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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳志傑 | |
| dc.contributor.author | Chien-Fu Cheng | en |
| dc.contributor.author | 鄭見福 | zh_TW |
| dc.date.accessioned | 2021-06-14T16:45:17Z | - |
| dc.date.available | 2014-10-03 | |
| dc.date.copyright | 2011-10-03 | |
| dc.date.issued | 2011 | |
| dc.date.submitted | 2011-08-12 | |
| dc.identifier.citation | Ali, M., Reddy, R. N. and Mazumder, M. K. (2008). Electrostatic charge effect on respirable aerosol particle deposition in a cadaver based throat cast replica. Journal of Electrostatics 66:401-406.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/40343 | - |
| dc.description.abstract | 摘要
了解微粒在呼吸道的沉積特性，不但有助於粒狀汙染物的暴露評估，對於呼吸道疾病的藥物輸送效率設計也能提供有用的建議。上呼吸道模型是研究呼吸道微粒沉積效率常見的方法，已被沿用多年，但是過去的研究證明上呼吸道模型能有效代表真人實際沉積情形的方式，均為收集文獻中人體實驗的資料來互相比較，至今仍未有研究嘗試比較同一受試者之上呼吸道模型與真人測試資料的差異。為了探討上呼吸道模型的研究結果是否能有效代表真人的沉積情形，本研究找一名非吸菸的健康成年男性當受試者，以其電腦斷層掃描 (computed tomography, CT) 影像為基礎製作上呼吸道模型。CT影像諮詢專業的耳鼻喉科醫師協助判斷，避免混淆鼻道與鼻竇的範圍。使用超音波霧化器與定量輸出霧化器產生微米級與次微米級微粒。微粒經過射源 (25 mCi Am241)，使整個氣膠團帶電呈波茲曼平衡。使用氣動微粒分徑器 (偵測粒徑範圍大於0.7微米) 和微粒電移動度掃瞄分徑器 (偵測粒徑範圍小於0.7微米) 來量測上下游的微粒分佈與濃度。真人量測鼻入口出沉積率時，次微米級微粒改用快速微粒電移動度粒徑分析儀量測。實驗結果發現真人測試時，暫停呼吸的方式會顯著影響沉積率。上呼吸道模型的鼻入口出壓降與沉積率均與真人測試的結果很相似。隨著抽氣流率增加，微米級微粒的沉積率也會增加，代表微米級微粒的沉積機制是慣性衝擊。 | zh_TW |
| dc.description.provenance | Made available in DSpace on 2021-06-14T16:45:17Z (GMT). No. of bitstreams: 1 ntu-100-R98841013-1.pdf: 922477 bytes, checksum: f96c703a5237fae66822f8ef2e8fae6d (MD5) Previous issue date: 2011 | en |
| dc.description.tableofcontents | 口試委員審定書 I
致謝 III 摘要 IV ABSTRACT V 目錄 VI 表目錄 VIII 圖目錄 IX 一、研究緣起與目的 1 二、文獻回顧 4 2-1 呼吸道模型製作方法 4 2-2 模型材質 5 2-3 測試微粒特性 6 2-4 呼吸模擬方式 6 2-5 吸氣與呼氣方向 8 三、實驗材料與方法 9 3-1 呼吸道模型 9 3-2 實驗系統與方法 10 3-3 實驗儀器與設備 12 4-1新舊上呼吸道模型參數比較 13 4-2微粒粒徑校正 14 4-3比較 FMPS、SMPS (long DMA)、SMPS (nano DMA)的量測結果 14 4-4壓降 15 4-5比較上呼吸道模型修正前後沉積率 16 4-6比較兩種暫停呼吸方式的沉積率差異 17 4-7比較受試者與上呼吸道模型的沉積率 17 五、結論與建議 18 六、參考文獻 19 表目錄 表1. 比較上呼吸道模型nasal route修正前後幾何參數 24 圖目錄 圖1. 沉積率測試系統圖 23 圖2. 比較修正前後鼻腔截面積 25 圖3. APS量測液態微粒之校正曲線 26 圖4. 比較FMPS、SMPS (long DMA)、SMPS (nano DMA) 的量測結果 27 圖5. 上呼吸道模型修正前後的壓降 28 圖6. 受試者與修正後上呼吸道模型的壓降 29 圖7. 比較上呼吸道模型修正前後沉積率 30 圖8. 鼻毛對沉積率的影響 31 圖9. 比較兩種閉氣方式的差異並以上呼吸道模型模擬不自覺吐氣的影響 32 圖10. 比較上呼吸道模型與真人測試結果 33 圖11. 比較本研究的真人測試資料與文獻數據的差異 34 | |
| dc.language.iso | zh-TW | |
| dc.subject | 電腦斷層掃描 | zh_TW |
| dc.subject | 上呼吸道模型 | zh_TW |
| dc.subject | 微粒沉積效率 | zh_TW |
| dc.subject | 真人測試 | zh_TW |
| dc.subject | computed tomography | en |
| dc.subject | in vivo measurement | en |
| dc.subject | aerosol deposition | en |
| dc.subject | cast | en |
| dc.title | 上呼吸道模型微粒沉積特性研究 | zh_TW |
| dc.title | Characteristics of Aerosol Deposition in Human Upper Airway Casts Based on Computed Tomography: an in vivo Validation | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 99-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 葉德輝,林文印,張振平,蕭大智 | |
| dc.subject.keyword | 上呼吸道模型,微粒沉積效率,電腦斷層掃描,真人測試, | zh_TW |
| dc.subject.keyword | cast,aerosol deposition,computed tomography,in vivo measurement, | en |
| dc.relation.page | 34 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2011-08-12 | |
| dc.contributor.author-college | 公共衛生學院 | zh_TW |
| dc.contributor.author-dept | 職業醫學與工業衛生研究所 | zh_TW |
| 顯示於系所單位： | 職業醫學與工業衛生研究所 | |
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