請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/34673
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 郭彥彬 | |
dc.contributor.author | Wan-hsien Yang | en |
dc.contributor.author | 楊椀纖 | zh_TW |
dc.date.accessioned | 2021-06-13T06:21:48Z | - |
dc.date.available | 2011-10-03 | |
dc.date.copyright | 2011-10-03 | |
dc.date.issued | 2011 | |
dc.date.submitted | 2011-07-25 | |
dc.identifier.citation | Allen, J. T., R. A. Knight, et al. (1999). 'Enhanced insulin-like growth factor binding protein-related protein 2 (Connective tissue growth factor) expression in patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis.' Am J Respir Cell Mol Biol 21(6): 693-700.
Angadi, P. V. and S. S. Rao 'Areca nut in pathogenesis of oral submucous fibrosis: revisited.' Oral Maxillofac Surg. Bae, J. Y., J. S. Choi, et al. (2008). '(-)Epigallocatechin gallate hampers collagen destruction and collagenase activation in ultraviolet-B-irradiated human dermal fibroblasts: involvement of mitogen-activated protein kinase.' Food Chem Toxicol 46(4): 1298-1307. Black, S. A., Jr., A. H. Palamakumbura, et al. (2007). 'Tissue-specific mechanisms for CCN2/CTGF persistence in fibrotic gingiva: interactions between cAMP and MAPK signaling pathways, and prostaglandin E2-EP3 receptor mediated activation of the c-JUN N-terminal kinase.' J Biol Chem 282(21): 15416-15429. Bogatkevich, G. S., A. Ludwicka-Bradley, et al. (2009). 'Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts.' Arthritis Rheum 60(11): 3455-3464. Bogatkevich, G. S., E. Tourkina, et al. (2001). 'Thrombin differentiates normal lung fibroblasts to a myofibroblast phenotype via the proteolytically activated receptor-1 and a protein kinase C-dependent pathway.' J Biol Chem 276(48): 45184-45192. Borle, R. M. and S. R. Borle (1991). 'Management of oral submucous fibrosis: a conservative approach.' J Oral Maxillofac Surg 49(8): 788-791. Bradham, D. M., A. Igarashi, et al. (1991). 'Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10.' J Cell Biol 114(6): 1285-1294. Brigstock, D. R. (1999). 'The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family.' Endocr Rev 20(2): 189-206. Brigstock, D. R., C. L. Steffen, et al. (1997). 'Purification and characterization of novel heparin-binding growth factors in uterine secretory fluids. Identification as heparin-regulated Mr 10,000 forms of connective tissue growth factor.' J Biol Chem 272(32): 20275-20282. Canniff, J. P., J. R. Batchelor, et al. (1985). 'HLA-typing in oral submucous fibrosis.' Tissue Antigens 26(2): 138-142. Carney, D. H., G. J. Herbosa, et al. (1986). 'Double-signal hypothesis for thrombin initiation of cell proliferation.' Semin Thromb Hemost 12(3): 231-240. Chambers, R. C., P. Leoni, et al. (2000). 'Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1.' J Biol Chem 275(45): 35584-35591. Chan, C. P., M. C. Chang, et al. (2008). 'Thrombin activates Ras-CREB/ATF-1 signaling and stimulates c-fos, c-jun, and c-myc expression in human gingival fibroblasts.' J Periodontol 79(7): 1248-1254. Chang, Y. C., K. W. Tai, et al. (1998). 'Cytotoxic and non-genotoxic effects of arecoline on human buccal fibroblasts in vitro.' J Oral Pathol Med 27(2): 68-71. Chang, Y. C., C. H. Tsai, et al. (2002). 'Elevated vimentin expression in buccal mucosal fibroblasts by arecoline in vitro as a possible pathogenesis for oral submucous fibrosis.' Oral Oncol 38(5): 425-430. Chang, Y. C., S. F. Yang, et al. (2002). 