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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 于宏燦(Hon-Tsen Yu) | |
| dc.contributor.author | Chia-Min Liao | en |
| dc.contributor.author | 廖家敏 | zh_TW |
| dc.date.accessioned | 2021-06-13T16:33:52Z | - |
| dc.date.available | 2007-07-13 | |
| dc.date.copyright | 2005-07-13 | |
| dc.date.issued | 2005 | |
| dc.date.submitted | 2005-07-09 | |
| dc.identifier.citation | 第一章 參考文獻
Adlerberth, I., B. Carlsson, P. Deman, F. Jalil, S. R. Khan, P. Larsson, L. Mellander, C. Svanborg, A. E. Wold and L. A. Hanson. 1991. Intestinal colonization with Enterobacteriaceae in Pakistani and Swedish hospital-delivered infants. Acta. Paed. Scand. 80: 602-610. Alexander, J. W., S. T. Boyce, G. F. Babcock, L. Gianotti, M. D. Peck, D. L. Dunn, T. Pyles, C. P. Childress and S. K. Ash. 1990. The process of microbial translocation. Ann. Surg. 212: 496-512. Aranow, J. S. and M. P. Fink. 1996. Determinants of intestinal barrier failure in critical illness. Br. J. Anaesth. 77: 71-81. Balmer, S. E., P. H. Scott and B. A. Wharton. 1989. Diet and fecal flora in the newborn-casein and whey proteins. Arch. Dis. Child. 64: 1678-1684. Bennet, R., M. Eriksson, C. E. Nord and R. Zetterstrom. 1986. Fecal bacterial microflora of newborn-infants during intensive-care management and treatment with five antibiotic regimens. Pediatr. Infect. Dis. J. 5: 533-539. Berg, R. D. and A. W. Garlington. 1979. Translocation of certain indigenous bacteria from the gastro-intestinal tract to the mesenteric lymph-nodes and other organs in a gnotobiotic mouse model. Infect. Immun. 23: 403-411. Boedeker, E. C. 1994. Adherent bacteria breaching the mucosal barrier. Gastroenterol. 106: 255-257. Borneman, J. and E. W. Triplett. 1997. Molecular microbial diversity in soils from eastern Amazonia: evidence for unusual microorganisms and microbial population shifts associated with deforestation. Appl. Environ. Microbiol. 63: 2647-2653. Brook, I., T. J. Macvittie and R. I. Walker. 1984. Recovery of aerobic and anaerobic-bacteria from irradiated mice. Infect. Immun. 46: 270-271. Brooks, S. G., J. May, P. Sedman, I. Tring, D. Johnstone, C. J. Mitchell and J. Macfie. 1993. Translocation of enteric bacteria in humans. Br. J. Surg. 80: 901-902. Bullen, C. L. and P. V. Tearle. 1976. Bifidobacteria in intestinal tract of infants in- vitro study. J. Med. Microbiol. 9: 335-333. Cummings, J. H., J. G. Banwell, H. N. Englyst, N. Coleman, I. Segal and D. Bersohn. 1990. The amount and composition of large bowel contents. Gastroenterol. 98: A408. Dahlberg, A. E. 1989. The functional role of ribosomal-RNA in protein synthesis. Cell. 57: 525 -529. Daly, K., C. S. Stewart, H. J. Flint and S. P. Shirazi-Beechey. 2001. Bacterial diversity within the equine large intestine as revealed by molecular analysis of cloned 16S rRNA genes. FEMS Microbiol. Ecol. 38: 141-151. De Rijk, P., J. M. Neefs, Y. Van de Peer and R. De Wachter. 1992. Compilation of small ribosomal subunit RNA sequences. Nucleic. Acids. Res. 20: 2075S-2089S. Devereux, R. and G. W. Mundfrom. 1994. A phylogenetic tree of 16S ribosomal-rRNA squences from sulfate-reducing bacteria in a sandy marine sediment. Appl. Environ. Microbiol. 60: 3437-3439. Dixon, M. T. and D. M. Hillis. 1993. Ribosomal-rRNA secondary structure -compensatory mutations and implications for phylogenetic analysis. Mol. Biol. Evol. 10: 256-267. Eckburg, P. B., E. M. Bik, C. N. Bernstein, E. Purdom, L. Dethlefsen, M. Sargent, S. R. Gill, K. E. Nelson and D. A. Relman. 2005. Diversity of the human intestinal microbial flora. Science. 308: 1635-1638. Falk, P. G., L. V. Hooper, T. Midtvedt and J. I. Gordon. 1998. Creating and maintaining the gastrointestinal ecosystem: What we know and need to know from gnotobiology. Microbiol. Mol. Biol. Rev. 62: 1157-1170. Favier, C. F., E. E. Vaughan, W. M. De Vos and A. D. L. Akkermans. 2002. Molecular monitoring of succession of bacterial communities in human neonates. Appl. Environ. Microbiol. 68: 219-226. Felisart, J., A. Rimola, V. Arroyo, R. M. Perezayuso, E. Quintero, P. Gines and J. Rodes. 