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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 劉春櫻 | |
dc.contributor.author | Yi-Jin Huang | en |
dc.contributor.author | 黃怡津 | zh_TW |
dc.date.accessioned | 2021-06-13T15:47:39Z | - |
dc.date.available | 2009-07-03 | |
dc.date.copyright | 2008-07-03 | |
dc.date.issued | 2008 | |
dc.date.submitted | 2008-06-29 | |
dc.identifier.citation | 參考文獻
(1) Lau, K. T.; Hui, D. Composites Part B 2002, 33, 263-277. (2) Kroto, H. W.; Heath, J. R.; Obrien, S. C.; Curl, R. F.; Smalley, R. E. Nature 1985, 318, 162-163. (3) Iijima, S. Nature 1991, 354, 56-58. (4) Iijima, S.; Ichihashi, T.; Ando, Y. Nature 1992, 356, 776-778. (5) Iijima, S.; Ichihashi, T. Nature 1993, 363, 603-605. (6) Bethune, D. S.; Kiang, C. H.; Devries, M. S.; Gorman, G.; Savoy, R.; Vazquez, J.; Beyers, R. Nature 1993, 363, 605-607. (7) Kim, S. N.; Rusling, J. F.; Papadimitrakopoulos, F. Adv. Mater. 2007, 19, 3214-3228. (8) Baxendale, M. J. Mater. Sci. - Mater. Electron. 2003, 14, 657-659. (9) Ebbesen, T. W. Carbon nanotubes: preparation and properties; CRC Press: Boca Raton 1997. (10) Vaisman, L.; Wagner, H. D.; Marom, G. Adv. Colloid Interface Sci. 2006, 128, 37-46. (11) Hamada, N.; Sawada, S.; Oshiyama, A. Phys. Rev. Lett. 1992, 68, 1579-1581. (12) Saito, R.; Fujita, M.; Dresselhaus, G.; Dresselhaus, M. S. Appl. Phys. Lett. 1992, 60, 2204-2206. (13) Wildoer, J. W. G.; Venema, L. C.; Rinzler, A. G.; Smalley, R. E.; Dekker, C. Nature 1998, 391, 59-62. (14) Odom, T. W.; Huang, J. L.; Kim, P.; Lieber, C. M. Nature 1998, 391, 62-64. (15) Ajayan, P. M. Chem. Rev. 1999, 99, 1787-1799. (16) Ajayan, P. M.; Ebbesen, T. W.; Ichihashi, T.; Iijima, S.; Tanigaki, K.; Hiura, H. Nature 1993, 362, 522-525. (17) Treacy, M. M. J.; Ebbesen, T. W.; Gibson, J. M. Nature 1996, 381, 678-680. (18) Yu, M. F.; Lourie, O.; Dyer, M. J.; Moloni, K.; Kelly, T. F.; Ruoff, R. S. Science 2000, 287, 637-640. (19) Wiles, P. G.; Abrahamson, J. Carbon 1978, 16, 341-349. (20) Ebbesen, T. W.; Ajayan, P. M. Nature 1992, 358, 220-222. (21) Wang, X. K.; Lin, X. W.; Dravid, V. P.; Ketterson, J. B.; Chang, R. P. H. Appl. Phys. Lett. 1995, 66, 2430-2432. (22) Cui, S.; Scharff, P.; Siegmund, C.; Schneider, D.; Risch, K.; Klotzer, S.; Spiess, L.; Romanus, H.; Schawohl, J. Carbon 2004, 42, 931-939. (23) Saito, Y.; Nishikubo, K.; Kawabata, K.; Matsumoto, T. J. Appl. Phys. 1996, 80, 