'Increased tissue inhibitor of metalloproteinase-1 expression and inhibition of gelatinase A activity in buccal mucosal fibroblasts by arecoline as possible mechanisms for oral submucous fibrosis.' Oral Oncol 38(2): 195-200. Chen, H. M., R. P. Hsieh, et al. (2004). 'HLA typing in Taiwanese patients with oral submucous fibrosis.' J Oral Pathol Med 33(4): 191-199. Chen, N., R. Bezzina, et al. (2009). 'Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet.' Nutr Res 29(11): 784-793. Chiang, C. P., R. P. Hsieh, et al. (2002). 'High incidence of autoantibodies in Taiwanese patients with oral submucous fibrosis.' J Oral Pathol Med 31(7): 402-409. Chiang, C. P., M. J. Lang, et al. (2000). 'Expression of p53 protein in oral submucous fibrosis, oral epithelial hyperkeratosis, and oral epithelial dysplasia.' J Formos Med Assoc 99(3): 229-234. Chiang, C. P., M. J. Lang, et al. (2000). 'Expression of proliferating cell nuclear antigen (PCNA) in oral submucous fibrosis, oral epithelial hyperkeratosis and oral epithelial dysplasia in Taiwan.' Oral Oncol 36(4): 353-359. Cohen, E. E., D. W. Davis, et al. (2009). 'Erlotinib and bevacizumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck: a phase I/II study.' Lancet Oncol 10(3): 247-257. Coughlin, S. R. (2000). 'Thrombin signalling and protease-activated receptors.' Nature 407(6801): 258-264. Cunningham, M. A., E. Rondeau, et al. (2000). 'Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis.' J Exp Med 191(3): 455-462. Dave, B. J., A. H. Trivedi, et al. (1992). 'Role of areca nut consumption in the cause of oral cancers. A cytogenetic assessment.' Cancer 70(5): 1017-1023. Dawes, K. E., A. J. Gray, et al. (1993). 'Thrombin stimulates fibroblast chemotaxis and replication.' Eur J Cell Biol 61(1): 126-130. de Waal, J., A. Olivier, et al. (1997). 'The fibroblast population in oral submucous fibrosis.' J Oral Pathol Med 26(2): 69-74. Deng, X., P. F. Mercer, et al. (2008). 'Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Galphaq and cooperation between ERK1/2 and Rho kinase signaling pathways.' Mol Biol Cell 19(6): 2520-2533. Deng, Y. T., H. M. Chen, et al. (2009). 'Arecoline-stimulated connective tissue growth factor production in human buccal mucosal fibroblasts: Modulation by curcumin.' Oral Oncol 45(9): e99-e105. Devika, P. T. and P. Stanely Mainzen Prince (2009). 'Preventive effect of (-)epigallocatechin gallate on lipids, lipoproteins, and enzymes of lipid metabolism in isoproterenol-induced myocardial infarction in rats.' J Biochem Mol Toxicol 23(6): 387-393. Dooley, A., X. Shi-Wen, et al. 'Modulation of collagen type I, fibronectin and dermal fibroblast function and activity, in systemic sclerosis by the antioxidant epigallocatechin-3-gallate.' Rheumatology (Oxford) 49(11): 2024-2036. Fager, G. (1995). 'Thrombin and proliferation of vascular smooth muscle cells.' Circ Res 77(4): 645-650. Favreau, F., R. Thuillier, et al. 'Anti-thrombin therapy during warm ischemia and cold preservation prevents chronic kidney graft fibrosis in a DCD model.' Am J Transplant 10(1): 30-39. Gao, R., D. K. Ball, et al. (2004). 'Connective tissue growth factor induces c-fos gene activation and cell proliferation through p44/42 MAP kinase in primary rat hepatic stellate cells.' J Hepatol 40(3): 431-438. Gao, R. and D. R. Brigstock (2003). 