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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 吳應寧 | |
| dc.contributor.author | Li-Wei Tseng | en |
| dc.contributor.author | 曾立偉 | zh_TW |
| dc.date.accessioned | 2021-06-13T16:29:15Z | - |
| dc.date.available | 2015-07-26 | |
| dc.date.copyright | 2011-07-26 | |
| dc.date.issued | 2011 | |
| dc.date.submitted | 2011-07-19 | |
| dc.identifier.citation | [1]Albini S, Zimmermann W, Neff F, Ehlers B, Hani H, Li H, Hussy D, Engels M, Ackermann M. Identification and quantification of ovine gammaherpesvirus 2 DNA in fresh and stored tissues of pigs with symptoms of porcine malignant catarrhal fever. J Clin Microbiol.;41:900-4. 2003
[2]Alcaraz A, Warren A, Jackson C, Gold J, McCoy M, Cheong SH, Kimball S, Sells S, Taus NS, Divers T, Li H. Naturally occurring sheep-associated malignant catarrhal fever in North American pigs. J Vet Diagn Invest. 21(2): 250-3, 2009. [3]Baxter SI, Pow I, Bridgen A, Reid HW. PCR detection of the sheep-associated agent of malignant catarrhal fever. Arch Virol. 132(1-2): 145-59, 1993. [4]Benetka V, Krametter-Froetscher R, Baumgartner W, Moestl K. Investigation of the role of Austrian ruminant wildlife in the epidemiology of malignant catarrhal fever viruses. J Wildl Dis. 45(2): 508-11, 2009. [5]Berezowski JA, Appleyard GD, Crawford TB, et al.: 2005, An outbreak of sheep-associated malignant catarrhal fever in bison (Bison bison) after exposure to sheep at a public auction sale. J Vet Diagn Invest. Jan;17(1):55-8 2005 [6]Brenner J, David D. Sheep-associated malignant catarrhal fever in cattle (SA-MCF). Recent clinical and epidemiological aspects in Israel. Isr J Vet Med.;60: 19-22. 2005 [7]Campolo M, Lucente MS, Mari V, Elia G, Tinelli A, Laricchiuta P, Caramelli M, Nava D, Buonavoglia C, Decaro N. Malignant catarrhal fever in a captive American bison (Bison bison) in Italy. J Vet Diagn Invest. 20(6): 843-6, 2008. [8]Costa EA, Bomfim MR, da Fonseca FG, Drumond BP, Coelho FM, Vasconcelos AC, Furtini R, Paixao TA, Tsolis RM, Santos RL, Resende M. Ovine herpesvirus 2 infection in Foal, Brazil. Emerg Infect Dis. 15(5): 844-5, 2009. [9]Coulter LJ, Reid HW. Isolation and expression of three open reading frames from ovine herpesvirus-2. J Gen Virol. 83(Pt 3):533-43. 2002 Mar [10]Crawford TB, Li H, O'Toole D. Diagnosis of malignant catarrhal fever by PCR using formalin-fixed, paraffin-embedded tissues. J Vet Diagn Invest. 11(2):111-6 1999 Mar [11]Crawford TB, Li H, Rosenburg SR, Norhausen RW, Garner MM. Mural folliculitis and alopecia caused by infection with goat-associated malignant catarrhal fever virus in two sika deer. J Am Vet Med Assoc. 15;221:843-7, 801. 2002 [12]Cunha CW, Otto L, Taus NS, Knowles DP, Li H. Development of a multiplex real-time PCR for detection and differentiation of malignant catarrhal fever viruses in clinical samples. J Clin Microbiol. 47(8): 2586-9, 2009. [13]Li H, Karney G, O'Toole D, Crawford TB. Long distance spread of malignant catarrhal fever virus from feedlot lambs to ranch bison. Can Vet J.;49(2):183-5. 2008 Feb [14]Li H, Keller J, Knowles DP, Crawford TB. Recognition of another member of the malignant catarrhal fever virus group: an endemic gammaherpesvirus in domestic goats. J Gen Virol. 2001;82:227-32. 2001 [15]Li H, Shen DT, O'Toole D, Knowles DP, Gorham JR, Crawford TB. Investigation of sheep-associated malignant catarrhal fever virus infection in ruminants by PCR and competitive inhibition enzyme-linked immunosorbent assay. J Clin Microbiol. 