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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 嚴震東(Chen-Tung Yen) | |
| dc.contributor.author | Meng-Tzu Hsieh | en |
| dc.contributor.author | 謝孟孜 | zh_TW |
| dc.date.accessioned | 2021-06-14T16:56:41Z | - |
| dc.date.available | 2009-08-05 | |
| dc.date.copyright | 2008-08-05 | |
| dc.date.issued | 2008 | |
| dc.date.submitted | 2008-07-30 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/40704 | - |
| dc.description.abstract | 慢性肌肉疼痛和其引起之痛覺過敏是難以治療的。利用酸性的生
理食鹽水(ph=4)重複注射於Sprague-Dawley(SD) 大鼠和許多品系的 小鼠的腓腸肌會產生持續的機械性痛覺過敏和慢性肌肉疼痛。此實驗 在研究杏仁核的活化與杏仁核T 型態鈣離子通道對於這種長期痛覺 過敏之發展的必要性。我們利用ERK 免疫化學組織染色和正子斷層 掃描 (PET) 來證實在酸誘導肌肉疼痛的動物中杏仁核受到活化。並 且經預埋大鼠雙側杏仁核的鋼管，注射兩種T型態鈣離子通道的阻斷 劑mibefradil和ethosuximide，可以防止SD大鼠在重複的注射酸性生 理食鹽水之後，對機械性刺激反應閾值下降的情形。綜合以上結果顯 示，杏仁核對於長期肌肉疼痛的產生上扮演重要角色。 | zh_TW |
| dc.description.abstract | Chronic muscle pain and hyperalgesia induced are disabling and difficult to treat.
Acidic Saline (pH=4.0) injected repeatedly into the gastrocnemius muscle produce persistent mechanical hyperalgesia and muscle pain in Sprague-Dawley (SD) rats and many mice strains. The objective of the present project was to test the hypothesis that activation of amygdala and amygdala T-type calcium channel is necessary in the development of this chronic hyperalgesia. We used the ERK immunochemistry stain and positron emission tomography (PET) scanner to demonstrate that activation of the amygdale in acid induced pain animals. Cannula was implanted bilaterally in both side of the amygdala of SD rats and two kinds of T-type calcium channel blockers, namely, mibefradil and ethosuximide, were injected. SD rats showed decrease of threshold to mechanical stimulation after repeated injection of acidic saline, and this sensitization phenomenon was prevented by pre-treatment of T-type calcium channel blockers in amygdale. The preliminary results suggest that amygdala play an important role in the expression of chronic muscle pain. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-14T16:56:41Z (GMT). No. of bitstreams: 1 ntu-97-R95b41022-1.pdf: 943746 bytes, checksum: d743ca41bfef722f24b19342028ee2e9 (MD5) Previous issue date: 2008 | en |
| dc.description.tableofcontents | 中文摘要................................................. 1
英文摘要................................................. 2 第一章 前言.............................................. 3 1.痛覺的傳遞路徑......................................... 3 2.酸誘導痛覺過敏現像..................................... 4 3.杏仁核與其傳輸路徑在痛覺傳遞上所扮演的角色............. 5 3.1.Spino-parabrachio-amygdaloid pain pathway............ 6 3.2.杏仁核中央區與痛覺之相關性........................... 7 4.T型鈣離子通道在疼痛中所扮演的角色...................... 8 5.研究目的............................................... 9 第二章 材料與方法....................................... 11 1.受試者................................................ 11 2.腦部手術.............................................. 11 3.藥品與藥物顱內注射.................................... 12 4.肌肉疼痛動物模式之誘導................................ 12 5.行為測試.............................................. 13 6.免疫組織化學染色...................................... 14 7.正子斷層造影.......................................... 15 8.統計分析.............................................. 16 第三章 實驗結果......................................... 17 1.重複注射酸性生理食鹽水於腓腸肌中導致雙側長期疼痛敏感化之現象.....................................................17 2.重複注射酸性生理食鹽水誘導杏仁核中ERK的活化........... 18 3. PET掃描影像顯示重複注射酸後杏仁核不對稱活化.......... 19 4.杏仁核內注射T型態鈣離子通道阻斷劑對於機械性痛覺敏感化之影響...................................................... 20 5.組織切片.............................................. 21 第四章 討論............................................. 22 1.酸誘導慢性肌肉疼痛大鼠動物模式之重建.................. 22 2.杏仁核中ERK活化與酸誘導之慢性肌肉疼痛之關係........... 23 3. PET 掃描影像重複證實杏仁核與酸誘導慢性肌肉疼痛之關係. 25 4.杏仁核T 型態鈣離子通道與酸誘導慢性肌肉疼痛之關係...... 27 參考文獻................................................ 29 附錄.................................................... 34 | |
| dc.language.iso | zh-TW | |
| dc.subject | 酸注射；杏仁核；肌肉疼痛 | zh_TW |
| dc.subject | acid injections | en |
| dc.subject | muscle pain | en |
| dc.subject | amygdala | en |
| dc.title | 杏仁核與酸注射引起之慢性肌肉疼痛之相關性 | zh_TW |
| dc.title | The Role of Amygdala in the Acid Induced Chronic Muscle Pain | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 96-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 曾凱元(Kai-Yuan Tzen),謝松蒼(Sung-Tsang Hsieh),陳志成(Chih-Cheng Chen),陳建璋(Chien-Chang Chen) | |
| dc.subject.keyword | 酸注射；杏仁核；肌肉疼痛, | zh_TW |
| dc.subject.keyword | acid injections,amygdala,muscle pain, | en |
| dc.relation.page | 52 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2008-07-30 | |
| dc.contributor.author-college | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 動物學研究所 | zh_TW |
| 顯示於系所單位： | 動物學研究所 | |
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