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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 林峰輝 | |
dc.contributor.author | Yu-Sheng Lee | en |
dc.contributor.author | 李育昇 | zh_TW |
dc.date.accessioned | 2021-06-13T08:22:50Z | - |
dc.date.available | 2005-07-26 | |
dc.date.copyright | 2005-07-26 | |
dc.date.issued | 2005 | |
dc.date.submitted | 2005-07-16 | |
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Wikipedia, the free encyclopedia < http://en.wikipedia.org/wiki/Corona_discharge> 29. Jhon, Mu Shik. “Characterization of wettability gradient surfaces prepared by corona discharge treatment” Journal of colloid and interface science;1992:151:563-570 30. Thome, J. “Ultra thin antibacterial polyammonium coatings on polymer surfaces.” Surface and Coatings Technology;2003:584-587 31. Iwasaki, Yasuhiko. “Nano-scale surface modification of a segmented polyurethane with a phospholipid polymer.” Biomaterials;2004:5353-5361 32. Johnson, A William. Invitation to organic chemistry. Toronto: Jones and Bartlett Publisher Canada, 1999. 33. Patrick, G.L. Instant Notes Organic Chemistry. Hong Kong: BIOS Scientific Publisher Limited, 2000. 34. Valuev, Ivan L. “Chemical modification of polymers with physiologically active species using water-soluble carbodiimides” Biomaterials;1998:41-43 35. VirtualText of Organic Chemistry. 1st Aug. 2004. Michigan State University, Department of Chemistry. <http://www.cem.msu.edu/~reusch/VirtualText/intro1.htm#contnt>. 36. Lee, Jin Ho. “Cell behaviour on polymer surfaces with different functional groups.” Biomaterials;1994:705-711 37. Chen, Jei. “Grafting copolymerisation of acrylamides onto preirradiated PP films.” Radiation Physics and Chemistry;1999:87-92 38. Juang, Tsi-wen. Personal Interview. September 10, 2004 39. Paul Teesdale-Spittle. 25th Oct. 2001. Victoria University of Wellington. http://www2.vuw.ac.nz/staff/paul_teesdale-spittle/ 40. Gurny, R. “Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications.” European Journal of Pharmaceutics and Biopharmaceutics; 2004;19-34 41. Peppas, Nikolaos A. “pH-Sensitive membranes from poly(vinyl alchohol) / poly (acrylic acid) interpenetrating networks.” Journal of Membrane Science; 1995:239-248 42. Bioteq. 2004. Bioteq Corporation < http://www.bioteq.com.tw/>. 43. Black, Jonathan. Biological performance of materials : fundamentals of biocompatibility. New Work: Marcel Dekker, Inc., 1992 44. Thomas Steffen. 19th May. 2004.. http://www.chem.uni-potsdam.de/tools/index.html 45. Opolski, 1997, Articles prepared from water-based hydrophilic coating compositions. United States Patent 6,238,799. May 29, 2001 | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/36921 | - |
dc.description.abstract | 導尿管已成為醫院裡不可或缺的醫療器材。但是目前常用的導尿管會引發多種併發症。導尿管引起的併發症包含插入或拔出時的痛覺、尿道受傷、細菌感染、尿管堵塞,以及凝血或結石。如果長時間使用可能會導致癌症或甚至死亡。許多文獻指出尿管表面的高摩擦力及蛋白質吸附是導致併發症的主要原因。因此要設法降低併發症的發生,尿管表面應該有潤滑塗層以及降低蛋白質吸附的能力。
聚氨酯(SPU)導尿管的表面改質設計分為四步驟:氧化,官能基之改善,EDC反應 以及水膠交聯。第一步驟是氧化SPU的表面, 使其產生羧基 (carboxyl group。第二步驟是利用丙烯酸(acrylic acid)增加更多的表面羧基以達到更好的水膠交聯。第三步驟是讓EDC與SPU表面的羧基反應,進而在下一步與胺基(amine group)反應。最後一步驟是水膠跟改質的表面反應產生氨基(amide bond)。 FTIR 的結果證明每一步驟的有效化學改質成果,水膠塗層不僅高度潤滑(-0.1642 mA AFM, lateral force mode)而且吸附少量的蛋白質(84.1 mg ± 5mg 經過24小時的蛋白質吸收)。此研究證明透過表面改質的SPU具有生物相容性並能抑制細菌的生長,有效解決併發症發生的問題。 | zh_TW |
dc.description.abstract | Currently, urinary catheters pose the risk of complications to any patients who wear them. In long term, these complications may result cancer or even death. Urinary catheter-related complications include discomfort during insertion and removal, urethra injury, bacteria infection, catheter obstruction, such as blood clotting or encrustation. High friction and protein adsorption of urinary catheter have been found to be primary causes of related complications. In order to reduce the risk of these complications, a catheter should have a slippery coating and abilities to minimize protein adsorption.
