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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 周宏農 | |
| dc.contributor.author | Chieh-Ting Lin | en |
| dc.contributor.author | 林界廷 | zh_TW |
| dc.date.accessioned | 2021-06-13T15:23:34Z | - |
| dc.date.available | 2010-07-24 | |
| dc.date.copyright | 2008-07-24 | |
| dc.date.issued | 2008 | |
| dc.date.submitted | 2008-07-23 | |
| dc.identifier.citation | Anish B. 2006. Neurological impact of vasopressin dysregulation and hyponatremia.
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Hunt SP, Pini A, Evan G. 1987. Induction of c-fos-like protein in spinal cord neurons following sensory stimulation. Nature 328(6131): 632-634. 36 Ishida H, Muramatsu N, Nukaya H, Kosuge T, Tsuji K. 1996. Study on neurotoxic shellfish poisoning involving the oyster, Crassostrea gigas, in New Zealand. Toxicon 34(9): 1050-1053. Ishida H, Nozawa A, Nukaya H, Tsuji K. 2004. Comparative concentrations of brevetoxins PbTx-2, PbTx-3, BTX-B1 and BTX-B5 in cockle, Austrovenus stutchburyi, greenshell mussel, Perna canaliculus, and Pacific oyster, Crassostrea gigas, involved neurotoxic shellfish poisoning in New Zealand. Toxicon 43(7): 779-789. Jacobson ER, Homer BL, Stacy BA, Greiner EC, Szabo NJ, Chrisman CL, Origgi F, Coberley S, Foley AM, Landsberg JH, Flewelling L, Ewing RY, Moretti R, Schaf S, Rose C, Mader DR, Harman GR, Manire CA, Mettee NS, Mizisin AP, Shelton GD. 2006. Neurological disease in wild loggerhead sea turtles Caretta caretta. Dis. Aquat. Organ. 70(1-2): 139-154. Johnson GL, Spikes JJ, Ellis S. 1985. Cardiovascular effects of brevetoxins in dogs. Toxicon 23(3): 505-515. Kennedy CJ, Schulman LS, Baden DG, Walsh PJ. 1992. Toxicokinetics of brevetoxin PbTx-3 in the gulf toadfish, Opsanus beta, following intravenous administration. Aquat. Toxicol. 22(1): 3-14. Kim SW, Frokiaer J, Nielsen S. 2007. Pathogenesis of oedema in nephrotic syndrome: role of epithelial sodium channel. Nephrology (Carlton) 12(3): 8-10. Kimm-Brinson KL, Ramsdell JS. 2001. The red tide toxin, brevetoxin, induces embryo toxicity and developmental abnormalities. Environ. Health Perspect. 109(4): 377-381. 37 Kirkpatrick B, Fleming LE, Backer LC, Bean JA, Tamer R, Kirkpatrick G, Kane T, Wanner A, Dalpra D, Reich A, Baden DG. 2006. Environmental exposures to Florida red tides: Effects on emergency room respiratory diagnoses admissions. Harmful Algae 5(5): 526-533. Lanteri-Minet M, Weil-Fugazza J, de Pommery J, Menetrey D. 1994. Hindbrain structures involved in pain processing as revealed by the expression of c-Fos and other immediate early gene proteins. Neurosci. 58(2): 287-298. Lefebvre KA, Trainer VL, Scholz NL. 2004. Morphological abnormalities and sensorimotor deficits in larval fish exposed to dissolved saxitoxin. Aquat. Toxicol. 66(2): 159-170. Liberona JL, Cárdenas JC, Reyes R, Hidalgo J, Molgó J, Jaimovich E. 2008. Sodium-dependent action potentials induced by brevetoxin-3 trigger both IP3 increase and intracellular Ca2+ release in rat skeletal myotubes. Cell Calcium doi:10.1016/j.ceca.2007.12.009 Lin YY, Risk M, Ray SM, Vanengen D, Clardy J, Golik J, James JC, Nakanishi K. 1981. Isolation and Structure of Brevetoxin-B from the Red Tide Dinoflagellate Ptychodiscus-Brevis (Gymnodinium breve). J. Am. Chem. Soc. 103(22): 6773-6775. Mattei C, Dechraoui MY, Molgo J, Meunier FA, Legrand AM, Benoit E. 1999. Neurotoxins targetting receptor site 5 of voltage-dependent sodium channels increase the nodal volume of myelinated axons. J. Neurosci. Res. 55(6): 666-673. Mattei C, Molgo J, Legrand AM, Benoit E. 1999. Ciguatoxins and brevetoxins: dissection of the neurobiological actions. J. Soc. Biol. 193(3): 329-344. Maucher JM, Briggs L, Podmore C, Ramsdell JS. 2007. Optimization of blood 38 collection card method/enzyme-linked immunoassay for monitoring exposure of bottlenose dolphin to brevetoxin-producing red tides. Environ. Sci. Technol. 41(2): 563-567. Milan DJ, Jones IL, Ellinor PT, MacRae CA. 2006. In vivo recording of adult zebrafish electrocardiogram and assessment of drug-induced QT prolongation. Am. J. Physiol. Heart Circ. Physiol. 291(1): H269-273. Mizell M, Romig ES. 1997. The aquatic vertebrate embryo as a sentinel for toxins: zebrafish embryo dechorionation and perivitelline space microinjection. Int. J. Dev. Biol. 41(2): 411-423. Morgan JI, Cohen DR, Hempstead JL, Curran T. 1987. Mapping patterns of c-fos expression in the central nervous system after seizure. Science 237(4811): 192-197. Naar J, Bourdelais A, Tomas C, Kubanek J, Whitney PL, Flewelling L, Steidinger K, Lancaster J, Baden DG. 2002. A competitive ELISA to detect brevetoxins from Karenia brevis (formerly Gymnodinium breve) in seawater, shellfish, and mammalian body fluid. Environ. Health Perspect. 