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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 牟中原 | |
| dc.contributor.author | Ya-Cheng Fang | en |
| dc.contributor.author | 方雅貞 | zh_TW |
| dc.date.accessioned | 2021-06-13T16:55:12Z | - |
| dc.date.available | 2014-07-27 | |
| dc.date.copyright | 2011-07-27 | |
| dc.date.issued | 2011 | |
| dc.date.submitted | 2011-07-14 | |
| dc.identifier.citation | References
(1) Yang, C. M.; Zhang, J., Chem. Eur. J. 2010, 16, 10854-10865. (2) Zhang, J.; Meng, X. G.; Zeng, X. C.; Yu, X. Q., Coord. Chem. Rev. 2009, 253, 2166-2177. (3) Zhou, Y.-H.; Fu, H.; Zhao, W.-X.; Chen, W.-L.; Su, C.-Y.; Sun, H. Z.; Ji, L.-N.; Mao, Z.-W., Inorg. Chem. 2007, 46, 734-739. (4) Chavan, S.; Srinivas, D.; Ratnasamy, P., J. Catal. 2000, 192286-192295. (5) Lee, C. H.; Lang, J.; Yen, C. W.; Shih, P. C.; Lin, T. S.; Mou, C. Y., J. Phys. Chem. B 2005, 109, 12277. (6) Lee, C. H.; Wong, S. T.; Lin, T. S.; Mou, C. Y., J. Phys. Chem. B 2005, 109, 775. (7) Wong, S.-T.; Lee, C.-H.; Lin, T.-S.; Mou, C.-Y., J. Catal. 2004, 228, 1-11. (8) Lee, C. H.; Lin, T. S.; Mou, C. Y., Nano Today 2009, 4, 165-179. (9) Lee, C. H.; Lin, H. C.; Cheng, S. H.; Lin, T. S.; Mou, C. Y., J. Phys. Chem. C 2009, 113, 16058-16069. (10) Lee, C. H.; Lang, J.; Yen, C. W.; Shih, P. C.; Lin, T. S.; Mou, C. Y., J. Phys. Chem. B 2005, 109, 12277-12286. (11) Thomas, J. M.; Raja, R., Topics in Catal. 2006, 40, 3-17. (12) Grigoropoulou, G.; Christoforidis, K. C.; Louloudi, M.; Deligiannakis, Y., Langmuir 2007, 23, 10407-10418. (13) Zois, D.; Vartzouma, C.; Deligiannakis, Y.; Hadjiliadis, N.; Casella, L.; Monzani, E.; Louloudi, M., J. Mol. Catal. A: Chem. 2007, 261, 306-317. (14) Abry, S.; Hibon, A.; Albela, B.; Banse, F.; Bonneviot, L., New J. Chem. 2009, 33, 484. (15) Hart, P. J.; Balbirnie, M. M.; Ogihara, N. L.; Nersissian, A. M.; Weiss, M. S.; Valentine, J. S.; Eisenberg, D., Biochem. 1999, 38, 2167. (16) Tainer, J. A.; Getzoff, E. D.; Richardson, J. S.; Richardson, D. C., Nature 1983, 306, 284. (17) Holm, R. H.; Kennepohl, P.; Solomon, E. I., Chem. Rev. 1996, 96, 2239. (18) Scandalios, J. G., Braz. J. Med. Biol. Res. 2005, 38, 995. (19) Novo, E.; Parola, M., Fibrous. Tissue. Repair 2008, 1, 1. (20) Cadenas, E.; Davies, K. J., Free. Radic. Biol. Med. 2000, 29, 222. (21) Halliwell, B.; Gutteridge, J. M. C., 1999, Free Radicals in Biology and Medicine Oxford, UK: Oxford University Press. (22) Babior, B. M., Blood 1999, 93, 1464. (23) Vignais, P. V., Cell. Mol. Life. Sci. 2002, 59, 1428. (24) Pritsos, C. A., Chem. Biol. Interact. 2000, 129, 195. (25) Vazquez, V. J.; Kalyanaramam, B., FEBS 2000, 481, 304. (26) Rojkind, M.; Domininguez, R. J. A.; Nieto, N.; Greenwel, P., Cell. Mol. Life Sci. 2002, 59, 1872. (27) Cadenas, E., Ann. Rev. Biochem. 1989, 58, 79. (28) Genestra, M., Cell Signal 2007, 19, 1807. (29) Forman, H. J., Free Radic. Biol. Med. 2007, 42, 926. (30) Stone, J. R.; Yang, S., Antioxid. Redox Signal. 2006, 8, 243. (31) D'Autreaux, B.; Toledano, M. B., Nat. Rev. Mol. Cell Biol. 2007, 8, 813. (32) James, P. K., Critical Rev. Toxicol. 1993, 23, 21. (33) Harrison, D.; Griendling, K. K.; Landmesser, U.; Hornig, B.; Drexler, H., Am. J. Cardiol. 2003, 91. (34) Pennathur, S.; Heinecke, J. W., Curr. Diab. Rep. 2007, 7, 257. (35) Maton, A.; Roshan, L.; Jean, H.; Charles, W. M.; Susan, J.; Maryanna, Q. W.; David, L.; Jill, D., Wright (1993). Human Biology and Health. Englewood Cliffs, New Jersey, USA: Prentice Hall. (36) Jankovic, J., J. Neurol. Neurosurg. Psychiatry. 