3062-3067. (24) Dresselhaus, M. S.; Dresselhaus, G.; Avouris, P. Carbon nanotubes : synthesis, structure, properties, and applications; New York : Springer: Berlin, 2001. (25) Guo, T.; Nikolaev, P.; Rinzler, A. G.; Tomanek, D.; Colbert, D. T.; Smalley, R. E. J. Phys. Chem. 1995, 99, 10694-10697. (26) Guo, T.; Nikolaev, P.; Thess, A.; Colbert, D. T.; Smalley, R. E. Chem. Phys. Lett. 1995, 243, 49-54. (27) Thess, A.; Lee, R.; Nikolaev, P.; Dai, H. J.; Petit, P.; Robert, J.; Xu, C. H.; Lee, Y. H.; Kim, S. G.; Rinzler, A. G.; Colbert, D. T.; Scuseria, G. E.; Tomanek, D.; Fischer, J. E.; Smalley, R. E. Science 1996, 273, 483-487. (28) Harris, P. J. F. Carbon 2007, 45, 229-239. (29) Joseyacaman, M.; Mikiyoshida, M.; Rendon, L.; Santiesteban, J. G. Appl. Phys. Lett. 1993, 62, 202-204. (30) Journet, C.; Bernier, P. Appl. Phys. A: Mater. Sci. Process. 1998, 67, 1-9. (31) Baker, R. T. K.; Harris, P. S.; Thomas, R. B.; Waite, R. J. J. Catal. 1973, 30, 86-95. (32) Baker, R. T. K. Carbon 1989, 27, 315-323. (33) Sinnott, S. B.; Andrews, R.; Qian, D.; Rao, A. M.; Mao, Z.; Dickey, E. C.; Derbyshire, F. Chem. Phys. Lett. 1999, 315, 25-30. (34) Long, R. Q.; Yang, R. T. J. Am. Chem. Soc. 2001, 123, 2058-2059. (35) Cai, Y. Q.; Jiang, G. B.; Liu, J. F.; Zhou, Q. X. Anal. Chem. 2003, 75, 2517-2521. (36) Cai, Y. Q.; Jiang, G. B.; Liu, J. F.; Zhou, Q. X. Anal. Chim. Acta 2003, 494, 149-156. (37) Zhou, Q. X.; Wang, W. D.; Xiao, J. P.; Wang, J. H.; Liu, G. G.; Shi, Q. Z.; Guo, G. L. Microchim. Acta 2006, 152, 215-224. (38) Wang, L. P.; Zhao, H. X.; Qiu, Y. M.; Zhou, Z. Q. J. Chromatogr. A 2006, 1136, 99-105. (39) Valcarcel, M.; Cardenas, S.; Simonet, B. M. Anal. Chem. 2007, 79, 4788-4797. (40) Kong, J.; Franklin, N. R.; Zhou, C. W.; Chapline, M. G.; Peng, S.; Cho, K. J.; Dai, H. J. Science 2000, 287, 622-625. (41) Collins, P. G.; Bradley, K.; Ishigami, M.; Zettl, A. Science 2000, 287, 1801-1804. (42) Campbell, J. K.; Sun, L.; Crooks, R. M. J. Am. Chem. Soc. 1999, 121, 3779-3780. (43) Yan, X. X.; Pang, D. W.; Lu, Z. X.; Lu, H. Q.; Tong, H. J. Electroanal. Chem. 2004, 569, 47-52. (44) Boo, H.; Jeong, R. A.; Park, S.; Kim, K. S.; An, K. H.; Lee, Y. H.; Han, J. H.; Kim, H. C.; Chung, T. D. Anal. Chem. 2006, 78, 617-620. (45) Zhang, M. G.; Smith, A.; Gorski, W. Anal. Chem. 2004, 76, 5045-5050. (46) Gooding, J. J. Electroanalysis 2002, 14, 1149-1156. (47) He, P. G.; Dai, L. M. Chem. Commun. 