The surface modification of SPU (segmented polyurethane) catheter is designed in four steps: oxidation, functionalities modification, EDC coupling, and hydrogel crosslinking. The first step oxidizes the SPU surface to create carboxyl functionalities. The second step utilizes acrylic acid to generate additional carboxyl functionalities for better crosslinking with hydrogel. The third step is coupling of EDC that will react with carboxyl groups on SPU surface and with amine group of final step. The last step is amide bond formation with amine groups of chitosan in hydrogel. FTIR results verified the chemical reaction of each reaction step. The resulting hydrogel coating not only had high degree of lubricity (-0.1642 mA in lateral force mode of AFM) but also absorbed minimal amount of protein . The surface modified SPU shows more biocompatible, and suppresses bacteria growth as well. | en |
dc.description.provenance | Made available in DSpace on 2021-06-13T08:22:50Z (GMT). No. of bitstreams: 1 ntu-94-R92548056-1.pdf: 888016 bytes, checksum: f121cb81d48d09420691b93f56afc2f7 (MD5) Previous issue date: 2005 | en |
dc.description.tableofcontents | Abstract I
摘要 II Table of Contents III List of Figures VI List of Tables VIII List of Equations IX 1 Introduction 1 1-1 Catheter Background 1 (1) History Polyurethane Catheter 1 (2) Segmented Polyurethane Characteristic 1 1-2 Application Environment 3 (1) General Design 3 (2) Urine Composition 4 (3) Urethra Anatomy and Physiology 5 1-3 Associated Complications 5 (1) Implant Interface - Hydrophobic vs. Hydrophilic 5 (2) Protein Adsorption 6 (3) Catheter-related Infection 7 (4) Blood Clotting 7 (5) Encrustation (urine stone) 8 1-4 Methods of Surface Modification 9 (1) Low Pressure Plasma Glowing Discharge Technique 10 (2) Ultraviolet Radiation Technique 10 (3) Corona Discharge Technique 11 (4) Aqueous Chemical Process 11 1-5 Other Methods for Surface Modifications 12 1-6 Scope of Study 13 2 Design Concept 14 2-1 SPU Surface Oxidization 14 2-2 Functionalities Modification 15 2-3 EDC Reaction and Coupling 16 2-4 Hydrogel Crosslinking 16 2-5 Chitosan/PVA Blending Hydrogel 17 3 Materials and Experiments 19 3-1 Experiment Equipment 19 3-2 Chemical Reagents 20 3-3 Experiment Flow Chart 22 3-4 Segmented Polyurethane Membrane 22 3-5 Oxidation 23 3-6 Functionalities Modification 24 3-7 EDC Reaction and Coupling 25 3-8 Hydrogel Crosslinking 26 3-9 LubriLAST™ Coating Preparation 28 3-10 Water Contact Angle Measurement 29 3-11 Atomic force microscope (AFM) 31 3-12 Fourier Transformation Infrared Spectroscopy (FTIR) 32 3-13 Cytotoxicity 32 (1) LDH Cytotoxicity Detection 32 (2) MTT Cell Proliferation Assay 35 3-14 Protein Adsorption Assay 37 3-15 Antibacterial Test 39 3-16 Antiseptic Effect Quantification 42 3-17 Water Content and Elution 44 3-18 Chitosan Graft Density 45 3-19 Statistical Analysis 46 4 Result and Discussion 47 4-1 Water Contact Angle 47 4-2 FTIR Analysis 49 (1) Oxidation 49 (2) Functionalities Modification Step 50 (3) Hydrogel Coating Step 50 4-3 AFM 51 4-4 Cytotoxicity 53 (1) LDH Cytotoxicity Detection Assay Analysis 53 (2) MTT Cell Proliferation Assay Analysis 57 4-5 Protein Adsorption Test 58 4-6 Antiseptic Test 60 4-7 Antiseptic Effect Quantification 70 4-8 Water Content and Elution Test 73 4-9 Chitosan Graft Density 75 5 Conclusion 76 6 Future Work 78 7 List of Reference 79 | |
dc.language.iso | en | |
dc.title | 利用表面改質以改善聚氨酯導尿管之表面性質 | zh_TW |
dc.title | Utilization of Surface Modification to Improve Surface Properties of Segmented Polyurethane Urinary Catheter | en |
dc.type | Thesis | |
dc.date.schoolyear | 93-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 洪敏雄,宋信文,曾厚 | |
dc.subject.keyword | 聚氨酯,導尿管,表面改質,水膠,蛋白質吸附,抑菌, | zh_TW |
dc.subject.keyword | segmented polyurethane,urinary catheter,surface modification,hydrogel,lubricous,protein adsorption,antiseptic, | en |
dc.relation.page | 92 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2005-07-19 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 醫學工程學研究所 | zh_TW |
顯示於系所單位: | 醫學工程學研究所 |
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