1985. Cefotaxime is more effective than is ampicillin- tobramycin in cirrhotics with severe infections. Hepatol. 5: 457-462. Frank, D. N. and N. R. Pace. 2001. Molecular-phylogenetic analyses of human gastrointestinal microbiota. Curr. Opin. Gastroenterol. 17: 52-57. Fukushima, R., L. Gianotti, J. W. Alexander and C. L. Wells. 1994. The primary site of bacterial translocation. Arch. Surg. 129: 53-58. Giovannoni, S. J., T. B. Britschgi, C. L. Moyer and K. G. Field. 1990. Genetic diversity in Sargasso Sea bacterioplankton. Nature. 345: 60-63. Godon, J. J., E. Zumstein, P. Dabert, F. Habouzit and R. Moletta. 1997. Molecular microbial diversity of an anaerobic digestor as determined by small-subunit rDNA sequence analysis. Appl. Environ. Microbiol. 63: 2802-2813. Gordon, J. I., L. V. Hooper, M. S. McNevin, M. Wong and L. Bry. 1997. Epithelial cell growth and differentiation.3. Promoting diversity in the intestine: conversations between the microflora, epithelium, and diffuse GALT. Am. J. Physiol.-Gastroint. Liver Physiol. 36: G565-G570. Guarner, C and Soriano, G. 2005. Bacterial translocation and its consequences in patients with cirrhosis. Eur. J. Gastroenterol. Hepatol. 17:27-31. Gustafss.B, T. Midtvedt and K. Strandbe. 1970. Effects of microbial contamination on cecum enlargement of germfree rats. Scand. J. Gastroenterol. 5: 309-&. Harmsen, H. J. M., G. R. Gibson, P. Elfferich, G. C. Raangs, A. C. M. Wildeboer-Veloo, A. Argaiz, M. B. Roberfroid and G. W. Welling. 1999. Comparison of viable cell counts and fluorescence in- situ hybridization using specific rRNA-based probes for the quantification of human fecal bacteria. FEMS Microbiol. Lett. 183: 125-129. Hooper, L. V. 2004. Bacterial contributions to mammalian gut development. Trends Microbiol. 12: 129-134. Hooper, L. V., L. Bry, P. G. Falk and J. I. Gordon. 1998. Host-microbial symbiosis in the mammalian intestine: exploring an internal ecosystem. Bioessays. 20: 336-343. Hooper, L. V. and J. I. Gordon. 2001. Commensal host-bacterial relationships in the gut. Science. 292: 1115-1118. Hooper, L. V., T. Midtvedt and J. I. Gordon. 2002. How host-microbial interactions shape the nutrient environment of the mammalian intestine. Annu. Rev. Nutr. 22: 283-307. Lan, P. T. N., H. Hayashi, M. Sakamoto and Y. Benno. 2002. Phylogenetic analysis of cecal microbiota in chicken by the use of 16S rDNA clone libraries. Microbiol. Immunol. 46: 371-382. Langendijk, P. S., F. Schut, G. J. Jansen, G. C. Raangs, G. R. Kamphuis, M. H. F. Wilkinson and G. W. Welling. 1995. Quantitative fluorescence in-situ hybridization of Bifidobacterium spp with genus-specific 16S ribosomal-rRNA-targeted probes and its application in fecal samples. Appl. Environ. Microbiol. 61: 3069-3075. Lefrock, J. L., C. A. Ellis and L. Weinstein. 1979. Impact of hospitalization on the aerobic fecal microflora. Am. J. Med. Sci. 277: 269-274. Lemaire, L., J. J. B. van Lanschot, C. P. Stoutenbeek, S. J. H. van Deventer, J. Dankert, H. Oosting and D. J. Gouma. 1999. Thoracic duct in patients with multiple organ failure: no major route of bacterial translocation. Ann. Surg. 229: 128-136. Leser, T. D., J. Z. Amenuvor, T. K. Jensen, R. H. Lindecrona, M. Boye and K. Moller. 2002. Culture-independent analysis of gut bacteria: the pig gastrointestinal tract microbiota revisited. Appl. Environ. Microbiol. 68: 673-690. Liu, W. T., T. L. Marsh, H. Cheng and L. J. Forney. 1997. Characterization of microbial diversity by determining terminal restriction fragment length polymorphisms of genes encoding 16S rRNA. Appl. Environ. Microbiol. 63: 4516-4522. Midtvedt, T. 1974. Microbial bile acid transformation. Am. J. Clin. Nutr. 27: 1341-1347. Midtvedt, T. 1989. Monitoring the functional state of the microflora. In Recent Advances in Microbial Ecology, ed. T Hattori, Y Ishida, Y Maruyama, RY Mortia, A Uchida. pp. 515-19. Tokyo: Japan Sci. Soc. Press. Midtvedt, T., B. Carlstedtduke, T. Hoverstad, A. C. Midtvedt, K. E. Norin and H. Saxerholt. 