'Low density lipoprotein receptor-related protein (LRP) is a heparin-dependent adhesion receptor for connective tissue growth factor (CTGF) in rat activated hepatic stellate cells.' Hepatol Res 27(3): 214-220. Gao, R. and D. R. Brigstock (2004). 'Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin alpha(v)beta(3) and heparan sulfate proteoglycan.' J Biol Chem 279(10): 8848-8855. Grotendorst, G. R. and M. R. Duncan (2005). 'Individual domains of connective tissue growth factor regulate fibroblast proliferation and myofibroblast differentiation.' FASEB J 19(7): 729-738. Grotendorst, G. R., H. Okochi, et al. (1996). 'A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene.' Cell Growth Differ 7(4): 469-480. Gupta, D. and S. C. Sharma (1988). 'Oral submucous fibrosis--a new treatment regimen.' J Oral Maxillofac Surg 46(10): 830-833. Hao, J., C. H. Kim, et al. (2007). 'Epigallocatechin-3 gallate prevents cardiac hypertrophy induced by pressure overload in rats.' J Vet Sci 8(2): 121-129. Haque, M. F., M. Harris, et al. (1998). 'Immunolocalization of cytokines and growth factors in oral submucous fibrosis.' Cytokine 10(9): 713-719. Haque, M. F., S. Meghji, et al. (2000). 'Oral submucous fibrosis patients have altered levels of cytokine production.' J Oral Pathol Med 29(3): 123-128. Haque, M. F., S. Meghji, et al. (2001). 'Interferon gamma (IFN-gamma) may reverse oral submucous fibrosis.' J Oral Pathol Med 30(1): 12-21. Harvey, W., A. Scutt, et al. (1986). 'Stimulation of human buccal mucosa fibroblasts in vitro by betel-nut alkaloids.' Arch Oral Biol 31(1): 45-49. Hasegawa, R., T. Chujo, et al. (1995). 'Preventive effects of green tea against liver oxidative DNA damage and hepatotoxicity in rats treated with 2-nitropropane.' Food Chem Toxicol 33(11): 961-970. Hastak, K., N. Lubri, et al. (1997). 'Effect of turmeric oil and turmeric oleoresin on cytogenetic damage in patients suffering from oral submucous fibrosis.' Cancer Lett 116(2): 265-269. Hattori, K., I. Naguro, et al. (2009). 'The roles of ASK family proteins in stress responses and diseases.' Cell Commun Signal 7: 9. Hollenberg, M. D. and S. J. Compton (2002). 'International Union of Pharmacology. XXVIII. Proteinase-activated receptors.' Pharmacol Rev 54(2): 203-217. Howell, D. C., N. R. Goldsack, et al. (2001). 'Direct thrombin inhibition reduces lung collagen, accumulation, and connective tissue growth factor mRNA levels in bleomycin-induced pulmonary fibrosis.' Am J Pathol 159(4): 1383-1395. Igarashi, A., H. Okochi, et al. (1993). 'Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair.' Mol Biol Cell 4(6): 637-645. Ito, Y., J. Aten, et al. (1998). 'Expression of connective tissue growth factor in human renal fibrosis.' Kidney Int 53(4): 853-861. Jacob, B. J., K. Straif, et al. (2004). 'Betel quid without tobacco as a risk factor for oral precancers.' Oral Oncol 40(7): 697-704. Jeng, J. H., M. C. Chang, et al. (2001). 'Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives.' Oral Oncol 37(6): 477-492. Jeng, J. H., C. L. Tsai, et al. (1999). 'Arecoline cytotoxicity on human oral mucosal fibroblasts related to cellular thiol and esterase activities.' Food Chem Toxicol 37(7): 751-756. Kakar, P. K., R. K. Puri, et al. (1985). 'Oral submucous fibrosis--treatment with hyalase.' J Laryngol Otol 99(1): 57-59. Kantarci, A., S. A. Black, et al. (2006). 