請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/36879完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 趙福杉 | |
| dc.contributor.author | Miao-Yueh Lu | en |
| dc.contributor.author | 盧妙月 | zh_TW |
| dc.date.accessioned | 2021-06-13T08:20:39Z | - |
| dc.date.available | 2006-07-22 | |
| dc.date.copyright | 2005-07-22 | |
| dc.date.issued | 2005 | |
| dc.date.submitted | 2005-07-19 | |
| dc.identifier.citation | 1.魏琮峰，“多通道為電極之研製與其胞外紀錄之分析”，台灣大學醫學工程研究所碩士論文，2003。
2.陳右穎，“大腦電位之電流源密度分析”，台灣大學電機工程研究所碩士論文，1998。 3.趙福杉，“神經複合動作電位和場電位分析及記錄系統之研製”，台灣大學電機工程研究所博士論文，1992。 4.陳建銘，“平面式多通道微電極陣列晶片系統之硏發”，台灣大學電機工程研究所碩士論文，2004。 5.陳定楷，“神經元-微電極介面特性自動量測系統之設計與實現”，南台科技大學電機工程研究所碩士論文，2003。 6.陳子熒，“三維微電極陣列於神經電信號之應用”，清華大學動力機械工程學系研究所碩士論文，2003。 7.C. A. Thomas, P. A. Springer, G. E. Leob, Y. Berwald-Netter, and L. M. Okun, “A miniature microelectrode array to monitor the bioelectric activity of cultured cells,” Exp. cell res., 74, pp. 61-66, 1972. 8.G. W. Gross, E. Rieske, G. W. Kreutzberg, and A. Meter, “A new fixed-array multi-microelectrode system designed for long-term monitoring of extracellular signal unit neuronal activity in vitro,” Neurosci. lett., 6. pp. 101-105, 1977. 9.U. Egert, B. Schlosshauer, S. Fennrich, W. Nisch, M. Fejtl, T. Knott, T. Muller, and H. Hammerle, “A novel organotypic long-term culture of the rat hippocampus on substrate-intergrated multielectrode array,” Brain Research. Protocols, 2, pp. 229-242, 1998. 10.Hiroaki Oka, Ken Shimono, Ryuta Ogawa, Hirokazu Sugihara, Makoto Taketani, “A new planar multielectrode array for extracellular recording: application to hippocampal acute slice,” J. neurosci. Methods., pp. 61–67, 1999. 11.R. Christopher deCharms, David T. Blake, Michael M. Merzenich, “A multielectrode implant device for the cerebral cortex,” J. neurosci. Methods., pp. 27-35, 1999. 12.P. K. Campbell, K. E. Jones, R. J. Huber, “A Silicon-Based, There-Dimensional Neural Interface: Manufacturing Processes for an Intracortical Electrode Array,” IEEE trans. Biomed. Eng., Vol. 38, NO. 8, August 1991. 13.P. Thiebaud, C. Beuret, M. Koudelka-Hep, etc. “An array of Pt-tip microelectrode for extracellular monitoring of activity of brain,” Biosens. Bioelectron., pp. 61-65, 1999. 14.Anne Tscherter, Marc O. Heuschkel, Philippe Renaud and Jurg Streit, “Spatiotemporal characterization of rhythmic activity in rat spinal cord slice cultures,” European Journal of Neuroscience, Vol. 14, pp. 179-190, 2001. 15.A. van Bergen, T. Papanikolaou, A. Schuker, A. Moller, B., “Long-term stimulation of mouse hippocampal slice culture on microelectrode array,” Brain Research. Protocols 11 123-133, 2003. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/36879 | - |
| dc.description.abstract | 本研究的目的是要建立一個神經細胞群體訊號的量測平台，從多通道平面微電極的研製到放大濾波電路的設計與製作及整體系統的測試及驗證。
在本研究中利用了半導體製程技術製作一個64通道的平面微電極，其量測電極至外部電極連接點的阻值約為10 ± 4.65 Ω，並已完成電極外部之打線及封膠，方便將電極所量測到的神經電訊號藉此連接板傳送到後端系統中進行運算及分析。 其次是自行設計製作了16通道的放大濾波電路模組，使之可同時量測場電位及多細胞神經動作電位，此放大濾波電路整體放大倍率為2500倍，濾波器的設計是利用二階Butterworth低通濾波器及二階Bessel的帶通濾波器，其濾波頻帶分別為0.1 - 100 Hz及300 Hz - 3 kHz。每一模組16通道的設計增加了量測系統運用的彈性及未來的擴張性，並搭配市售之類比數位轉換介面達成整體神經細胞群體訊號的量測平台。 | zh_TW |
| dc.description.abstract | This study is to set up a measurement platform for the recording of neural ensemble. A 64-channel microelectrode, amplifiers, and filters were therefore designed and implemented.
