請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/40715
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 張璞曾(Fok-Ching Chong) | |
dc.contributor.author | Yi-Hui Wu | en |
dc.contributor.author | 吳怡慧 | zh_TW |
dc.date.accessioned | 2021-06-14T16:57:09Z | - |
dc.date.available | 2011-08-05 | |
dc.date.copyright | 2008-08-05 | |
dc.date.issued | 2008 | |
dc.date.submitted | 2008-07-29 | |
dc.identifier.citation | 1. Appel RE. Possibility of microcavitation from diagnostic ultrasound. IEEE Trans Ultrason Ferroelectr Freq Control. 1986;33(2):139-42.
2. Bain JR, Mackinnon SE, Hunter DA. Functional evaluation of complete sciatic, peroneal, and posterior tibial nerve lesions in the rat. Plast Reconstr Surg. 1989;83(1):129–38. 3. Baker KG, Robertson VJ, Duck FA. A review of therapeutic ultrasound: biophysical effects. Phys Ther. 2001;81(7):1351-8. 4. Bolt DM, Burba DJ, Hubert JD, Strain GM, Hosgood GL, Henk WG, Cho DY. Determination of functional and morphologic changes in palmar digital nerves after nonfocused extracorporeal shock wave treatment in horses. Am J Vet Res. 2004;65(12):1714-8. 5. Boucaud A, Garrigue MA, Machet L, Vaillant L, Patat F. Effect of sonication parameters on transdermal delivery of insulin to hairless rats. J Control Release. 2002;81(1-2):113-9. 6. Brown FF, Robinson ME, Riley JL 3rd, Gremillion HA, McSolay J, Meyers G. Better palpation of pain: reliability and validity of a new pressure pain protocol in TMD. Cranio. 2000;18(1):58-65. 7. Burgess S, Zderic V, Vaezy S. Image-guided acoustic hemostasis for hemorrhage in the posterior liver. Ultrasound Med Biol. 2007;33(1):113-9. 8. Busse JW, Bhandari M, Kulkarni AV, Tunks E. The effect of low-intensity pulsed ultrasound therapy on time to fracture healing: a meta-analysis. CMAJ. 2002;166(4):437-41. 9. Chan AH, Fujimoto VY, Moore DE, Held RT, Paun M, Vaezy S. In vivo feasibility of image-guided transvaginal focused ultrasound therapy for the treatment of intracavitary fibroids. Fertil Steril. 2004;82(3):723-30. 10. Chaussy C, Schmiedt E, Jocham D, Brendel W, Forssmann B, Walther V. First clinical experience with extracorporeally induced destruction of kidney stones by shock waves. J Urol. 1982;127(3):417-20. 11. Coodley EL. Bursitis and post-traumatic lesions: management with combined use of ultrasound and intra-articular hydrocortisone. Am Pract Dig Treat. 1960;11:181-8. 12. Crisci AR, Ferreira AL. Low-intensity pulsed ultrasound accelerates the regeneration of the sciatic nerve after neurotomy in rats. Ultrasound Med Biol. 2002;28(10):1335-41. 13. da Cunha A, Parizotto NA, Vidal Bde C. The effect of therapeutic ultrasound on repair of the achilles tendon (tendo calcaneus) of the rat. Ultrasound Med Biol. 2001;27(12):1691-6. 14. Durst HB, Blatter G, Kuster MS. Osteonecrosis of the humeral head after extracorporeal shock-wave lithotripsy. J Bone Joint Surg Br. 2002;84(5):744–6. 15. Fellinger K, Schmid J. Pathophysiology of rheumatism in the light of modern rheumatism therapy. Wien Klin Wochenschr. 1954;66(11):183-9. 16. Foley JL, Little JW, Starr FL 3rd, Frantz C, Vaezy S. Image-guided HIFU neurolysis of peripheral nerves to treat spasticity and pain. Ultrasound Med Biol. 2004;30(9):1199-207. 17. Foley JL, Little JW, Vaezy S. Image-guided high-intensity focused ultrasound for conduction block of peripheral nerves. Ann Biomed Eng. 2007;35(1):109-19. 