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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 林欽塘(Chin-Tarng Lin) | |
| dc.contributor.author | Yi-Ting Lin | en |
| dc.contributor.author | 林怡婷 | zh_TW |
| dc.date.accessioned | 2021-06-13T06:40:57Z | - |
| dc.date.available | 2007-08-04 | |
| dc.date.copyright | 2005-08-04 | |
| dc.date.issued | 2005 | |
| dc.date.submitted | 2005-07-31 | |
| dc.identifier.citation | Albini, A; Iwamoto, Y; Kleinman, HK; Martin, GR; Aaronson, SA; Kozlowski, JM; McEwan, RN (1987). A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res. 15; 47(12):3239-3245
Bellahcene, A., Castronovo, V (1995). Increased expression of osteonectin and osteopontin, two bone matrix proteins, in human breast cancer. Am. J. Pathol. 146(1):95-100 Bernhard EJ, Gruber SB and Muschel RJ. Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells (1994). Proc Natl Acad Sci USA. 10; 91(10):4293-4297 Bigg HF, Morrison CJ, Butler GS, Bogoyevitch MA, Wang Z, Soloway PD, Overall CM (2001). Tissue inhibitor of metalloproteinases-4 inhibits but does not support the activation of gelatinase A via efficient inhibition of membrane type 1-matrix metalloproteinase. Cancer Res 1; 61(9):3610-3618 Bradshaw AD, Sage EH (2001). SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury. J Clin Invest. 107(9):1049-1054 Brekken RA, Sage EH (2001). SPARC, a matricellular protein: at the crossroads of cell-matrix communication. Matrix Biol. 19(8):816-827 Brekken RA, Puolakkainen P, Graves DC, Workman G, Lubkin SR, Sage EH (2003). Enhanced growth of tumors in SPARC null mice is associated with changes in the ECM. J Clin Invest. 111(4):487-495 Chan SH (1990). Aetiology of nasopharyngeal carcinoma. Ann Acad Med Singapore. 19(2):201-207 Cheng YJ., Hildesheim A., Hsu MM., Chen IH., Brinton LA., Levine PH., Chen CJ. and Yang CJ (1999). Cigarette smoking, alcohol consumption and risk of nasopharyngeal carcinoma in Taiwan. Cancer Causes Control. 10(3):201-207 Cheung ST, Huang DP, Hui Angela BY, Lo KW, Ko CW, Tsang YS, Wong N, Whitney BM, Lee Joseph CK (1999). Nasopharyngeal carcinoma cell line (C666-1) consistently harbouring Epstein-Barr virus. Int J Cancer. 24; 83(1):121-126 Chlenski A, Liu S, Crawford SE, Volpert OV, DeVries GH, Evangelista A, Yang Q, Salwen HR, Farrer R, Bray J, Cohn SL (2002). SPARC is a key Schwannian-derived inhibitor controlling neuroblastoma tumor angiogenesis. Cancer Res. 15; 62(24):7357-7363 de-The G, Sohier R, Ho JH, Freund R (1973). Nasopharyngeal carcinoma. IV. Evolution of complement-fixing antibodies during the course of the disease. Int J Cancer. 15; 12(2):368-377 de The G (1982). Epidemiology of the Epstein Barr virus and associated disease. In: Herpes Viruses. Ed. B. Riozman, Plenum Press, New York, Vol. A 1, p. 25 de The G (1984). Virus-associated lymphomas, leukaemias and immunodeficiencies in Africa. IARC Sci Publ. (63):727-744 Ellerbroek SM., and Stack MS (1999). Membrane associated matrix metalloproteinases in metastasis. Bioessays. 21 (11):940-949 Fong YY. and Chan WC (1973). Bacterial production of dimethyl nitrosamine in salted fish. Nature 243: 421 Fong YY, and Walsh EO (1971). Carcinogenic nitrosamines in cantonese salt dried fish. Lancet ii: 1032 Fedder M, and Gonzalez MF (1985). Nasopharyngeal carcinoma – Brief review. Am J Med 79: 365 Fidler IJ (2003). The pathogenesis of cancer metastasis: The ‘seed and soil’ hypothesis revisited. Nat Rev Cancer 3:453–458 Ford R, Wang G, Jannati P, Adler D, Racanelli P, Higgins PJ, Staiano-Coico L (1993). Modulation of SPARC expression during butyrate-induced terminal differentiation of cultured human keratinocytes: regulation via a TGF-beta-dependent pathway. Exp Cell Res. 206(2):261-275 Framson PE, Sage EH (2004). SPARC and tumor growth: where the seed meets the soil? J Cell Biochem. 