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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳青周 | |
| dc.contributor.author | Ya-Jen Chang | en |
| dc.contributor.author | 張雅貞 | zh_TW |
| dc.date.accessioned | 2021-06-13T17:26:23Z | - |
| dc.date.available | 2005-01-24 | |
| dc.date.copyright | 2005-01-24 | |
| dc.date.issued | 2005 | |
| dc.date.submitted | 2005-01-18 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/39341 | - |
| dc.description.abstract | 本論文探討急性呼吸道徵候群冠狀病毒(SARS-CoV)感染肺細胞，或幽門螺旋桿菌(Helicobactor pylori)感染胃上皮細胞，引發發炎或致癌基因包括ICAM-1、IL-8、COX-2或cyclin D1表現之訊息傳遞路徑。
IFN-γ在肺上皮細胞NCI-H292磷酸化STAT1的Y701，受PKC和Src kinase 之調控，IFN-γ和TPA均可活化c-Src而磷酸化STAT1之Y701，且增加這兩者之交互作用。IFN-γ可磷酸化JAK1/2和PLC-γ 之tyrosine，後者之作用受AG490 (JAK 抑制劑)抑制，IFN-γ並增加JAK1/2 和PLCγ之交互作用，表示JAK1/2 可調控PLC-γ的活化，此結果結合先前之發現，證實IFN-γ經由JAK1/2活化PLC-γ、PKC、c-Src 和STAT1；AG490可抑制IFN-γ所引發之JAK1/2 和STAT1之交互作用，但是對TPA之此項作用無影響，因此IFN-γ可經由兩種路徑引發ICAM-1之表現，一為JAK1/2 /PLCγ/PKC/c Src/STAT1，另一為JAK1/2直接活化STAT1。 SARS-CoV 棘蛋白可引發肺細胞釋放IL-8。轉殖SARS-CoV 棘蛋白可活化 IL-8 promoter與AP1，對NF- | zh_TW |
| dc.description.abstract | The mechanism of SARS-CoV or Helicobactor pylori infection-induced inflammation or carcinogenesis was investigated in this study. Several novel signaling pathways were explored in the regulation of ICAM-1, IL-8, COX-2, or cyclin D1 gene expression.
In lung epithelial NCI-H292 cells, the signaling pathway for IFN- | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T17:26:23Z (GMT). No. of bitstreams: 1 ntu-94-D90443006-1.pdf: 34256774 bytes, checksum: 83b42e8ae7f5fc0728d301d8fe7952aa (MD5) Previous issue date: 2005 | en |
| dc.description.tableofcontents | 縮寫表 (Abbreviations)...............................................................................1
中文摘要 (Abstract in Chinese)..................................................................5 英文摘要 (Abstract in English)...................................................................9 第一章、 緒論 (Introduction)...............................................................................13 第一節、 嚴重急性呼吸道症候群 (Severe Acute Respiratory Syndrome,SARS) 之發炎反應.......................................13 第二節、 幽門螺旋桿菌 (Helicobacter pylori, H. pylori) 感染與胃癌形成之相關機轉..........................................31 第三節、 第二型環氧化酶 (Cyclooxygenase-2, COX-2) 與腫瘤之關係..................................................................51 第四節、 血管新生與腫瘤之形成..................................................57 第五節、 細胞周期素D1 (Cyclin D1) 之結構、表現與功能…..63 研究動機..............................................................................................70 第二章、 實驗材料與方法 (Materials and Methods)............................73 第三章、 SARS-CoV在肺細胞引發發炎基因表現之探討 (SARS-CoV-induced inflammatory gene expression in lung cells)……………………………………………………….....91 第一節、 丙型干擾素 (IFN-γ)引發肺細胞表現黏著分子之 機轉探討...........................................................................91 第二節、 SARS冠狀病毒引發介白質-8 (Interleukin 8, IL-8) 釋放之機轉......................................................................111 第四章、 幽門螺旋桿菌在胃細胞引發致癌基因表現之探討 (H. pylori induced gene expression in gastric cancer cells)………..…..131 第一節、 幽門螺旋桿菌引發第二型環氧化酶表現之機 轉探討..............................................................................131 第二節、 幽門螺旋桿菌引發血管新生與癌細胞轉移之機轉探 討.....................................................................................153 第三節、 幽門螺旋桿菌引發細胞周期素D1表現與細胞週期調控之 機轉…………………………………………………….176 第五章、 結論與未來展望 (Conclusions and Perspectives)……..…..195 參考文獻 (References)..............................................................................199 著作發表與獎項 (Publications and Honors).............................................237 | |
| dc.language.iso | zh-TW | |
| dc.subject | 癌症 | zh_TW |
| dc.subject | 急性呼吸道徵候群 | zh_TW |
| dc.subject | 幽門桿菌 | zh_TW |
| dc.subject | 發炎 | zh_TW |
| dc.subject | 訊息傳遞 | zh_TW |
| dc.subject | 感染 | zh_TW |
| dc.subject | signal transduction | en |
| dc.subject | cancer | en |
| dc.subject | SARS | en |
| dc.subject | Helicobacter pylori | en |
| dc.subject | inflammation | en |
| dc.subject | infection | en |
| dc.title | 感染引發之發炎與致癌機轉之探討 | zh_TW |
| dc.title | Regulatory mechanisms of infection-induced inflammation and carcinogenesis | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 93-1 | |
| dc.description.degree | 博士 | |
| dc.contributor.oralexamcommittee | 林肇堂,吳明賢,楊春茂,賴明宗,楊泮池 | |
| dc.subject.keyword | 急性呼吸道徵候群,癌症,感染,訊息傳遞,發炎,幽門桿菌, | zh_TW |
| dc.subject.keyword | inflammation,cancer,infection,SARS,Helicobacter pylori,signal transduction, | en |
| dc.relation.page | 237 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2005-01-19 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 藥理學研究所 | zh_TW |
| 顯示於系所單位： | 藥理學科所 | |
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