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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 陳俊宏(Jiun-Hong Chen) | |
dc.contributor.author | Jia-Jun Liao | en |
dc.contributor.author | 廖嘉駿 | zh_TW |
dc.date.accessioned | 2021-06-14T16:43:08Z | - |
dc.date.available | 2008-08-04 | |
dc.date.copyright | 2008-08-04 | |
dc.date.issued | 2008 | |
dc.date.submitted | 2008-07-31 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/40237 | - |
dc.description.abstract | Sphingosin 1-Phosphate(S1P)是一種由人體自然製造的小分子水解磷酸脂,其主要的來源為血小板以及被活化的巨嗜細胞。S1P已知能夠經由其第一型特異性受器(S1P1) 來調控T細胞的生長和移動,但對於型干擾素(IFN-)表現的抑制,卻是目前在cytokine的調控上,S1P唯一確定的功能。我之前的研究顯示,S1P能夠促進S1P1大量表現(S1P1-overexpressed)CD4 T細胞分化成為Th17細胞,並分泌interleukin-17(IL-17)。因此我認為,在原生型的小鼠脾臟CD4 T細胞上,S1P可能也具有相同的功能。研究結果顯示,S1P能夠增加IL-17蛋白質的表現量、抑制IFN-和IL-4的分泌,並促進Th17細胞的分化。S1P對於IL-17表現的調控,可能是經由其特異性受器S1P1來達成的。同時,S1P的功能會受到IFN-、IL-4和IL-27的抑制。細胞訊息傳遞路徑的研究指出,S1P可能是透過Gi、Protein Kinase C以及轉錄因子NF-B來誘發IL-17基因的表現。此外,我也證實了S1P1特異性抑制劑FTY720能夠有效的預防S1P所造成的IL-17表現量增加以及Th17細胞的分化。本研究為首度在體外培養(in vitro)的環境下證明,S1P能夠促進Th17細胞的分化和IL-17的表現。同時,我亦為免疫抑制劑FTY720的作用機轉,提出了一個新的理論基礎。 | zh_TW |
dc.description.abstract | Sphingosine 1-phosphate (S1P) in blood and lymph controls T cell traffic and proliferation through type 1 S1P receptor (S1P1) signals, but suppression of IFN-γ generation has been the only consistently observed effect on T cell cytokines. That S1P enhances development of Th17 cells from antigen-challenged transgenic S1P1-overexpressing CD4 T cells suggested that the S1P-S1P1 axis may promote expansion of Th17 cells in wild type mice. In a model of development of Th17 cells from CD4 T cells stimulated by anti-CD3 plus anti-CD28 antibodies and a mixture of TGF-β1, IL-1 and IL-6, S1P enhanced their number and IL-17-generating activity the same as IL-23. As for IL-23 enhancement of development of Th17 cells, that by S1P was prevented by IL-4 plus IFN-γ and by IL-27. Prevention of S1P augmentation of Th17 cell development by the S1P receptor agonist and downregulator FTY720 implies that FTY720 immunosuppression is attributable partially to inhibition of Th17-mediated inflammation. | en |
dc.description.provenance | Made available in DSpace on 2021-06-14T16:43:08Z (GMT). No. of bitstreams: 1 ntu-97-R93b41018-1.pdf: 599728 bytes, checksum: bc622b9646a79bf9a979afcd11492ca3 (MD5) Previous issue date: 2008 | en |
dc.description.tableofcontents | 目錄
頁碼 口試委員會審定書•••••••••••••••••••••••••I 誌謝••••••••••••••••••••••••••••••II 中文摘要••••••••••••••••••••••••••••III 英文摘要••••••••••••••••••••••••••••IV 目錄•••••••••••••••••••••••••••••••V 圖目錄•••••••••••••••••••••••••••••VI Introduction•••••••••••••••••••••••••••1 Materials and Methods••••••••••••••••••••••10 Results•••••••••••••••••••••••••••••14 Discussion•••••••••••••••••••••••••••19 References•••••••••••••••••••••••••••27 | |
dc.language.iso | en | |
dc.title | Sphingosine 1-Phosphate誘發小鼠Th17細胞分化之研究 | zh_TW |
dc.title | Alternative Signaling of Th17 Development by Sphingosing 1-Phosphate | en |
dc.type | Thesis | |
dc.date.schoolyear | 96-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 宋延齡(Yes-Ling Song),李士傑(Shyh-Jye Lee) | |
dc.subject.keyword | Sphingosine 1-Phosphate,Th17 Cells,IL-17,分化,免疫抑制, | zh_TW |
dc.subject.keyword | Sphingosine 1-Phosphate,Th17 Cells,IL-17,Differentiation,FTY720, | en |
dc.relation.page | 53 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2008-08-01 | |
dc.contributor.author-college | 生命科學院 | zh_TW |
dc.contributor.author-dept | 動物學研究所 | zh_TW |
顯示於系所單位: | 動物學研究所 |
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