18. Fry FJ, Sanghvi NT, Foster RS, Bihrle R, Hennige C. Ultrasound and microbubbles: their generation, detection and potential utilization in tissue and organ therapy--experimental. Ultrasound Med Biol. 1995;21(9):1227-37. 19. Fry WJ, Barnard JW, Fry EJ, Krumins RF, Brennan JF. Ultrasonic lesions in the mammalian central nervous system. Science. 1955;122(3168):517-8. 20. Halar EM, DeLisa JA, Brozovich FV. Peroneal nerve conduction velocity: the importance of temperature correction. Arch Phys Med Rehabil. 1981;62(9):439–43. 21. Hong CZ, Liu HH, Yu J. Ultrasound thermotherapy effect on the recovery of nerve conduction in experimental compression neuropathy. Arch Phys Med Rehabil. 1988;69(6):410-4. 22. Hu D, Hu R, Berde CB. Neurologic evaluation of infant and adult rats before and after sciatic nerve blockade. Anesthesiology. 1997;86(4):957–65. 23. Hynynen K. The threshold for thermally significant cavitation in dog’s thigh muscle in vivo. Ultrasound Med Biol. 1991;17(2):157-69. 24. Johns LD. Nonthermal effects of therapeutic ultrasound: the frequency resonance hypothesis. J Athl Train. 2002;37(3):293-9. 25. Kennedy JE, Wu F, ter Haar GR, Gleeson FV, Phillips RR, Middleton MR, Cranston D. High-intensity focused ultrasound for the treatment of liver tumours. Ultrasonics. 2004;42(1-9):931-5. 26. Kim HJ, Greenleaf JF, Kinnick RR, Bronk JT, Bolander ME. Ultrasound-mediated transfection of mammalian cells. Hum Gene Ther. 1996;7(11):1339-46. 27. Kim TY, Jung DI, Kim YI, Yang JH, Shin SC. Anesthetic effects of lidocaine hydrochloride gel using low frequency ultrasound of 0.5 MHz. J Pharm Pharm Sci. 2007;10(1):1-8. 28. Leung MC, Ng GY, Yip KK. Effect of ultrasound on acute inflammation of transected medial collateral ligaments. Arch Phys Med Rehabil. 2004;85(6):963-6. 29. Liu HM, Chao CM, Hsieh JY, Jiang CC. Humeral head osteonecrosis after extracorporeal shock-wave treatment for rotator cuff tendinopathy. A case report. J Bone Joint Surg Am. 2006;88(6):1353–6. 30. Loew M, Jurgowski W, Mau HC, Thomsen M. Treatment of calcifying tendinitis of rotator cuff by extracorporeal shock waves: a preliminary report. J Shoulder Elbow Surg. 1995;4(2):101-6. 31. Manganotti P, Amelio E. Long-term effect of shock wave therapy on upper limb hypertonia in patients affected by stroke. Stroke. 2005;36(9):1967-71. 32. Masters DB, Berde CB, Dutta SK, Griggs CT, Hu D, Kupsky W, Langer R. Prolonged regional nerve blockade by controlled release of local anesthetic from a biodegradable polymer matrix. Anesthesiology. 1993;79(2):340–6. 33. Merino G, Kalia YN, Delgado-Charro MB, Potts RO, Guy RH. Frequency and thermal effects on the enhancement of transdermal transport by sonophoresis. J Control Release. 2003;88(1):85-94. 34. Miller DL, Thomas RM. Thresholds for hemorrhages in mouse skin and intestine induced by lithotripter shock waves. Ultrasound Med Biol. 1995;21(2):249–57. 35. Mitragotri S, Kost J. Low-frequency sonophoresis: a noninvasive method of drug delivery and diagnostics. Biotechnol Prog. 2000;16(3):488-92. 36. Mitragotri S, Kost J. Transdermal delivery of heparin and low-molecular weight heparin using low-frequency ultrasound. Pharm Res. 2001;18(8):1151-6. 37. Monti D, Giannelli R, Chetoni P, Burgalassi S. Comparison of the effect of ultrasound and of chemical enhancers on transdermal permeation of caffeine and morphine through hairless mouse skin in vitro. Int J Pharm. 