2008, 79, 368. (37) McMurray, J. J.; Pfeffer, M. A., Lancet 2005, 365, 1877. (38) Wijesinghe, M.; Perrin, K.; Ranchord, A.; Simmonds, M.; Weatherall, M.; Beasley, R., Heart 2009, 95, 198. (39) Berchtold, N. C.; Cotman, W., Neurobiol. Aging 1998, 19, 173. (40) What is Alzheimer's disease? Alzheimers.org.uk. http://www.alzheimers.org.uk/site/scripts/documents_info.php?documentID=100. (41) Yan, F.; Yang, W. K.; Li, X. Y.; Lin, T. T.; Lun, Y. N.; Lin, F. L.; Lv, S. W.; Yan, G. L.; Liu, J. Q.; Shen, J. C.; Mu, Y.; Luo, G. M., Biochim. Biophys. Acta 2008, 1780, 869. (42) DeLano, W. L., The PyMOL Molecular Graphics System DeLano Scientific, San Carlos, CA, USA., 2002. (43) Isabel, A. A.; Diane, E. C., Biochim. Biophys. Acta 2010, 1804, 263. (44) Perry, J. J. P.; Shin, D. S.; Getzoff, E. D.; Tainer, J. A., Biochim. Biophys. Acta 2010, 1804, 245. (45) DiDonato, M.; Craig, L.; Huff, M. E.; Thayer, M. M.; Cardoso, R. M.; Kassmann, C. J.; Lo, T. P.; Bruns, C. K.; Powers, E. T.; Kelly, J. W.; Getzoff, E. D.; Tainer, J. A., J. Mol. Biol. 2003, 332, 601. (46) Borgstahl, G. E.; Parge, H. E.; Hickey, M. J.; Beyer Jr., W. F.; Hallewell, R. A.; Tainer, J. A., Cell 1992, 71, 107. (47) Lah, M. S.; Dixon, M. M.; Pattridge, K. A.; Stallings, W. C.; Fee, J. A.; Ludwig, M. L., Biochem. 1995, 34, 1646. (48) Barondeau, D. P.; Kassmann, C. J.; Bruns, C. K.; Tainer, J. A.; Getzoff, E. D., Biochemistry 2004, 43, 8038. (49) Mathur, R. N.; Murthy, J. R.; Sicignano, A.; Tanaka, N.; Rossmann, M. G., J. MOl. Biol. 1981, 152, 465. (50) Vainshtein, B. K.; Melik, A. W. R.; Barynin, V. V.; Vagin, A. A.; Grebenko, A. I., Nature 1981, 293, 411. (51) Chelikania, P.; Fitab, I.; Loewen, P. C., Cell. Mol. Life Sci. 2004, 61, 192. (52) Cotgreave, I. A.; Moldeus, P.; Brattsand, R.; Hallberg, A.; Andersson, C. M.; Engman, L., Biochem. Pharmacol. 1992, 43, 793. (53) Armstrong, R. N., Chem. Res. Toxicol. 1997, 10, 2. (54) Van, B. P., J.Chem. Biol. Interact. 2000, 129, 61. (55) Leiro, J. M.; Alvarez, E.; Arranz, J. A.; Siso, I. G.; Orallo, F., Biochem. Pharmacol. 2003, 65, 1361. (56) McCord, J. M.; Edeas, M. A., Biomed. & Pharmacother. 2005, 59, 139. (57) Edwards, R. A.; Baker, H. M.; Whittaker, M. M.; Whittaker, J. W.; Jameson, G. B.; Baker, E. N., J. Biol. Inorg. Chem. 1998, 3, 161. (58) Antonyuk, S. V.; Strange, R. W.; Marklund, S. L.; Hasnain, S. S., J. Mol. Biol. 2009, 388, 310. (59) McCord, J. M.; Fridovich, I., J. Biol. Chem. 1969, 244, 6049. (60) Tainer, J. A.; Getzoff, E. D.; Beem, K. M.; Richardson, J. S.; Richardson, D. C., J. Mol. Biol. 1982, 160, 181. (61) Getzoff, E. D.; Cabelli, D. E.; Fisher, C. L.; Parge, H. E.; Viezzoli, M. S.; Banci, L.; Hallewell, R. A., Nature 1992, 358, 347. (62) Ferraroni, M.; Rypniewski, W. R.; Bruni, B.; Orioli, P.; Mangani, S., J. Biol. Inorg. Chem. 1998, 3, 411. (63) Richardson, J. S., Nature 1977, 268, 495. (64) Bordo, D.; Pesce, A.; Bolognesi, M., E.; M., S.; Falconi, M.; Desideri, A., In Handbook of Metalloproteins, Vol. 2, 2001. (65) Messerschmidt, A.; Huber, R.; Poulos, T. L.; Wieghardt, K., Wiley & Sons: Chichester, 2001. (66) Getzoff, E. D.; Tainer, J. A.; Weiner, P. K.; Kollman, P. A.; Richardson, J. S.; Richardson, D. C., Nature 1983, 306, 287. (67) Bannister, J. V.; Parker, M. W., Proc. Natl. Acad. Sci. U.S.A. 1985, 82, 149. (68) Wayne, F.; Beyer, J.; Irwin, F.; Guy, T. M.; Robert, H., J. Biol. Chem. 1987, 262, 11182. (69) Polticelli, F.; Battistoni, A.; O’Neill, P.; Rotilio, G.; Desideri, A., Protein Sci. 1998, 7, 2354. (70) Stroppolo, M. E.; Falconi, M.; Caccuri, A. M.; Desideri, A., Cell. Mol. Life Sci. 2001, 58, 1451. (71) Pelmenschikov, V.; Siegbahn, P. E. M., Inorg. Chem. 2005, 44, 3344. (72) Hart, P. J.; Balbirnie, M. M.; Ogihara, N. L.; Nersissian, A. M.; Weiss, M. S.; Valentine, J. S.; Eisenberg, D., Biochem. 1999, 38, 2167. (73) Koppenol, W. H.; Rodgers, M. A. J.; Powers, E. L., Eds.; In Oxygen and Oxyradicals in Chemistry and Biology, Academic Press: New York, 1981. (74) Miller, A. F., Curr. Opin. Chem. Biol. 2004, 8, 162. (75) Konecny, R.; Li, J.; Fisher, C. L.; Dillet, V.; Bashford, D.; Noodleman, L., Inorg. Chem. 1993, 38, 940. (76) Noodleman, L.; Lovell, T.; Han, W. G.; Li, J.; Himo, F., Chem. Rev. 2004, 104, 459. (77) Klug-Roth, D.; Fridovich, I.; Rabani, J., J. Am. Chem. Soc. 1973, 95, 2786. (78) Fielden, E. M.; Roberts, P. B.; Bray, R. C.; Lowe, D. J.; Mautner, G. N.; Rotilio, G.; Calabrese, L., Biochem. J. 1974, 139, 49. (79) Morpurgo, L.; Giovagnoli, C.; Rotilio, G., Biochim. Biophys. Acta 1973, 322, 204. (80) Rotilio, G.; calabrese, L.; Mondovi, B.; Blumberg, W. E., J. Biol. Chem. 1974, 249, 3157. (81) Michael, E.; Mcadam, E.; Martin, F.; Francois, L.; Lilia, C.; Dino, C.; R., G., Biochem. J. 1977, 167, 271. (82) Lawrenec, G. D.; Sawyer, D. T., Biochem. 