1; 92(4):679-690 Funk SE, Sage EH (1991). The Ca2(+)-binding glycoprotein SPARC modulates cell cycle progression in bovine aortic endothelial cells. Proc Natl Acad Sci USA. 1; 88(7):2648-2652 Funk SE, Sage EH., (1993). Differential effects of SPARC and cationic SPARC peptides on DNA synthesis by endothelial cells and fibroblasts. J. Cell. Physiol. 154, 53-63 Golembieski WA, Ge S, Nelson K, Mikkelsen T, Rempel SA (1999). Increased SPARC expression promotes U87 glioblastoma invasion in vitro. Int. J. Dev. Neurosci. 17, 463-472 Gilles C, Bassuk JA, Pulyaeva H, Sage EH, Foidart JM, Thompson EW (1998). SPARC_osteonectin induces matrix metalloproteinase 2 activation in human breast cancer cell lines. Cancer Res. 58, 5529-5536 Henle G and Henle W (1976). Epstein Barr virus specific IgA serum antibodies as an outstanding feature of nasopharyngeal carcinoma. Int J Cancer 17: 1 Ho JH (1971). Incidence of nasopharyngeal cancer in Hongkong. UICC Bull Cancer 9: 5 Ho CK, Lo WC, Huang PH, Wu MT, Christiani DC, Lin CT (1999). Suspected nasopharyngeal carcinoma in three workers with long-term exposure to sulphuric acid vapour. Occup Environ Med. 56(6):426-428 Hohenester E, Maurer P, Hohenadl C, Timpl R, Jansonius JN, Engel J (1996). Structure of a novel extracellular Ca+2-binding module in BM-40. Nat. Struct. Biol. 3, 67-73 Hohenester E, Maurer P, Timpl R 1997). Crystal structure of a pair of follistatin-like and EF-hand calcium-binding domains in BM-40. EMBO J. 16, 3778-3786 Huang DP, Ho JHC, Saw D, Teoh TB (1978). Carcinoma of the nasal and paranasal regions in rats fed Cantonese salted marine fish, in Nasopharyngeal Carcinoma: Etiology and Control (de The G, Ito Y, eds) pp.315-328. IARC Scientific Publications No.20, International Agency for Research on Cancer, Lyon Iacobuzio-Donahue CA, Argani P, Hempen PM, Jones J, Kern SE. (2002). The desmoplastic response to infiltrating breast carcinoma: Gene expression at the site of primary invasion and implications for comparisons between tumor types. Cancer Res 62:5351–5357 International Agency for Research on Cancer (1997). Epstein Barr virus and Kaposi’s sarcoma, herpes virus/human herpes virus. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, (Vol 70) Iruela-Arispe ML, Lane TF, Redmond D et al., (1995). Expression of SPARC during development of the chicken chorioallantoic membrane: evidence for regulated proteolysis in vivo. Mol. Biol. Cell 6, 327-343 Jacob K, Webber M, Benayahu D, Kleinman HK (1999). Osteonectin promotes prostate cancer cell migration and invasion: a possible mechanism for metastasis to bone. Cancer Res. 59, 4453-4457 Jiang Y, Goldberg ID, Shi YE (2002). Complex roles of tissue inhibitors of metalloproteinases in cancer. Oncogene. 