2001;229(1-2):131-7. 38. Murata R, Ohtori S, Ochiai N, Takahashi N, Saisu T, Moriya H, Takahashi K, Wada Y. Extracorporeal shockwaves induce the expression of ATF3 and GAP-43 in rat dorsal root ganglion neurons. Auton Neurosci. 2006;128(1-2):96-100. 39. Ohl CD, Wolfrum B. Detachment and sonoporation of adherent HeLa-cells by shock wave-induced cavitation. Biochim Biophys Acta. 2003;1624(1–3):131–8. 40. Ohtori S, Inoue G, Mannoji C, Saisu T, Takahashi K, Mitsuhashi S, Wada Y, Takahashi K, Yamagata M, Moriya H. Shock wave application to rat skin induces degeneration and reinnervation of sensory nerve fibers. Neurosci Lett. 2001;315(1-2):57-60. 41. Overgaard J, Gonzalez Gonzalez D, Hulshof MC, Arcangeli G, Dahl O, Mella O, Bentzen SM. Randomised trial of hyperthermia as adjuvant to radiotherapy for recurrent or metastatic malignant melanoma. European Society for Hyperthermic Oncology. Lancet. 1995;345(8949):540-3. 42. Paik NJ, Cho SH, Han TR Ultrasound therapy facilitates the recovery of acute pressure-induced conduction block of the median nerve in rabbits. Muscle Nerve. 2002;26(3):356-61. 43. Ramirez A, Schwane JA, McFarland C, Starcher B. The effect of ultrasound on collagen synthesis and fibroblast proliferation in vitro. Med Sci Sports Exerc. 1997;29(3):326-32. 44. Raso VV, Barbieri CH, Mazzer N, Fasan VS. Can therapeutic ultrasound influence the regeneration of peripheral nerves? J Neurosci Methods. 2005;142(2):185-92. 45. Rompe JD, Hopf C, Kullmer K, Heine J, Burger R, Nafe B. Low-energy extracorporal shock wave therapy for persistent tennis elbow. Int Orthop. 1996a;20(1):23-7. 46. Rompe JD, Hopf C, Nafe B, Burger R. Low-energy extracorporeal shock wave therapy for painful heel: a prospective controlled single-blind study. Arch Orthop Trauma Surg. 1996b;115(2):75-9. 47. Rosenthal D, Murphy F, Gottschalk R, Baxter M, Lycka B, Nevin K. Using a topical anaesthetic cream to reduce pain during sharp debridement of chronic leg ulcers. J Wound Care. 2001;10(1):503-5. 48. Sarifakioglu N, Terzioglu A, Cigsar B, Aslan G. EMLA and ear surgery: is it possible to achieve full-thickness anesthesia with EMLA? Dermatol Surg. 2004;30(3):395-8. 49. Shiau JM, Su HP, Chen HS, Hung KC, Lin SE, Tseng CC. Use of a topical anesthetic cream (EMLA) to reduce pain after hemorrhoidectomy. Reg Anesth Pain Med. 2008;33(1):30-5. 50. Skolarikos A, Alivizatos G, de la Rosette J. Extracorporeal shock wave lithotripsy 25 years later: complications and their prevention. Eur Urol. 2006;50(5):981–90. 51. Smith NB, Lee S, Shung KK. Ultrasound-mediated transdermal in vivo transport of insulin with low-profile cymbal arrays. Ultrasound Med Biol. 2003;29(8):1205-10. 52. Stewart JD. Focal peripheral neuropathies, 2nd edn. New York: Raven Press, 1993;Ch 2:11–33. 53. Sturtevant B. Shock wave physics of lithotriptors. In: Smith AD, Badlani GH, Bagley DH, Clayman RV, Jordan GH, Kavoussi LR, Lingeman JE, Preminger GM, Segura JW, eds. Smith’s textbook of endourology. St Louis: Quality Medical Publishing, 1996:529–52. 54. Tachibana K, Tachibana S. Transdermal delivery of insulin by ultrasonic vibration. J Pharm Pharmacol. 1991;43(4):270-1. 55. Tachibana K. Transdermal delivery of insulin to alloxan-diabetic rabbits by ultrasound exposure. Pharm Res. 1992;9(7):952-4. 