1979, 18, 3045. (83) Patel, R. N.; Singh, N.; Shukla, K. K.; Gundla, V. L. N.; Chauhan, U. K., J. Inorg. Biochem. 2005, 99, 651. (84) Li, D. F.; Li, S.; Yang, D. X.; Yu, J. H.; Huang, J.; Li, Y. Z.; Tang, W. X., Inorg. Chem. 2003, 42, 6071. (85) Patel, R. N.; Kumar, S.; Pandeya, K. B., J. Inorg. Biochem. 2002, 89, 61. (86) De Vos, D. E.; Jacobs, P. A., Catal. Today 2000, 57, 105. (87) Patel, R. N.; Pandeya, K. B., J. Inorg. Biochem. 1998, 72, 109. (88) Pierre, J. L.; Chautemps, P.; Refaif, S.; Beguin, C.; Elmarzouki, A.; Serratrice, G.; Saintaman, E.; Rey, P., J. Am. Chem. Soc. 1995, 117, 1965. (89) Bhirud, R. G.; Srivastava, T. S., Inorg. Chim. Acta 1991, 179, 125. (90) Coughlin, P. K.; Martin, A. E.; Dewan, J. C.; Watanabe, E. I.; Bulkowski, J. E.; Lehn, J. M.; Lippard, S. J., Inorg. Chem. 1984, 23, 1004. (91) Masaaki, S.; Suguru, N.; Miyoshi, U.; Jun-ichi, N., Chem. Commun. 1984, 1661. (92) Tabbı`, G.; Driessen, W. L.; Reedijk, J.; Bonomo, R. P.; Veldman, N.; Spek, A. L., Inorg. Chem. 1997, 36, 1168. (93) Bonomo, R. P.; Conte, E.; Marcelli, R. A.; Sontoro, M.; Tabi, G. J., J. Inorg. Biochem. 1994, 53, 127. (94) Fu, H.; Zhou, Y.-H.; Chen, W.-L.; Deqing, Z.-G.; Tong, M.-L.; Ji, L.-N.; Mao, Z.-W., J. Am. Chem. Soc. 2006, 128, 4924. (95) Corma, A., Chem. Rev. 1997, 97, 2373. (96) Cope´ret, C., New J. Chem. 2004, 28, 1. (97) Belser, T.; Sto¨hr, M.; Pfaltz, A., J. Am. Chem. Soc. 2005, 127, 8720. (98) Crudden, C. M.; Sateesh, M.; Lewis, R., J. Am. Chem. Soc. 2005, 127, 10045. (99) Balaji, T.; El-Safty, S. A.; Matsunaga, H.; Hanaoka, T.; Mizukami, F., Angew. Chem., Int. Ed. 2006, 45, 1. (100) Zapilk, C.; Liang, Y.; Nerdal, W.; Anwander, R., Chem. Eur. J. 2007, 13, 3169. (101) Feng, X.; Fryxell, G. E.; Wang, L. Q.; Kim, A. Y.; Liu, J.; Kemner, K. M., Science 1997, 276, 923. (102) Lam, K. F.; Yeung, K. L.; McKay, G., Langmuir 2006, 22, 9632. (103) Yan, Z.; Li, G. T.; Mu, L.; Tao, S. Y., J. Mater. Chem. 2006, 16, 1717. (104) Minakuchi, H.; Nakanishi, K.; Soga, N.; Ishizuka, N.; Tanaka, N., Anal. Chem. 1996, 68, 3498. (105) Katiyar, A.; Pinto, N. G., Small 2006, 2, 644. (106) Han, Y.; Lee, S. S.; Ying, J. Y., Chem. Mater. 2007, 19, 2292. (107) Tao, S. Y.; Li, G. T.; Zhu, H. S., J. Mater. Chem. 2006, 16, 4521. (108) Basabe-Desmonts, L.; Reinhoudt, D. N.; Crego-Calama, M., Chem. Soc. Rev. 2007, 36, 993. (109) Stevens, N.; Akins, D. L., Sens. Actuators B 2007, 123, 59. (110) Igor, I. S.; Brian, G. T.; Supratim, G.; Victor, S. Y. L., Adv. Funct. Mater. 2007, 17, 1225. (111) Sing, K. S. W.; Everett, D. H.; Haul, R. A. W.; Moscou, L.; Pierotti, R. A.; Rouquerol, J.; Siemieniewska, T., Pure Appl. Chem. 1985, 57, 603. (112) Renzo, F. D.; Testa, F.; Chen, J. D.; Cambon, H.; Galarneau, A.; Plee, D.; Fajula, F., Micropor. Mesopor. Mater. 1999, 28, 437. (113) Tanev, P. T.; Pinnavaia, T. J., Chem. Mater. 1996, 8, 2068. (114) Cai, Q.; Luo, Z. S.; Pang, W. Q.; Fan, Y. W.; Chen, X. H.; Cui, F. Z., Chem. Mater. 2001, 13, 258. (115) Davidson, A., Curr. Opin. Colloid Interface Sci. 2002, 7, 92. (116) Lin, H. P.; Kao, C. P.; Mou, C. Y.; Liu, S. B., J. Phys. Chem. B 2000, 104, 7885. (117) Huo, Q. S.; Margolese, D. I.; Stucky, G. D., Chem. Mater. 1996, 8, 1147. (118) Beck, J. S.; VartUli, J. C.; Roth, W. J.; Leonowicz, M. E.; Kresge, C. T.; Schmitt, K. D.; Chu, C. T.-W.; Olson, D. H.; Sheppard, E. W.; McCullen, S. B.; Higgins, J. B.; Schlenkert, J. L., J. Am. Chem. Soc. 1992, 114, 10834. (119) Raimondi, M. E.; Seddon, J. M., Liq. Cryst. 1999, 26, 305. (120) Kresge, C. T.; Leonowicz, M. E.; Roth, W. J.; Vartuli, J. C.; Beck, J. S., Nature 1992, 359, 710. (121) Huo, Q. S.; Margolese, D. I.; Ciesla, U.; Feng, P. Y.; Gier, T. E.; Sieger, P.; Leon, R.; Petroff, P. M.; Schuth, F.; Stucky, G. D., Nature 1994, 368, 317. (122) Tanev, P. T.; Pinnavaia, T. J., Science 1995, 267, 865. (123) Bagshaw, S. A.; Prouzet, E.; Pinnavaia, T. J., Science 1995, 269, 1242. (124) Parasuraman, S.; B., S. K.; S., C. G., Ind. Eng. Chem. Res. 2001, 40, 3237. (125) Lai, C. Y.; Trewyn, B. G.; Jeftinija, D. M.; Jeftinija, K.; Xu, S.; Jeftinija, S.; Lin, V. S.