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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/37758完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 邱文英 | |
| dc.contributor.author | Tsung-Min Huang | en |
| dc.contributor.author | 黃琮閔 | zh_TW |
| dc.date.accessioned | 2021-06-13T15:42:19Z | - |
| dc.date.available | 2010-07-11 | |
| dc.date.copyright | 2008-07-11 | |
| dc.date.issued | 2008 | |
| dc.date.submitted | 2008-07-04 | |
| dc.identifier.citation | 1. R. M. Fitch, “The homogeneous nucleation of polymer colloid,” Br.Polym. J. 5, 467(1973)
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/37758 | - |
| dc.description.abstract | 本實驗為水膠配方開發，藉由不同的配方組成、合成方法，來改變水膠的結構，進而影響其黏著力、熟成時間、膠體強度等物理性質。之後引入添加溫感型的高分子於水膠結構中，使其具有溫度敏感的特性。最後探討不同的水膠結構設計及物理性質，以及溫度敏感高分子複合水膠於藥物控制釋放系統之適用性。
本研究以丙烯酸(AA)、丙烯酸鈉(SA，sodium acrylate)之共聚物NP-700為主，並混以羧甲基纖維素鈉 (sodium carboxymethyl cellulose，CMC)構成水膠，並以乳化聚合方式合成之溫度敏感型poly(NIPAAm-co-AA) micro-gel水溶液引入水膠結構中，利用Al3+作為交聯劑，形成溫度敏感高分子複合水膠。觀察不同的水膠型態、熟成情形、交聯度對膨潤性質及黏著力的影響，並以熊果素為模擬藥物，進行複合水膠薄膜中藥物釋放與擴散性質研究，觀察摻混不同形態溫度敏感型乳液對複合水膠薄膜藥物控制釋放之影響。 | zh_TW |
| dc.description.abstract | In this research, different prescriptions and steps were adopted to change the structure of hydrogel. Thus, the adhesion force, time for mature and mechanical strength of hydrogel could be studied. Furthermore, by adding thermal responsive polymer to hydrogel, the complex hydrogel could be sensitive to temperature. Finally, composition and its physical properties of hydrogel, and the applicability of complex hydrogel in drug release control system was investigated.
Acrylic acid / sodium acrylate copolymer (NP-700) and sodium carboxymethyl cellulose were used to syntheses hydrogel in the presence of aluminum ion to interact with carboxyl group in this research. Thermal responsive poly(NIPAAm-co-AA) micro-gel solution was obtained by emulsion polymerization and introduced to the hydrogel. The adhesion force, time for mature, crosslinking degree and swelling ratio of complex hydrogel were observed. Finally, Arbutin was the drug used in the experiment for researching the drug releasing and its diffusion mathematical model of complex hydrogel film. The effect of the morphology of the thermal sensitive polymer in complex hydrogel film on drug releasing was studied too. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T15:42:19Z (GMT). No. of bitstreams: 1 ntu-97-R95524037-1.pdf: 2859691 bytes, checksum: 94448524d8da753031043b3c21d8a976 (MD5) Previous issue date: 2008 | en |
