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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 李文宗 | |
dc.contributor.author | Hsiao-Yuan Huang | en |
dc.contributor.author | 黃筱元 | zh_TW |
dc.date.accessioned | 2021-06-13T06:54:08Z | - |
dc.date.available | 2005-08-31 | |
dc.date.copyright | 2005-08-04 | |
dc.date.issued | 2005 | |
dc.date.submitted | 2005-07-27 | |
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The Environment And Disease: Association Or Causation? Proc R Soc Med, 58: 295-300, 1965. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/35467 | - |
dc.description.abstract | 探討基因與疾病相關性的病例對照研究中,許多研究進行基因劑量分析。作者發現其中約有三分之一的研究,其定義高危險基因型(高危險基因)的方式是依資料本身該基因型頻率(基因頻率)病例組大於對照組而定。作者進行蒙地卡羅模擬,發現此種定義方式下即使各基因座與疾病無相關,亦會呈現偽陽性的基因劑量關係。作者提出排列校正方法,可以成功地校正各偏差。本研究所提方法執行容易且校正效果良好,可望成為基因劑量效應研究之標準程序。 | zh_TW |
dc.description.abstract | Many case-control association studies performed the “gene-dose analysis” to investigate the association between multiple loci and the disease. The authors found that the researchers in about one-third of these studies defined the high-risk genotypes (high-risk alleles) as those that have higher genotype frequencies (allele frequencies) in the case group than in the control in the study. The authors performed Monte-Carlo simulation and found that even though there is no association between each locus and the disease, this kind of definition will show false-positive gene-dose relationships. The authors proposed a permutation correction method which is easy to perform and can correct the biases very effectively. The permutation correction method may become a standard procedure for a valid gene-dose analysis in the days to come. | en |
dc.description.provenance | Made available in DSpace on 2021-06-13T06:54:08Z (GMT). No. of bitstreams: 1 ntu-94-R92842015-1.pdf: 191821 bytes, checksum: 11da3b493a4498aeb2fe6cc48c77dbf8 (MD5) Previous issue date: 2005 | en |
dc.description.tableofcontents | 中文摘要………………………………………………………………………….….I
英文摘要………………………………………………………………………….…II 目錄…………………………………………………………………………………III 表格目錄……………………………………………………………………………IV 前言…………………………………………………………………………………..1 蒙地卡羅模擬………………………………………………………………………..3 排列校正方法………………………………………………………………………..5 討論…………………………………………………………………………………..7 參考文獻……………………………………………………………………………..9 附錄:電腦模擬程式………………………………………………………………17 表格目錄 表1. 不同基因座數及樣本數下之基因劑量分析。各基因座不連鎖。……..….13 表2. 不同基因座數及樣本數下之基因劑量分析。各基因座間連鎖不平衡( =0.3)。……………………………………………………………………14 表3. 不同基因座數及樣本數下之排列校正後基因劑量分析。各基因座不連鎖。 ………………………………………………………………………………...15 表4. 不同基因座數及樣本數下之排列校正後基因劑量分析。各基因座間連鎖不平衡( =0.3)。……………………………………………………………….16 | |
dc.language.iso | zh-TW | |
dc.title | 遺傳相關研究中的基因劑量分析:潛在的偏差及其校正方法 | zh_TW |
dc.title | Gene-Dose Analysis in Genetic Association Studies:A Potential Bias and its Correction | en |
dc.type | Thesis | |
dc.date.schoolyear | 93-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 陳為堅,蕭朱杏 | |
dc.subject.keyword | 基因劑量分析,排列校正方法,流行病學方法學,遺傳流行病學, | zh_TW |
dc.subject.keyword | gene-dose analysis,permutation correction method,epidemiologic methods,genetic epidemiology, | en |
dc.relation.page | 28 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2005-07-28 | |
dc.contributor.author-college | 公共衛生學院 | zh_TW |
dc.contributor.author-dept | 流行病學研究所 | zh_TW |
顯示於系所單位: | 流行病學與預防醫學研究所 |
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