-Y., J. Am. Chem. Soc. 2003, 125, 4451. (126) Lin, Y. S.; Tsai, C. P.; Huang, H. Y.; Kuo, C. T.; Hung, Y.; Huang, D. M.; Chen, Y. C.; Mou, C. Y., Chem. Mater. 2005, 17, 4570. (127) Yang, C. M.; Liu, P. H.; Ho, Y. F.; Chiu, C. Y.; Chao, K. J., Chem. Mater. 2003, 15, 275. (128) Yang, C. M.; Zibrowius, B.; Schmidt, W.; Schu¨ th, F., Chem. Mater. 2003, 15, 3739. (129) Newville, M., J. Synchrotron Radiat. 2005, 12, 537. (130) Jiang, D. T.; Heald, S. M.; Sham, T. K.; Stillman, M. J., J. Am. Chem. Soc. 1994, 116, 11004. (131) Zabinsky, S.; Rehr, J. J.; Ankudinov, I. A.; Albers, R. C.; Eller, M. J., Phys. Rev. B. 1995, 52, 2995. (132) Newville, M., J. Synchrotron Radiat. 2001, 8, 322. (133) Lu, F.; Wu, S. H.; Hung, Y.; Mou, C. Y., Small 2009, 5, 1408– 1413. (134) Lin, H. P.; Mou, C. Y., J.Cluster Sci. 1999, 10, 271. (135) Liu, Y.; Zhang, W. Z.; Pinnavaia, T. J., Angew. Chem. Int. Ed. 2001, 40, 1255-1258. (136) Beaucham, C.; Fridovic, I., Anal. Biochem. 1971, 44, 276. (137) Sorenson, J. R. J., Prog. Med. Chem. 1989, 26, 437. (138) Droege, W., Oxidative Stress, Disease and Cancer, ed. K. K. Singh, Imperial College Press, London, 2006, p. 2885. (139) Slemmer, J. E.; Shacka, I. J.; Sweeney, M. I.; Weber, J. T., Curr. Med. Chem. 2008, 15, 404. (140) Hiroyuki, K.; Charles, J. E.; Takuji, M.; Elaine, C.; C., S. F.; Pak, H. C., Proc. Natl. Acad. Sci. USA 1991, 88, 11158. (141) Konstantina, S.; Spyros, P. P.; Catherine, P. R.; Robby, K.; Aris, T.; John, C. P., Trans. Metal Chem. 2005, 24, 541. (142) Salvemini, D.; Muscoli, C.; Riley, D. P.; Cuzzocrea, S., Pulm. Pharmacol. Ther. 2002, 15, 439. (143) Riley, D.; Schall, O. F., Adv. Inorg. Chem. 2006, 59, 233. (144) Yoshihiko, Q., Anal. Biochem. 1984, 142, 290. (145) Ulrich, W.; Lutz, M. S.; Edmund, L., J. Mol. Catal. 1981, 13, 249. (146) Raso, A. G.; Fiol, J. J.; Adrover, B.; Tauler, P.; Pons, A.; Mata, I.; Espinosa, E.; Molins, E., Polyhedron 2003, 22, 3255. (147) Szila´gyi, I.; Labadi, I.; Hernadi, K.; Palinko, I.; Fekete, I.; Korecz, L.; Rockenbauer, A.; Kiss, T., New J. Chem. 2005, 29, 740. (148) Shephard, D. S.; Zhou, W. Z.; Maschmeyer, T.; Matters, J. M.; Roper, C. L.; Parsons, S.; Johnson, B. F. G.; Duer, M. J., Angew. Chem. Int. Ed. 1998, 37, 2719-2723. (149) Lu, Q.; Luo, Q. H.; Dai, A. B.; Zhoub, Z. Y.; Hu, G. Z., Chem. Commun. 1990, 1429. (150) Mao, Z. W.; Chen, M. Q.; Tan, X. S.; Liu, J.; Tang, W. X., Inorg. Chem. 1995, 34, 2889. (151) Clark, T.; Alex, A.; Beck, B.; Burkhardt, F.; Chandrasekhar, J.; Gedeck, P.; Horn, A.; Hutter, M.; Martin, B.; Rauhut, G.; Sauer, W.; Schindler, T.; Steinke, T., (2003-2005), VAMP 2008. Accelrys Inc Erlangen, SanDiego. http://www.accelrys.com. (152) Liu, L.; Chen, S. H.; A., F.; W., Y. C.; Y., M. C.; I., K. A.; E., M.; J., L., J. Phys. Condens. Matter 2006, 18, S2261. (153) Szila´gyi, I.; Laba´di, I.; Hernadi, K.; Pa´linko, I.; Nagy, N. V.; Korecz, L.; Rockenbauer, A.; Kele, Z.; Kiss, T., J. Inorg. Biochem. 2005, 99, 1619. (154) Tomlinson, A. A. G.; Hathaway, B. J., J. Chem. Soc. (A) 1968, 2578. (155) Abragam, A.; Bleaney, B., (1970) Electron Paramagnetic Resonance of Transition Ions, Ch 1977. (156) Hathaway, B. J.; Billing, D. E., Coord. Chem. Rev. 1970, 5, 143. (157) Bertini, I.; Scozzafava, A., 1981, Copper(II) as Probe in Substituted Metalloproteins, Narcel Dekker, New York. (158) Murali, A.; Chang, Z. X.; Ranjit, K. T.; Krishna, R. M.; Kurshev, V.; Kevan, L., J. Phys. Chem. B 2002, 106, 6913. (159) Beem, K. M.; Rich, W. E.; Rajagopa, K. V., J. Biol. Chem. 1974, 249, 7298. (160) Palivan, C. G.; Balasubramanian, V.; Goodman, B. A., Eur. J. Inorg. Chem. 2009, 2009, 4634. (161) Palivan, C. G.; Goodman, B. A., Recent Research Developments in Inorganic and Organometallic Chemistry, Pandalai, India 2001, 2141. (162) Sakaguchi, U.; Addison, A. W., J.C.S. Dalton 1979, 600. (163) Palivan, C. G.; Balasubramanian, V.; Goodman, B. A., Eur. J. Inorg. Chem. 2009, 2009, 4634-4639. (164) Lee, C. H.; Lin, T. S.; Mou, C. Y., Nano Today 2009, 4, 165. (165) Tabbı`, G.; Driessen, W. L.; Reedijk, J.; Bonomo, R. P.; Veldman, N.; Spek, A. L., Inorg. Chem. 1997, 36, 1168. (166) Dutta, S.; Padhye, S.; Ahmed, F.; Sarkar, F., Inorg. Chim. Acta 2005, 358, 3617. (167) Verdejo, B.; Blasco, S.; E., E. G.; Lloret, F.; Gavi˜na, P.; Soriano, C.; Tatay, S.; Jim´enez, H. R.; A., D. e.; Latorre, J., Dalton Trans. 