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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳秀熙,張淑惠 | |
| dc.contributor.author | Yen-Po Yeh | en |
| dc.contributor.author | 葉彥伯 | zh_TW |
| dc.date.accessioned | 2021-06-13T16:59:30Z | - |
| dc.date.available | 2006-02-18 | |
| dc.date.copyright | 2005-02-18 | |
| dc.date.issued | 2005 | |
| dc.date.submitted | 2005-02-03 | |
| dc.identifier.citation | 1. Alland D, Kalkut GE, Moss AR, et al. Transmission of tuberculosis in New York city. An anlysis by DNA fingerprinting and conventional epidemiologic methods N Engl J Med 1994;330:1710-6.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/39053 | - |
| dc.description.abstract | The resurgence of tuberculosis (TB) in Taiwan began since 1991, with a later tremendous soar-up after 1996. The epidemiological characteristics of TB in Taiwan have two points and one emerging issue. The first is the high coverage, i.e. more than 90%, of BCG vaccination in the general population. The second is the persistent high (around three to four times that of general population) TB incidence in the aboriginal mountain townships. The interference of BCG vaccination with tuberculin skin test (TST) is important and should determine the feasibility of TST as a tool for detecting TB infection in Taiwan, when TST was increasingly used for contact investigation and treatment of latent TB infection (LTBI) during the past decade. The unusual high TB incidence in aboriginal mountain areas raises the question: whether the resurgence of TB in Taiwan could be attributed to the preponderance of TB cases in the aboriginal? What’s the major pattern of transmission links between mountain areas and their surroundings? Answers to these questions have profound implications for developing TB control strategies in Taiwan. The emerging issue pertains to the increasing number of foreign laborers from countries with high-prevalence of TB. During past decade, more than 350,000 immigrants have entered this country as workers, housewives and babysitters. The potential impact of immigrant TB needs further evaluation. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T16:59:30Z (GMT). No. of bitstreams: 1 ntu-94-F85821204-1.pdf: 2032403 bytes, checksum: be80152235d97423603b97fd8885d5cd (MD5) Previous issue date: 2005 | en |
| dc.description.tableofcontents | 致謝 vii
Abstract viii Specific Aims xiii Chapter 1 Introduction 1 Chapter 2 Literature Review 12 I. General Review of Tuberculosis 12 1. Global Burden of Tuberculosis 12 2. Disease Natural History of Tuberculosis 13 3. Transmission of Tuberculosis 15 4. Recent Findings of Molecular Epidemiology and the Re-definition of Contacts 16 5. Infective Sources of Tuberculosis 19 6. Risk of Developing Tuberculosis Following Infection 21 7. Models for the Disease Natural History of Tuberculosis 22 8. Control Strategy of Tuberculosis 23 9. Tuberculin Skin Test 24 10. BCG Vaccination and TST 25 11. Treatment of Latent Tuberculosis Infection 27 12. Revisit to TB Control Strategies 32 13. TB Control Strategies: US Experience 33 II. Tuberculosis in Taiwan 36 1. Mortality 36 2. Morbidity 37 3. Human Immunodeficiency Virus and Tuberculosis 38 4. Anti-tuberculosis Drug Resistance 39 III. Interpretation of Incidence of Tuberculosis in Mountain Areas and Surrounding Townships: Dose-response Relationship by Geographic Analysis 40 IV. Brief Summary 46 Chapter 3 Materials and Methods 50 Part I Tuberculin Reactivity in Adults after 50 Years of Universal Bacille Calmette-Guerin Vaccination 1. Study Subjects 2. BCG Vaccination and Cut-off Point for Positive TSTs 3. Historical Data on Annual Risk of Tuberculosis Infection 4. Statistical Analysis 50 Part II Molecular Epidemiology of Tuberculosis in Mountain Areas and Surrounding Townships in Middle Taiwan 1. Study Population 2. Setting 3. Mycobacterium tuberculosis Isolates and RFLP Analysis 4. Epidemiological Investigation 54 Part III Estimating Reproductive Number of Tuberculosis in Selected Population 1. Target Population and Data Source 2. Mathematical Model for Estimating Reproductive Number 3. Procedure of Assessment 4. Model Specification 59 Part IV A Cost-effective Analysis of Tuberculosis Control Strategies in Taiwan IV-1. A Stochastic Model for the Disease Natural History of Tuberculosis 1. Model Specification 2. Model Description IV-2. Procedure Assessment 61 Chapter 4 Results 65 Part I 65 Part II 67 Part III 69 Part IV 70 Chapter 5 Discussion 73 Part I 73 Part II 77 Part III 79 Part IV 80 Chapter 6 Conclusion 82 Reference 83 Tables 99 Figure Legends 116 Figures 118 Articles in press or submitting 127 | |
| dc.language.iso | en | |
| dc.subject | 結核病 | zh_TW |
| dc.subject | 台灣 | zh_TW |
| dc.subject | BCG vaccine | en |
| dc.subject | Adult | en |
| dc.subject | Tuberculin test | en |
| dc.subject | Tuberculosis | en |
| dc.title | 台灣結核病流行病學重探 | zh_TW |
| dc.title | Re-investigating Epidemiology, Prevention and Economic Evaluation of Tuberculosis in Taiwan | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 93-1 | |
| dc.description.degree | 博士 | |
| dc.contributor.oralexamcommittee | 索任,張鴻仁,賴信志,何美鄉 | |
| dc.subject.keyword | 台灣,結核病, | zh_TW |
| dc.subject.keyword | Adult,Tuberculin test,BCG vaccine,Tuberculosis, | en |
| dc.relation.page | 135 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2005-02-04 | |
| dc.contributor.author-college | 公共衛生學院 | zh_TW |
| dc.contributor.author-dept | 流行病學研究所 | zh_TW |
| 顯示於系所單位： | 流行病學與預防醫學研究所 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-94-1.pdf 未授權公開取用 | 1.98 MB | Adobe PDF |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。