2004, 348-349. (48) Valcarcel, M.; Simonet, B. M.; Cardenas, S.; Suarez, B. Anal. Bioanal. Chem. 2005, 382, 1783-1790. (49) Saridara, C.; Mitra, S. Anal. Chem. 2005, 77, 7094-7097. (50) Karwa, M.; Mitra, S. Anal. Chem. 2006, 78, 2064-2070. (51) Stadermann, M.; McBrady, A. D.; Dick, B.; Reid, V. R.; Noy, A.; Synovec, R. E.; Bakajin, O. Anal. Chem. 2006, 78, 5639-5644. (52) Yuan, L. M.; Ren, C. X.; Li, L.; Ai, P.; Yan, Z. H.; Zi, M.; Li, Z. Y. Anal. Chem. 2006, 78, 6384-6390. (53) Li, Y.; Chen, Y.; Xiang, R.; Ciuparu, D.; Pfefferle, L. D.; Horwath, C.; Wilkins, J. A. Anal. Chem. 2005, 77, 1398-1406. (54) Kwon, S. H.; Park, J. H. J. Sep. Sci. 2006, 29, 945-952. (55) Terabe, S.; Otsuka, K.; Ichikawa, K.; Tsuchiya, A.; Ando, T. Anal. Chem. 1984, 56, 111-113. (56) Watari, H. Chem. Lett. 1991, 3, 391-394. (57) Wallingford, R. A.; Ewing, A. G. Adv. Chromatogr. 1989, 29, 1-76. (58) Nilsson, C.; Nilsson, S. Electrophoresis 2006, 27, 76-83. (59) Neiman, B.; Grushka, E.; Gun, J.; Lev, O. Anal. Chem. 2002, 74, 3484-3491. (60) Huang, M. F.; Kuo, Y. C.; Huang, C. C.; Chang, H. T. Anal. Chem. 2004, 76, 192-196. (61) Viberg, P.; Jornten-Karlsson, M.; Petersson, P.; Spegel, P.; Nilsson, S. Anal. Chem. 2002, 74, 4595-4601. (62) Spegel, P.; Schweitz, L.; Nilsson, S. Anal. Chem. 2003, 75, 6608-6613. (63) Akbay, C.; Rizvi, S. A. A.; Shamsi, S. A. Anal. Chem. 2005, 77, 1672-1683. (64) Castagnola, M.; Zuppi, C.; Rossetti, D. V.; Vincenzoni, F.; Lupi, A.; Vitali, A.; Meucci, E.; Messana, I. Electrophoresis 2002, 23, 1769-1778. (65) Suarez, B.; Simonet, B. M.; Cardenas, S.; Valcarcel, M. J. Chromatogr. A 2006, 1128, 282-289. (66) Xiong, X.; Ouyang, J.; Baeyens, W. R. G.; Delanghe, J. R.; Shen, X. M.; Yang, Y. P. Electrophoresis 2006, 27, 3243-3253. (67) Xu, Y.; Li, S. F. Y. Electrophoresis 2006, 27, 4025-4028. (68) Luong, J. H. T.; Bouvrette, P.; Liu, Y. L.; Yang, D. Q.; Sacher, E. J. Chromatogr. A 2005, 1074, 187-194. (69) Wang, Z. H.; Luo, G. A.; Chen, J. F.; Xiao, S. F.; Wang, Y. M. Electrophoresis 2003, 24, 4181-4188. (70) Moliner-Martinez, Y.; Cardenas, S.; Valcarcel, M. Electrophoresis 2007, 28, 2573-2579. (71) Suarez, B.; Simonet, B. M.; Cardenas, S.; Valcarcel, M. Electrophoresis 2007, 28, 1714-1722. (72) Islam, M. F.; Rojas, E.; Bergey, D. M.; Johnson, A. T.; Yodh, A. G. Nano Lett. 2003, 3, 269-273. (73) Strano, M. S.; Moore, V. C.; Miller, M. K.; Allen, M. J.; Haroz, E. H.; Kittrell, C.; Hauge, R. H.; Smalley, R. E. J. Nanosci. Nanotechnol. 