2007, 4726. (168) Ohtsu, H.; Shimazaki, Y.; Odani, A.; Yamauchi, O.; Mori, W.; Itoh, S.; Fukuzumi, S., J. Am. Chem. Soc. 2000, 122, 5733. (169) Eugenio, G.; Giovanni, M., J. Chem. Educ. 2006, 83, 1229. (170) Yue, S. M.; Xu, H. B.; Ma, J. F.; Su, Z. M.; Kan, Y. H.; Zhang, H. J., Polyhedra 2006, 25, 635. (171) Goodman, B. A.; Raynor, J. B., Adv. Inorgchem. Radiochem. 1978, 35, 701. (172) Valko, M.; Mazúr, M.; Pelikán, P.; Kovácik, I.; Baran, P.; Valigura, D., Collect. Czech. Chem. Commun. 1990, 55, 1660. (173) Muller, J.; Felix, K.; Maichle, C.; Lengfelder, E.; Strahle, J.; Weser, U., Inorg. Chim. Acta 1995, 233, 11. (174) Santos, M. L. P.; Alario, A. F.; Mangrich, A. S.; Ferreira, M. C., 1998, 71, 71. (175) Salvemini, D.; Riley, D. P.; Cuzzocrea, S., Nature Rev. Drug Discov. 2002, 1, 367. (176) Ruiz, M.; Perello, L.; Ortiz, R.; Castineiras, A.; Maichlemossmer, C.; Canton, E., J. Inorg. Biochem. 1995, 59, 801. (177) Riley, D. P., Chem. Rev. 1999, 99, 2573. (178) Yang, D.; Li, S.; Li, D.; Chen, M.; Huang, J.; Tang, W., Polyhedron 2003, 22, 925. (179) Patel , M. N.; Parmar, P. A.; Gandhi, D. S., Bioorg. Med. Chem. 2010, 18, 1227. (180) Patel, M. N.; Parmar, P. A.; Gandhi, D. S., Bioorg. Med. Chem. 2010, 18, 1227. (181) Casanova, J.; Alzuet, G. F., S.; Latorre, J.; Ramirez, J. A., J. Borras, Inorg. Chim. Acta 2000, 304, 170. (182) Casanova, J.; Alzuet, G.; Borras, J.; Carugo, O., J. Chem. Soc. Dalton Trans. 1996, 2239. (183) Dutta, S.; Padhye, S.; Ahmed, F.; Sarkar, F., Inorganica Chimica Acta 2005, 358, 3617. (184) Cleveland, D. W.; Rothstein, J. D., From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS, Nat. Rev. Neurosci. 2 (2001) 2806–2819. (185) Williams, D. R., (1971) The Metals of Life, Van Nostrand-Reinhold: London. (186) Sorenson, J. R. J., J. Med. Chem. 1976, 19, 135. (187) Brown, D. H.; Lewis, A. E.; Smith, W. E.; Teape, J. W., J. Med. Chem. 1989, 23, 729. (188) Sheu, S.-S.; Nauduri, D.; Anders, M. W., Biochim. Biophys. Acta, Mol. Basis Dis. 2006, 1762, 256–265. (189) Gems, D.; Partridge, L., Cell. Metab. 2008, 7, 200. (190) Diego-Otero, Y.; Romero-Zerbo, Y.; Bekay, R.; Decara, J.; Sanchez, L.; Rodriguez-Fonseca, F.; Arco-Herrera, I., Neuropsychopharmacology 2009, 34, 1011. (191) Lin, Y. S.; Wu, S. H.; Hung, Y.; Chou, Y. H.; Chang, C.; Lin, M. L.; Tsai, C.-P.; Mou, C. Y., Chem. Mater. 2006, 18, 5170-5172. (192) Wu, S. H.; Lin, Y. S.; Hung, Y.; Chou, Y. H.; Hsu, Y. H.; Chang, C.; Mou, C. Y., Chem. Biochem. 2008, 9, 53-57. (193) Coti, K. K.; Belowich, M. E.; Liong, M.; Ambrogio, M. W.; Lau, Y. A.; Khatib, H. A.; Zink, J. I.; Khashab, N. M.; Stoddart, J. F., Nanoscale 2009, 1, 16-39. (194) Jeffrey S. Souris a, Chia-Hung Lee b,1, Shih-Hsun Cheng c,d, Chin-Tu Chen a, Chung-Shi Yang b,; Ja-an A. Ho e, C.-Y. M., Leu-Wei Lo, Biomaterials 2010, 31, 5564. (195) Lee, C. H.; Cheng, S. H.; Huang, I. P.; Souris, J. S.; Yang, C. S.; Mou, C. Y.; Lo, L. W., Angew. Chem. Int. Ed. 2010, 49, 8214. (196) Muhammad, F.; Guo, M.; Qi, W.; Sun, F.; Wang, A.; Guo, Y.; Zhu, G., J. Am. Chem. Soc. 2011, 133, 8778. (197) Vallet-Regi, M.; Colilla, M.; Gonzalez, B., Chem. Soc. Rev. 2011, 40, 596-607. (198) Rahbari, R.; Sheahan, T.; Modes, V., Biotechniques 2009, 46, 277. (199) Slater, T. F.; Sawyer, B.; Straeuli, U., Biochim. Biophys. Acta 1963, 77, 383. (200) Mossman, T., J. Immunol. Meth. 1983, 65, 55. (201) Carmichael, J.; DeGraff, W. G.; Gazdar, A. F.; Minna, J. D.; Mitchell, J. B., Cancer Res. 1987, 47, 936. (202) Scudiero, D. A.; Shoemaker, R. H.; Paull, K. D.; Monks, A.; Tierney, S.; Nofziger, T. H.; Currens, M. J.; Seniff, D.; Boyd, M. R., Cancer Res. 1988, 48, 4827. (203) Weislow, O. S.; Kiser, R.; Fine, D. L.; Bader, J.; Shoemaker, R. H.; Boyd, M. R., J. Natl. Cancer Inst. 1989, 81, 577. (204) Cory, A. H.; Owen, T. C.; Barltrop, J. A.; Cory, J. G., Cancer Commun. 1991, 3, 207. (205) Roehm, N. W.; Rodgers, G. H.; Hatfield, S. M.; Glasebrook, A. L., J. Immunol. Meth. 1991, 142, 257. (206) Vistica, D. T.; Skehan, P.; Scudiero, D. A.; Monks, A.; Pittman, A.; Boyd, M. R., Cancer Res. 1991, 51, 2515. (207) James, S. B.; James, E. G., Environment Health Persprctives 1984, 55, 37. (208) Okada, H.; Mak, T. W., Nat. Rev. Cancer 2004, 4, 592. (209) Haystead, T. A.; Dent, P.; Wu, J.; Haystead, C. M.; Sturgill, T. W., FEBS Lett. 1992, 306, 17. (210) Robbins, D. J.; Cobb, M. H., Mol. Biol. Cell 1992, 3, 299. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/38973 | - |