'Epithelial and connective tissue cell CTGF/CCN2 expression in gingival fibrosis.' J Pathol 210(1): 59-66. Kawai, K., N. H. Tsuno, et al. (2003). 'Epigallocatechin gallate, the main component of tea polyphenol, binds to CD4 and interferes with gp120 binding.' J Allergy Clin Immunol 112(5): 951-957. Khan, S. G., S. K. Katiyar, et al. (1992). 'Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: possible role in cancer chemoprevention.' Cancer Res 52(14): 4050-4052. Ko, Y. C., T. A. Chiang, et al. (1992). 'Prevalence of betel quid chewing habit in Taiwan and related sociodemographic factors.' J Oral Pathol Med 21(6): 261-264. Ko, Y. C., Y. L. Huang, et al. (1995). 'Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan.' J Oral Pathol Med 24(10): 450-453. Kumar, A., A. Bagewadi, et al. (2007). 'Efficacy of lycopene in the management of oral submucous fibrosis.' Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103(2): 207-213. Kuo, M. Y., H. M. Chen, et al. (1995). 'Collagen biosynthesis in human oral submucous fibrosis fibroblast cultures.' J Dent Res 74(11): 1783-1788. Kwan, H. W. (1976). 'A statistical study on oral carcinomas in Taiwan with emphasis on the relationship with betel nut chewing: a preliminary report.' Taiwan Yi Xue Hui Za Zhi 75(9): 497-505. Landis-Piwowar, K. R., V. Milacic, et al. (2008). 'Relationship between the methylation status of dietary flavonoids and their growth-inhibitory and apoptosis-inducing activities in human cancer cells.' J Cell Biochem 105(2): 514-523. Lau, L. F. and S. C. Lam (1999). 'The CCN family of angiogenic regulators: the integrin connection.' Exp Cell Res 248(1): 44-57. Leask, A. 'Thrombin-induced CCN2 expression as a target for anti-fibrotic therapy in scleroderma.' J Cell Commun Signal 4(2): 111-112. Leask, A. and D. J. Abraham (2003). 'The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology.' Biochem Cell Biol 81(6): 355-363. Leask, A., S. Sa, et al. (2001). 'The control of ccn2 (ctgf) gene expression in normal and scleroderma fibroblasts.' Mol Pathol 54(3): 180-183. Li, R., Y. G. Huang, et al. (2004). '(-)-Epigallocatechin gallate inhibits lipopolysaccharide-induced microglial activation and protects against inflammation-mediated dopaminergic neuronal injury.' J Neurosci Res 78(5): 723-731. Licari, L. G. and J. P. Kovacic (2009). 'Thrombin physiology and pathophysiology.' J Vet Emerg Crit Care (San Antonio) 19(1): 11-22. Ma, R. H., C. C. Tsai, et al. (1995). 'Increased lysyl oxidase activity in fibroblasts cultured from oral submucous fibrosis associated with betel nut chewing in Taiwan.' J Oral Pathol Med 24(9): 407-412. Macfarlane, S. R., M. J. Seatter, et al. (2001). 'Proteinase-activated receptors.' Pharmacol Rev 53(2): 245-282. Maher, R., P. Aga, et al. (1997). 'Evaluation of multiple micronutrient supplementation in the management of oral submucous fibrosis in Karachi, Pakistan.' Nutr Cancer 27(1): 41-47. Maher, R., A. J. Lee, et al. (1994). 'Role of areca nut in the causation of oral submucous fibrosis: a case-control study in Pakistan.' J Oral Pathol Med 23(2): 65-69. Mauviel, A. (1993). 'Cytokine regulation of metalloproteinase gene expression.' J Cell Biochem 53(4): 288-295. Meghji, S., A. Scutt, et al. (1987). 'An in-vitro comparison of human fibroblasts from normal and oral submucous fibrosis tissue.' Arch Oral Biol 32(3): 213-215. Mitroulis, I., K. Kambas, et al. 