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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 林文澧 | |
dc.contributor.author | Tze-Yuan Cheng | en |
dc.contributor.author | 鄭茲元 | zh_TW |
dc.date.accessioned | 2021-06-13T08:01:16Z | - |
dc.date.available | 2006-07-29 | |
dc.date.copyright | 2005-07-29 | |
dc.date.issued | 2005 | |
dc.date.submitted | 2005-07-22 | |
dc.identifier.citation | 楊鎮澤,'扇形渦狀相位調變式超音波換能器結合機械掃描系統於
超音波熱手術之探討' 台大醫工所碩士論文, 2004 楊士弘,'超音波熱手術於乳癌的治療' 台大醫工所碩士論文, 2004 Patankar. Suhas V : Numerical Heat Transfer and Fluid Flow Washington : Hemisphere Pub. Corp.; New York : McGraw Hill.1980 Bohris C, Jenne J, Rastert R, Simiantonakis I,Brix G,Spoo J, Hlavac M,Nemeth R, Huber P, Debus J: MR monitoring of focused ultrasound surgery in a breast tissue model in vivo. MAGNETIC RESONANCE IMAGING 2001, 19(2):167-175. Cain C. A. and Umemura S. I.: Concentric-ring and sector-vortex phase-array applicator for ultrasound hyperthermia. IEEE TRANSACTIONS ON MICROWAVE THEORY TECHNOLOGY, 1986, 34(1): 542-551. Cheng K, Roemer R: Optimal power deposition patterns for ideal high temperature therapy/hyperthermia treatments. INTERNATIONAL JOURNAL OF HYPERTHERMIA 2004, 20(1):57-72. Daum D, Hynynen K: Thermal dose optimization via temporal switching in ultrasound surgery. IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL 1998, 45(1):208-215. Fan X, Hynynen K: The Effects of Curved Tissue Layers on The Power Deposition Patterns of Therapeutic Ultrasound Beams. MEDICAL PHYSICS 1994, 21(1):25-34. Fan X, Hynynen K: Ultrasound surgery using multiple sonications -Treatment time considerations. ULTRASOUND IN MEDICINE AND BIOLOGY 1996, 22(4):471-482. Gianfelice D, Khiat A, Amara M, Belblidia A, Boulanger Y: MRimaging-guided focused US ablation of breast cancer: Histopathologic assessment of effectiveness-initial experience.RADIOLOGY 2003, 227(3):849-855. Hengst S, Ehrenstein T, Herzog H, Beck A, Utz-Billing I, David M, Felix R,Ricke J: MR-guided focussed ultrasound surgery (MRgFUS) - a new noninvasive therapy modality. RADIOLOGE 2004, 44(4):339-346. Huber P, Jenne J, Rastert R, Simiantonakis I, Sinn H, Strittmatter H, von Fournier D, Wannenmacher M, Debus J: A new noninvasive approach in breast cancer therapy using magnetic resonance imaging-guided focused ultrasound surgery. CANCER RESEARCH 2001, 61(23):8441-8447. Huber P, Rastert R, Simiantonakis I, Roder D, Hlavac M, Wannenmacher M,Debus J, Jenne J: Magnetic-resonance-guided therapy with focused ultrasound. Noninvasive surgery for mammary carcinomas. RADIOLOGE 2001, 41(2):173-+. Hynynen K, Pomeroy O, Smith D, Huber P, McDannold N, Kettenbach J,Baum J, Singer S, Jolesz F: MR imaging-guided focused ultrasound surgery of fibroadenomas in the breast: A feasibility study.RADIOLOGY 2001, 219(1):176-185. Jolesz F, Kullervo Hynynen: Magnetic Resonance Image-guided Focus Ultrasound Surgery The Cancer Journal 2002, 8 (Supplement1): S100 -S112 Kacher D, Jolesz F: MR imaging-guided breast ablative therapy.RADIOLOGIC CLINICS OF NORTH AMERICA 2004, 42(5):947-+. Lin W, Liang T, Yen J, Liu H, Chen Y: Optimization of power deposition and a heating strategy for external ultrasound thermal therapy.MEDICAL PHYSICS 2001, 28(10):2172-2181. Lin W, Liauh C, Chen Y, Liu H, Shieh M: Theoretical study of temperatureelevation at muscle/bone interface during ultrasound hyperthermia.MEDICAL PHYSICS 2000, 27(5):1131-1140. Lin W, Yen J, Chen Y, Cheng K, Shieh M: Specific absorption rate ratio patterns of cylindrical ultrasound transducers for breast