56. Tachibana K, Tachibana S. Use of ultrasound to enhance the local anesthetic effect of topically applied aqueous lidocaine. Anesthesiology. 1993;78(6):1091-6. 57. Takahashi N, Ohtori S, Saisu T, Moriya H, Wada Y. Second application of low-energy shock waves has a cumulative effect on free nerve endings. Clin Orthop Relat Res. 2006;443:315–9. 58. ter Haar G. Therapeutic ultrasound. Eur J Ultrasound. 1999;9(1):3-9. 59. Uchida T, Sanghvi NT, Gardner TA, Koch MO, Ishii D, Minei S, Satoh T, Hyodo T, Irie A, Baba S. Transrectal high-intensity focused ultrasound for treatment of patients with stage T1b-2n0m0 localized prostate cancer: a preliminary report. Urology. 2002;59(3):394-8. 60. Umemura S, Yumita N, Nishigaki R, Umemura K. Sonochemical activation of hematoporphyrin: a potential modality for cancer treatment. Proc. IEEE Ultrasonics Symp. 1989:955-960. 61. Von Heijne M, Bredlöv B, Söderhäll S, Olsson GL. Propofol or propofol--alfentanil anesthesia for painful procedures in the pediatric oncology ward. Paediatr Anaesth. 2004;14(8):670-5. 62. Wanden SJ. A new direction for ultrasound therapy in sports medicine. Sports Med. 2003;33(2):95-107. 63. Wang CJ, Huang HY, Yang K, Wang FS, Wong M. Pathomechanism of shock wave injuries on femoral artery, vein and nerve. An experimental study in dogs. Injury. 2002;33(5):439-46. 64. Wang CJ, Wang FS, Yang KD, Weng LH, Hsu CC, Huang CS, Yang LC. Shock wave therapy induces neovascularization at the tendon-bone junction. A study in rabbits. J Orthop Res. 2003;21(6):984–9. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/40715 | - |
dc.description.abstract | 治療用聲波(therapeutic acoustic wave)包含體外震波治療(extracorporeal shock wave therapy)、物理治療用超音波(therapeutic ultrasound)與高能聚焦超音波治療(high intensity focused ultrasound)等,近來多運用於軟組織的治療,更有學者進一步應用於治療中樞神經疾病所引起之肢體痙攣與周邊神經的燒灼。然而,治療機轉尚不明確而且治療模式尚未建立,對於周邊神經除破壞外,是否會造成其它的效果也不得而知。故本研究利用動物實驗探討震波及超音波治療對於周邊神經之影響,可進一步的使用於治療痙攣或者是周邊神經引起之疼痛。另外,也利用治療用聲波配合止痛藥物,以經皮導入的方式,加速藥物達到止痛的效果。
首先乃在了解震波及高能聚焦超音波是否有神經阻斷效果及其可逆性,以震波或高能聚焦超音波施於大鼠之坐骨神經,並分析其神經電生理信號、功能性評估、以及神經切片之形態變化,了解不同治療劑量對周邊神經的影響;結果顯示震波治療可造成神經傳導速度短暫的小幅下降,並且不影響功能性動作,顯示了震波治療對周邊神經的高安全性,而高能聚焦超音波可造成神經傳導的阻斷長達一個月。 此文,本文亦研究震波與超音波治療對於促進藥物吸收之影響,並提出以神經電生理信號分析評估止痛藥物導入效果之方法。結果顯示震波治療對於促進藥物吸收之效果並不如超音波治療顯著,超音波導入止痛藥物將可應用於表面神經之麻醉,而達到止痛之效果,神經電生理信號評估並也達到客觀分析止痛藥物導入之效果,大幅改進目前無法量化之研究方式。 | zh_TW |
dc.description.abstract | The use of therapeutic acoustic waves in extracorporeal shock wave therapy (ESWT), therapeutic ultrasound and high intensity focused ultrasound (HIFU) were found to be effective in many clinical fields. Recently, ESWT was shown to be effective in reducing muscle tone among stroke patients. HIFU was also used to ablate peripheral nerve of rat in order to reduce spasticity and pain. However, the mechanism, treatment protocols, and biological effects of acoustic wave on peripheral nerve still remained unknown. On the other side, combined acoustic wave and drug treatment such as sonophoresis is also helpful. Some researchers suggested that the nerve function could be altered by sonophoresis but still lacking a clarify protocol to implement. The purpose of this dissertation was to explore: (1) the direct effects of shockwave and ultrasound on peripheral nerve; and (2) the quantitative effect of sonophoresis on peripheral nerve, both via animal studies.