1987. Establishment of a biochemically active intestinal ecosystem in ex-germ-free rats. Appl. Environ. Microbiol. 53: 2866-2871. Moeseneder, M. M., J. M. Arrieta, G. Muyzer, C. Winter and G. J. Herndl. 1999. Optimization of terminal-restriction fragment length polymorphism analysis for complex marine bacterioplankton communities and comparison with denaturing gradient gel electrophoresis. Appl. Environ. Microbiol. 65: 3518-3525. Moore, W. E. C. and L. V. Holdeman. 1974. Human fecal flora - normal flora of 20 Japanese-Hawaiians. Appl. Microbiol. 27: 961-979. Morgan, J. A. T. and D. Blair. 1998. Trematode and monogenean rRNA ITS2 secondary structures support a four-domain model. J. Mol. Evol. 47: 406-419. Muyzer, G. and N. B. Ramsing. 1995. Molecular methods to study the organization of microbial communities. Water Sci. Technol. 32: 1-9. Nagashima, K., T. Hisada, M. Sato and J. Mochizuki. 2003. Application of new primer-enzyme combinations to terminal restriction fragment length polymorphism profiling of bacterial Populations in human Feces. Appl. Environ. Microbiol. 69: 1251-1262. Neut, C., E. Bezirtzoglou, C. Romond, H. Beerens, M. Delcroix and A. M. Noel. 1987. Bacterial-colonization of the large-intestine in newborns delivered by cesarean-section. Zentralbl Bakteriol. 266: 330-337. Noller, H. F. 1984. Structure of ribosomal-rRNA. Annu. Rev. Biochem. 53: 119-162. Orti, G., P. Petry, J. I. R. Porto, M. Jegu and A. Meyer. 1996. Patterns of nucleotide change in mitochondrial ribosomal RNA genes and the phylogeny of piranhas. J. Mol. Evol. 42: 169-182. Owens, W. E. and R. D. Berg. 1980. Bacterial translocation from the gastrointestinal tract of athymic (Nu-Nu) mice. Infect. Immun. 27: 461-467. Paster, B. J., F. E. Dewhirst, S. M. Cooke, V. Fussing, L. K. Poulsen and J. A. Breznak. 1996. Phylogeny of not-yet-cultured spirochetes from termite guts. Appl. Environ. Microbiol. 62: 347-352. Pignata, C., G. Budillon, G. Monaco, E. Nani, R. Cuomo, G. Parrilli and F. Ciccimarra. 1990. Jejunal bacterial overgrowth and intestinal permeability in children with iImmunodeficiency syndromes. Gut. 31: 879-882. Powell, D. W. 1981. Barrier function of epithelia. Am. J. Physiol. 241: G275-G288. Rimola, A., J. M. Salmeron, G. Clemente, L. Rodrigo, A. Obrador, M. L. Miranda, C. Guarner, R. Planas, R. Sola, V. Vargas, F. Casafont, F. Marco, M. Navasa, R. Banares, V. Arroyo and J. Rodes. 1995. 2 Different dosages of cefotaxime in the treatment of spontaneous bacterial peritonitis in cirrhosis-results of a prospective, randomized, multicenter study. Hepatol. 21: 674-679. Rotimi, V. O. and B. I. Duerden. 1981. The development of the bacterial-flora in normal neonates. J. Med. Microbiol. 14: 51-62. Sakamoto, M., H. Hayashi and Y. Benno. 2003. Terminal restriction fragment length polymorphism analysis for human fecal microbiota and its application for analysis of complex bifidobacterial communities. Microbiol. Immunol. 47: 133-142. Salzman, N. H., H. de Jong, Y. Paterson, H. J. M. Harmsen, G. W. Welling and N. A. Bos. 2002. Analysis of 16S libraries of mouse gastrointestinal microflora reveals a large new group of mouse intestinal bacteria. Microbiology-(UK). 148: 3651-3660. Savage, D. C. 1977. Microbial ecology of gastrointestinal-tract. Annu. Rev. Microbiol. 31: 107 -133. Savage, D. C. 1986. Gastrointestinal microflora in mammalian nutrition. Annu. Rev. Nutr. 6: 155 -178. Savage, D. C., J. E. Siegel, J. E. Snellen and D. D. Whitt. 1981. Transit-time of epithelial-cells in the small-intestines of germ-free mice and ex-germfree mice associated with indigenous microorganisms. Appl. Environ. Microbiol. 42: 996-1001. Schmidt, T. M., E. F. Delong and N. R. Pace. 1991. Analysis of a marine picoplankton community by 16S ribosomal-RNA gene cloning and sequencing. J. Bacteriol. 173: 4371 -4378. Sedman, P. C., J. Macfie, P. Sagar, C. J. Mitchell, J. May, B. Manceyjones and D. Johnstone. 1994. The prevalence of gut translocation in humans. Gastroenterol. 107: 643-649. Simpson, J. M., V. J. McCracken, B. A. White, H. R. Gaskins and R. I. Mackie. 