2003, 3, 81-86. (74) Yurekli, K.; Mitchell, C. A.; Krishnamoorti, R. J. Am. Chem. Soc. 2004, 126, 9902-9903. (75) Lago, R. M.; Tsang, S. C.; Lu, K. L.; Chen, Y. K.; Green, M. L. H. J. Chem. Soc., Chem. commun 1995, 1355-1356. (76) Hwang, K. C. J. Chem. Soc., Chem. commun 1995, 173-174. (77) Goyanes, S.; Rubiolo, G. R.; Salazar, A.; Jimeno, A.; Corcuera, M. A.; Mondragon, I. Diamond Relat. Mater. 2007, 16, 412-417. (78) Tsang, S. C.; Harris, P. J. F.; Green, M. L. H. Nature 1993, 362, 520-522. (79) Liu, J.; Rinzler, A. G.; Dai, H. J.; Hafner, J. H.; Bradley, R. K.; Boul, P. J.; Lu, A.; Iverson, T.; Shelimov, K.; Huffman, C. B.; Rodriguez-Macias, F.; Shon, Y. S.; Lee, T. R.; Colbert, D. T.; Smalley, R. E. Science 1998, 280, 1253-1256. (80) Wang, Y. B.; Iqbal, Z.; Malhotra, S. V. Chem. Phys. Lett. 2005, 402, 96-101. (81) Hill, D. E.; Lin, Y.; Rao, A. M.; Allard, L. F.; Sun, Y. P. Macromolecules 2002, 35, 9466-9471. (82) Eitan, A.; Jiang, K. Y.; Dukes, D.; Andrews, R.; Schadler, L. S. Chem. Mater. 2003, 15, 3198-3201. (83) Hiura, H.; Ebbesen, T. W.; Tanigaki, K. Adv. Mater. 1995, 7, 275-276. (84) Ago, H.; Kugler, T.; Cacialli, F.; Salaneck, W. R.; Shaffer, M. S. P.; Windle, A. H.; Friend, R. H. J. Phys. Chem. B 1999, 103, 8116-8121. (85) Lordi, V.; Yao, N.; Wei, J. Chem. Mater. 2001, 13, 733-737. (86) Xing, Y. C. J. Phys. Chem. B 2004, 108, 19255-19259. (87) Lu, K. L.; Lago, R. M.; Chen, Y. K.; Green, M. L. H.; Harris, P. J. F.; Tsang, S. C. Carbon 1996, 34, 814-816. (88) Zhang, J.; Zou, H. L.; Qing, Q.; Yang, Y. L.; Li, Q. W.; Liu, Z. F.; Guo, X. Y.; Du, Z. L. J. Phys. Chem. B 2003, 107, 3712-3718. (89) http://www.sciscape.org/news_detail.php?news_id=1746. (90) Gentili, A. Anal. Bioanal. Chem. 2007, 387, 1185-1202. (91) Donato, M. G.; Vandeneeckhout, E.; Vandenbossche, W.; Sandra, P. J. Pharm. Biomed. Anal. 1993, 11, 197-201. (92) Macia, A.; Borrull, F.; Aguilar, C.; Calull, M. Electrophoresis 2003, 24, 2779-2787. (93) Macia, A.; Borrull, F.; Calull, M.; Aguilar, C. Electrophoresis 2004, 25, 3441-3449. (94) Chen, Y. L.; Wu, S. M. Anal. Bioanal. Chem. 2005, 381, 907-912. (95) Zinellu, A.; Carru, C.; Sotgia, S.; Porqueddu, E.; Enrico, P.; Deiana, L. Eur. J. Pharm. Sci. 2005, 24, 375-380. (96) Chen, Y. L.; Jong, Y. J.; Wu, S. M. J. Chromatogr. A 2006, 1119, 176-182. (97) Zhang, P.; Xu, G. W.; Xiong, J. H.; Zheng, Y. F.; Shi, X. Z.; Yang, Q.; Wei, F. S. J. Sep. Sci. 