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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 陳保中 | |
dc.contributor.author | Chia-Jung Hsieh | en |
dc.contributor.author | 謝佳容 | zh_TW |
dc.date.accessioned | 2021-06-13T07:03:58Z | - |
dc.date.available | 2007-10-03 | |
dc.date.copyright | 2005-10-03 | |
dc.date.issued | 2005 | |
dc.date.submitted | 2005-07-27 | |
dc.identifier.citation | 一、出生體重及懷孕週數別新生兒及嬰兒死亡率
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Contemporary-use pesticides in personal air samples during pregnancy and blood samples at delivery among urban minority mothers and newborns. Environmental Health Perspectives. 111(5):749-56, 2003 May 14. Berkowitz GS. Wetmur JG. Birman-Deych E. Obel J. Lapinski RH. Godbold JH. Holzman IR. Wolff MS. In utero pesticide exposure, maternal paraoxonase activity, and head circumference. Environmental Health Perspectives. 112(3):388-91, 2004 Mar. 15. Eskenazi B. Harley K. Bradman A. Weltzien E. Jewell NP. Barr DB. Furlong CE. Holland NT. Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population. Environmental Health Perspectives. 112(10):1116-24, 2004 Jul. 16. Perera FP. Rauh V. Tsai WY. Kinney P. Camann D. Barr D. Bernert T. Garfinkel R. Tu YH. Diaz D. Dietrich J. Whyatt RM. Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population. Environmental Health Perspectives. 111(2):201-5, 2003 Feb. 17. Berkowitz GS. Obel J. Deych E. Lapinski R. Godbold J. Liu Z. Landrigan PJ. Wolff MS. Exposure to indoor pesticides during pregnancy in a multiethnic, urban cohort. Environmental Health Perspectives. 111(1):79-84, 2003 Jan. 18. Chen J. Kumar M. Chan W. Berkowitz G. Wetmur JG. Increased influence of genetic variation on PON1 activity in neonates. Environmental Health Perspectives. 111(11):1403-9, 2003 Aug. 19. Levario-Carrillo M. Amato D. Ostrosky-Wegman P. Gonzalez-Horta C. Corona Y. Sanin LH. Relation between pesticide exposure and intrauterine growth retardation. Chemosphere. 55(10):1421-7, 2004 Jun. 20. Vidair CA. Age dependence of organophosphate and carbamate neurotoxicity in the postnatal rat: extrapolation to the human. Toxicology & Applied Pharmacology. 196(2):287-302, 2004 Apr 15. 21. Johnson DE, Seidler FJ, Slotkin TA. Early biochemical detection of delayed neurotoxicity resulting from developmental exposure to chloropyrifos. Brain Res Bull 1998;45:143–147. 22. Young JG. Eskenazi B. Gladstone EA. Bradman A. Pedersen L. Johnson C. Barr DB. Furlong CE. Holland NT. Association between in utero organophosphate pesticide exposure and abnormal reflexes in neonates. Neurotoxicology. 26(2):199-209, 2005 Mar. 23. Jeng SF. Tsao CC. Chen LC. Teng RJ. Yau KI. Jan MH. Reliability of the Neonatal Neurobehavioral Examination--Chinese version. Early Human Development. 45(3):191-202, 1996 Jul 19. 24. Jeng SF. Yau KI. Teng RJ. Neurobehavioral development at term in very low-birthweight infants and normal term infants in Taiwan. Early Human Development. 51(3):235-45, 1998 Jul 10. 25. Lubin JH. Colt JS. Camann D. Davis S. Cerhan JR. Severson RK. Bernstein L. Hartge P. Epidemiologic evaluation of measurement data in the presence of detection limits. Environmental Health Perspectives. 112(17):1691-6, 2 26. Barr DB. Barr JR. Driskell WJ. Hill RH Jr. Ashley DL. Needham LL. Head SL. Sampson EJ. Strategies for biological monitoring of exposure for contemporary-use pesticides. Toxicology & Industrial Health. 