110(2): 179-185. Naar JP, Flewelling LJ, Lenzi A, Abbott JP, Granholm A, Jacocks HM, Gannon D, Henry M, Pierce R, Baden DG, Wolny J, Landsberg JH. 2007. Brevetoxins, like ciguatoxins, are potent ichthyotoxic neurotoxins that accumulate in fish. Toxicon 50(5): 707-723. Novak AE, Taylor AD, Pineda RH, Lasda EL, Wright MA, Ribera AB. 2006. Embryonic and larval expression of zebrafish voltage-gated sodium channel alpha-subunit genes. Dev. Dyn. 235(7): 1962-1973. Peng YG, Ramsdell JS. 1996. Brain Fos induction is a sensitive biomarker for the 39 lowest observed neuroexcitatory effects of domoic acid. Fund. 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Measurement of brevetoxin levels by radioimmunoassay of blood collection cards after acute, long-term, and low-dose exposure in mice. Environ. Health Perspect. 111(13): 1595-1600. Woofter RT, Brendtro K, Ramsdell JS. 2005. Uptake and elimination of brevetoxin in blood of striped mullet (Mugil cephalus) after aqueous exposure to Karenia brevis. Environ. Health Perspect. 113(1): 11-16. Yu FH, Catterall WA. 2003. Overview of the voltage-gated sodium channel family. 42 Genome Biol. 4(3): 207. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/37292 | - |
| dc.description.abstract | 短裸甲藻毒素 (PbTxs)為含有兩大類化學架構差異的多環醚類毒素，皆由渦鞭毛藻的凱倫藻屬 (Karenia)中的藻種所產生，當此類有毒藻形成水華，會造成大量魚類和其他海洋生物的暴斃以及神經性貝毒的危害。為比較兩類PbTxs毒性上的差異，利用PbTx-1和 PbTx-2分別代表Type-A 和Type-B PbTx觀察對斑馬魚胚發育的影響。結果顯示浸泡於不同濃度的PbTxs下，會對斑馬魚胚的畸形率和存活率造成不同程度的影響，而PbTxs所造成的毒性乃源自於鈉離子的存在，且毒力可經由鈉離子通道抑制劑，例如河豚毒素 (TTX) 來抑制減弱。另外PbTx-1會導致心臟及神經有c-fos的大量表現，並使心跳速率不正常，但是這些異常現象在PbTx-2的處理中並不明顯。由於這些差異，說明了此兩類毒素主架構上的不同造成對不同鈉離子通道間的親和力有所差異，並產生了發育致畸時的某些不同表現。 | zh_TW |
| dc.description.abstract | Brevetoxins (PbTxs) are polyether toxins with two series of different chemical structures. They are produced by the red tide dinoflagellate species belonging to genus Karenia that cause massive fish and ocean creature fatalities and neurotoxic shellfish poisoning in human. To compare the toxicity between two types of PbTxs, I used PbTx-1 and PbTx-2 to represent the Type-A and Type-B PbTxs and observed their effects on zebrafish development. By the exposure of PbTxs at different concentrations to zebrafish embryo, I had determined the differential effects of PbTx-1 and PbTx-2 on embryonic abnormality and survival of zebrafish. In addition, the effects of PbTxs were demonstrated to be dependent on the presence of sodium and could be alleviated by the sodium channels blocker TTX. Lastly, I showed that PbTx-1, but less potent by PbTx-2 greatly enhanced the expression of c-fos in the heart and neuronal regions, which was correlated to the inhibition on the heart beats of zebrafish embryo. Those differential effects of PbTx-1 and PbTx-2 reflect the major structural difference between the two toxins which causes different affinity on sub-types of sodium channels that differentially expressed during development. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T15:23:34Z (GMT). No. of bitstreams: 1 ntu-97-R94b45002-1.pdf: 1378767 bytes, checksum: a4ff84d4651d11faf71dfa584c48fa91 (MD5) Previous issue date: 2008 | en |
| dc.description.tableofcontents | 中文摘要......................................... i
Abstract......................................... ii Introduction..................................... 1 Materials and Methods............................ 11 Result........................................... 19 Discussion........................................25 Reference.........................................32 Tables............................................42 Figures.......................................... 45 | |
| dc.language.iso | en | |
| dc.subject | c-fos | zh_TW |
| dc.subject | 短裸甲藻毒素 | zh_TW |
| dc.subject | 斑馬魚 | zh_TW |
| dc.subject | 鈉離子通道 | zh_TW |
| dc.subject | brevetoxin | en |
| dc.subject | zebrafish | en |
| dc.subject | c-fos | en |
| dc.subject | voltage-gated sodium channel | en |
| dc.title | 不同短裸甲藻毒素主幹在斑馬魚發育、心搏速率和c-fos表現上的相同與差異影響 | zh_TW |
| dc.title | Consistent and inconsistent effects of different brevetoxin skeletons on the development, heart rate and c-fos expression in zebrafish | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 96-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 嚴宏洋,蔡明正,李士傑 | |
| dc.subject.keyword | 短裸甲藻毒素,斑馬魚,鈉離子通道,c-fos, | zh_TW |
| dc.subject.keyword | brevetoxin,zebrafish,voltage-gated sodium channel,c-fos, | en |
| dc.relation.page | 56 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2008-07-23 | |
| dc.contributor.author-college | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 漁業科學研究所 | zh_TW |
| 顯示於系所單位： | 漁業科學研究所 | |
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