2003, 26, 1527-1532. (98) Orlandini, S.; Fanali, S.; Furlanetto, S.; Marras, A. M.; Pinzauti, S. J. Chromatogr. A 2004, 1032, 253-263. (99) Macia, A.; Borrull, F.; Calull, M.; Aguilar, C. J. Chromatogr. A 2006, 1117, 234-245. (100) Dey, J.; Mohanty, A.; Roy, S.; Khatua, D. J. Chromatogr. A 2004, 1048, 127-132. (101) Macia, A.; Borrull, F.; Calull, M.; Aguilar, C. Electrophoresis 2005, 26, 970-979. (102) Macia, A.; Borrull, F.; Calull, M.; Aguilar, C. Chromatographia 2006, 63, 149-154. (103) Orlandini, S.; Furlanetto, S.; Pinzauti, S.; D'Orazio, G.; Fanali, S. J. Chromatogr. A 2004, 1044, 295-303. (104) De Rossi, A.; Desiderio, C. J. Chromatogr. A 2003, 984, 283-290. (105) Mangelings, D.; Tanret, I.; Matthijs, N.; Maftouh, M.; Massart, D. L.; Vander Heyden, Y. Electrophoresis 2005, 26, 818-832. (106) Fanali, S.; Catarcini, P.; Presutti, C. J. Chromatogr. A 2003, 994, 227-232. (107) Manetto, G.; Bellini, M. S.; Deyl, Z. J. Chromatogr. A 2003, 990, 281-289. (108) Kim, Y. T.; Ito, Y.; Tadai, K.; Mitani, T.; Kim, U. S.; Kim, H. S.; Cho, B. W. Appl. Phys. Lett. 2005, 87, 234106. (109) Yu, R. Q.; Chen, L. W.; Liu, Q. P.; Lin, J. Y.; Tan, K. L.; Ng, S. C.; Chan, H. S. O.; Xu, G. Q.; Hor, T. S. A. Chem. Mater. 1998, 10, 718-722. (110) Liu, Z. L.; Lin, X. H.; Lee, J. Y.; Zhang, W.; Han, M.; Gan, L. M. Langmuir 2002, 18, 4054-4060. (111) Lennon, D.; Lundie, D. T.; Jackson, S. D.; Kelly, G. J.; Parker, S. F. Langmuir 2002, 18, 4667-4673. (112) Xing, Y. C.; Li, L.; Chusuei, C. C.; Hull, R. V. Langmuir 2005, 21, 4185-4190. (113) Ajayan, P. M.; Iijima, S. Nature 1993, 361, 333-334. (114) Zhou, O.; Fleming, R. M.; Murphy, D. W.; Chen, C. H.; Haddon, R. C.; Ramirez, A. P.; Glarum, S. H. Science 1994, 263, 1744-1747. (115) Cech, J.; Curran, S. A.; Zhang, D. H.; Dewald, J. L.; Avadhanula, A.; Kandadai, M.; Roth, S. Phys. Status Solidi B 2006, 243, 3221-3225. (116) Curran, S. A.; Cech, J.; Zhang, D. H.; Dewald, J. L.; Avadhanula, A.; Kandadai, M.; Roth, S. J. Mater. Res. 2006, 21, 1012-1018. (117) Zhao, W.; Song, C. H.; Pehrsson, P. E. J. Am. Chem. Soc. 2002, 124, 12418-12419. (118) Revilla, A. L.; Havel, J.; Jandik, P. J. Chromatogr. A 1996, 745, 225-232. (119) Schmitt-Kopplin, P.; Hertkorn, N.; Garrison, A. W.; Freitag, D.; Kettrup, A. Anal. Chem. 1998, 70, 3798-3808. (120) Lee, G. W.; Kumar, S. J. Phys. Chem. B 2005, 109, 17128-17133. (121) Pehourcq, F.; Jarry, C.; Bannwarth, B. J. Pharm. Biomed. Anal. 2003, 33, 137-144. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/37857 | - |