The goal of first study was to clarify the effect of shockwave and HIFU lay on the nerve blockade and its reversibility. Shockwave or HIFU was applied on the sciatic nerve of rats. The electrophysiological and microscopic changes were observed and the functional index of nerve was evaluated under different intensity, frequency, and treatment duration. Collected results indicated that shockwave can induce reversible segmental demyelination in large-diameter fibers, with the electrophysiological changes being positively related to the intensity of the shockwaves. There were no significant changes in functional tests between sham and shockwave treatment groups. Besides, HIFU treatment could block the nerve conduction and affect the functional activities of rats for at least one month. Next, the transdermal drug delivery of shockwave and therapeutic ultrasound was investigated. A new method for evaluating the effect of sonophoresis in analgesic drug objectively was also conducted. The results suggested that the therapeutic ultrasound was effective as a carrier of transdermal drug delivery in promoting the surface anesthesia of analgesic drug. However, the shockwave sonophoresis was not as effective as ultrasound. The electrophysiological method also achieved the goal of quantifying the sonophoresis of analgesic drug objectively. | en |
dc.description.provenance | Made available in DSpace on 2021-06-14T16:57:09Z (GMT). No. of bitstreams: 1 ntu-97-F92921122-1.pdf: 8670726 bytes, checksum: c6498e10db9ee82774d7099a0f0f3938 (MD5) Previous issue date: 2008 | en |
dc.description.tableofcontents | 誌謝 i
摘要 iii ABSTRACT v TABLE OF CONTENTS vii LIST OF ABBREVIATIONS ix LIST OF FIGURES xi LIST OF TABLES xiii CHAPTER 1 INTRODUCTION 1 1.1 Motivation 1 1.2 Objective 3 1.3 Dissertation Organization 4 CHAPTER 2 BACKGROUND 5 2.1 Pain Mechanism 5 2.2 Therapeutic Ultrasound 9 2.3 Shockwave Therapy 14 CHAPTER 3 DIRECT APPLICATION OF ACOUSTIC WAVES 17 3.1 The Effects of Acoustic Wave on Peripheral Nerve 17 3.2 Materials and Methods 20 3.2.1 Experimental Animals 20 3.2.2 Shockwave Treatment 22 3.2.3 High Intensity Focused Ultrasound Treatment 24 3.2.4 Motor Nerve Conduction Studies 26 3.2.5 Functional Activity Assessment 29 3.2.6 Morphological Observation 32 3.2.7 Statistical Analysis 33 3.3 Results 34 3.3.1 Macro Observation after Treatment 34 3.3.2 Motor Nerve Conduction Studies 36 3.3.3 Functional Activity Assessment 38 3.3.4 Morphological Observation 42 3.4 Discussion 45 CHAPTER 4 ACOUSTIC SONOPHORESIS 49 4.1 Sonophoresis of Drugs 49 4.2 Materials and Methods 51 4.2.1 Eutectic Mixture of Local Anesthetics (EMLA) 51 4.2.2 Experimental Animals 52 4.2.3 Ultrasound Treatment 53 4.2.4 Shockwave Treatment 55 4.2.5 Heat Treatment 55 4.2.6 Sensory Conduction Studies 58 4.2.7 Statistical Analysis 59 4.3 Results 60 4.3.1 Latency of Action Potential 60 4.3.2 Time for Reduction in Velocity 62 4.3.3 Amplitude of Action Potential 64 4.3.4 Time for Reduction in Amplitude 66 4.4 Discussion 68 CHAPTER 5 CONCLUSION AND FUTURE WORK 71 5.1 Conclusion 71 5.2 Future Work 74 REFERENCES 77 PAPER LIST 85 | |
dc.language.iso | en | |
dc.title | 治療用聲波對於周邊神經之影響 | zh_TW |
dc.title | The Therapeutic Effects of Acoustic Waves on Peripheral Nerves | en |
dc.type | Thesis | |
dc.date.schoolyear | 96-2 | |
dc.description.degree | 博士 | |
dc.contributor.coadvisor | 陸哲駒(Jer-Junn Luh),陳文翔(Wen-Shian Chen) | |
dc.contributor.oralexamcommittee | 賴金鑫(Jin-Shin Lai),郭德盛(Te-Son Kuo),黃義侑(Yi-You Huang),林耀仁(Yaw-Jen Lin),詹曉龍(Hsiao-Long Chan) | |
dc.subject.keyword | 體外震波治療,超音波治療,高能聚焦超音波治療,神經電生理信號,超音波經皮導入, | zh_TW |
dc.subject.keyword | Extracorporeal shockwave therapy,therapeutic ultrasound,high intensity focused ultrasound,electrophysiology,sonophoresis, | en |
dc.relation.page | 86 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2008-07-30 | |
dc.contributor.author-college | 電機資訊學院 | zh_TW |
dc.contributor.author-dept | 電機工程學研究所 | zh_TW |
顯示於系所單位: | 電機工程學系 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-97-1.pdf 目前未授權公開取用 | 8.47 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。