28;21(14):2245-2252 Kelm Jr RJ, Swords NA, Orfeo T, Mann KG (1994). Osteonectin in matrix remodeling. A plasminogen osteonectin collagen complex. J. Biol. Chem. 269, 30147-30153 Kupprion C, Motamed K, Sage EH (1998). SPARC (BM-40, osteonectin) inhibits the mitogenic effect of vascular endothelial growth factor on microvascular endothelial cells. J. Biol. Chem. 273, 29635-29640 Lane TF, Sage EH (1994). The biology of SPARC, a protein that modulates cell matrix interactions. FASEB J. 8, 163-173 Lavine PH, Conelly RR, Nilman G, Easten J (1988). Epstein Barr virus serology in the control of nasopharyngeal carcinoma. Cancer Detect Prev 12: 357 Le Bail B, Faouzi S, Boussarie L, et al., (1999). Osteonectin/SPARC is overexpressed in human hepatocellular carcinoma. J Pathol 189:46 – 52 Ledda F, Bravo AI, Adris S, Bover L, Mordoh J, Podhajcer OL (1997). The expression of the secreted protein acidic and rich in cysteine (SPARC) is associated with the neoplastic progression of human melanoma. J Invest Dermatol. 108(2):210-214 Lin TM, Chen KP, Lin CC, Hsu MM, Tu SM, Chiang TC, Jung PF, Hirayama T (1973). Retrospectives study on nasopharyngeal carcinoma. J Natl Cancer Inst 51: 1403 Lin CT, Lin CR, Tan GK, Chen W, Dee AN, Chan WY (1997). The mechanism of Epstein-Barr virus infection in nasopharyngeal carcinoma cells. Am J Pathol. 150(5):1745-1756 Liu FF (2002). Novel gene therapy approach for nasopharyngeal carcinoma. Semin Cancer Biol. 12(6):505-515 Lu SJ, Day NE, Degos L, Lepage V, Wang PC (1990). Linkage of a nasopharyngeal carcinoma susceptibility locus to the HLA region. Nature (Lond.) 346, 470–471 Maeng HY, Song SB, Choi DK, et al., (2002). Osteonectin-expressing cells in human stomach cancer and their possible clinical significance. Cancer Lett 184:117 – 121 Mannello F, Gazzanelli G. (2001). Tissue inhibitors of metalloproteinases and programmed cell death: conundrums, controversies and potential implications. Apoptosis. 6(6):479-482 Massi D, Franchi A, Borgognoni L, Reali UM, Santucci M (1999). Osteonectin expression correlates with clinical outcome in thin cutaneous malignant melanomas. Hum Pathol. 30(3):339-344 Maurer P, Mayer U, Bruch M et al., (1992). High-affinity and low-affinity calcium binding and stability of the multidomain extracellular 40-kDa basement membrane glycoprotein (BM-40/SPARC/osteonectin). Eur. J. Biochem. 205, 233-240 Mok SC, Chan WY, Wong KK, Muto MG., Berkowitz RS (1996). SPARC, an extracellular matrix protein with tumor-suppressing activity in human ovarian epithelial cells. Oncogene, 12:1895-1901 Motamed K, Sage EH (1998). SPARC inhibits endothelial cell adhesion but not proliferation through a tyrosine phosphorylation-dependent pathway. J. Cell. Biochem. 70, 543-552 Nagasse H and Woessner Jr JF (1999). J. Biol. Chem., 274, 21491-21494 Nischt R, Wallich M, Reibetanz M, Baumann P, Krieg T, Mauch C (2001). BM-40 and MMP-2 expression are not coregulated in human melanoma cell lines. Cancer Lett. 26;162(2):223-30 Noloy PJ, Chung YT, Krivitsky PB. and Kim RC (1985). Squamous carcinoma of the nasopharynx. West J Med 143: 66 Oberender H, Nowak R, Donvier BE, Venka V, Tetrin W, Kankel N (1989). EBV specific antibodies in patients with nasopharyngeal carcinoma (A four year follow up). Laryngorhinologie 68: 181 Oh J, Takahashi R, Kondo S, Mizoguchi A, Adachi E, Sasahara RM, Nishimura S, Imamura Y, Kitayama H, Alexander DB, Ide C, Horan TP, Arakawa T, Yoshida H, Nishikawa S, Itoh Y, Seiki M, Itohara S, Takahashi C, Noda M (2001). The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell 14;107(6):789-800 Paget S (1889). The distribution of secondary growths in cancer of the breast. Lancet 1, 571−573 Porte H, Chastre E, Prevot S, Nordlinger B, Empereur S, Basset P, Chambon P, Gespach C (1995). Neoplastic progression of human colorectal cancer is associated with overexpression of the stromelysin-3 and BM-40/SPARC genes. Int J Cancer. 