'The multivalent activity of the tissue factor-thrombin pathway in thrombotic and non-thrombotic disorders as a target for therapeutic intervention.' Expert Opin Ther Targets 15(1): 75-89. Moutasim, K. A., V. Jenei, et al. 'Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis.' J Pathol. Murti, P. R., R. B. Bhonsle, et al. (1995). 'Etiology of oral submucous fibrosis with special reference to the role of areca nut chewing.' J Oral Pathol Med 24(4): 145-152. Nelken, N. A., S. J. Soifer, et al. (1992). 'Thrombin receptor expression in normal and atherosclerotic human arteries.' J Clin Invest 90(4): 1614-1621. Ni, W. F., C. H. Tsai, et al. (2007). 'Elevated expression of NF-kappaB in oral submucous fibrosis--evidence for NF-kappaB induction by safrole in human buccal mucosal fibroblasts.' Oral Oncol 43(6): 557-562. Paradis, V., D. Dargere, et al. (1999). 'Expression of connective tissue growth factor in experimental rat and human liver fibrosis.' Hepatology 30(4): 968-976. Phatak, A. G. (1995). 'Oral submucous fibrosis.' BMJ 310(6983): 871. Pillai, R., P. Balaram, et al. (1992). 'Pathogenesis of oral submucous fibrosis. Relationship to risk factors associated with oral cancer.' Cancer 69(8): 2011-2020. Pindborg, J. J., P. R. Murti, et al. (1984). 'Oral submucous fibrosis as a precancerous condition.' Scand J Dent Res 92(3): 224-229. Pindborg, J. J. and S. M. Sirsat (1966). 'Oral submucous fibrosis.' Oral Surg Oral Med Oral Pathol 22(6): 764-779. Qin, S., J. F. Alcorn, et al. (2011). 'Epigallocatechin-3-Gallate Reduces Airway Inflammation in Mice through Binding to Proinflammatory Chemokines and Inhibiting Inflammatory Cell Recruitment.' J Immunol 186(6): 3693-3700. Rade, J. J., A. H. Schulick, et al. (1996). 'Local adenoviral-mediated expression of recombinant hirudin reduces neointima formation after arterial injury.' Nat Med 2(3): 293-298. Ragosta, M., W. L. Barry, et al. (1996). 'Effect of thrombin inhibition with desulfatohirudin on early kinetics of cellular proliferation after balloon angioplasty in atherosclerotic rabbits.' Circulation 93(6): 1194-1200. Rai, B., J. Kaur, et al. 'Possible action mechanism for curcumin in pre-cancerous lesions based on serum and salivary markers of oxidative stress.' J Oral Sci 52(2): 251-256. Rajalalitha, P. and S. Vali (2005). 'Molecular pathogenesis of oral submucous fibrosis--a collagen metabolic disorder.' J Oral Pathol Med 34(6): 321-328. Rajendran, R. (1994). 'Oral submucous fibrosis: etiology, pathogenesis, and future research.' Bull World Health Organ 72(6): 985-996. Rajendran, R., V. Rani, et al. (2006). 'Pentoxifylline therapy: a new adjunct in the treatment of oral submucous fibrosis.' Indian J Dent Res 17(4): 190-198. Rajendran, R. and Vidyarani (2004). 'Familial occurrence of oral submucous fibrosis: report of eight families from northern Kerala, south India.' Indian J Dent Res 15(4): 139-144. Reichart, P. A. and H. P. Phillipsen (1998). 'Betel chewer's mucosa--a review.' J Oral Pathol Med 27(6): 239-242. Ricupero, D. A., D. C. Rishikof, et al. (1999). 'Regulation of connective tissue growth factor expression by prostaglandin E(2).' Am J Physiol 277(6 Pt 1): L1165-1171. Rocha, S., R. Generalov, et al. (2011). 'Epigallocatechin gallate-loaded polysaccharide nanoparticles for prostate cancer chemoprevention.' Nanomedicine (Lond) 6(1): 79-87. Rullier, A., J. Gillibert-Duplantier, et al. (2008). 