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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 邵耀華(Yio-Wha Shau) | |
| dc.contributor.author | Chia-Ching Lin | en |
| dc.contributor.author | 林家慶 | zh_TW |
| dc.date.accessioned | 2021-06-13T06:53:28Z | - |
| dc.date.available | 2005-08-01 | |
| dc.date.copyright | 2005-08-01 | |
| dc.date.issued | 2005 | |
| dc.date.submitted | 2005-07-28 | |
| dc.identifier.citation | [1] Barnett GO, Mallos AJ, Shapiro A. Relationship of aortic pressure and diameter in the dog. J Appl Pysiol. 1961; 16; 545-548
[2] Cheng WF, Lee CN, Chu JS, Chen CA, Chen TM, Shau WY, Hsieh CY, Hsieh FJ. Vascularity index as a novel parameter for the in vivo assessment of angiogenesis in patients with cervical carcinoma. American Cancer Society 1999; 85（3）; 651-657 [3] Chen CN, Cheng YM, Lin MT, Hsieh FJ, Lee PH, Chang KJ. Association of color doppler vascularity index and microvessel density with survival in patients with gastric cancer. Ann Surg. 2002; 235（4）; 512-518 [4] Durick JE, Winter 3rd TC, Schmiedl UP, Cry DR, Starr 3rd FL, Mack LA. Renal perfusion: pharmacologic changes depicted with power doppler US in an animal model. Radiology 1995; 197; 615-617 [5] Donald CP. Veterinary Drug Handbook( ed.). Iowa-State; 2002 [6] Eytan O, Har-Toov J, Fait G. Vascularity index distribution within the testis : a technique for guiding testicular sperm extraction. Ultrasound Med.& Biol. 2001; 27(9); 1171-1176 [7] Fung YC. Biodynamics：Circulation. Springer-Verlag; 1984 [8] Giebisch G. Homer W. Smith’s contribution to renal physiology. J nephrol 2004; 17; 159-165 [9] Gordon IL, Wesley R, Wong DH, Ingegno MD, Spivak B, Wilson SE. Effect of dopamine on renal blood flow and cardiac output, Arch Surg. 1995; 130（8）; 864-868 [10] Kenton AR, Martin PJ, Evans DH. Power doppler: an advance over colour doppler for transcranial imaging? Ultrasound Med. & Biol.1996; 22(3); 313-317 [11] Sugawara M, Niki K, Furuhata H, Ohnishi S,Suzuki S. Relationship between the pressure and diameter of the carotid artery in humans. Heart and Vessels. 2000; 15; 49-51 [12] Nagao M, Murase K, Saeki H, Mochizuki T, Sugata S, Ikezoe J. Pulsating renal blood flow distribution measured using power doppler ultrasound: correlation with hypertension. Hypertens Res. 2002; 25（5）; 697-702 [13] Nichols WW, O'Rourke MF. McDonald's blood flow in arteries. Lindon Edward Arnold; 1990 [14] Ohte N, Narita H, Sugawara M, Niki K, Okada T, Harada A, Hayano J, Kimura G. Clinical usefulness of carotid arterial wave intensity in assessing left ventricular systolic and early diastolic performance. Heart Vessels. 2003; 18; 107-111 [15] Rubin JM, Bude RO, Carson PL, Bree RL, Adler RS. Power doppler US: a potentially useful alternative to mean frequency-based color doppler US, Radiology 1994; 190; 853-856 [16] Sugawara M, Kondoh Y, Uchida K, Jones CJH. Wave intensity:a new index of ventriculoareterial interaction. BioMed Eng. 1995; 9; 22–27 [17] Kuwa T, Cancio LC, Sondeen JL, Matylevich N, Jordan BS, McManus AT, Goodwin CW. Evaluation of renal cortical perfusion by noninvasive power Doppler ultrasound during vascular occlusion and reperfusion, J Trauma. 