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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 徐善慧 | |
dc.contributor.author | Cheng-Wei Chen | en |
dc.contributor.author | 陳正瑋 | zh_TW |
dc.date.accessioned | 2021-05-13T08:39:40Z | - |
dc.date.available | 2016-03-08 | |
dc.date.available | 2021-05-13T08:39:40Z | - |
dc.date.copyright | 2016-03-08 | |
dc.date.issued | 2016 | |
dc.date.submitted | 2016-02-11 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/3981 | - |
dc.description.abstract | 材料表面的性質如親疏水性對生物相容性有很大的影響,因此若應用於生醫領域需要特別注意。許多高分子當所處環境改變時,化學結構會有表面重排的現象。而表面重排的程度與速率與化學結構、表面改質和不同溶液環境有關,故須加以探討以得知如何改變材料之性質以進行改質。本研究探討水性生物可分解聚胺酯製成之薄膜,在引入銀奈米粒子前後於不同溶液(二次去離子水、PBS及培養液)水接觸角隨時間之變化,以探討聚胺酯、銀奈米粒子與不同環境間的互動。此外也觀察軟鏈段被部分取代之聚胺酯薄膜,於不同溶液中水接觸角隨時間的變化,以得知化學結構如何影響表面親水性的變化。另外以有機溶劑溶解聚胺酯重新成膜,研究不同溶液環境中成膜,對之後水接觸角變化的影響。最後探討殼聚醣薄膜加入銀奈米粒子前後,於不同溶液中表面親水性的變化,以了解殼聚醣、銀奈米粒子和鈣離子等之間的互動。同時也以全反射式紅外線光譜計算出表面硬鏈段比例,以驗證表面重排現象與趨勢。透過歸納以上水接觸角變化之原因,可得知如何調整材料表面重排現象與以利於不同生醫用途之用。 | zh_TW |
dc.description.abstract | The surface properties such as hydrophilicity of material have a huge influence on the biocompatibility and therefore should be considered carefully when the material is applied in the biomedical field. Various types of polymers respond to different environments, for which the functional groups close to the surface may undergo rearrangement. The extent and rate of the surface rearrangement depend on chemical structure, surface modification and different solutions in which the material is immersed. Therefore, finding factors accounting for the changes of surface properties is essential to adjust to different applications. In this study, films of waterborne polyurethane (PU) and those contain silver nanoparticle (Ag NPs) were immersed in double-deionized water (DDW), phosphate-buffered saline (PBS) and αMEM medium, and the water contact angles varying with time were measured. The interactions between PU, Ag NPs and the environment was investigated. In addition, PU with a part of soft segment replaced with different diols were also studied to find out how the different chemical structure affect the hydrophilicity of the surface of PU films. PU films were dissolved in organic solvent and new films were prepared. By measuring the water contact angles changing with time of these films in aqueous solutions, we could determine whether the solvent in which the films formed influence the surface properties. Films of biological polymers chitosan were also studied to better understand the interaction between chitosan, Ag NPs and calcium ions. Moreover, attenuated total reflectance spectroscopy was conducted for selected films to determine the ratio of hard segment near the surface to demonstrate the surface rearrangement. By finding the causes for the change of surface properties, we would be able to fine-tune the surface rearrangement in order to make the material suitable for different biomedical applications. | en |