33(8): 2048-53, 1995. [16]Li H, Taus NS, Lewis GS, Kim O, Traul DL Crawford TB. Shedding of ovine herpesvirus 2 in sheep nasal secretions: the predominant mode for transmission. J Clin Microbiol.;42:5558-64. 2004 [17]Loken T, Bosman AM, van Vuuren M. Infection with Ovine herpesvirus 2 in Norwegian herds with a history of previous outbreaks of malignant catarrhal fever. J Vet Diagn Invest. 21(2): 257-61, 2009. [18]Moore DA, Kohrs P, Baszler T, Faux C, Sathre P, Wenz JR, Eldridge L, Li H. Outbreak of malignant catarrhal fever among cattle associated with a state livestock exhibition. J Am Vet Med Assoc. 237(1):87-92, 2010. [19]Munday JS, French AF, Smith A, Wang J, Squires RA. Probable malignant catarrhal fever presented as transient generalised crusting dermatitis in a cow. N Z Vet J. 56:89-93. 2008 [20]Neimanis AS, Hill JE, Jardine CM, Bollinger TK. Sheep-associated malignant catarrhal fever in free-ranging moose (Alces alces) in Saskatchewan, Canada. J Wildl Dis. 45(1): 213-7, 2009. [21]O'Toole D, Li H, Sourk C, Montgomery DL, Crawford TB. Malignant catarrhal fever in a bison (Bison bison) feedlot, 1993-2000. Vet Diagn Invest. 14:183-93. 2002 [22]O'Toole D, Taus NS, Montgomery DL, Oaks JL, Crawford TB, Li H. Intra-nasal inoculation of American bison (Bison bison) with ovine herpesvirus-2 (OvHV-2) reliably reproduces malignant catarrhal fever. Vet Pathol.;44(5): 655-62, 2007. [23]Schultheiss PC, Collins JK, Austgen LE, DeMartini JC. Malignant catarrhal fever in bison, acute and chronic cases. J Vet Diagn Invest. 10(3): 255-62, 1998. [24]Schultheiss PC, Van Campen H, Spraker TR, Bishop C, Wolfe L, Podell B. Malignant catarrhal fever associated with ovine herpesvirus-2 in free-ranging mule deer in Colorado. J Wildl Dis. 43(3):533-7, 2007. [25]Shulaw WP, Oglesbee M. An unusual clinical and pathological variant of malignant catarrhal fever in a white-tailed deer. J Wildl Dis. Jan;25(1): 112-7, 1989. [26]Traul DL, Taus NS, Lindsay Oaks J, O'Toole D, Rurangirwa FR, Baszler TV, Li H. Validation of nonnested and real-time PCR for diagnosis of sheep-associated malignant catarrhal fever in clinical samples. J Vet Diagn Invest. 19(4): 405-8, 2007. [27]Vikoren T, Li H, Lillehaug A, Jonassen CM, Bockerman I, Handeland K. Malignant catarrhal fever in free-ranging cervids associated with OvHV-2 and CpHV-2 DNA. J Wildl Dis. 42(4):797-807. 2006 Oct | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/38273 | - |
| dc.description.abstract | 惡性卡他熱 （ Malignant Catarrhal Fever; MCF ）是一種系統性、致命的病毒性傳染病，主要發生於牛及多種馴養及野生的偶蹄類動物。造成惡性卡他熱感染的病源是皰疹病毒屬下的多種病毒，包含α皰疹病毒第一型 (AHV-1)、α皰疹病毒第二型 (AHV-2 )、綿羊皰疹病毒第二型 (OHV-2)、山羊皰疹病毒第二型 (CpHV-2)及MCFV-WTD。
在2008年10月到12月間，台灣地區的野生動物園曾經發生圈養的台灣水鹿突發性大量死亡，組織切片下發現淋巴結大區域的出血壞死、腸道黏膜出血壞死及系統性多器官血管壞死和血管炎，經病理學診斷懷疑為惡性卡他熱。該野生動物園內的所有動物是採集體混養的飼養方式，為了確定感染各種不同的反芻動物的惡性卡他熱病原種類，自2008年七月開始收集動物園內反芻動的物器官生體，和血液樣本，以巢氏聚合酶鍊鎖反應檢測惡性卡他熱病毒，並綜合屍體解剖的病理結果，分析感染不同種反芻動物的惡性卡他熱病毒及不同種反芻動物的惡性卡他熱潛伏感染情形。結果顯示，造成此野生動物園內惡性卡他熱集體感染的病原為綿羊皰疹病毒第二型，其在園內多種反芻動物上都呈現陽性顯性感染，但在園內的綿羊及山羊多為不顯性感染，此病毒在美洲野牛發病多為急性型惡性卡熱，動物於發病後2到3天後死亡。已將感染發病的動物做單獨隔離，並將園區內容易感染發病的反芻獸與病毒的保毒宿主綿羊和山羊做區隔，避免感染情形繼續擴大。 | zh_TW |
| dc.description.abstract | Malignant catarrhal fever (MCF) is a fatal, systemic disease of cattle and other domestic and wild cloven-hoofed animals. Malignant catarrhal fever is caused by several viruses in the genus Rhadinovirus of the family Herpesviridae (subfamily Gammaherpesvirinae), including Alcelaphine herpesvirus 1 (AHV-1), Alcelaphine herpesvirus 2 (AHV-2), Ovine herpesvirus 2 (OHV-2), and Caprine herpesvirus 2 (CpHV-2) and a virus of unknown origin, currently called MCFV-WTD.