2004; 56; 618-624 [18] Noble VE, Brown DFMB. Renal ultrasound. Emerg med Clin N Am. 2004; 22; 641-659 [19] Wei K, Le E, Bin JP, Kaul S. Quantification of renal blood flow with contrast-enhanced ultrasound. Journal of the American College of Cardiology 2001; 37（4）; 1135-1140 [20] Watanabe H, Kawai M, Sibata T, Hara M, Furuhata H, Mochizuki S. Noninvasive measurement of aortic pressure waveform by ultrasound. Heart Vessels. 1998; 13; 79-86 [21] Zubarev AV. Ultrasound of renal vessels. Eur. Radiol. 2001; 11; 1902 -1915 [22] Guytton, AC, Hall JE.原著, 林佑穗,袁宗凡 編譯; 新編蓋統醫用生理學; 合記圖書; 2000 [23] Heinz V.原著, 黃基礎 編譯; Renal Function; 藝軒圖書; 1991 [24] 楊順聰; 臨床高等醫療儀器系統-原理與應用; 藝軒圖書; 1989 [25] 包舜華; 超音波動態影像分析技術與臨床醫學應用; 台灣大學應用力學研究所博士論文; 2004 [26] 王碩盟; 超音波新的應用方式：血管指標與協頻分析對於移植腎臟的評估;台灣大學臨床醫學研究所碩士論文; 2002 | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/35452 | - |
| dc.description.abstract | 本文研究血液灌流指數VI（Vascularity Index）其所代表血液動力學之意義，主要利用非侵襲性超音波(Echo)系統與侵襲性血流血壓量測系統，以犬隻腎臟為平台，量測其血液灌流量特徵，採用實驗室開發之醫學影像處理軟體分析超音波影像，以探討VI與壓力波和流量波之相關性。
實驗對象為年齡9個月至5歲，重量為14至25公斤之健康犬隻，量測部位為左邊腎臟，非侵襲性實驗總共進行11隻狗的實驗，同時擷取腎臟血管及腹腔大動脈影像資料，針對當中取樣頻率較高的4隻狗將腎臟血管分成葉間動脈（上游）、弓狀動脈（中游）、末稍小動脈（下游）三個部分，並對此三個部分的VI波形，與腹腔大動脈的變形波及流量波進行比對，由比對結果得下游週邊血管統計分析上的相關性高於上、中游血管，VI與變形波迴歸分析的判定係數（ ）分別有0.9371、0.9755、0.8962、0.9037的相關性。藥物實驗總共進行3隻狗的實驗，針對2組較佳的資料資料分析，結果得給藥後平均血壓有下降的趨勢，由86 ± 1 mmHg下降至70 ± 2、72 ± 2、72 ± 1 mmHg，由於Dopamine所影響的是腎臟的血流，以致於給藥後的VI和給藥前腹腔大動脈變形波之間的相關性降低。 | zh_TW |
| dc.description.abstract | This study aimed at investigating the physical meaning of VI（Vascularity Index）, using color duplex ultrasound. The renal hemodynamics of canine was used as the testing platform for the quantification of VI using a medical imaging analysis software developed in house. The dynamics power Doppler VI were compared with the pressure waveform and flow waveform measured upstream at the abdominal aorta.
Eleven health dogs aged from nine mouths to five years old, weighted 14- 25 Kg were used in this study. Ultrasonic scanning was focused on the left renal of each dog non-invasively. Both the Doppler spectrum of the renal blood flow and the M-mode image of the abdominal aorta were recorded. Among the test cases, four dogs were selected to differentiate the renal blood vessels at various sections of the kidney; namely interlobar artery（top）、 arcuate artery（middle）、arteriole（below）. Comparing the VI waveforms that obtained from various renal sections with the aortic diameter deformation waveform (which is considered as an alternative pressure waveform) we find the VI waveform from arteriole has a higher correlation statistically than the interlobar artery and the arcuate artery. The corresponding regression analysis were about 0.9371、0.9755、0.8962、0.9037 for these renal VI and the pressure waveform. Dopamine was also used to control the renal blood flow of canine without much alteration of physiological conditions. The blood pressure changed slightly from 86 ± 1 mmHg to 70 ± 2, 72 ± 2 and 72 ± 1 mmHg. Because of the Dopamine affected the renal blood vessels, the regression coefficient between the VI waveform and pressure waveform decreased due to the pharmaceutical action. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T06:53:28Z (GMT). No. of bitstreams: 1 ntu-94-R91543061-1.pdf: 2812766 bytes, checksum: 4be7b0f982e0df35496b81331595e432 (MD5) Previous issue date: 2005 | en |