| dc.description.tableofcontents | 中文摘要 I
Abstract II 目錄 III 表目錄 VI 圖目錄 VII 第一章 緒論 1 2-1 高分子乳膠顆粒的合成 3 2-1-1 簡介 3 2-1-2 乳化聚合反應的成核機構 4 2-2環境敏感型高分子 5 2-2-1 溫度敏感型高分子 6 2-2-2 LCST的形成原因 6 2-2-3 膨潤理論 7 2-3 藥物控制釋放技術 7 第三章 藥物控制釋放機構 9 3-1 藥物在豬皮中擴散(24) 9 3-2 含藥物水膠薄膜於PBS 水溶液中藥物釋放 11 3-3 含藥物水膠薄膜貼附於豬皮上穿透釋放(24-25) 13 3-3-1 同時考慮水膠薄膜與豬皮內的擴散 14 3-3-2 將水膠視為reservoir 只考慮豬皮擴散係數 18 第四章 實驗方法 19 4-1 實驗藥品 19 丙烯酸(AA)、丙烯酸鈉 (SA, sodium acrylate)共聚物 21 14. SMBS4-2 實驗儀器 21 4-2 實驗儀器 22 4-3 實驗流程 25 4-3-1 實驗流程圖 25 4-3-2 溫度敏感型poly(NIPAAm-co-AA)乳膠微粒的合成(38) 26 4-3-3 溫度敏感型水溶性poly(NIPAAm-co-AA)的合成(35) 27 4-3-4 水膠薄膜的合成 28 4-3-5 複合水膠薄膜藥物釋放分析方法 29 4-3-6 含藥物水膠薄膜於PBS 水溶液中釋放實驗 29 4-3-6 含藥物水膠薄膜於PBS 水溶液中釋放實驗 30 4-3-7 藥物於豬皮中擴散實驗 31 4-3-8 含藥物水膠薄膜貼附於豬皮釋放實驗 32 4-4-1 溫度敏感型poly(NIPAAm-co-AA)乳膠微粒的合成方法(38) 33 4-4-2 溫度敏感型水溶性poly(NIPAAm-co-AA)的合成方法(35) 34 4-4-3 溫度敏感型乳膠微粒的透析 35 4-4-4 水膠薄膜合成方法 36 4-5 性質測定 37 4-5-1 poly(NIPAAm-co-AA)水溶液固含量測定 37 4-5-2 poly(NIPAAm-co-AA)顆粒型態觀察-TEM 37 4-5-3 poly(NIPAAm-co-AA)之LCST測試實驗 38 4-5-4 水膠薄膜型態觀察-SEM 38 4-5-5 水膠薄膜黏著力測試 38 4-5-6 水膠薄膜膨潤性測試 38 4-5-7 藥物釋放測試 39 第五章 結果與討論 43 5-1 水膠薄膜製作 43 5-1-1 水膠薄膜配方 43 5-1-2 水膠薄膜合成方法 46 5-1-3 黏著力測試 46 5-2 溫度敏感型poly(NIPAAm-co-AA)之合成 47 5-3 溫度敏感型poly(NIPAAm-co-AA)型態觀察 48 5-4 溫度敏感型poly(NIPAAm-co-AA) LCST測試 49 5-5 溫度敏感型poly(NIPAAm-co-AA)複合水膠薄膜製備與物性分析 49 5-5-1 實驗配方 50 5-5-2 合成方法 51 5-5-3 膨潤性測試 52 5-5-4 溫度敏感型poly(NIPAAm-co-AA)複合水膠薄膜型態觀察-SEM 53 5-5-5 藥物釋放實驗 53 第六章 結論 59 參考文獻 61 附錄 92 | |
| dc.language.iso | zh-TW | |
| dc.subject | 溫度敏感性 | zh_TW |
| dc.subject | 氮-異丙基丙烯醯胺 | zh_TW |
| dc.subject | 水膠 | zh_TW |
| dc.subject | 藥物釋放 | zh_TW |
| dc.subject | thermo-sensitive | en |
| dc.subject | drug release | en |
| dc.subject | hydrogel | en |
| dc.subject | N-isopropylacrylamide | en |
| dc.title | 高黏著力之溫度敏感型水膠配方之開發及其藥物釋放研究 | zh_TW |
| dc.title | Synthesis of high adhesive and thermo-sensitive acrylate hydrogels and its controlled drug release study | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 96-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 董崇民,邱聯華,王鐘毅 | |
| dc.subject.keyword | 氮-異丙基丙烯醯胺,水膠,藥物釋放,溫度敏感性, | zh_TW |
| dc.subject.keyword | N-isopropylacrylamide,hydrogel,drug release,thermo-sensitive, | en |
| dc.relation.page | 92 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2008-07-07 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 化學工程學研究所 | zh_TW |
| 顯示於系所單位： | 化學工程學系 | |
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