| dc.description.abstract | 銅鋅超氧歧化酵素(superoxide dismutase)是一種抗氧化金屬媒，其普遍存在人體和動、植物細胞裏。一般生理上會引起氧化壓力(oxidative stress)，進而傷害細胞、破壞DNA，甚至造成細胞凋亡(apoptosis)。銅鋅超氧歧化酵素在此扮演著重要的清除超氧離子自由基的角色，使超氧離子自由基轉化形成毒性較小的二氧化氫產物。
我們經由模擬銅鋅超氧歧化酵素的活性中心結構，設計合成一系列同核(Cu(II)-Cu(II))或異核(Cu(II)-Zn(II))雙金屬錯合物，並藉由不同合成方法將錯合物附載到規則性孔洞材料的內表面，用來了解催化超氧離子自由基的活性與機制。另外，藉由嫁接帶有正電荷的官能基(TMAC)與不同孔洞大小的載體更進一步地觀察促進超氧歧化反應的因素。我們利用不同鑑定方法：UV-Vis, EPR and EXAFS 了解活性中心金屬銅的幾何結構與活性之間的關聯。並且透過NBT assay 活性測試實驗尋找最佳的模擬超氧歧化酵素的仿生材料。 在應用上，藉由本實驗室之前所開發出來的具有FITC 螢光物的中孔洞奈米粒子(FITC-MSN)，由於之前已確定它具有進入細胞的能力，於是將生物模擬銅鋅金屬錯合物附載在材料內表面上，進一步地研究它們在細胞中的毒性測試與活性表現。 | zh_TW |
| dc.description.abstract | Copper zinc superoxide dismutase (CuZnSOD) is an antioxidant metalloenzyme to catalyze the dismutation of superoxide anion radical (O2－․) into hydrogen peroxide and oxygen to reduce the steady-state concentration of O2－․. A series of imidazolate-bridged homo- and hetero- dinuclear Cu(II)-Cu(II) and Cu(II)-Zn(II) model compounds were synthesized and encapsulated into various mesoporous silica/aluminosilicates (MPS/Al-MPS) to mimic the structure and functionalities of CuZnSOD enzyme. Inspired by the local environments of guanidinium group in the native CuZnSOD enzyme in facilitating the superoxide dismutation, we carefully modified the silanol surface of MPS with N-trimethoxysilylpropyl-N,N,N-trimethyl-ammonium chloride (TMAC) to prepare MPS-N+ to yield the needed local environment for the active site of model compounds and to facilitate the disproportionation of O2－․. We employed the following spectroscopic techniques: UV-Vis, EPR and EXAFS to characterize the active site-Cu(II) ion of the immobilized mimic complexes, and to obtain the structural information of Cu(II) and Zn(II) centers confined in MPSs. The O2－․ disproportionation activity of mimic complexes was measured by nitro blue tetrazolium (NBT) assay. The encapsulated complexes yielded good stability against hydrothermal treatment and enhanced the O2－․ disproportionation activity in various MPS solids. The spectroscopic studies further allow us to establish the structure-reactivity relationship between the nanostructure of MPS and the efficacy of the superoxide dismutation in MPS, and to elucidate the mechanism of the SOD-like activity of immobilized model compounds in MPS. Furthermore, we utilized the oxidative damage model of HeLa cells to study the protective effect of mimic materials in the presence of paraquat (PQ) oxidant. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T16:55:12Z (GMT). No. of bitstreams: 1 ntu-100-D95223008-1.pdf: 6754728 bytes, checksum: 505b8f08105967188acfefba706d8e1a (MD5) Previous issue date: 2011 | en |
| dc.description.tableofcontents | Table of Contents
List of Figure Captions................................. VI List of Table Captions................................. XIII List of Scheme Captions.................................. XV Chapter 1 Introduction.................................. 1 Abbreviations............................... 7 Chapter 2 Oxidative Stress and Antioxidants............................... 8 2.1 Reactive Oxygen Species (ROS)............................... 8 2.1.1 The Superoxide Anion Radical (O2－․)............................... 10 2.1.2 Hydrogen Peroxide (H2O2)............................... 11 2.1.3 Hydroxyl Radicals (․OH)............................... 12 2.2 The Action of Antioxidant Enzymes on ROS............................... 15 2.2.1 Non-Enzymatic Systems............................... 