1999. Application of denaturant gradient gel electrophoresis for the analysis of the porcine gastrointestinal microbiota. J. Microbiol. Methods. 36: 167-179. Spaeth, G., T. Gottwald, R. D. Specian, M. R. Mainous, R. D. Berg and E. A. Deitch. 1994. Secretory immunoglobulin-A, intestinal mucin, and mucosal permeability in nutritionally induced bacterial translocation in rats. Ann. Surg. 220: 798-808. Springer, M. S. and E. Douzery. 1996. Secondary structure and patterns of evolution among mammalian mitochondrial 12S rRNA molecules. J. Mol. Evol. 43: 357-373. Steffen, E. K. and R. D. Berg. 1983. Relationship between cecal population--levels of indigenous bacteria and translocation to the mesenteric lymph nodes. Infect. Immun. 39: 1252-1259. Stockbruegger, R. W. 1985. Bacterial overgrowth as a consequence of reduced gastric acidity. Scand. J. Gastroenterol. 20: 7-16. Suau, A., R. Bonnet, M. Sutren, J. J. Godon, G. R. Gibson, M. D. Collins and J. Dore. 1999. Direct analysis of genes encoding 16S rRNA from complex communities reveals many novel molecular species within the human gut. Appl. Environ. Microbiol. 65: 4799-4807. Such, J., C. Guarner, J. Enriquez, J. L. Rodriguez, I. Seres and F. Vilardell. 1988. Low C-3 in cirrhotic ascites predisposes to spontaneous bacterial peritonitis. J. Hepatol. 6: 80-84. Tannock, G. W. 2001. Molecular assessment of intestinal microflora. Am. J. Clin. Nutr. 73: 410S -414S. Vaughan, E. E., H. Heilig, E. G. Zoetendal, R. Satokari, J. K. Collins, A. D. L. Akkermans and W. M. de Vos. 1999. Molecular approaches to study probiotic bacteria. Trends Food Sci. Technol. 10: 400-404. Vazquez-Torres, A., J. Jones-Carson, A. J. Baumler, S. Falkow, R. Valdivia, W. Brown, M. Le, R. Berggren, W. T. Parks and F. C. Fang. 1999. Extraintestinal dissemination of Salmonella by CD18-expressing phagocytes. Nature. 401: 804-808. Venema, J. and D. Tollervey. 1999. Ribosome synthesis in Saccharomyces cerevisiae. Annu. Rev. Genet. 33: 261-311. Wang, H. Y. and S. C. Lee. 2002. Secondary structure of mitochondrial 12S rRNA among fish and its phylogenetic applications. Mol. Biol. Evol. 19: 138-148. Wagner, R. 1994. The regulation of ribosomal RNA synthesis and bacterial cell growth. Arch. Microbiol. 161: 100-109. Weller, R., J. W. Weller and D. M. Ward. 1991. 16S ribosomal-RNA sequences of uncultivated hot-spring cyanobacterial mat inhabitants retrieved as randomly primed cDNA. Appl. Environ. Microbiol. 57: 1146-1151. Wells, C. L. 1990. Relationship between intestinal microecology and the translocation of intestinal bacteria. Antonie. Van Leeuwenhoek. 58: 87-93. Wells, C. L., M. A. Maddaus, S. L. Erlandsen and R. L. Simmons. 1988. Evidence for the phagocytic transport of intestinal particles in dogs and rats. Infect. Immun. 56: 278-282. Wells, C. L., M. A. Maddaus, C. M. Reynolds, R. P. Jechorek and R. L. Simmons. 1987a. Role of anaerobic flora in the translocation of aerobic and facultatively anaerobic intestinal bacteria. Infect. Immun. 55: 2689-2694. Wells, C. L., M. A. Maddaus and R. L. Simmons. 1987b. Role of the macrophage in the translocation of intestinal bacteria. Arch. Surg. 122: 48-53. Wheeler, W. C. and R. L. Honeycutt. 1988. Paired sequence difference in ribosomal-RNAs - evolutionary and phylogenetic implications. Mol. Biol. Evol. 5: 90-96. Whitford, M. F., R. J. Forster, C. E. Beard, J. H. Gong and R. M. Teather. 1998. Phylogenetic analysis of rumen bacteria by comparative sequence analysis of cloned 16S rRNA genes. Anaerobe. 4: 153-163. Wiest, R. and H. C. Rath. 2003. Bacterial translocation in the gut. Best Pract. Res. Clin. Gastroenterol. 17: 397-425. Wilson, K. H. and R. B. Blitchington. 1996. Human colonic biota studied by ribosomal DNA sequence analysis. Appl. Environ. Microbiol. 62: 2273-2278. Woese, C. R., O. Kandler and M. L. Wheelis. 