dc.description.abstract | 本研究係以羧化多層奈米碳管(multi-walled carbon nanotubes containing carboxyl groups, c-MWNTs)為緩衝溶液添加物,於毛細管電泳中扮演偽靜相的角色,應用於非類固醇抗炎性藥物(non-steroidal anti- inflammatory drugs, NSAIDs)之分離。由於奈米碳管屬於疏水性,利用硝酸/硫酸混合溶液經過超音波震盪進行氧化反應,藉由FT-IR、ESCA和TEM之方法鑑定,發現最佳作用時間為4 h,成功使奈米碳管表面官能基化來提升水溶性且保留奈米碳管完美的管狀結構。奈米碳管為黑色物質會干擾UV偵測,所以本實驗緩衝溶液中c-MWNTs含量為0.02 mg/ml。經由比較硼酸緩衝溶液與磷酸緩衝溶液的穩定性,發現硼酸緩衝溶液可輔助c-MWNTs懸浮。因此,以硼酸緩衝溶液(75 mM, pH 10)添加0.02 mg/ml c-MWNT再利用有機修飾劑(MeOH, EtOH, 1-pro- panol, 2-propanol, 1-butanol)來提升解析度,發現分析物滯留時間延長,電流值變小,而且隨著碳鏈的增加,c-MWNTs的穩定度下降,分析物的解析度也降低,其中以5 % MeOH的效果最好。本研究並且發現低溫有助於其解析度的提升。在硼酸緩衝溶液(75 mM, pH 10)添加0.02 mg/ml c-MWNTs和5 % MeOH於電壓12 kV低溫進樣(0℃),滯留時間為:indoprofen < ketoprofen < suprofen < fenoprofen < flurbiprofen < naproxen,平均理論板數為8.6×104 m-1,分析物滯留時間的RSD值為2.22% (n = 3),而羧化多層奈米碳管可提供π - π interaction、hydrophobic interaction、electrostatic interaction和hydrogen bond。本研究並與MEKC (75 mM borate buffer, 50 mM SDS, pH 10)比較,發現滯留時間為suprofen < naproxen < ketoprofen < fenoprofen < indoprofen < flurbiprofen,平均理論板數為3.6×104 m-1,分析物滯留時間的RSD值為1.85% (n = 3)。本研究以c-MWNTs 作為偽靜相,相較於MEKC具有高理論板數和多樣性作用力,可以成功分離六種pKa值相近的非類固醇抗炎性藥物。 | zh_TW |
dc.description.abstract | A functionalized multiwalled carbon nanotubes (c-MWNTs) as a pseudostationary phase for the capillary eletrophoretic separation of non-steroidal anti-inflammatory drugs (NSAIDs) was described. In order to increase hydrophilicity of the multiwalled carbon nanotubes (MWNTs) in an aqueous electrolyte, a sonochemical process was used to treat MWNTs in concentrated nitric/sulfuric acid mixture. Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and electron spectroscopy for chemical analysis system (ESCA) were used for the characterization of the oxidized MWNTs. The c-MWNTs afforded sieving mechanism, π-π interaction, hydrophobic interaction, hydrogen bond, and electrostatic interaction to separate NSAIDs, providing a different separation mode from sodium dodecyl sulfate (SDS) micelles. The effect of important factors such as pH and concentration of running buffer, separation voltage, organic modifiers and injection temperature were investigated to acquire the optimum conditions. The optimum experimental conditions for the separation of a drug mixture, which consisted of indoprofen, ketoprofen, suprofen, naproxen, flurbiprofen