16 2.2.2 Enzymatic Systems............................... 17 2.2.2.1 Superoxide Dismutases (SODs)............................... 17 2.2.2.2 Catalases (CAT)............................... 18 2.2.2.3 Peroxidases............................... 20 2.3 Superoxide Dismutase (SOD)............................... 22 2.4 Model Compounds to Mimic CuZnSOD............................... 29 Abbreviations............................... 33 Chapter 3 Materials and Experimental Methods............................... 35 3.1 Mesoporous Silica (MPS)............................... 35 3.1.1 MCM-41............................... 41 3.1.2 Mesoporous Silica Nanoparticle (MSN)............................... 43 3.1.3 SBA-15............................... 44 3.2 Characterization methods and Instruments............................... 46 3.2.1 N2 Adsorption-Desorption Isotherms............................... 46 3.2.2 Powder X-ray Diffraction (XRD)............................... 46 3.2.3 Elemental Analyses (EA)............................... 47 3.2.4 Mass Spectrometric Techniques............................... 47 3.2.5 UV-Visible and Diffuse Reflectance UV-Visible Spectroscopy............................... 47 3.2.6 Thermogravimetric Analyses (TGA)............................... 47 3.2.7 Zeta-Potential (ξ)............................... 48 3.2.8 Electron Paramagnetic Resonance (EPR)............................... 48 3.2.9 Transmission Electron Microscopy (TEM)............................... 48 3.2.10 X-ray Absorption Fine Structure (XAFS): X-ray Absorption Near-Edge Structure (XANES) and Extended X-Ray absorption Fine structure (EXAFS)...............................51 3.3 Syntheses of Mesoporous Silica Materials............................... 51 3.3.1 MSN............................... 51 3.3.2 Particulate SBA-15 and Al-SBA-15............................... 52 3.3.3 Particular Al-MCM-41 and Al-MCM-41-N+............................... 52 3.3.4 MCM-41-SH............................... 53 3.4 SOD-like Activity Measurements............................... 54 3.4.1 SOD-like Activity Assay............................... 54 3.4.1.1 Reaction of Riboflavin and L-methionie to Generate O2－․............................... 54 3.4.1.2 Quantitative Determination of NBT Reduction with O2 －․............................... 55 Abbreviations............................... 58 Chapter 4 Bio-inspired Design of a Cu-Zn-Imidazolate Mesoporous Silica Catalyst System for Superoxide Dismutation ...............................60 4.1 Introduction............................... 60 4.2 Experimental Section............................... 63 4.2.1 Chemicals................................ 63 4.2.2 Preparation of Model Compound [(N3)Cu-μ-Im-Zn(N4)](ClO4)3·CH3OH (CZS)................................ 63 4.2.3 Immobilization of CZS in Mesoporous Silicas................................ 64 4.2.3.1 Ionic Exchange................................ 64 4.2.3.2 Covalent Binding................................ 65 4.3 Results and Discussion............................... 67 4.3.1 Model Structure of CZS................................ 67 4.3.2 Chemical Analysis (ESI-MS and ICP-MS)................................ 68 4.3.3 Zeta Potential (ξ)................................ 72 4.3.4 TEM................................ 73 4.3.5 XRD Studies................................ 75 4.3.6 N2 Sorption Study................................ 78 4.3.7 TGA Study................................ 80 4.3.8 UV-Vis Spectra................................ 81 4.3.9 EPR Spectra................................ 83 4.3.10 Cu and Zn K-edge XANES and EXAFS Studies................................ 91 4.3.11 SOD-like Activity................................ 97 4.4 Conclusions............................... 106 Abbreviations............................... 108 Chapter 5 Synthesis, Structure and SOD-like Activity of Imidazolate-Bridged Cu(II)-Cu(II) and Cu(II)-Zn(II) Catalyst Systems to Mimic CuZnSOD...............................110 5.1 Introduction............................... 110 5.2 Experimental Section............................... 113 5.2.1 Materials............................... 