6): 1287-94. Mohammed, R. A., Green, A., El-Shikh, S., Paish, E. C., Ellis, I. O., Martin, S. G. Prognostic significance of vascular endothelial cell growth factors -A, -C and -D in breast cancer and their relationship with angio- and lymphangiogenesis. Br J Cancer 2007; 96(7): 1092-100. Mohammed, R. A., Martin, S. G., Gill, M. S., Green, A. R., Paish, E. C., Ellis, I. O. Improved methods of detection of lymphovascular invasion demonstrate that it is the predominant method of vascular invasion in breast cancer and has important clinical consequences. Am J Surg Pathol 2007; 31(12): 1825-33. Nakamura, Y., Yasuoka, H., Tsujimoto, M., Imabun, S., Nakahara, M., Nakao, K., Nakamura, M., Mori, I., Kakudo, K. Lymph vessel density correlates with nodal status, VEGF-C expression, and prognosis in breast cancer. Breast Cancer Res Treat 2005; 91(2): 125-32. Nakamura, Y., Yasuoka, H., Tsujimoto, M., Kurozumi, K., Nakahara, M., Nakao, K., Kakudo, K. Importance of lymph vessels in gastric cancer: a prognostic indicator in general and a predictor for lymph node metastasis in early stage cancer. J Clin Pathol 2006; 59(1): 77-82. Neville, B.W., Damm, D.D., Allen, C.M., Bouquot, J.E. Epithelial Pathology. In: Oral and Maxillofacial Pathology, third edition. 2009. Saunders, an imprint of Elsevier Inc. Nose, K., Saito, H., Kuroki, T. Isolation of a gene sequence induced later by tumor-promoting 12-O-tetradecanoylphorbol-13-acetate in mouse osteoblastic cells (MC3T3-E1) and expressed constitutively in ras-transformed cells. Cell Growth Differ 1990; 1(11): 511-8. Ohno, F., Nakanishi, H., Abe, A., Seki, Y., Kinoshita, A., Hasegawa, Y., Tatematsu, M., Kurita, K. Regional difference in intratumoral lymphangiogenesis of oral squamous cell carcinomas evaluated by immunohistochemistry using D2-40 and podoplanin antibody: an analysis in comparison with angiogenesis. J Oral Pathol Med 2007; 36(5): 281-9. Okada, H., Danoff, T. M., Kalluri, R., Neilson, E. G. Early role of Fsp1 in epithelial-mesenchymal transformation. Am J Physiol 1997; 273(4 Pt 2): F563-74. Ordonez, N. G. D2-40 and podoplanin are highly specific and sensitive immunohistochemical markers of epithelioid malignant mesothelioma. Hum Pathol 2005; 36(4): 372-80. Ordonez, N. G. Podoplanin: a novel diagnostic immunohistochemical marker. Adv Anat Pathol 2006; 13(2): 83-8. Ozawa, M., Baribault, H., Kemler, R. The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. Embo J 1989; 8(6): 1711-7. Padera, T. P., Kadambi, A., di Tomaso, E., Carreira, C. M., Brown, E. B., Boucher, Y., Choi, N. C., Mathisen, D., Wain, J., Mark, E. J., Munn, L. L., Jain, R. K. Lymphatic metastasis in the absence of functional intratumor lymphatics. Science 2002; 296(5574): 1883-6. Peinado, H., Portillo, F., Cano, A. Transcriptional regulation of cadherins during development and carcinogenesis. Int J Dev Biol 2004; 48(5-6): 365-75. Philippe, C., Philippe, B., Fouqueray, B., Perez, J., Lebret, M., Baud, L. Protection from tumor necrosis factor-mediated cytolysis by platelets. Am J Pathol 1993; 143(6): 1713-23. Polesello, C. and Payre, F. Small is beautiful: what flies tell us about ERM protein function in development. Trends Cell Biol 2004; 14(6): 294-302. Rishi, A. K., Joyce-Brady, M., Fisher, J., Dobbs, L. G., Floros, J., VanderSpek, J., Brody, J. S., Williams, M. C. Cloning, characterization, and development expression of a rat lung alveolar type I cell gene in embryonic endodermal and neural derivatives. Dev Biol 1995; 167(1): 294-306. Rubbia-Brandt, Terris, B., Giostra, E., Dousset, B., Morel, P., Pepper, M. S. Lymphatic