20;64(1):70-75 Porte H, Triboulet JP, Kotelevets L, Carrat F, Prevot S, Nordlinger B, DiGioia Y, Wurtz A, Comoglio P, Gespach C, Chastre E (1998). Overexpression of stromelysin-3, BM-40/SPARC, and MET genes in human esophageal carcinoma: implications for prognosis. Clin. Cancer Res., 4:1375-1382 Porter PL, Sage EH, Lane TF, Funk SE, Gown AM (1995). Distribution of SPARC in normal and neoplastic human tissue. J Histochem Cytochem. 43(8):791-800 Puolakkainen PA, Brekken RA, Muneer S, Sage EH (2004). Enhanced growth of pancreatic tumors in SPARC-null mice is associated with decreased deposition of extracellular matrix and reduced tumor cell apoptosis. Mol Cancer Res. 2(4):215-224 Reedman BM, Klein G (1973). Cellular localization of an Epstein Barr virus (EBV) associated complement-fixing antigen in producer and non-producer Iymphoblastoid cell lines. Int J Cancer 11: 499 Rempel SA, Golembieski WA, Ge S, Lemke N, Elisevich K, Mikkelsen T, Gutierrez JA (1998). SPARC: a signal of astrocytic neoplastic transformation and reactive response in human primary and xenograft gliomas. J Neuropathol Exp Neurol. 57(12):1112-1121 Rempel SA, Ge S, Gutierrez JA (1999). SPARC: A potential diagnostic marker of invasive meningiomas. Clin Cancer Res 5:237–241 Rich JN, Shi Q, Hjelmeland M, Cummings TJ, Kuan C-T, Bigner DD, Counter CM, Wang XF (2003). Bone-related genes expressed in advanced malignancies induce invasion and metastasis in a genetically defined human cancer model. J Biol Chem 278:15951–15957 Rous GC, Walrath J, Stayner LT, Kaplan SA, Flannery JT Blair A (1987). Nasopharyngeal cancer, sinonasal cancer and occupation related to formaldehyde: A case control study. J Natl Cancer Inst 76: 1221 Ryu B, Jones J, Hollingsworth MA, Hruban RH, Kern SE (2001). Invasion-specific genes in malignancy: Serial analysis of gene expression comparisons of primary and passaged cancers. Cancer Res 61:1833–1838 Sakai N, Baba M, Nagasima Y, Kato Y, Hirai K, Kondo K, Kobayashi K, Yoshida M, Kaneko S, Kishida T, Kawakami S, Hosaka M, Inayama Y, Yao M (2001). SPARC expression in primary human renal cell carcinoma: upregulation of SPARC in sarcomatoid renal carcinoma. Hum. Pathol., 32:1064-1070 Sangaletti S, Stoppacciaro A, Guiducci C, Torrisi MR, Colombo MP (2003). Leukocyte, rather than tumorproduced SPARC, determines stroma and collagen type IV deposition in mammary carcinoma. J Exp Med 198:1475–1485 Sasahara RM, Takahashi C, Noda M (1999). Involvement of the Sp1 site in ras-mediated downregulation of the RECK metastasis suppressor gene. Biochem Biophys Res Commun. 2;264(3):668-675 Sasaki T, Gohring W, Mann K. et al., (1997). Limited cleavage of extracellular matrix protein BM-40 by matrix metalloproteinases increases its affinity for collagens. J. Biol. Chem. 272, 9237-9243 Sasaki T, Hohenester E, Gohring W, Timpl R (1998). Crystal structure and mapping by site-directed mutagenesis of the collagen-binding epitope of an activated form of BM-40/SPARC/osteonectin. EMBO J. 17, 1625-1634 Sato N, Fukushima N, Maehara N, Matsubayashi H, Koopmann J, Su GH, Hruban RH, Goggins M (2003). SPARC/osteonectin is a frequent target for aberrant methylation in pancreatic adenocarcinoma and a mediator of tumor-stromal interactions. Oncogene. 7;22(32):5021-5030 Schultz C, Lemke N, Ge S, Golembieski WA, Rempel SA (2002). Secreted protein acidic and rich in cysteine promotes glioma invasion and delays tumor growth in vivo. Cancer Res., 62:6270-6277 Schwarzbauer JE, Spencer CS (1993). The Caenorhabditis elegans homologue of the extracellular calcium binding protein SPARC_osteonectin affects nematode body morphology and mobility. Mol. Biol. Cell 4, 941-952 Shankavaram UT, DeWitt DL, Funk SE, Sage EH, Wahl LM (1997). Regulation of human monocyte matrix metalloproteinases by SPARC. J Cell Physiol. 