113 5.2.2 Preparation of Model Compounds to Mimic CuZnSOD............................... 113 5.2.2.1 [(bipy)2Cu-μ-Im-Cu(bipy)2](ClO4)3·H2O (DCB)............................... 113 5.2.2.2 [(phen)2Cu-μ-Im-Cu(phen)2](ClO4)3 (DCP)............................... 114 5.2.2.3 [(bipy)2Cu-μ-Im-Zn(bipy)2](ClO4)3·H2O (CZB)............................... 114 5.2.2.4 [(phen)2Cu-μ-Im-Zn(phen)2](ClO4)3 (CZP)............................... 115 5.2.2.5 [(bipy)2Cu-μ-Pbi-Zn(pbi)](ClO4)2 (CZPbi)............................... 116 5.2.3 Immobilization of Mimic Complexes in Al-MCM-41 via Ionic Exchange................................ 117 5.3 Results and Discussions............................... 118 5.3.1 Chemical Analysis (ESI-MS, ICP-MS and EA)................................ 118 5.3.2 Zeta Potential (ζ)................................ 126 5.3.3 XRD Study............................... 127 5.3.4 N2 Sorption Study................................ 128 5.3.5 TGA Study................................ 131 5.3.6 Magnetic Property of CZPbi................................ 132 5.3.7 UV-Vis Spectra................................ 133 5.3.8 EPR Spectra................................ 135 5.3.9 SOD-like Activity................................ 149 5.4 Conclusions............................... 155 Abbreviations............................... 157 Chapter 6 Protection of HeLa Cells against ROS Stressor by CuZnSOD Mimic Systerm...............................159 6.1 Introduction ...............................159 6.2 Experimental Section............................... 161 6.2.1 Nanoparticle Preparation ...............................161 6.2.2 Immobilization of Model Compounds into FITC-MSN via Ionic Exchange...............................161 6.2.3 Cell Culture............................... 162 6.2.4 WST-1 Analysis for Mimic Materials............................... 162 6.2.5 Cell Uptake and Flow Cytametry Analysis............................... 163 6.2.6 Preparation of Whole-Cell Protein............................... 163 6.2.7 Western Blotting Analysis............................... 164 6.3 Results and Discussions............................... 166 6.3.1 Characterization of Mimic Materials................................ 166 6.3.2 SOD-like Activity................................ 169 6.3.3 The Biocompatibility of Mimic Materials................................ 170 6.3.4 The Antioxidant Ability................................ 173 6.3.4.1 Effect of Inhibition Axidative Stress on HeLa Cell with Treatment of Mimic Materials................................173 6.3.4.2 HeLa Cell Survival with p38 MAPK by Western Blot Analysis................................179 6.4 Conclusions............................... 181 Abbreviations ...............................182 Chapter 7 Conclusions ...............................183 Reference ...............................187 | |
| dc.language.iso | en | |
| dc.subject | 細胞保護劑 | zh_TW |
| dc.subject | 米技術 | zh_TW |
| dc.subject | 孔洞 | zh_TW |
| dc.subject | 性材料 | zh_TW |
| dc.subject | 仿生酵素 | zh_TW |
| dc.subject | 銅鋅離 | zh_TW |
| dc.subject | 子錯化物 | zh_TW |
| dc.subject | CuZnSOD | en |
| dc.subject | cell protection | en |
| dc.subject | nanotechnology | en |
| dc.subject | mesoporous materials | en |
| dc.subject | mimic enzyme | en |
| dc.title | 仿生酵素 : 銅鋅錯合物系列模擬超氧歧化酵素的合成及其鑑定 | zh_TW |
| dc.title | Bio-mimic Enzyme: Synthesis and Characterization of Cu(II)-Cu(II) and Cu(II)-Zn(II) Catalyst System Mimicking the Superoxide Dismutase | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 99-2 | |
| dc.description.degree | 博士 | |
| dc.contributor.oralexamcommittee | 林天送,張啟光,陳長謙,俞聖法,陳炳宇 | |
| dc.subject.keyword | 奈,米技術,孔洞,性材料,仿生酵素,銅鋅離,子錯化物,細胞保護劑, | zh_TW |
| dc.subject.keyword | nanotechnology,mesoporous materials,mimic enzyme,CuZnSOD,cell protection, | en |
| dc.relation.page | 204 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2011-07-15 | |
| dc.contributor.author-college | 理學院 | zh_TW |
| dc.contributor.author-dept | 化學研究所 | zh_TW |
| 顯示於系所單位： | 化學系 | |
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