'Protease-activated receptor 1 knockout reduces experimentally induced liver fibrosis.' Am J Physiol Gastrointest Liver Physiol 294(1): G226-235. Scutt, A., S. Meghji, et al. (1987). 'Stabilisation of collagen by betel nut polyphenols as a mechanism in oral submucous fibrosis.' Experientia 43(4): 391-393. Segarini, P. R., J. E. Nesbitt, et al. (2001). 'The low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor is a receptor for connective tissue growth factor.' J Biol Chem 276(44): 40659-40667. Sen, S., G. Talukder, et al. (1989). 'Betel cytotoxicity.' J Ethnopharmacol 26(3): 217-247. Shah, N. and P. P. Sharma (1998). 'Role of chewing and smoking habits in the etiology of oral submucous fibrosis (OSF): a case-control study.' J Oral Pathol Med 27(10): 475-479. Sheng, R., Z. L. Gu, et al. (2009). 'EGCG inhibits proliferation of cardiac fibroblasts in rats with cardiac hypertrophy.' Planta Med 75(2): 113-120. Shieh, D. H., L. C. Chiang, et al. (2004). 'Effects of arecoline, safrole, and nicotine on collagen phagocytosis by human buccal mucosal fibroblasts as a possible mechanism for oral submucous fibrosis in Taiwan.' J Oral Pathol Med 33(9): 581-587. Shieh, T. Y. and J. F. Yang (1992). 'Collagenase activity in oral submucous fibrosis.' Proc Natl Sci Counc Repub China B 16(2): 106-110. Sinor, P. N., P. C. Gupta, et al. (1990). 'A case-control study of oral submucous fibrosis with special reference to the etiologic role of areca nut.' J Oral Pathol Med 19(2): 94-98. Sirsat, S. M. and J. J. Pindborg (1967). 'Subepithelial changes in oral submucous fibrosis.' Acta Pathol Microbiol Scand 70(2): 161-173. Smith, A., B. Giunta, et al. (2010). 'Nanolipidic particles improve the bioavailability and alpha-secretase inducing ability of epigallocatechin-3-gallate (EGCG) for the treatment of Alzheimer's disease.' Int J Pharm 389(1-2): 207-212. Squier, C. A. and N. W. Johnson (1975). 'Permeability of oral mucosa.' Br Med Bull 31(2): 169-175. Sundqvist, K., Y. Liu, et al. (1989). 'Cytotoxic and genotoxic effects of areca nut-related compounds in cultured human buccal epithelial cells.' Cancer Res 49(19): 5294-5298. Surh, Y. J., J. K. Kundu, et al. (2005). 'Redox-sensitive transcription factors as prime targets for chemoprevention with anti-inflammatory and antioxidative phytochemicals.' J Nutr 135(12 Suppl): 2993S-3001S. Tai, Y. S., B. Y. Liu, et al. (2001). 'Oral administration of milk from cows immunized with human intestinal bacteria leads to significant improvements of symptoms and signs in patients with oral submucous fibrosis.' J Oral Pathol Med 30(10): 618-625. Tang, X. D., X. Zhou, et al. (2008). '[Effects of green tea extract on expression of human papillomavirus type 16 oncoproteins-induced hypoxia-inducible factor-1alpha and vascular endothelial growth factor in human cervical carcinoma cells].' Zhonghua Yi Xue Za Zhi 88(40): 2872-2877. Tedeschi, E., H. Suzuki, et al. (2002). 'Antiinflammatory action of EGCG, the main component of green tea, through STAT-1 inhibition.' Ann N Y Acad Sci 973: 435-437. Thangjam, G. S., P. Agarwal, et al. (2009). 'Transglutaminase-2 regulation by arecoline in gingival fibroblasts.' J Dent Res 88(2): 170-175. Thangjam, G. S. and P. Kondaiah (2009). 'Regulation of oxidative-stress responsive genes by arecoline in human keratinocytes.' J Periodontal Res 44(5): 673-682. Thomas, S. J. and R. MacLennan (1992). 