173(3):327-334 Simons MJ, Chao SM, Wee GD, Shanmugaratnam K, Goh EH, Ho JHC, Chao JCW, Dharmalingam S, Prasad U, Betuel H, Day NE, deThe G (1978). Nasopharyngeal carcinoma and histocompatibility antigens. In: Nasopharyngeal Carcinoma: Etiology and Control. Eds. G. de The and Y. Ito. IARC Scientific Publication 20: 271 Swaroop A, Hogan BL, Francke U (1988). Molecular analysis of the cDNA for human SPARC_osteonectin_BM-40: sequence, expression, and localization of the gene to chromosome 5q31-q33. Genomics 2, 37-47 Tai IT, Dai M, Owen DA, Chen LB (2005). Genome-wide expression analysis of therapy-resistant tumors reveals SPARC as a novel target for cancer therapy. J Clin Invest. 1;115(6):1492-1502 Takahashi C, Sheng Z, Horan TP, Kitayama H, Maki M, Hitomi K, Kitaura Y, Takai S, Sasahara RM, Horimoto A, et al. (1998). Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK. Proc. Natl. Acad. Sci. USA 95, 13221–13226 Thomas R, True LD, Bassuk JA, Lange PH, Vessella RL (2000). Differential expression of osteonectin/SPARC during human prostste cancer progression. Clin. Cancer Res., 6:1140-1149 Termine JD, Kleinman HK, Whitson SW, Conn KM, Mc-Garvey ML, Martin GR (1981). Osteonectin, a bone-specific protein linking mineral to collagen. Cell 26, 99-105 Tsai ST, Jin YT, Mann RB, Ambinder RF (1998). Epstein-Barr virus detection in nasopharyngeal tissues of patients with suspected nasopharyngeal carcinoma. Cancer. 15; 82(8):1449-53 Visscher DW, Hoyhtya M, Ottosen SK, Liang CM, Sarkar FH, Crissman JD and Fridman R. (1994). Int. J. Cancer, 59, 339-344 Wang CS, Lin KH, Chen SL, Chan YF, Hsueh S (2004). Overexpression of SPARC gene in human gastric carcinoma and its clinic-pathologic significance. Br J Cancer. 29; 91(11):1924-1930 Wu HC, Lin YJ, Lee JJ, Liu YJ, Liang ST, Peng Y, Chiu YW, Wu CW, Lin CT (2003). Functional analysis of EBV in nasopharyngeal carcinoma cells. Lab Invest. 83(6):797-812 Wu HC, Lu TY, Lee JJ, Hwang JK, Lin YJ, Wang CK, Lin CT (2004). MDM2 expression in EBV-infected nasopharyngeal carcinoma cells. Lab Invest. 84 (12):1547-1556 Yamanaka M, Kanda K, Li NC, Fukumori T, Oka N, Kanayama HO, Kagawa S (2001). Analysis of the gene expression of SPARC and its prognostic value for bladder cancer. J Urol. 166(6):2495-2499 Yan Q, Sage EH, (1999). SPARC, a matricellular glycoprotein with important biological functions. J. Histochem. Cytochem. 47, 1495-1506 Yang ZH (1988). Study and analysis of EBV/EBNA and EBV/ DNA in biopsies from patients with nasopharyngeal carcinoma. Chung -Kuo-I-Hsueh -Ko-HSheh- YuanHSush-Pao 10: 14 Yiu GK, Chan WY, Ng SW, Chan PS, Cheung KK, Berkowitz RS, Mok SC (2001). SPARC (secreted protein acidic and rich in cysteine) induces apoptosis in ovarian cancer cells. Am J Pathol 159:609–622 Zhang HY, Qo G, Deng ZW, Yao TH, Glaser R (1989). Epstein Barr virus DNA in nasopharyngeal biopsies. Virus Res 12: 53 Zeng Y, Zhong JM, Li LY, Wang PZ, Tang H, Ma YR, Zhu JS, Pan WJ, Liu YX, Wei ZN, et al., (1983). Follow-up studies on Epstein-Barr virus IgA/VCA antibody-positive persons in Zangwu County, China. Intervirology. 20(4):190-194 Zou X, Li J, Lu S, Song X, Wang X, Guo L, Li J, Lin Q, Ye J (1992). Volatile N-nitrosamines in salted fish samples from high and low-risk areas for NPC in China. Chinese Med Sci J 7: 201 | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/35101 | - |