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dc.description.tableofcontents | 口試委員會審定書........................................................................................................ i
致謝............................................................................................................................... ii 摘要.............................................................................................................................. iii Abstract ....................................................................................................................... iv 圖目錄............................................................................................................................x 表目錄......................................................................................................................... xii 第一章 文獻回顧……………………………………………………………………1 1.1.表面重排高分子與生醫應用………………………………………………..1 1.2.表面重排高分子改質………………………………………………………..3 1.3. 無機奈米粒子與生醫應用…………………………………………………4 1.4. 奈米粒子毒性與表面改質…………………………………………………5 1.4.1. 奈米粒子毒性……………………………………………………….6 1.4.2. 表面改質…………………………………………………………….8 1.5. 聚胺酯………………………………………………………………………9 1.5.1. 油性與水性聚胺酯………………………………………………….9 1.5.2. 生物可降解聚胺酯………………………………………………...11 1.5.3. 水性聚胺酯奈米粒子與生醫應用………………………………...12 1.6. 殼聚糖與生醫運用………………………………………………………..13 1.7. 研究動機與目的…………………………………………………………..14 第二章 研究方法……………………………………………………………………16 2.1. 研究架構…………………………………………………………………..16 2.2. 水性生物可降解聚胺酯薄膜之製備……………………………………..19 2.2.1. 水性生物可降解聚胺酯薄膜之製備……………………………...18 2.2.2. 水性生物可降解聚胺酯薄膜包覆銀奈米粒子之製備…………...21 2.3. 不同軟鏈段取代之聚胺酯薄膜之製備…………………………………..22 2.4. 油性成膜之聚胺酯薄膜之製備…………………………………………..22 2.5. 殼聚糖薄膜之製備………………………………………………………..23 2.5.1. 殼聚醣薄膜之製備………………………………………………...23 2.5.2. 殼聚醣薄膜包覆銀奈米粒子之製備……………………………...23 第三章 實驗結果……………………………………………………………………23 3.1. 水性生物可降解聚胺酯與包覆銀奈米子後製成之薄膜………………..25 3.1.1. 水性生物可降解聚胺酯與包覆銀奈米粒子後製成之薄膜……...25 3.1.2. 水接觸角分析……………………………………………………...25 3.1.3. 減弱性全反射式紅外線光譜分析………………………………...26 3.2. 軟鏈段部分取代之聚胺酯薄膜…………………………………………..26 3.2.1. 軟鏈段部分取代之聚胺酯薄膜…………………………………...26 3.2.2. 水接觸角分析……………………………………………………...27 3.2.3. 減弱性全反射式紅外線光譜分析………………………………...28 3.2.4. 吸水率…………………………………………………………….28 3.3. 以DMAc溶解後重新製備之水性生物可降解聚胺酯薄膜…………….28 3.3.1. 以DMAc溶解後重新製備之水性生物可降解聚胺酯薄膜……..28 3.3.2. 水接觸角分析……………………………………………………...29 3.3.3 減弱性全反射式紅外線光譜分析…………………………………29 3.4. 殼聚醣與包覆銀奈米粒子後製成之薄膜………………………………..30 3.4.1. 殼聚醣與包覆銀奈米粒子後製成之薄膜………………………...30 3.4.2. 水接觸角分析……………………………………………………...30 第四章 討論…………………………………………………………………………32 4.1. 水性生物可降解聚胺酯與包覆銀奈米子後製成之薄膜………………..32 4.1.1. 水接觸角與減弱性全反射式紅外線光譜分析…………………...32 4.2. 軟鏈段部分取代之聚胺酯薄膜…………………………………………..34 4.2.1. 水接觸角分與減弱性全反射式紅外線光譜分析………………...34 4.2.2. 吸水率……………………………………………………………...35 4.3. 