vessel density and vascular endothelial growth factor-C expression correlate with malignant behavior in human pancreatic endocrine tumors. Clin Cancer Res 2004; 10(20): 6919-28. Salgado, R., Vermeulen, P. B., Benoy, I., Weytjens, R., Huget, P., Van Marck, E., Dirix, L. Y. Platelet number and interleukin-6 correlate with VEGF but not with bFGF serum levels of advanced cancer patients. Br J Cancer 1999, 80(5-6): 892-7. Salven, P., Orpana, A., Joensuu, H. Leukocytes and platelets of patients with cancer contain high levels of vascular endothelial growth factor. Clin Cancer Res 1999; 5(3): 487-91. Schacht, V., Dadras, S. S., Johnson, L. A., Jackson, D. G., Hong, Y. K., Detmar, M. Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. Am J Pathol 2005; 166(3): 913-21. Schacht, V., Ramirez, M. I., Hong, Y. K., Hirakawa, S., Feng, D., Harvey, N., Williams, M., Dvorak, A. M., Dvorak, H. F., Oliver, G., Detmar, M. T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. Embo J 2003; 22(14): 3546-56. Schipper, J. H., Frixen, U. H., Behrens, J., Unger, A., Jahnke, K., Birchmeier, W. E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis. Cancer Res 1991; 51(23 Pt 1): 6328-37. Scholl, F. G., Gamallo, C., Vilaro, S., Quintanilla, M. Identification of PA2.26 antigen as a novel cell-surface mucin-type glycoprotein that induces plasma membrane extensions and increased motility in keratinocytes. J Cell Sci 1999; 112 ( Pt 24): 4601-13. Schoppmann, S. F., Bayer, G., Aumayr, K., Taucher, S., Geleff, S., Rudas, M., Kubista, E., Hausmaninger, H., Samonigg, H., Gnant, M., Jakesz, R., Horvat, R. Prognostic value of lymphangiogenesis and lymphovascular invasion in invasive breast cancer. Ann Surg 2004; 240(2): 306-12. Shibahara, J., Kashima, T., Kikuchi, Y., Kunita, A., Fukayama, M. Podoplanin is expressed in subsets of tumors of the central nervous system. Virchows Arch 2006; 448(4): 493-9. Shields, J. D., Borsetti, M., Rigby, H., Harper, S. J., Mortimer, P. S., Levick, J. R., Orlando, A., Bates, D. O. Lymphatic density and metastatic spread in human malignant melanoma. Br J Cancer 2004; 90(3): 693-700. Shimoyama, Y. and Hirohashi, S. Expression of E- and P-cadherin in gastric carcinomas. Cancer Res 1991; 51(8): 2185-92. Shinohara, M., Hiraki, A., Ikebe, T., Nakamura, S., Kurahara, S., Shirasuna, K., Garrod, D. R. Immunohistochemical study of desmosomes in oral squamous cell carcinoma: correlation with cytokeratin and E-cadherin staining, and with tumour behaviour. J Pathol 1998; 184(4): 369-81. Sipos, B., Klapper, W., Kruse, M. L., Kalthoff, H., Kerjaschki, D., Kloppel, G. Expression of lymphangiogenic factors and evidence of intratumoral lymphangiogenesis in pancreatic endocrine tumors. Am J Pathol 2004; 165(4): 1187-97. Sipos, B., Kojima, M., Tiemann, K., Klapper, W., Kruse, M. L., Kalthoff, H., Schniewind, B., Tepel, J., Weich, H., Kerjaschki, D., Kloppel, G. Lymphatic spread of ductal pancreatic adenocarcinoma is independent of lymphangiogenesis. J Pathol 2005; 207(3): 301-12. Sobin, L. H. and Fleming, I. D. TNM Classification of Malignant Tumors, fifth edition (1997). Union Internationale Contre le Cancer and the American Joint Committee on Cancer. Cancer 1997; 80(9): 1803-4. Stacker, S. A., Caesar, C., Baldwin, M. E., Thornton, G. E., Williams, R. A., Prevo, R., Jackson, D. G., Nishikawa, S., Kubo, H., Achen, M. G. VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. Nat Med 2001; 7(2): 186-91. Stefansson, I. M., Salvesen, H. B., Akslen, L. A. Vascular proliferation is important for clinical progress of endometrial cancer. Cancer