'Slaked lime and betel nut cancer in Papua New Guinea.' Lancet 340(8819): 577-578. Tilakaratne, W. M., M. F. Klinikowski, et al. (2006). 'Oral submucous fibrosis: review on aetiology and pathogenesis.' Oral Oncol 42(6): 561-568. Tipoe, G. L., T. M. Leung, et al. 'Epigallocatechin-3-gallate (EGCG) reduces liver inflammation, oxidative stress and fibrosis in carbon tetrachloride (CCl4)-induced liver injury in mice.' Toxicology 273(1-3): 45-52. Trivedy, C., D. Baldwin, et al. (1997). 'Copper content in Areca catechu (betel nut) products and oral submucous fibrosis.' Lancet 349(9063): 1447. Trivedy, C., S. Meghji, et al. (2001). 'Copper stimulates human oral fibroblasts in vitro: a role in the pathogenesis of oral submucous fibrosis.' J Oral Pathol Med 30(8): 465-470. Trivedy, C., K. A. Warnakulasuriya, et al. (1999). 'The upregulation of lysyl oxidase in oral submucous fibrosis and squamous cell carcinoma.' J Oral Pathol Med 28(6): 246-251. Tsai, C. C., R. H. Ma, et al. (1999). 'Deficiency in collagen and fibronectin phagocytosis by human buccal mucosa fibroblasts in vitro as a possible mechanism for oral submucous fibrosis.' J Oral Pathol Med 28(2): 59-63. Tsai, C. H., M. Y. Chou, et al. (2003). 'The up-regulation of cyclooxygenase-2 expression in human buccal mucosal fibroblasts by arecoline: a possible role in the pathogenesis of oral submucous fibrosis.' J Oral Pathol Med 32(3): 146-153. Tsai, C. H., S. F. Yang, et al. (2007). 'The upregulation of cystatin C in oral submucous fibrosis.' Oral Oncol 43(7): 680-685. Tsai, C. H., S. F. Yang, et al. (2005). 'Raised keratinocyte growth factor-1 expression in oral submucous fibrosis in vivo and upregulated by arecoline in human buccal mucosal fibroblasts in vitro.' J Oral Pathol Med 34(2): 100-105. Tsai, C. H., S. F. Yang, et al. (2005). 'The upregulation of insulin-like growth factor-1 in oral submucous fibrosis.' Oral Oncol 41(9): 940-946. Tsai, C. H., S. F. Yang, et al. (2004). 'Regulation of interleukin-6 expression by arecoline in human buccal mucosal fibroblasts is related to intracellular glutathione levels.' Oral Dis 10(6): 360-364. Tsai, C. H., S. F. Yang, et al. (2009). 'Augmented heme oxygenase-1 expression in areca quid chewing-associated oral submucous fibrosis.' Oral Dis 15(4): 281-286. Wynn, T. A. (2007). 'Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases.' J Clin Invest 117(3): 524-529. Yang, S. F., Y. S. Hsieh, et al. (2007). 'Increased plasminogen activator inhibitor-1/tissue type plasminogen activator ratio in oral submucous fibrosis.' Oral Dis 13(2): 234-238. Yang, S. F., Y. S. Hsieh, et al. (2003). 'The upregulation of type I plasminogen activator inhibitor in oral submucous fibrosis.' Oral Oncol 39(4): 367-372. Yang, S. F., C. H. Tsai, et al. (2008). 'The upregulation of heat shock protein 47 expression in human buccal fibroblasts stimulated with arecoline.' J Oral Pathol Med 37(4): 206-210. Yang, Y. H., C. H. Chen, et al. (2005). 'Incidence rates of oral cancer and oral pre-cancerous lesions in a 6-year follow-up study of a Taiwanese aboriginal community.' J Oral Pathol Med 34(10): 596-601. Yang, Y. H., H. Y. Lee, et al. (2001). 'Epidemiological survey of oral submucous fibrosis and leukoplakia in aborigines of Taiwan.' J Oral Pathol Med 30(4): 213-219. Yanjia, H. and J. Xinchun (2007). 