tumors.MEDICAL PHYSICS 1998, 25(6):1041-1048. Liu H, Chen Y, Yen J, Lin W: Treatment time reduction for large thermallesions by using a multiple 1D ultrasound phased array system.PHYSICS IN MEDICINE AND BIOLOGY 2003, 48(9):1173-1190. Lu X, Burdette E, Bornstein B, Hansen J, Svensson G: Design of an ultrasonic therapy system for breast cancer treatment.INTERNATIONAL JOURNAL OF HYPERTHERMIA 1996, 12(3):375-399. Malinen M, Huttunen T, Hynynen K, Kaipio J: Simulation study for thermaldose optimization in ultrasound surgery of the breast. MEDICAL PHYSICS 2004, 31(5):1296-1307. Moros E, Fan X, Straube W: Ultrasound power deposition model for the chest wall. ULTRASOUND IN MEDICINE AND BIOLOGY 1999,25(8):1275-1287. Noguchi M: Minimally invasive surgery for small breast cancer. J Surg Oncol 2003, 84(2):94-101; discussion 102. Sasaki K, Azuma T, Kawabata K, Shimoda M, Kokue E, Umemura S: Effect of split-focus approach on producing larger coagulation in swine liver. ULTRASOUND IN MEDICINE AND BIOLOGY 2003,29(4):591-599. Shanno, D.F.: Conditioning of Quasi-Newton Methods for Function Minimization.Mathematics of Computing 1970 , 24 :647-656, Takegami, K, Kaneko Y, Watanabe T, Maruyama T, Matsumoto Y, Nagawa H.:Polyacrylamide gel containing egg white as new model for irradiation experiments using focused ultrasound.Ultrasound Med Biol 2004, 30(10):1419-22. Wu F, Wang Z, Cao Y, Chen W, Bai J, Zou J, Zhu H: A randomised clinical trial of high-intensity focused ultrasound ablation for the treatment of patients with localised breast cancer. BRITISH JOURNAL OF CANCER 2003, 89(12):2227-2233. Wu F, Wang Z, Chen W, Wang W, Gui Y, Zhang M, Zheng G, Zhou Y, Xu G, Li M et al: Extracorporeal high intensity focused ultrasound ablation in the treatment of 1038 patients with solid carcinomas in China: an overview. ULTRASONICS SONOCHEMISTRY 2004,11(3-4):149-154. Wu F, Wang Z, Chen W, Zou J, Bai J, Zhu H, Li K, Xie F, Jin C, Su H et al: Extracorporeal focused ultrasound surgery for treatment of human solid carcinomas: Early Chinese clinical experience. ULTRASOUND IN MEDICINE AND BIOLOGY 2004, 30(2):245-260. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/36449 | - |
dc.description.abstract | 基於非侵入式的優點,超音波熱手術是乳癌治療的理想方式,然而依據以往的臨床經驗,治療時間過長以及肋骨過熱,一直是亟待改善的問題。為此,本研究以分離聚焦型換能器為主體,建構一組以腫瘤目標為旋轉中心的治療系統,並提出一套與之相輔的加熱策略。該策略將換能器以45 度的入射角配置,並運用換能器三種互補性的聚焦模式,由數個分散的路徑對目標進行切換加熱,期望能達到提升治療效率,並且減輕肋骨過熱的目標。由電腦模擬的結果顯示,對於中心距離肋骨界面2cm 以上的目標,該策略可在不加入冷卻時間,以及肋骨溫度低於50°C 的前提下,完成8立方公分腫瘤目標的加熱,所形成的熱劑量分布趨於完整而集中,有效地改善了乳癌熱手術的治療品質。此外,本研究藉由活體外組織的燒灼實驗,也確認了加熱策略在軟組織中所形成的焦斑形態,以及骨組織界面的溫升程度,皆與模擬的結果相接近。 | zh_TW |
dc.description.abstract | Because of less invasiveness, focused ultrasound has become apromising tool for localized tumor therapy. Clinical tests of breast tumorablation, however, have shown that the main problems are long treatment time and rib heating. In this study, a target rotating system based on split-focused ultrasound transducer is constructed, and an appropriate heating strategy is designed to cooperate with the system. The transducer is oriented in an angle of 45 degrees to heat the target via temporal switching from separate paths. The aims of the strategy are to increase the therapeutic efficiency and to alleviate rib heating. For targets with a distance more than 2cm from the rib,the results of simulation demonstrated that the strategy could accomplish heating of target with volume 8cm3 without cooling-time interval,and the temperature of the rib was maintain below 50°c during heating process.The distribution of thermal dose tended to be intact and dense after the treatment.Furthermore,the simulation results were also examined by phantom experiments.Both the heating pattern and measured temperature rise of bones matched the simulation results well. | en |