By utilizing the semiconductor processes, a 64-channel microelectrode was implemented in this thesis. The impedance of each electrode, measured with respect to the connecting pad, is only 10 ± 4.56 Ω. The bonding and package of this 64-chanel microelectrode was successfully tested, and enabling the transmission of the detected neuronal activities to the host system for signal processing. Further, a module each with a 16-channel amplifiers and 32-channel filters was designed and fully tested. This module can be used to measure field potential and multi-unit action potential at the same time. The gain of the amplifiers is programmed at 2500, whereas the passbands of the filters are 0.1 - 100 Hz for the Butterworth lowpass filters and 300 Hz – 3 kHz for the Bessel filters. The 2nd-order Butterworth lowpass filter is designed for field potential recording, while the 2nd-order Bessel bandpass filter was for extra-cellular multi-unit recording. A further advantage of the module design for the signal conditioning unit is the flexibility and expandability. This measurement system, in accompany with the A/D convector card, has successfully set up an indispensable platform for the recording of multichannel field potentials as well as action potentials. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T08:20:39Z (GMT). No. of bitstreams: 1 ntu-94-R92548017-1.pdf: 1082262 bytes, checksum: 90abf34b1b694c0f44f665e79098a00a (MD5) Previous issue date: 2005 | en |
| dc.description.tableofcontents | 致謝.....................................................Ⅱ
中文摘要.................................................Ⅲ 英文摘要.................................................Ⅳ 內容目錄.................................................Ⅴ 圖目錄.................................................. Ⅵ 表目錄...................................................Ⅷ 第一章 緒論.............................................1 1.1 研究動機........................................1 1.2 研究背景........................................3 1.3 研究目的........................................6 第二章 平面多通道微電極之研製...........................7 2.1 電極設計與規格..................................7 2.2 電極製作材料與方法流程.........................11 2.3 電極特性測試、銲線、封膠及其結果...............21 第三章 量測系統之製作..................................26 3.1 系統設計原理與架構.............................27 3.2 電路製作與特性量測.............................31 第四章 討論............................................36 第五章 參考資料........................................37 | |
| dc.language.iso | zh-TW | |
| dc.subject | 多通道記錄系統 | zh_TW |
| dc.subject | 神經群量測 | zh_TW |
| dc.subject | 多通道微電極 | zh_TW |
| dc.subject | Multi-channel microelectrode | en |
| dc.subject | Ensemble recording | en |
| dc.subject | Multi-channel recoding system | en |
| dc.title | 64通道微電極量測系統之研製 | zh_TW |
| dc.title | Development of a 64-channel Microelectrode System | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 93-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 郭德盛,鄭國順,黃基礎,林啟萬,楊龍杰 | |
| dc.subject.keyword | 神經群量測,多通道微電極,多通道記錄系統, | zh_TW |
| dc.subject.keyword | Ensemble recording,Multi-channel microelectrode,Multi-channel recoding system, | en |
| dc.relation.page | 39 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2005-07-19 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 醫學工程學研究所 | zh_TW |
| 顯示於系所單位： | 醫學工程學研究所 | |
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