and fenoprofen were using a mixture of borate buffer (75 mM, pH 10)-methanol (95:5, v/v) containing 0.02 mg/ml c-MWNTs as background electro- lyte by low injection temperature and an applied voltage of +12 kV with UV detection at 214 nm. The separation of these drugs could be achieved with an average plat number of 8.6×104 m-1. Finally, the procedure was applied to analyze NSAIDs spiked in urine sample with satisfactory results. | en |
dc.description.provenance | Made available in DSpace on 2021-06-13T15:47:39Z (GMT). No. of bitstreams: 1 ntu-97-R95223077-1.pdf: 6932798 bytes, checksum: 70c63e738fcb7b057131ae42e8765c84 (MD5) Previous issue date: 2008 | en |
dc.description.tableofcontents | 摘要 i
Abstract iii 目錄 iv 圖目錄 viii 表目錄 xii 第一章 緒論 1 第一節 奈米碳管 1 1-1 奈米碳管之歷史 1 1-2 奈米碳管之物理性質 6 1-3 奈米碳管之製備方法 15 1-4 奈米碳管之生長機制 20 1-5 奈米碳管於分析科學之應用 21 第二節 奈米碳管於電泳層析法之應用 26 2-1 前言 26 2-2 非共價方式(物理性) 27 2-3 共價方式(化學性) 30 第三節 非類固醇抗炎性藥物 34 3-1 前言 34 3-2 藥理作用 34 3-3 非類固醇抗炎性藥物之介紹 35 3-4 非類固醇抗炎性藥物之分析 40 第四節 研究動機 45 第二章 實驗部分 46 第一節 實驗儀器 46 1-1 自組裝毛細管電泳系統 46 2-1 其他實驗操作儀器 47 第二節 藥品 49 2-1 緩衝溶液 49 2-2 分析藥品 49 2-3 FT-IR之檢測樣品所需用藥 50 第三節 官能基化奈米碳管的製備與鑑定 51 3-1 氧化多層奈米碳管的實驗步驟 51 3-2 氧化多層奈米碳管以FT-IR鑑定的樣品處理 51 3-3 氧化多層奈米碳管以ESCA鑑定的樣品處理 51 3-4 氧化多層奈米碳管以TEM鑑定的樣品處理 52 第四節 毛細管電層析之實驗操作 53 4-1 藥品配置 53 4-2 毛細管電層析之操作條件 53 第三章 結果與討論 55 第一節 官能基化奈米碳管的特性描述 55 1-1 氧化多層奈米碳管方法探討 55 1-2 氧化多層奈米碳管之FT-IR鑑定 56 1-4 氧化多層奈米碳管之ESCA鑑定 58 1-3 氧化多層奈米碳管之TEM鑑定 60 第二節 非類固醇抗炎性藥物的分離 67 2-1 硼酸緩衝溶液pH值之影響 67 2-2 硼酸緩衝溶液離子濃度之影響 72 2-3 分析電壓之影響 77 2-4 有機修飾劑之影響 80 2-5 緩衝溶液之組成 89 2-6 低溫樣品進樣對分離之影響 92 2-7 偵測極限之探討 95 第三節 分離機制之探討 97 第四節 真實樣品之分析 102 第四章 結論 104 參考文獻 105 | |
dc.language.iso | zh-TW | |
dc.title | 以官能基奈米碳管偽靜相應用於非類固醇抗炎性藥物的毛細管電泳分離 | zh_TW |
dc.title | Functionalized carbon nanotubes as pseudostationary phase for capillary electrophoretic separation of NSAIDs | en |
dc.type | Thesis | |
dc.date.schoolyear | 96-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 陳俊顯,孫毓璋 | |
dc.subject.keyword | 奈米碳管,非類固醇抗炎性藥物, | zh_TW |
dc.subject.keyword | carbon nanotubes,non-steroidal anti-inflammatory drugs, | en |
dc.relation.page | 113 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2008-06-30 | |
dc.contributor.author-college | 理學院 | zh_TW |
dc.contributor.author-dept | 化學研究所 | zh_TW |
顯示於系所單位: | 化學系 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-97-1.pdf 目前未授權公開取用 | 6.77 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。