1990. Towards a natural system of organisms - proposal for the domains Archaea, Bacteria, and Eucarya. Proc. Natl. Acad. Sci. U. S. A. 87: 4576-4579. Zoetendal, E. G., A. D. L. Akkermans, W. M. Akkermans-van Vliet, A.G.M.. de Visser and W. M. de Vos. 2001a. The host genotype affects the bacterial community in the human gastrointestinal tract. Microb. Ecol. Health. Dis. 13: 129-34. Zoetendal, E. G. 2001b. Molecular characterization of bacterial communities in the human gastrointestinal tract. PhD thesis, Wageningen Univ. 186pp. 第二章 參考文獻 Alexander, J. W., S. T. Boyce, G. F. Babcock, L. Gianotti, M. D. Peck, D. L. Dunn, T. Pyles, C. P. Childress and S. K. Ash. 1990. The process of microbial translocation. Ann. Surg. 212: 496-512. Altschu., S. F., A. A. Madden, J. Schaffer, Z. Z. Zhang, W. Miller and D. J. Lipman. 1997. Gapped BLAST and PSI- BLAST:A new generation of protein database search programs. Nucleic. Acids. Res. 25: 3389-3402. Available at http://www.ncbi.nlm.nih.gov/BLAST/. Benson, D. A., I. Karsch-Mizrachi, D. J. Lipman, J. Ostell, B. A. Rapp, and D. L. Wheeler. 2000.GenBank. Nucleic. Acids. Res. 28: 15-18. Berg, R. D. and A. W. Garlington. 1979. Translocation of certain indigenous bacteria from the gastro-intestinal tract to the mesenteric lymph-nodes and other organs in a gnotobiotic mouse model. Infect. Immun. 23: 403-411. Bonnet, R., A. Suau, J. Dore, G. R. Gibson and M. D. Collins. 2002. Differences in rDNA libraries of faecal bacteria derived from 10- and 25-cycle PCRs. Int. J. Sys. Evol. Microbiol. 52: 757-763. Brooks, G. F., J. S. Butel and L. N. E. Ornston. 1995. Jawetz, Melnick & Adelberg's medical microbiology. Appleton & Lange, Norwalk, Conn. Chen, M. Y., G. H. Lin, Y. T. Lin and S. S. Tsay. 2002. Meiothermus taiwanensis sp. nov., a novel filamentous, thermophilic species isolated in Taiwan. Int. J. Sys. Evol. Microbiol. 52: 1647-1654. Coenye, T., J. Goris, P. V. De Vos, P. and J. J. LiPuma. 2003. Clastification of Ralstonia pickettii-like isolates from the environment and clinical samples as Ralstonia insidiosa sp. nov. Int. J. Sys. Evol. Microbiol. 53: 1075-1080. Collins, M., P. A. Lawson, A. Willems, J. J. Cordoba, J. Fernandez-Garazabal, P. Garcia, J. Cai, H. Hipper and J. A. E. Farrow. 1994. The phylogeny of the genus Clostridium: proposal of five new genera and eleven new species combinations. 44: 812-826. Ding, L. and A. Yokota. 2004. Proposals of Curvibacter gracilis gen. nov., sp. nov. and Herbaspirillum putei sp. nov. for bacterial strains isolated from well water and reclassification of [Pseudomonas] huttiensis, [Pseudomonas] lanceolata, [Aquaspirillum] delicatum and [Aquaspirillum] autotrophicum as Herbaspirillum huttiense comb. nov., Curvibacter lanceolatus comb. nov., Curvibacter delicatus comb. nov. and Herbaspirillum autotrophicum comb. nov. Int. J. Sys. Evol. Microbiol. 54: 2223-2230. Eckburg, P. B., E. M. Bik, C. N. Bernstein, E. Purdom, L. Dethlefsen, M. Sargent, S. R. Gill, K. E. Nelson and D. A. Relman. 2005. Diversity of the human intestinal microbial flora. Science. Published online April 14 2005; 10.1126/science.1110591 (Science Express Reports). Felisart, J., A. Rimola, V. Arroyo, R. M. Perezayuso, E. Quintero, P. Gines and J. Rodes. 1985. Cefotaxime is more effective than is ampicillin-tobramycin in cirrhotics with severe infections. Hepatol. 5: 457-462. Frank, A. H., H. J. M. Harmsen, G. C. Raangs, G. J. Jansen, F. Schut and G. W. Welling. 1998. Variations of bacterial populations in human feces measured by fluorescent in- situ hybridization with group-specific 16S rRNA-targeted oligonucleotide probes. Appl. Environ. Microbiol. 64: 3336-3345. Frank, D. N. and N. R. Pace. 2001. Molecular-phylogenetic analyses of human gastrointestinal microbiota. Curr. Opin. Gastroenterol. 17: 52-57. Frank, D. N., G. B. Spiegelman, W. Davis, E. Wagner, E. Lyons and N. R. Pace. 2003. Culture-independent molecular analysis of microbial constituents of the healthy human outer ear. J. Clin. Microbiol. 41: 295-303. Garcia-Tsao, G. 2004. Gut microflora in the pathogenesis of the complications of cirrhosis. Best Pract. Res. Clin. Gastroenterol. 18: 353-372. Gibson, G. R., E. R. Beatyy, X. Wang and J. H. Cummings. 1995. Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterol. 108: 975 -982. Godon, J. J., E. Zumstein, P. Dabert, F. Habouzit and R. Moletta. 