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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 戴政(John Jen Tai) | |
| dc.contributor.author | Wen-Yung Chiu | en |
| dc.contributor.author | 邱文雍 | zh_TW |
| dc.date.accessioned | 2021-06-13T15:30:19Z | - |
| dc.date.available | 2008-08-08 | |
| dc.date.copyright | 2008-08-08 | |
| dc.date.issued | 2008 | |
| dc.date.submitted | 2008-07-15 | |
| dc.identifier.citation | 戴政(2002)遺傳流行病學—基因定位之遺傳設計與分析方法。藝軒，臺北。
吳性慧(2006)利用親子二元體資料建立尋找疾病基因的相關分析。臺灣大學生物醫學統計組碩士論文。 曾貞寧(2004)合併染病同胞對資料其標識基因之下傳/不下傳訊息與同源全等基因訊息的連鎖分析方法。臺灣大學生物醫學統計組碩士論文。 陳旭奎(2004)合併染病同胞對資料之標識基因下傳/不下傳訊息與同源全等基因訊息的連鎖分析方法(Ⅱ)：一個最小合併變異數方法。臺灣大學生物醫學統計組碩士論文。 Bahadur, R. R. (1960) Stochastic comparison of tests. Annals of Mathematical Statistics 31: 276-95. Blackweder, W.C. and Elston, R.C. (1985) A comparison of sib-pair linkage tests for disease susceptibility loci. Genetic Epidemiology 2: 85-97. Brown, M.B. (1975) A method for combining non-independent, one sided test of significance. Biometrics 31:987-992. Camp, N.J. (1997) Genomewide transmission/disequilibrium testing: consideration of the genotype relative risk at disease loci. American Journal of Human Genetics 61:1424-1430. Dudbridge, F. (2003) Pedigree disequilibrium tests for multilocus haplotypes. Genetic Epidemiology 25: 115–121. Falk, C.T. and Rubinstein, P. (1987) Haplotype relative risk: an easy reliable way to construct a proper control sample for risk calculations. Annals of Human Genetics 51:227-233. Fisher, R.A. (1932) Statistical Methods for Research Workers. London: Oliver and Boyd. Glass, G.V. (1976) Primary, secondary, and meta-analysis of research. Educational Researcher 5:3-8. Kost, J.T. and McDermott, M.P. (2002) Combining dependent P-values. Statistics and Probability Letters 60:183-190. Littell, R. and Folks, L. (1971) Asymptotic optimality of Fisher’s method of combining independent tests. Journal of the American Statistical Association 66:802-806. Lu, Y. and Fang, J.Q. (2003) Advanced Medical Statistics. New Jersey : World Scientific. Makambi, K.H. (2003) Weighted inverse chi-square method for correlated significance test. Journal of Applied Statistics 30:225-234. Martin, E.R.,Monk, S.A.,Warren, L.L. and Kaplan, N.L. (2000) A test for linkage and association in general pedigree:the pedigree disequilibrium test. American Journal of Human Genetics 67:146-154. Martin, E.R., Bass, M.P. and Kaplan, N.L. (2001) Correcting for a potential bias in the pedigree disequilibrium test. American Journal of Human Genetics 68:1065–1067. Martin, E.R., Bass, M.P., Gilbert, J.R., Pericak-Vance, M.A., and Hauser, E.R. (2003) Genotype-based association test for general pedigrees: the genotype-PDT. Genetic Epidemiology 25: 203–213. Morton, N.E. (1955) Sequential test for the detection of linkage. American Journal of Human Genetics 7:277-318. Munafo`, M.R., and Flint, J. (2004) Meta-analysis of genetic association Studies. Trends in Genetics 20:439-444 Ott, J. (1989) Statistical properities of the haplotype relative risk. Genetic Epidemiology 6:127-130. Schaid, D.J., McDonnell, S.K., Hebbring, S.J., Cunningham, J.M., and Thibodeau, S.N. (2005) Nonparametric tests of association of multiple genes with human disease. American Journal of Human Genetics 76:780-793. Spielman, R.S.,McGinnis, R.E. and Ewens, W.J. (1993) Transmission test for linkage disequilibrium, the insulin gene region and insulin-dependent diabetes mellitus(IDDM). American Journal of Human Genetics 52:506-516. Tai, J.J. and Hou, C.D. (2006) On the combination of transmission /disequilibrium test and mean test for linkage detection using affected sib pairs. Computational Statistics and Data Analysis 50:1072-1089. Tippett, L.M.C. (1931) The Methods of Statistics.London:Williams and Norgate. Wang, J.Y., Hou, C.D. and Tai, J.J. (2008) A robust linkage analysis method using combined allele sharing and transmission disequilibrium information from case-parent tetrad families. Annals of Human Genetics 72: 575-587. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/37499 | - |