In October-December 2008, in a safari park in Taiwan, a large number of domestic Formosan Sambar suddenly died. According to pathological finding, there were multifocal lymph node necrotizing and hemorrhage, intestinal mucosa necrotizing and hemorrhage, vascular necrotizing and vasculitis in multiple organs, and were suspected MCF infection. All herbivores housed together in free safari or exhibits. Since 2008, in order to confirm which pathogen caused MCF infection in different kinds of ruminants, we have collected fresh necropsy samples and blood samples from ruminants in the zoo. Then we used nest-PCR for detection and differentiation of MCF viruses from these samples. The results showed the pathogen which caused MCF infection is ovine herpesvirus type 2 (OHV-2) and a lot of ruminants in the zoo were showed positive. Sheep and goat have inapparent infection with OHV-2, American bison showed acute infection with OHV-2. The American bison infected with OHV-2 usually died within two to three days. In order to control infection of OHV-2, isolating animals with clinical signs and separating susceptible animals from sheep, goats or other suspected reservoir hosts in the zoo is important. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T16:29:15Z (GMT). No. of bitstreams: 1 ntu-100-R98643013-1.pdf: 4591236 bytes, checksum: 050f80024a3cf981159da6b8d8311c4b (MD5) Previous issue date: 2011 | en |
| dc.description.tableofcontents | 口試委員會審定 #
誌謝 i 中文摘要 ii ABSTRACT iii CONTENTS v LIST OF FIGURES vii LIST OF TABLES ix Chapter 1 General Introduction 1 Chapter 2 Paper Review 4 2.1 Etiology of malignant catarrhal fever 4 2.2 OHV-2 caused MCF in the zoo 4 2.3 Pathology of MCF 5 2.4 PCR detection of OHV-2 5 Chapter 3 Material and Methods 7 3.1 Sample Collection 7 3.2 DNA purification from tissue 7 3.3 DNA purification from buffy coat 8 3.4 Primer design 9 3.5 DNA amplification reaction by Nest-PCR 9 3.6 Gel electrophoresis and fragment identification 10 3.7 Sequencing of Nest-PCR products 10 Chapter 4 Result 11 4.1 Pathological examination 11 4.2 Nucleotide sequence analysis 11 4.3 Situation of MCF infection of animals in the zoo 12 Chapter 5 Discussion 13 Chapter 6 Conclusions 16 REFERENCE 17 Appendix-Figure 21 Appendix-Table 30 | |
| dc.language.iso | en | |
| dc.subject | 綿羊疱 | zh_TW |
| dc.subject | 反芻獸 | zh_TW |
| dc.subject | 美洲野牛 | zh_TW |
| dc.subject | 疹病毒第二型 | zh_TW |
| dc.subject | 惡性卡他熱 | zh_TW |
| dc.subject | ruminant | en |
| dc.subject | American bison | en |
| dc.subject | MCF | en |
| dc.subject | ovine herpesvirus type 2 | en |
| dc.title | 動物園內反芻獸的惡性卡他熱病毒感染調查 | zh_TW |
| dc.title | Investigation of Malignant Catarrhal Fever Virus Infected Ruminants in The Zoo | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 99-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 季昭華,張本恒 | |
| dc.subject.keyword | 反芻獸,美洲野牛,惡性卡他熱,綿羊疱,疹病毒第二型, | zh_TW |
| dc.subject.keyword | ruminant,American bison,MCF,ovine herpesvirus type 2, | en |
| dc.relation.page | 31 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2011-07-19 | |
| dc.contributor.author-college | 獸醫專業學院 | zh_TW |
| dc.contributor.author-dept | 臨床動物醫學研究所 | zh_TW |
| 顯示於系所單位： | 臨床動物醫學研究所 | |
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