| dc.description.tableofcontents | 誌 謝……………….……………………………………………I
中文摘要………………………………………………………………II 英文摘要…………………………………………………………… III 內文目錄………………………………………………………………IV 圖表目錄………………………………………………………………VI 第一章 緒論……………………………………………………… 1 1-1前言………………………………………………………… 1 1-2文獻回顧…………………………………………………… 3 1-3 研究背景與動機…………………………………………… 6 1-4 論文架構…………………………………………………… 7 第二章 研究原理………………………………………………… 10 2-1超音波量測系統………………………………………… 10 2-1-1超音波基本原理……………………………………… 11 2-1-2 超音波顯示模式………………….…………………… 11 2-2腎臟生理學……………………………………………… 13 2-3血液灌流量指數…….…………………………………15 2-3-1 VI…………………..………….…………………… 15 2-3-2 DFVI…………………..…………………………… 16 第三章 研究方法及設備………………….……………………… 19 3-1 實驗方法簡述……………………………………… 19 3-2 實驗設備…………………………………………… 19 3-3 實驗動物…………………………………………… 21 3-4 實驗流程…………………………………………… 21 3-4-1 前置作業…………………………….………… 21 3-4-2 非侵襲性動物實驗………………….………… 21 3-4-3 侵襲性動物實………………………….……… 22 3-4-4 非侵襲性動物實驗(Dopamine藥物實驗).. 23 3-5資料處理與分析……………………………………… 24 3-5-1資料收集……………………………………… 24 3-5-2資料分析…………………………….………… 24 第四章 結果與討論…………………………………………… 33 4-1 波形分析……………………………………………… 33 4-1-1 腎臟血流的壓力、流量波形分析……………… 33 4-1-2 VI、DFVI波形分析………………………… 36 4-1-3 Correlation Map的應用…………….…… 38 4-2 不同部位VI、DFVI波形和腹腔大動脈血管之變形波、流速波 的比對………………………………….………………… 42 4-2-1 葉間動脈（上游）VI、DFVI波形和腹腔大動脈血管之 變形波、流速波的比對……………………….……… 46 4-2-2 弓狀動脈（中游）VI、DFVI波形和腹腔大動脈血管之 變形波、流速波的比對………………..……… 55 4-2-3 末稍小動脈（下游）VI、DFVI波形和腹腔大動脈血管之 變形波、流速波的比對……………………… 64 4-3 Dopamine藥物給予的影響…………………………… 73 4-4 VI、DFVI波形和變形波、流速波波形的相似性… 77 4-5 討論…………………………………………………… 81 4-5-1 壓力波與變形波比對之探討……………………..81 4-5-2 Correlation Map說明………………………… 81 4-5-3 Dopamine藥物實驗之探討………..…………….82 4-5-4 實驗討論…………………………………………… 83 第五章 結論…………………………………………………… 85 5-1 結論………………………………………………… 85 5-2 未來展望…………………………………………… 86 參考文獻………………………………………………………… 87 | |
| dc.language.iso | zh-TW | |
| dc.subject | 血液灌流指數VI | zh_TW |
| dc.subject | 葉間動脈 | zh_TW |
| dc.subject | 弓狀動脈 | zh_TW |
| dc.subject | 末稍小動脈 | zh_TW |
| dc.subject | 腹腔大動脈 | zh_TW |
| dc.subject | Vascularity Index | en |
| dc.subject | aorta | en |
| dc.subject | arteriole | en |
| dc.subject | arcuate artery | en |
| dc.subject | interlobar artery | en |
| dc.title | 以犬隻腎臟超音波探討血液灌流指數之物理意義 | zh_TW |
| dc.title | Investigation of Physics of Vascularity Index Using Canine Renal Model | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 93-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.coadvisor | 徐久忠(Jeou-Jong Shyu) | |
| dc.contributor.oralexamcommittee | 陳炯年,許智欽 | |
| dc.subject.keyword | 血液灌流指數VI,葉間動脈,弓狀動脈,末稍小動脈,腹腔大動脈, | zh_TW |
| dc.subject.keyword | Vascularity Index,interlobar artery,arcuate artery,arteriole,aorta, | en |
| dc.relation.page | 89 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2005-07-28 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 應用力學研究所 | zh_TW |
| 顯示於系所單位： | 應用力學研究所 | |
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