Res 2006; 66(6): 3303-9. Stoker, M. and Perryman, M. An epithelial scatter factor released by embryo fibroblasts. J Cell Sci 1985; 77: 209-23. Straume, O., Jackson, D. G., Akslen, L. A. Independent prognostic impact of lymphatic vessel density and presence of low-grade lymphangiogenesis in cutaneous melanoma. Clin Cancer Res 2003; 9(1): 250-6. Sun, J. G., Wang, Y., Chen, Z. T., Zhuo, W. L., Zhu, B., Liao, R. X., Zhang, S. X. Detection of lymphangiogenesis in non-small cell lung cancer and its prognostic value. J Exp Clin Cancer Res 2009; 28: 21. Tahashi, Y., Matsuzaki, K., Date, M., Yoshida, K., Furukawa, F., Sugano, Y., Matsushita, M., Himeno, Y., Inagaki, Y., Inoue, K. Differential regulation of TGF-beta signal in hepatic stellate cells between acute and chronic rat liver injury. Hepatology 2002; 35(1): 49-61. Takeichi, M. Functional correlation between cell adhesive properties and some cell surface proteins. J Cell Biol 1977;75(2 Pt 1): 464-74. Thiery, J. P. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002; 2(6): 442-54. Tohma, Y., Yamashima, T., Yamashita, J. Immunohistochemical localization of cell adhesion molecule epithelial cadherin in human arachnoid villi and meningiomas. Cancer Res 1992; 52(7): 1981-7. Umbas, R., Schalken, J. A., Aalders, T. W., Carter, B. S., Karthaus, H. F., Schaafsma, H. E., Debruyne, F. M., Isaacs, W. B. Expression of the cellular adhesion molecule E-cadherin is reduced or absent in high-grade prostate cancer. Cancer Res 1992; 52(18): 5104-9. van Roy, F. and Berx, G. The cell-cell adhesion molecule E-cadherin. Cell Mol Life Sci 2008, 65(23): 3756-88. Verheul, H. M., Hoekman, K., Lupu, F., Broxterman, H. J., van der Valk, P., Kakkar, A. K., Pinedo, H. M. Platelet and coagulation activation with vascular endothelial growth factor generation in soft tissue sarcomas. Clin Cancer Res 2000; 6(1): 166-71. Vleminckx, K., Vakaet, L., Jr., Mareel, M., Fiers, W., van Roy, F. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell 1991; 66(1): 107-19. Watanabe, M., Okochi, E., Sugimoto, Y., Tsuruo, T. Identification of a platelet-aggregating factor of murine colon adenocarcinoma 26: Mr 44,000 membrane protein as determined by monoclonal antibodies. Cancer Res 1988; 48(22): 6411-6. Watanabe, M., Sugimoto, Y., Tsuruo, T. Expression of a Mr 41,000 glycoprotein associated with thrombin-independent platelet aggregation in high metastatic variants of murine B16 melanoma. Cancer Res 1990; 50(20): 6657-62. Weidner, N., Semple, J. P., Welch, W. R., Folkman, J. Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. N Engl J Med 1991; 324(1): 1-8. Wetterwald, A., Hoffstetter, W., Cecchini, M. G., Lanske, B., Wagner, C., Fleisch, H., Atkinson, M. Characterization and cloning of the E11 antigen, a marker expressed by rat osteoblasts and osteocytes. Bone 1996; 18(2): 125-32. Wheelock, M. J., Shintani, Y., Maeda, M., Fukumoto, Y., Johnson, K. R. Cadherin switching. J Cell Sci 2008; 121(Pt 6): 727-35. Wicki, A. and Christofori, G. The potential role of podoplanin in tumour invasion. Br J Cancer 2007; 96(1): 1-5. Wicki, A., Lehembre, F., Wick, N., Hantusch, B., Kerjaschki, D., Christofori, G. Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton. Cancer Cell 2006; 9(4): 261-72. Williams, H. K., Sanders, D. S., Jankowski, J. A., Landini, G., Brown, A. M. Expression of cadherins and catenins in oral epithelial dysplasia and squamous cell carcinoma. J Oral Pathol Med 1998; 27(7): 308-17. Wu, Z., Yang, L., Cai, L., Zhang, M., Cheng, X., Yang, X., Xu, J. Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an alpha-smooth muscle actin-Cre transgenic mouse. Respir Res 2007; 8: 1. Xu, X., Gimotty, P. A., Guerry, D., Karakousis, G., Van Belle, P., Liang, H., Montone, K., Pasha, T., Ming, M. E., Acs, G., Feldman, M., Barth, S., Hammond, R., Elenitsas, R., Zhang, P. J., Elder, D. E. Lymphatic invasion revealed by multispectral imaging is common in primary melanomas and associates with prognosis. Hum Pathol 2008; 39(6): 901-9. Yamada, K., Jordan, R., Mori, M., Speight, P. M. The relationship between E-cadherin expression, clinical stage and tumour differentiation in oral squamous cell carcinoma. Oral Dis 1997; 3(2): 82-5. Yanjia, H. and Xinchun, J. The role of epithelial-mesenchymal transition in oral squamous cell carcinoma and oral submucous fibrosis. Clin Chim Acta 2007; 383(1-2): 51-6. Yoshida-Noro, C., Suzuki, N., Takeichi, M. Molecular nature of the calcium-dependent cell-cell adhesion system in mouse teratocarcinoma and embryonic cells studied with a monoclonal antibody. Dev Biol 1984; 101(1): 19-27. Yuan, P., Temam, S., El-Naggar, A., Zhou, X., Liu, D. D., Lee, J. J., Mao, L. Overexpression of podoplanin in oral cancer and its association with poor clinical outcome. Cancer 2006; 107(3): 563-9. Zeng, Y., Opeskin, K., Horvath, L. G., Sutherland, R. L., Williams, E. D. Lymphatic vessel density and lymph node metastasis in prostate cancer. Prostate 2005; 65(3): 222-30. Zimmer, G., Oeffner, F., Von Messling, V., Tschernig, T., Groness, H. J., Klenk, H. D., Herrler, G. Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium. Biochem J 1999; 341 ( Pt 2): 277-84. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/41306 | - |
dc.description.abstract | 背景和目的:在上皮癌入侵的過程中,穩定的上皮細胞會出現類似間葉細胞的形態轉變,此過程稱為EMT(epithelial-mesenchymal transition)。具有淋巴組織的特異性的標記– podoplanin – 牽涉到許多人類上皮癌的腫瘤入侵,因此在本實驗中,我們研究了podoplanin與 “鈣黏著素E“(E-cadherin)在正常黏膜、口腔上皮變異、及口腔鱗狀細胞癌的表現來了解他們與腫瘤入侵、臨床病理特徵、及病人存活狀況的相關性。
材料和方法:透過免疫組織化學染色方法來評估podoplanin與鈣黏著素E於正常口腔黏膜、口腔上皮變異、口腔鱗狀細胞癌的表現。計算podoplanin及鈣黏著素E在正常口腔黏膜、口腔上皮變異、口腔鱗狀細胞癌細胞、及口腔鱗狀細胞癌腫瘤內外的淋巴管密度的標記分數,並評估此分數與臨床病理特徵及口腔鱗狀細胞癌病人存活的相關性。 結果: 我們發現腫瘤周圍的的淋巴管密度的減少與較大的腫瘤(P = 0.000)、遠端轉移(P = 0.023)、及較高的臨床分級(P = 0.001)有顯著關係。除此之外,腫瘤內的平均淋巴管密度的減少也與較大的腫瘤(P = 0.010) 顯著相關。在口腔鱗狀細胞癌的病人中,腫瘤周圍淋巴管密度小於34條血管/每100倍視野者,比大於等於34條血管/每100倍視野者有明顯較差的全存活率(P = 0.036)及疾病特異存活率(P = 0.020)。同時,在口腔鱗狀細胞癌病人中podoplanin的表現有顯著增加,並與局部淋巴轉移(P = 0.026)、遠端轉移(P = 0.021)、及較差的組織分化(P = 0.013)相關。且在口腔鱗狀細胞癌的病人中,podoplanin標計分數大於等於20%者,比小於20%者有明顯較差的全存活率(P = 0.033)。鈣黏著素E的減少在口腔鱗狀細胞癌病人與較年輕的族群(P = 0.002)、局部淋巴轉移(P = 0.016)、及較差的組織分化(P = 0.001)顯著相關。在口腔鱗狀細胞癌的病人中,podoplanin標計分數小於150%者,比大於等於150%者有明顯較差的全存活率(P = 0.016)及疾病特異存活率(P = 0.005)。而且在podoplanin表現高的腫瘤侵入前緣(invasion front)則發現鈣黏著素E明顯減少。 結論:腫瘤周圍的淋巴管密度可用做生物標記來預測口腔鱗狀細胞癌病人的腫瘤大小、臨床分級和預後。在口腔癌化的過程中發現有podoplanin表現的明顯增加及鈣黏著素E的減少,且與口腔鱗狀細胞癌病人的淋巴轉移及較差的預後相關。這顯示podoplanin及鈣黏著素E的標記分數也許可作為預測口腔鱗狀細胞癌的淋巴轉移及預後的有效生物標記。在大部分的口腔鱗狀細胞癌中,podoplanin鈣黏著素E可能是以EMT的方式參與腫瘤入侵,然而口腔鱗狀細胞癌入侵機制仍需要更進一步的研究。 | zh_TW |
dc.description.abstract | Background and purposes: The transformation from stable epithelial cell to the mesenchymal phenotype, named as epithelial-mesenchymal transition (EMT), was noted in the process of carcinoma invasion. The podoplanin, a specific lymphatic marker, is involved in the process of the cancer invasion in a variety of human carcinomas. In this study, we investigated the expression of podoplanin and E-cadherin in the normal oral mucosa (NOM), oral epithelial dysplasia (OED), and oral squamous cell carcinoma (OSCC) samples to understand their association with tumor invasion, clinicopathological parameters, and patients’ survival.