15(1-2):168-79, 1999 Jan-Mar. 27. Barr DB. Barr JR. Maggio VL. Whitehead RD Jr. Sadowski MA. Whyatt RM. Needham LL. A multi-analyte method for the quantification of contemporary pesticides in human serum and plasma using high-resolution mass spectrometry. Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences. 778(1-2):99-111, 2002 Oct 5 28. Sunaga M. Yoshida M. Hara I. Metabolism and urinary excretion of chlorpyrifos in rats. Nippon Eiseigaku Zasshi - Japanese Journal of Hygiene. 43(6):1124-9, 1989 Feb. 29. Hanke W. Romitti P. Fuortes L. Sobala W. Mikulski M. The use of pesticides in a Polish rural population and its effect on birth weight. International Archives of Occupational & Environmental Health. 76(8):614-20, 2003 Oct. 30. Dabrowski S. Hanke W. Polanska K. Makowiec-Dabrowska T. Sobala W. Pesticide exposure and birthweight: an epidemiological study in Central Poland. [Journal Article] International Journal of Occupational Medicine & Environmental Health. 16(1):31-9, 2003. 31. Chanda SM. Harp P. Liu J. Pope CN. Comparative developmental and maternal neurotoxicity following acute gestational exposure to chlorpyrifos in rats.] J ournal of Toxicology & Environmental Health. 44(2):189-202, 1995 Feb. 32. Chanda SM. Pope CN. Neurochemical and neurobehavioral effects of repeated gestational exposure to chlorpyrifos in maternal and developing rats. Pharmacology, Biochemistry & Behavior. 53(4):771-6, 1996 Apr. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/35668 | - |
dc.description.abstract | 研究背景:農藥在世界上已被大量使用,而其主要用途是用來作為預防及殺死害蟲及用在農田作物上或居家的蟲害控制。在台灣,每年大約有500種農藥被允許使用,其使用量每年大約有10萬公噸。而在2003台灣使用最大量的農藥是有機磷殺蟲劑,其中更以陶斯松的使用量為最多。此種非持續性農藥被使用在室內及室外、都市及鄉村地區,在食物、飲用水、農田、家中、學校及公園中都能被發現。在室內的使用後,有機磷農藥都還能穩定的持續幾天或幾星期。以陶斯松為例,在室內分噴灑後其還能持續至少兩週以上。而其暴露可能的健康影響仍然尚未清楚,因此探討其健康危害就很重要。目前有三個美國的研究指出農藥暴露對於出生體重,頭圍,身長及出生週數有些微影響但未一致的結論。而其對於神經行為發展的影響在人類流行病學研究上是欠缺且上無定論的,因此此研究目的即探討有陶斯松暴露對於嬰兒生長及神經行為發展的影響。
研究設計:此研究設計是一橫斷性的研究。研究的族群是在2004年8月至2005年1月在臺北生產的孕婦及其嬰兒共81對。為了控制其他可能的影響出生結果的危險因子,我們剔除產婦年齡低於18歲或高於40歲、有抽煙史的產婦。我們在其產前即將其列入研究,並以結構性問卷進行問卷訪視、並收集母親血液、尿液及新生兒臍帶血,並分析臍帶血中陶斯松濃度,最後我們透過複迴歸統計方法探討暴露對出生結果及神經行為發展的影響。 結果:複線性迴歸統計結果發現,較高的臍帶血陶斯松濃度和較短的出生身長及較低的出生體重計有顯著的相關。而邏輯斯廻歸結果也顯示較高的臍帶血陶斯松濃度和較低出生身長及SGA 有關。 | zh_TW |
dc.description.abstract | Background: Pesticides were widespread used all over the world. They were substances that were used to prevent or destroy pests, and were wildly used in agriculture on crops, and at homes for pest control. More than five hundred kinds of pesticides were licensed for use in Taiwan, and more than ten thousands metric tons of pesticides were applied annually. Organophosphates were the largest amount of used pesticides in Taiwan in 2003, and chlorpyrifos was the most one. These pesticides were used indoors and outdoors in either urban or rural areas, and could be found in food, water, agricultures, homes, schools, and parks. In the indoor settings, they could still remain stable for days or weeks; for example, chlorpyrifos could persist for at least two weeks after spreading. The potential health effect was still unknown, and exploring the health effect was important. Only three recent studies in the U.S. had reported inconsistent and slight effect on birth weight, head circumference, birth length and gestational age. The effect for neurodevelopment on human study was absence and not concluded. Thus, the aim of the study was to explore the risk of organophosphate pesticides on fetal growth and neurodevelopment.