| dc.description.abstract | 為了研究鼻咽癌的腫瘤形成機制 (tumorigenicity)，我們使用互補去氧核糖核酸微矩陣分析 (cDNA microarray analysis) 訊息核糖核苷酸 (mRNA) 在鼻咽癌細胞和正常鼻黏膜上皮細胞之間的表現量。我們找出了一些有差異性表現的基因。SPARC (也稱做骨連接蛋白) 是在這些非常有趣的基因群的其中一個。用及時定量聚合酶連鎖反應 (quantitative real-time RT-PCR) 和西方墨點法分析SPARC的訊息核糖核苷酸及蛋白質在鼻咽癌、肝癌和其他腫瘤細胞株、正常上皮細胞的表現情況，並用外科手術取下的檢體做免疫染色，我們發現SPARC的訊息核糖核苷酸及蛋白質在鼻咽癌和肝癌細胞株及外科手術檢體的腫瘤細胞表現相當的少，但在正常上皮細胞及一些間質細胞有適當的表現。當藉由四環黴素 (Tetracyclin) 去誘導的 (Tet-On) 載體 (pBIG2i) 含有SPARC的互補去氧核糖核酸建構，去感染鼻咽癌和肝癌的細胞而建立之穩定細胞株，去研究SPARC的蛋白質在這些細胞株的功能。可以發現這個基因在體外培養及動物體內實驗都會部分的抑制腫瘤細胞的生長、侵犯和誘導死亡。然而，在帶有SPARC基因表現的免疫不全老鼠中，這個基因只能輕微的抑制腫瘤轉移的活性。SPARC會抑制腫瘤細胞的生長及轉移的調控是藉由提高RECK基因表現，及降低bFGF基因的表現。由此可下個推論，SPARC基因在鼻咽癌和肝癌的腫瘤形成機制中扮演一個類似抑制制癌基因的角色。 | zh_TW |
| dc.description.abstract | To investigate nasopharyngeal carcinoma (NPC) tumorigenicity, we used cDNA microarray analysis of mRNA expression between NPC cell lines and normal nasal mucosa epithelial cells. We have identified some altered expressed genes. In which one of the very interested genes is SPARC (also called osteonectin). By quantitative real-time RT-PCR and Western blot analysis of SPARC mRNA and protein expressions in NPC, HCC and other tumor cell lines, normal epithelial cell types, and immunostaining of surgical specimens, we found that SPARC mRNA and protein expressions are relatively weakly expressed in NPC and HCC cell lines and tumor cells in surgical specimens, but well expressed in normal epithelial cells and some stromal cells. When a tet-on plasmid (pBIG2i) containing SPARC-cDNA was constructed and transfected to the NPC and HCC cells to establish the stable lines, the function of SPARC protein in these lines were investigated. It was found that this gene could partially inhibit tumor cell proliferation, invasion and induce apoptosis in vitro and in vivo. However, in SCID mice bearing SPARC (+) NPC xenograft, tumor metastatic activity was mildly inhibited by this gene. The regulation of suppressive effect of SPARC on tumor cell proliferation and invasion is due to up-regulation of RECK and down-regulation of bFGF gene expression. It is concluded that SPARC gene play a role as an oncosuppressor-like gene in NPC and HCC tumorigenesis. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T06:40:57Z (GMT). No. of bitstreams: 1 ntu-94-R92444006-1.pdf: 4767616 bytes, checksum: 8c33bd54c97e8714b0983463bc4198bf (MD5) Previous issue date: 2005 | en |
| dc.description.tableofcontents | 中文摘要…1
ABSTRACT…2 INTRODUCTION…3 MATERIALS & METHODS…11 RESULTS…17 DISCUSSION…24 FIGURES…30 REFERENCE…51 | |
| dc.language.iso | en | |
| dc.subject | SPARC | zh_TW |
| dc.subject | 鼻咽癌 | zh_TW |
| dc.subject | 肝癌 | zh_TW |
| dc.subject | SPARC | en |
| dc.subject | Nasopharyngeal Carcinoma | en |
| dc.subject | Hepatocellular Carcinoma | en |
| dc.title | SPARC基因表達在鼻咽癌和肝癌中之功能分析 | zh_TW |
| dc.title | Functional Analysis of SPARC Gene Expression in Nasopharyngeal Carcinoma and Hepatocellular Carcinoma | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 93-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.coadvisor | 吳漢忠(Han-Chung Wu) | |
| dc.contributor.oralexamcommittee | 黃昭蓮,施修明,郭明良 | |
| dc.subject.keyword | 鼻咽癌,肝癌,SPARC, | zh_TW |
| dc.subject.keyword | Nasopharyngeal Carcinoma,Hepatocellular Carcinoma,SPARC, | en |
| dc.relation.page | 61 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2005-08-01 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 病理學研究所 | zh_TW |
| 顯示於系所單位： | 病理學科所 | |
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