Materials and methods: The expression of podoplanin and E-cadherin in NOM, OED, and OSCC samples was evaluated by immunohistochemistry. The podoplanin and E-cadherin labeling scores (LSs) for NOM, OED, and OSCC samples and the intratumoral and peritumoral lymphatic vessel densities (iLVD and pLVD) in OSCC samples were counted and correlated with clinicopathological parameters and survival of OSCC patients. Results: We found that there was a significant reduction of the mean pLVD in OSCCs with larger tumor size (P = 0.000), with distant metastasis (P = 0.023), and with more advanced clinical stage (P = 0.001). In addition, there was also a significant decrease of the mean iLVD in OSCCs with larger tumor size (P = 0.010). OSCC patient with the pLVD < 34 vessels/100× field had a significantly poorer overall (P = 0.036) and disease-specific survival (P = 0.020) than those with the pLVD > 34 vessels/100× field. A significant increase in podoplanin expression was found in OSCCs with regional lymph node metastasis (P = 0.026), distant metastasis (P = 0.021), and less histologic differentiation (P = 0.013). Moreover, OSCC patient with the podoplanin LS > 20% had a significantly poorer overall survival than those with the podoplanin LS < 20% (P = 0.033). There was a significant decrease in E-cadherin expression in younger OSCC patients (P = 0.002) and in OSCCs with regional lymph node metastasis (P = 0.016) and less histologic differentiation (P = 0.001). OSCC patient with the E-cadherin LS < 150% had a significantly poorer overall (P = 0.016) and disease-specific survival (P = 0.005) than those with the E-cadherin LS > 150%. Furthermore, cancer cells in the invasion front with high podoplanin expression showed a significant loss of E-cadherin. Conclusions: The pLVD may act as a biomarker to predict the T status, clinical stage, and prognosis of OSCC patients. An increase of podoplanin expression and a loss of E-cadherin expression are noted during oral carcinogenesis and are associated with more lymph node metastasis and poorer prognosis of OSCC patients. This suggests that both podoplanin and E-cadherin LSs may be useful biomarkers for prediction of tumor metastasis in OSCCs and prognosis of OSCC patients. The podoplanin and E-cadherin may be involved in cancer invasion with EMT in most OSCCs. However, further studies on the mechanisms of OSCC invasion are needed. | en |
dc.description.provenance | Made available in DSpace on 2021-06-15T00:15:33Z (GMT). No. of bitstreams: 1 ntu-98-R96422002-1.pdf: 8271899 bytes, checksum: 97fc18ca12beb26d541926363fc22b50 (MD5) Previous issue date: 2009 | en |
dc.description.tableofcontents | 國立臺灣大學碩士學位論文 口試委員會審定書 .................................................1
謝誌 ...............................................................................................................6 中文摘要.........................................................................................................7 Abstract ........................................................................................................9 Introduction ...............................................................................................11 Literature Review ........................................................................................13 I. Tumor invasion .................................................................................13 II. Tumor lymphatic system ...................................................................15 III. E-cadherin ........................................................................................19 IV. Podoplanin ........................................................................................21 Purposes of this study .................................................................................28 Materials and Methods ..........................................................................29 I. Patients and specimens ...................................................................29 II. Immunostain ........................................................................................31 III. Scoring ...............................................................................................33 IV. Statistical analysis ..........................................................................34 Results ......................................................................................................36 I. Correlations between lymphatic vessel density in OSCC samples and clinicopathological parameters of OSCC patients ........................................36 II. Podoplanin and E-cadherin expressions in NOM, OED, and OSCC samples ....................................................................................................................37 III. Correlations between podoplanin or E-cadherin expression in OED samples and clinicopathological parameters of OED patients ...................38 IV. Correlations between podoplanin or E-cadherin expression in OSCC samples and clinicopathological parameters of OSCC patients ...................38 V. Correlation between podoplanin and E-cadherin expression ............39 Discussion ...............................................................................................40 I. Correlations between lymphatic vessel density and clinicopathological parameters of OSCC patients ...................................................................40 II. Podoplanin expression in NOM, OED, and OSCC samples ...................41 III. E-cadherin expression in NOM, OED, and OSCC samples ...................44 IV. Correlation between podoplanin and E-cadherin expression in OSCC samples ......................................................................................................45 Conclusions ...............................................................................................47 References ...............................................................................................48 Tables ......................................................................................................67 Figure legends ........................................................................................74 Figures ......................................................................................................78 | |
dc.language.iso | en | |
dc.title | Podoplanin及E-cadherin (鈣黏著素E) 於口腔鱗狀細胞癌與口腔上皮變異之表現 | zh_TW |
dc.title | Expression of podoplanin and E-cadherin in oral squamous cell carcinoma and oral epithelial dysplasia | en |
dc.type | Thesis | |
dc.date.schoolyear | 97-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 關學婉,張龍昌 | |
dc.subject.keyword | podplanin,鈣黏著素E,腫瘤入侵,淋巴管密度,口腔鱗狀細胞癌, | zh_TW |
dc.subject.keyword | podoplanin,E-cadherin,tumor invasion,lymphatic vessel density,oral squamous cell carcinoma, | en |
dc.relation.page | 91 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2009-06-16 | |
dc.contributor.author-college | 牙醫專業學院 | zh_TW |
dc.contributor.author-dept | 臨床牙醫學研究所 | zh_TW |
顯示於系所單位: | 臨床牙醫學研究所 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-98-1.pdf 目前未授權公開取用 | 8.08 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。