1997. Molecular microbial diversity of an anaerobic digestor as determined by small-subunit rDNA sequence analysis. Appl. Environ. Microbiol. 63: 2802-2813. Good, I. J. 1953. The population frequencies of species and the estimation of population parameters. Biometrica. 40: 237-264. Govan, J. R. and V. Deretic. 1996. Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia. Microbiol. Rev. 60: 539-574. Guarner, C., B. A. Runyon, S. Young, M. Heck and M. Y. Sheikh. 1997. Intestinal bacterial overgrowth and bacterial translocation in cirrhotic rats with ascites. J. Hepatol. 26: 1372 -1378. Guarner, C. and G. Shriano. 2005. Bacterial translocation and its consequences in patients with cirrhosis. Eur. J. Gastroenterol. Hepatol. 17: 27-31. Hold, G. L., S. E. Pryde, V. J. Russell, E. Furrie and H. J. Flint. 2002. Assessment of microbial diversity in human colonic samples by 16S rDNA sequence analysis. FEMS Microbiol. Rev. 39: 33-39. Hooper, L. V. and J. I. Gordon. 2001. Commensal host-bacterial relationships in the gut. Science. 292: 1115-1118. Hooper, L. V., T. Midtvedt and J. I. Gordon. 2002. How host-microbial interactions shape the nutrient environment of the mammalian intestine. Annu. Rev. Nutr. 22: 283-307. Huelsenbeck, J. P. and F. Ronquist. 2001. MRBAYES: Bayesian inference of phylogenetic trees. Bioinformatics. 17: 754-755. Kane, T. D., S. R. Johnson, J. W. Alexander, G. F. Babcock and C. K. Ogle. 1996. Detection of intestinal bacterial translocation using PCR. J. Surg. Res. 63: 59-63. Kimura, M. 1980. A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. J. Mol. Evol. 16: 111-120. Kumar, S., K. Tamura and M. Nei. 2004. MEGA3: Integrated software for molecular evolutionary genetics analysis and sequence alignment. Brief. Bioinform.5:150-163. Langendijk, P. S., F. Schut, G. J. Jansen, G. C. Raangs, G. R. Kamphuis, M. H. F. Wilkinson and G. W. Welling. 1995. Quantitative fluorescence in-situ hybridization of Bifidobacterium spp with genus-specific 16S ribosomal-rRNA-targeted probes and its application in fecal samples. Appl. Environ. Microbiol. 61: 3069-3075. Linde, H. J., J. Hahn, E. Holler and N. Lehn. 2002. Septicemia due to Acinetobacter junii. J. Clin. Microbiol. 40: 2696-2697. Ludwig, J. A. and Reynolds, J. F. 1988. Statistical ecology. Wiley, New York. U. S. A. McLaughlin, R. W., H. Vali, P. C. K. Lau, R. G. E. Palfree, A. D. Ciccio, M. Sirois, D. Ahmad, R. Villemur, M. Desrosiers and E. C. S. Chan. 2002. Are there naturally occurring pleomorphic bacteria in the blood of healthy humans? J. Clin. Microbiol. 40: 4771-4775. Nagashima, K., T. Hisada, M. Sato and J. Mochizuki. 2003. Application of new primer-enzyme combinations to terminal restriction fragment length polymorphism profiling of bacterial Populations in human Feces. Appl. Environ. Microbiol. 69: 1251-1262. Nikkari, S., I. J. McLaughlin, W. Bi, D. E. Dodge and D. A. Relman. 2001. Does blood of healthy subjects contain bacterial ribosomal DNA? J. Clin. Microbiol. 39: 1956-1959. Page, R. D. M. 1996. TREEVIEW: An application to display phylogenetic trees on personal computers. Comput. Appl. Biosci. 12: 357-358. Paton, A. W. and J. C. Paton. 1996. Enterobacter cloacae producing a shiga-like toxin II-related cytotoxin associated with a case of hemolytic-uremic syndrome. J. Clin. Microbiol. 34: 463-465. Sahly, H., S. Schubert, J. Harder, P. Rautenberg, U. Ullmann, J. Schroder and R. Podschun. 2003. Burkholderia is highly resistant to human beta-defensin 3. Antimicrob. Agents Chemother. 47: 1739-1741. Sakamoto, M., H. Hayashi and Y. Benno. 2003. Terminal restriction fragment length polymorphism analysis for human fecal microbiota and its application for analysis of complex bifidobacterial communities. Microbiol. Immunol. 47: 133-142. Savage, D. C., J. E. Siegel, J. E. Snellen and D. D. Whitt. 1981. Transit-time of epithelial-cells in the small-intestines of germ-free mice and ex-germfree mice associated with indigenous microorganisms. Appl. Environ. Microbiol. 