Material and Methods: This study was a cross-sectional in design. The study populations were the mothers who gave births in Taipei between August 2004 and January 2005 and their infants. A total of 81 pregnancy women were included in the study. To control potential risk factors for adverse birth outcomes, we excluded women if they were younger than 18 years old or older then 40 years old, or had the history of cigarette smoking. We enrolled them before delivery, interviewed by a structured questionnaire, and collected mother’s blood and urine and umbilical cord blood and analysis chlorpyrifos concentration in cord blood. We shall use multiple regression models to explore the effect of chlorpyrifos exposure on birth outcomes and neurodevelopment. Results: For multiple linear regression models, we found that the associations between birth length and birth weight and cord plasma chlorpyrifos were significantly. For multiple logistic regression models, we found that the associations between birth length and small for gestational age (SGA) and cord plasma chlorpyrifos were significantly. | en |
dc.description.provenance | Made available in DSpace on 2021-06-13T07:03:58Z (GMT). No. of bitstreams: 1 ntu-94-R92841014-1.pdf: 483725 bytes, checksum: 527912637c7ad140649678c4a13b31df (MD5) Previous issue date: 2005 | en |
dc.description.tableofcontents | Birth Weight- and Gestational Age-Specific Neonatal and Infant Mortality
致謝 2 Table of Content 4 List of Tables 5 List of Figure 7 Introduction 8 Material and Methods 9 Data sources 9 Study population 9 Statistics 10 Results 11 Discussion 12 References 26 Appendix 27 Table 1. Characteristics of gestational age between 20 weeks and 44 weeks newborns between 1998 and 2002 in Taiwan (n=1,339,951) 14 Table 2. Modeling early neonatal mortality rate (per thousand) in male live births between 1998 and 2002 in Taiwan 16 Table 3. Modeling neonatal mortality rate (per thousand) in male live births between 1998 and 2002 in Taiwan 17 Table 4. Modeling infant mortality rate (per thousand) in male live births between 1998 and 2002 in Taiwan 18 Table 5. Modeling early neonatal mortality rate (per thousand) in female live births between 1998 and 2002 in Taiwan 19 Table 6. Modeling neonatal mortality rate (per thousand) in female live births between 1998 and 2002 in Taiwan 20 Table 7. Modeling infant mortality rate (per thousand) in female live births between 1998 and 2002 in Taiwan 21 Table 8 .Poisson regression model result for mortality rate by different gender 22 Table 9. Male live births by birth weight and gestational age between 1998 and 2002 in Taiwan 27 Table 10. Early neonatal deaths in male live births between 1998 and 2002 in Taiwan 28 Table 11. Neonatal deaths in male live birth between 1998 and 2002 in Taiwan 29 Table 12. Infant deaths in male live births between 1998 and 2002 in Taiwan 30 Table 13. Early neonatal mortality rate (per thousand) in male live birth between 1998 and 2002 in Taiwan 31 Table 14. Neonatal mortality rate (per thousand) in male live births between 1998 and 2002 in Taiwan 32 Table 15. Infant mortality rate (per thousand) in male live births between 1998 and 2002 in Taiwan 33 Table 16. Female live births by birth weight and gestational age between 1998 and 2002 in Taiwan 34 Table 17. Early neonatal deaths in female live births between 1998 and 2002 in Taiwan 36 Table 18. Neonatal deaths in female live births between 1998 and 2002 in Taiwan 37 Table 19. Infant deaths in female live births between 1998 and 2002 in Taiwan 38 Table 20. Early neonatal mortality rate (per thousand) in female live births between 1998 and 2002 in Taiwan 39 Table 21. Neonatal mortality rate (per thousand) in female live births between 1998 and 2002 in Taiwan 40 Table 22. Infant mortality rate (per thousand) in female live births between 1998 and 2002 in Taiwan 41 List of Figure Figure 1.The birth weight-specific mortality rate by gender between 1998 and 2002 in Taiwan 24 Figure 2. The gestational age-specific mortality rate by gender between 1998 and 2002 in Taiwan 25 Exploring the Risk of Chlorpyrifos on Fetal Growth and Neonatal Neurobehavior 摘要 44 Abstract 45 Table of Contents 47 List of Tables 48 Introduction 49 Material and Methods 51 Study population and design 51 Questionnaire 51 Biological sample collection and analysis 52 Birth outcomes 52 Neurodevelopment 53 Statistical analysis 53 Results 55 Discussion 61 Referencd 64 Appendix 1- literature Review 68 Appendix 2 - Inform Consent 78 Table 1. Distribution of maternal characteristics in Taiwan birth cohort study 57 Table 2. Distribution of infant characteristics in Taiwan birth cohort study 58 Table 3 Linear regression models of the concentrations of log10 transform chlorpyrifos concentration (ppb) in umbilical cord blood with birth outcomes and Neonatal Neurobehavioral examination score 59 Table 4 Univariate and multiple logistic regression models of the concentrations of chlorpyrifos (ppb) in umbilical cord blood with birth outcome and Neonatal Neurobehavioral examination score 60 | |
dc.language.iso | en | |
dc.title | 一、出生體重及懷孕週數別新生兒及嬰兒死亡率 二、探討陶斯松暴露對胎兒成長及神經行為發展之影響 | zh_TW |
dc.title | 1.Birth Weight- and Gestational Age-Specific Neonatal and Infant Mortality 2.Exploring the Risk of Chlorpyrifos on Fetal Growth and Neonatal Neurobehavior | en |
dc.type | Thesis | |
dc.date.schoolyear | 93-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 鄭素芳,蘇怡寧,李宏萍,張火炎,劉惠美 | |
dc.subject.keyword | 陶斯松,出生結果,有機磷,出生體重,頭圍,身長,出生週數,神經行為, | zh_TW |
dc.subject.keyword | Chlorpyrifos,birth outcomes,organophosphatesChlorpyrifos,birth outcomes,organophosphates,birth weight,head circumference,birth length,gestational birth weight,head circumference,birth length,gestational, | en |
dc.relation.page | 80 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2005-07-27 | |
dc.contributor.author-college | 公共衛生學院 | zh_TW |
dc.contributor.author-dept | 職業醫學與工業衛生研究所 | zh_TW |
顯示於系所單位: | 職業醫學與工業衛生研究所 |
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