| dc.description.abstract | 以家庭為基礎的相關研究中，傳遞不平衡檢定是最常使用的方法之一。在一組病體-親本三元體家庭中，傳遞不平衡檢定透過異質型的親本萃取一個特定標識對偶基因之下傳/不下傳訊息，建構以家庭為基礎的病體-對照設計，這樣的訊息雖然對標識基因與疾病基因間相關性提供部分資訊，但是對於三元體家庭資料而言，它並非唯一的相關訊息。根據這個想法，在本論文中將提出另一種相關訊息-相似度於檢定過程中，我們使用已知的方法將下傳/不下傳訊息與相似度訊息予以合併，並建構兩個新的相關檢定。在某些情況下，模擬研究顯示我們的方法表現較傳遞不平衡檢定好。 | zh_TW |
| dc.description.abstract | The transmission/disequilibrium test (TDT) is one of the most popularly used methods in family-based association studies. Based on a set of case-parent triad families, the TDT extracts information of transmission and nontransmission (TNT) of a particular marker allele from heterozygous parents to create a family-based case control design. Such a type information though does provide some information for association between a maker and a disease, it may not the only resource of association information contained in the triad families. According to this idea in this thesis we thus introduce another association information, the similarity into the testing procedure. We use the existing combination methods to combine information of the TNT and similarity to obtain two new association tests. Simulation studies show that our methods outperform the TDT in some situations. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T15:30:19Z (GMT). No. of bitstreams: 1 ntu-97-R95842010-1.pdf: 12526485 bytes, checksum: 00b7b3479b5ffeb2c68bb19e221d0e52 (MD5) Previous issue date: 2008 | en |
| dc.description.tableofcontents | 第一章 緒論...............................1
1.1 連鎖分析..............................1 1.2 相關分析..............................2 1.3 合併方法..............................3 1.4 研究動機..............................5 1.5 研究目的..............................6 第二章 文獻回顧...........................7 2.1 資料結構與符號定義....................7 2.1.1 資料結構..........................7 2.1.2 符號定義..........................8 2.2 傳遞不平衡檢定 .......................11 2.3 相似度檢定...........................14 第三章 研究方法.........................19 3.1 合併訊息檢定法 .......................19 3.2 費雪合併檢定法........................23 第四章 模擬研究..........................26 4.1 模擬步驟..............................26 4.2 模擬設定...............................27 4.3 傳遞不平衡檢定與相似度檢定之模擬比較...28 4.4 傳遞不平衡檢定、相似度檢定、合併訊息檢定與費雪合併檢定之模擬比較...................................31 第五章 結論與建議.........................34 參考文獻...................................37 附錄Ⅰ：隱性遺傳模式下，病體—親本三元體疾病基因座與標識基因座基因型連帶基因下傳/不下傳訊息條件機率之推導....41 附錄Ⅱ：隱性遺傳模式下，病體—親本三元體疾病基因座與標識基因座基因型之相似度訊息條件機率之推導...............42 附錄Ⅲ：費雪合併檢定統計量 服從卡方分配自由度為 之證明推導過程...............................................47 附錄Ⅳ：在虛無假設為真情況下，下傳/不下傳訊息檢定統計量 與相似度檢定統計量 之相關係數 之推導過程.............48 附錄Ⅴ：傳遞不平衡檢定與相似度檢定之型一誤差及檢定力..51 附錄Ⅵ：傳遞不平衡檢定、相似度檢定、合併訊息檢定與費雪合併檢定之型一誤差及檢定力.............................62 | |
| dc.language.iso | zh-TW | |
| dc.title | 合併親子三元體資料標識基因下傳/不下傳訊息與相似度訊息之相關分析方法 | zh_TW |
| dc.title | Combining Transmission/Nontransmission Information
and Similarity Information for Association Tests Using Case-Parent Triad Data | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 96-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 陳秀熙,張淑惠,黃崑明,王俊毅 | |
| dc.subject.keyword | 相關分析,相似度檢定,傳遞不平衡檢定, | zh_TW |
| dc.subject.keyword | association studies,similarity test,transmission/disequilibrium test, | en |
| dc.relation.page | 80 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2008-07-16 | |
| dc.contributor.author-college | 公共衛生學院 | zh_TW |
| dc.contributor.author-dept | 流行病學研究所 | zh_TW |
| 顯示於系所單位： | 流行病學與預防醫學研究所 | |
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