42: 996-1001. Siau, H. S., K. Y. Yuen, P. L. Ho, W. K. Luk, S. S. Y. Wong, P. C. Y. Woo, R. A. Lee and W. T. Hui. 1998. Identification of Acinetobacters on blood agar in presence of D-glucose by unique browning effect. J. Clin. Microbiol. 36: 1404-1407. Simpson, E. H. 1949. Measurement of diversity. Nature. 163: 688. Spencer, R. C. 1995. The emergence of epidemic, multiple-antibiotic-resistant Stenotrophomonas (Xanthomonas) maltophilia and Burkholderia (Pseudomonas) cepacia. J. Host. Infect. 30: 453S-463S. Suau, A., R. Bonnet, M. Sutren, J. J. Godon, G. R. Gibson, M. D. Collins and J. Dore. 1999. Direct analysis of genes encoding 16S rRNA from complex communities reveals many novel molecular species within the human gut. Appl. Environ. Microbiol. 65: 4799-4807. Such, J., C. Guarner, J. Enriquez, J. L. Rodriguez, I. Seres and F. Vilardell. 1988. Low C-3 in cirrhotic ascites predisposes to spontaneous bacterial peritonitis. J. Hepatol. 6: 80-84. Such, J. and B. A. Runyon. 1998. Spontaneous bacterial peritonitis. Clin. Infect. Dis. 27: 669- 674. Such, J., R. Frances, C. Munoz, P. Zapater, J. A. Casellas, A. Cifuentes, F. Rodriguez-Valera, S. Pascual, J. Sola-Vera, F. Carnicer, F. Uceda, J. M. Palazon and M. Perez-Mateo. 2002. Detection and identification of bacterial DNA in patients with cirrhosis and culture-negative, nonneutrocytic ascites. Hepatol. 36: 135-141. Tannock, G. W. 2001. Molecular assessment of intestinal microflora. Am. J. Clin. Nutr. 73: 410S-414S. Tedeschi, G. G., Amici, D., Pararelli, M. 1969. Incorporation of nucleotides and amino-acids in human erythrocyte suspensions : possible relation with a diffuse infection of mycoplasms or bacteria in the L form. Nature. 222: 1285-1286. Thompson, J. D., Gibson, T. J., Plewniak, F., Jeanmougin, F. and Higgins, D. G. 1997. The ClustalX windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic. Acids. Res. 25:4876-4882. Trotha, R., G. Guetnther, W. Konig and B. Konig. 2002. Disseminated infection due to Blastobacter denitrificans following routine appendectomy in an adolescent. J. Clin. Microbiol. 40: 3538-3539. Valdezate, S., A. Vindel, E. Loza, F. Baquero and R. Canton. 2001. Antimicrobial susceptibilities of unique Stenotrophomonas maltophilia clinical strains. Antimicrob. Agents Chemother. 45: 1581-1584. Vandamme, P. and T. Coenye. 2004. Taxonomy of the genus Cupriavidus: a tale of lost and found. Int. J. Sys. Evol. Microbiol. 54: 2285-2289. von Graevenitz, A., J. Bowman, C. Del Notaro and M. Ritzler. 2000. Human infection with Halomonas venusta following fish bite. J. Clin. Microbiol. 38: 3123-3124. Wang, X., S. P. Heazlewood, D. O. Krause and T. H. J. Florin. 2003. Molecular characterization of the microbial species that colonize human ileal and colonic mucosa by using 16S rDNA sequence analysis. J. Appl. Microbiol. 95: 508-520. Wheeler, W. C. and R. L. Honeycutt. 1988. Paired sequence difference in ribosomal-RNAs - evolutionary and phylogenetic implications. Mol. Biol. Evol. 5: 90-96. Wiest, R. and H. C. Rath. 2003. Bacterial translocation in the gut. Best Pract. Res. Clin. Gastroenterol. 17: 397-425. Wilson, K. H. and R. B. Blitchington. 1996. Human colonic biota studied by ribosomal DNA sequence analysis. Appl. Environ. Microbiol. 62: 2273-2278. Wintzingerode, F. V., U. B. Goel and E. Stackebrandt. 1997. Determination of microbial diversity in environmental samples: pitfalls of PCR-based rRNA analysis. FEMS Microbiol. Rev. 21: 213-229. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/38448 | - |
| dc.description.abstract | 人體的腸道中分佈著數量龐大且複雜的微生物群落，然而，大部份的腸道微生物以傳統培養的方式與技術仍難以得之。目前大部份微生物學家均以細菌的小單元核糖體RNA基因(16S rDNA)為主，藉由不同的分析方法，如：ARDRA (RFLP)、DGGE、TGGE、T-RFLP、FISH，等；用以區分不同菌種之遺傳變異與組成，以作為細菌分類的依據。