dc.description.provenance | Made available in DSpace on 2021-06-13T08:01:16Z (GMT). No. of bitstreams: 1 ntu-94-R92548009-1.pdf: 4134570 bytes, checksum: 39e5bd85a57f4bfff89c1a3e870fbcae (MD5) Previous issue date: 2005 | en |
dc.description.tableofcontents | 摘要.................................... I
Abstract.............................. . II 第一章 緒論...........................................1 1.1 導言..............................................1 1.2 熱治療歷史回顧....................................1 1.3 超音波熱手術......................................2 1.4 超音波熱治療在乳癌的應用......................3 1.5 研究目的..........................................5 第二章 理論分析與模擬方法..........................6 2.1 緒論..............................................6 2.2 波動方程式......................................6 2.3 雷利-薩瑪菲爾德繞射積分式.............7 2.4 介質的能量衰減與吸收......................8 2.5 溫度場的計算......................................9 2.6 熱劑量的計算....................................10 2.7 行經多層介質之壓力場模擬............10 2.8 波源表面之壓力計算........................14 2.9 針對乳房之壓力場模擬....................15 2.10 針對乳房之溫度場模擬..................17 第三章 治療規劃.................................18 3.1 換能器架構........................................18 3.2 單次照射熱劑量最佳化....................19 3.3 加熱策略原則....................................21 3.4 系統配置............................................23 第四章 實驗材料與方法...............................24 4.1 換能器特性........................................24 4.2 電源系統............................................27 4.3 組織仿體............................................28 4.4 換能器聚焦形態測試實驗................28 4.5 分次加熱之治療效能實驗................29 第五章 模擬結果......................................31 5.1 換能器聚焦形態模擬........................31 5.2 單次加熱之驅動參數........................34 5.3 換能器配置........................................37 5.4 換能器平行入射之治療效果............39 5.5 換能器45 度角入射之治療效果......44 5.6 血液灌流率變化對治療效果的影響.............56 5.7 降低換能器負載的方式....................60 5.8 增加照射路徑的治療效果................68 5.9 四個換能器兩階段加熱....................73 第六章 實驗結果.........................................77 6.1 換能器聚焦效果測試........................77 6.2 聚焦模式切換加熱實驗....................79 6.3 45 度入射角分次加熱實驗.............80 6.4 骨組織溫度量測................................82 第七章 討論........................................87 7.1 單次加熱參數之特性........................87 7.2 入射角對加熱效果的影響................87 7.3 四個換能器同時驅動的優點............89 7.4 增加照射路徑對能量分配的影響....90 7.5 實驗結果的參考意義........................90 7.6 肋骨過熱的可能性............................91 第八章 結論與未來展望...............................92 參考文獻.......................................94 附錄A – 界面熱傳導係數...............98 附錄B - Quasi-Newton Method.......................99 | |
dc.language.iso | zh-TW | |
dc.title | 聚焦型超音波應用於乳癌熱手術之研究 | zh_TW |
dc.title | Investigation of Focused Ultrasound Thermal Surgery for Breast Tumors | en |
dc.type | Thesis | |
dc.date.schoolyear | 93-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 江惠華,陳文翔,王士豪,陳永耀 | |
dc.subject.keyword | 聚焦型超音波,熱手術,乳癌,治療規劃, | zh_TW |
dc.subject.keyword | Focused Ultrasound,Thermal Surgery,Breast Tumors,Treatment Planning, | en |
dc.relation.page | 100 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2005-07-22 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 醫學工程學研究所 | zh_TW |
顯示於系所單位: | 醫學工程學研究所 |
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