以DMAc溶解後重新製備之水性生物可降解聚胺酯薄膜…………….35 4.3.1. 水接觸角分析與減弱性全反射式紅外線光譜分析……………...35 4.4. 殼聚醣與包覆銀奈米粒子後製成之薄膜………………………………..36 4.4.1. 水接觸角分析……………...............................................................36 第五章 結論…………………………………………………………………………38 參考文獻……………………………………………………………………………..55 圖 2-1. 實驗架構圖…………………………………………………………………18 圖 2-2. PCL100聚胺酯合成步驟圖…………………………………………………20 圖 3-1. PCL100及PCL100包覆奈米銀離子薄膜浸泡於二次去離子水中接觸角 隨時間之變化………………………………………………………………………..46 圖 3-2. PCL100及PCL100包覆奈米銀離子薄膜浸泡於PBS中接觸角隨時間之變化…………………………………………………………………………………..46 圖 3-3. PCL100及PCL100包覆奈米銀離子薄膜浸泡於medium中接觸角隨時間之變化………………………………………………………………………………..47 圖 3-4. PCL100、EB20PCL80、HB20PCL80及LL20PCL80薄膜浸泡於二次去離子水中接觸角隨時間之變化…………………………………………………………..47 圖 3-5. PCL100及EB20PCL80薄膜浸泡於PBS中接觸角隨時間之變化………48 圖 3-6. PCL100及EB20PCL80薄膜浸泡於medium中接觸角隨時間之變化…..48 圖 3-7. PCL100及以DMAc重新溶解之PCL100薄膜浸泡於二次去離子水中接觸角隨時間之變化……………………………………………………………………..49 圖 3-8. 殼聚醣及殼聚醣包覆銀奈米粒子薄膜浸泡於二次去離子水中接觸角隨時間之變化……………………………………………………………………………..49 圖 3-9. 殼聚醣及殼聚醣包覆銀奈米粒子薄膜浸泡於PBS中接觸角隨時間之變化……………………………………………………………………………………..50 圖 3-10. 殼聚醣及殼聚醣包覆銀奈米粒子薄膜浸泡於medium中接觸角隨時間之變化…………………………………………………………………………………..50 圖 3-11. PCL100及PCL100包覆奈米銀離子薄膜浸泡於二次去離子水中表面硬鏈 段比例隨時間之變化………………………………………………………………..51 圖 3-12. PCL100薄膜浸泡於 (A)二次去離子水 (B)PBS (C)medium 及EB20PCL80薄膜浸泡於 (D)二次去離子水 (E)PBS (F)medium 後ATR-IR光譜隨時間變化……………………………………………………………………………..51 圖 3-13. (A) PCL100 (B)EB20PCL80浸泡於不同溶液後表面硬鏈段比例隨時間之變化…………………………………………………………………………………..52 圖 3-14. PCL100及EB20PCL80浸泡於(A)二次去離子水 (B)PBS (C)medium 中表面硬鏈段比例隨時間之變化………………………………………………………..53 圖 3-15. (A)PU/Ag (B)PU/DMAc薄膜浸泡於二次離子水後ATR-IR光譜隨時間變化……………………………………………………………………………………..54 圖3-16. PCL100及PCL100/DMAc薄膜浸泡於二次去離子水中表面硬鏈段比例隨時間之變化…………………………………………………………………………..54 表 2-1. PCL100聚胺酯配方與比例…………………………………………………21 表 2-2. PCL100聚胺酯包覆銀奈米粒子薄膜製備之成分比例……………………22 表 2-3. 殼聚醣包覆銀奈米粒子薄膜製備之成分比例……………………………23 表 3-1. PCL100、PCL100包覆銀奈米粒子及以DMAc重新溶解之PCL100薄膜於不同溶液中水接觸角隨時間之變化數值……………………………………………..43 表 3-2. EB20PCL80、LL20PCL80及HB20PCL80薄膜於不同溶液中水接觸角隨時間之變化數值………………………………………………………………………..44 表 3-3. 殼聚醣及殼聚醣包覆銀奈米粒子薄膜於不同溶液中水接觸角隨時間之變化數值………………………………………………………………………………..45 表 3-4. 各種PU薄膜24小時之吸水率……………………………………………..45 | |
dc.language.iso | zh-TW | |
dc.title | 水性可降解聚胺酯與殼聚醣薄膜之表面重排現象 | zh_TW |
dc.title | Surface rearrangement of waterborne biodegradable polyurethane and chitosan films | en |
dc.type | Thesis | |
dc.date.schoolyear | 104-1 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 張振榮,戴念國,謝馥羽 | |
dc.subject.keyword | 表面重排,水性生物可降解聚胺酯,銀奈米粒子,殼聚醣, | zh_TW |
dc.subject.keyword | surface rearrangement,waterborne biodegradable polyurethane,silver nanoparticles,chitosan, | en |
dc.relation.page | 65 | |
dc.rights.note | 同意授權(全球公開) | |
dc.date.accepted | 2016-02-13 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 高分子科學與工程學研究所 | zh_TW |
顯示於系所單位: | 高分子科學與工程學研究所 |
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