本研究利用分子生物學的方法來探究人體的腸道細菌，分析其組成與變異，用以建立一個人體腸道細菌相藍圖，將來可應用於臨床醫學上與人體相關之腸胃道疾病與細菌感染之研究上。因此，本研究取得一個正常人的糞便檢體，並設計普遍性引子(universal primer)，行聚合酶鏈鎖反應(PCR)以放大細菌之16S rDNA片段，再利用轉殖(cloning)的方式，複製轉殖之16S rDNA片段。再隨機選擇序列進一步作定序分析，藉由比對序列之相似性，用以建立親緣關係樹，以作為細菌組成之分析與分類之依據，並建構一個人體腸道菌相之16S rDNA基因資料庫。所得序列間有98%的相似度者，則為歸為同一操作型分類單元(OTU)或單型(phylotype)。本研究所得之259條序列或clones共可分成11個群，共占細菌界(domain Bacteria)之四個門(phylum)，主要為：Firmicutes (49.8%)、Bacteroidetes (40.9%)、Proteobacteria (8.9%)與Verrucomicrobia (0.4%)。其中有15個clones (16.7 %)為新的單型，多數為已知之菌種。 臨床研究上，許多人體之感染性疾病，均與腸道細菌的轉移有相關。在此，為探究肝硬化病人併發自發性腹膜炎之致病機制，取得病人之血液與腹水檢體，並與正常人之血液檢體做對照，並利用聚合酶鏈鎖反應與無性繁殖的方式，檢測其血液與腹水中潛在之細菌。最終取得100條序列，進一步作親緣關係之分析結果，所得之菌種可分成三大群，主要以α-proteobacteria, β- proteobacteria與γ-proteobacteria為主。並包含Deinococci一小支分群。此外，值得關切的是正常人的血液中含有Stenotrophomonas maltophilia之菌種。而肝硬化併發腹水之病患的血液與腹水中各含有不同的菌種，如：Ralstonia gilardii、Burkholderia symbiont、Blastobacter denitrificans、Acinetobacter johnsonii、Ralstonia insidiosa等相關菌種。而在臨床研究上亦發現S. maltophilia與B. denitrificans等相關菌種具有抗藥性，易造成重症病人感染之症狀。 | zh_TW |
| dc.description.abstract | There are numbers of microflora incubating at human intestinal tract, but there are still 60-80% microbes can't be cultivated in vitro.Using 16S rDNA as a genetic marker and different analytic method, such as:ARDRA (RFLP), DGGE, TGGE, T-RFLP, FISH,etc. to investigate the composition of microflora and classification will be the modern method.
This study will use molecular method to investigate the human intestinal microflora composition and its clinical application. Using universal primer and PCR to amplify bacterial 16S rDNA in human fecal sample, random cloning and sequencing to obtain the sequences.Sequence similarity higher than 98% will be the same OTU or phylotype. Final obtained 259 sequences can be classified into 11 groups, 4 phyla:Firmicutes (49.8%)、Bacteroidetes (40.9%)、Proteobacteria (8.9%) and Verrucomicrobia (0.4%).There are 15 sequences (16.7%) will be novel phylotype, most sequeces are known. There are many clinical infectious diseases related to human intestinal bacterial translocation. In order to investigate the pathogenesis of spontaneous bacterial peritonitis, we obtained patients blood and ascites to co-operate with PCR and random cloning to screen the bacterial DNA. Finally obtained 100 bacterial sequences and can be classified into 3 groups,α-proteobacteria, β- proteobacteria and γ-proteobacteria respectively.In addition, we also found that there are bacterias in health person's blood, mainly Stenotrophomonas maltophilia and other species, such as Ralstonia gilardii、Burkholderia symbiont、Blastobacter denitrificans、Acinetobacter johnsonii、Ralstonia insidiosa. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T16:33:52Z (GMT). No. of bitstreams: 1 ntu-94-R92B41002-1.pdf: 2783314 bytes, checksum: b38e81ed091ada6beb279e92444f3f19 (MD5) Previous issue date: 2005 | en |
| dc.description.tableofcontents | 目 錄
致 謝 …………………………………………………………………… Ι 摘 要 …………………………………………………………………… Ⅲ 目 錄 …………………………………………………………………… Ⅳ 第一章 人體腸道菌相之研究 1. 前言 ……………………………………………………………..…… 1 2. 腸道微生物 ……………………………………………………..…… 1 3. 腸道微生物相之研究法 ………………………………………..…… 5 4. 臨床上之一個應用 ……………………………………………..….... 9 5. 參考文獻 ………………………………………………………..….... 15 6. 表 ………………………………………………………………………. 22 7. 圖 ………………………………………………………………………. 24 第二章 人體腸道菌相與其在臨床上的一個應用 1. 前言 ……………………………………………………………………. 27 2. 材料與方法 ……………………………………………………………. 29 3. 結果 …………………………………………………………………. 35 4. 討論 …………………………………………………………………… 47 5. 參考文獻 ……………………………………………………………….. 58 6. 表 ……………………………………………………………………… 63 7. 圖 …………………………………………………………………….... 78 | |
| dc.language.iso | zh-TW | |
| dc.subject | 自發性細菌感染腹膜炎 | zh_TW |
| dc.subject | 人體腸道菌 | zh_TW |
| dc.subject | 小單元核糖體DNA | zh_TW |
| dc.subject | human intestinal microflora | en |
| dc.subject | SBP | en |
| dc.subject | 16SrDNA | en |
| dc.title | 人體腸道菌相與其在臨床上的一個應用 | zh_TW |
| dc.title | Human Intestinal Microflora and Its Clinical Application | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 93-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 張慧羽,陳俊堯,徐以信 | |
| dc.subject.keyword | 人體腸道菌,小單元核糖體DNA,自發性細菌感染腹膜炎, | zh_TW |
| dc.subject.keyword | human intestinal microflora,16SrDNA,SBP, | en |
| dc.relation.page | 90 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2005-07-10 | |
| dc.contributor.author-college | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 動物學研究研究所 | zh_TW |
| 顯示於系所單位： | 動物學研究所 | |
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