'The role of epithelial-mesenchymal transition in oral squamous cell carcinoma and oral submucous fibrosis.' Clin Chim Acta 383(1-2): 51-56. Yasuda, Y., M. Shimizu, et al. (2009). '(-)-Epigallocatechin gallate prevents carbon tetrachloride-induced rat hepatic fibrosis by inhibiting the expression of the PDGFRbeta and IGF-1R.' Chem Biol Interact 182(2-3): 159-164. Yu, C. C., M. J. Hsu, et al. (2009). 'Thrombin-induced connective tissue growth factor expression in human lung fibroblasts requires the ASK1/JNK/AP-1 pathway.' J Immunol 182(12): 7916-7927. Yumei, F., Y. Zhou, et al. (2006). 'The antifibrogenic effect of (-)-epigallocatechin gallate results from the induction of de novo synthesis of glutathione in passaged rat hepatic stellate cells.' Lab Invest 86(7): 697-709. Yusuf, H. and S. L. Yong (2002). 'Oral submucous fibrosis in a 12-year-old Bangladeshi boy: a case report and review of literature.' Int J Paediatr Dent 12(4): 271-276. Zhen, M. C., Q. Wang, et al. (2007). 'Green tea polyphenol epigallocatechin-3-gallate inhibits oxidative damage and preventive effects on carbon tetrachloride-induced hepatic fibrosis.' J Nutr Biochem 18(12): 795-805. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/34673 | - |
dc.description.abstract | 許多研究指出凝血酶 (thrombin) 和纖維化疾病有關。 先前研究指出結締組織生長因子 (CTGF) 也在許多纖維化疾病中扮演了重要角色。 Thrombin 可以誘導肺纖維母細胞表現CTGF。 我們先前研究發現口腔黏膜下纖維化症 (Oral submucous fibrosis,OSF) 組織中CTGF 表現量有明顯增加。檳榔鹼 arecoline 可以誘導正常人類頰黏膜纖維母細胞 (human buccal mucosal fibroblasts,BMFs)表現CTGF。 Arecoline 刺激CTGF過度表現可能是嚼食檳榔誘導OSF發生的機轉之一。 雖然OSF的致病機轉尚未完全清楚,目前認為檳榔嚼塊長期持續摩擦口腔黏膜產生微創傷合併檳榔成份引起化學刺激所導致的反應,為OSF的主要成因。 過去研究主要著重於檳榔成份引起化學刺激的反應, 雖然早期研究發現OSF病患唾液中有thrombin-like物質,微創傷引發thrombin釋出扮演的角色則未有研究。本研究發現thrombin 能以濃度與時間相關性來刺激BMFs 的CTGF表現。 Thrombin受器 (protease-activated receptors,PARs ) N端合成胜肽SFLLRN (PAR1 作用劑) 也可刺激BMFs 的CTGF表現,但PAR3, PAR4 作用劑卻無法刺激BMFs 的CTGF表現。 前處理抗氧化劑NAC、ASK-1抑制劑thioredoxin以及JNK抑制劑SP600125可以抑制Thrombin誘導的CTGF表現所抑制。 而PI3K抑制劑LY294002、 ERK抑制劑PD98059以及p38 MAPK抑制劑SB203580則不影響CTGF表現量。 BMF中thrombin透過 PAR1/ ROS/ ASK/ JNK 路徑誘導CTGF表現,可能是嚼檳榔產生微創傷誘導OSF發生的機轉之一。 另外我們亦發現綠茶酚EGCG可抑制BMF中thrombin誘導CTGF的表現。 冀望未來可以藉由抑制CTGF來達到抑制或治療口腔黏膜下纖維化症。 | zh_TW |
dc.description.abstract | Thrombin has been implicated in fibrotic disorders of several organs such as kidney, liver, and lung. Connective tissue growth factor (CTGF) is associated with the onset and progression of fibrosis in many human tissues and was found to overexpress in oral submucous fibrosis (OSF). OSF is the result of persistent chemical irritation from areca nut (AN) constituents and the mechanical trauma to the oral mucosa from the coarse fibers of AN. Mechanical trauma could lead to activation of the coagulation cascade. In this study, we showed that thrombin stimulated CTGF synthesis in human buccal mucosal fibroblasts (BMFs). The effect of thrombin could be mimicked with a selective proteinase activated receptors 1 (PAR1)-activating peptide and was completely abolished with the specific thrombin serine protease inhibitor PPACK, indicating that thrombin mediated this effect via the proteolytic activation of PAR1. These results suggested that thrombin produced by microtrauma during AN chewing may contribute to the pathogenesis of OSF by up-regulating CTGF expression in BMFs. Pretreatment with antioxidant N-acetyl-L-cysteine, ASK1 inhibitor thioredoxin, JNK inhibitor SP600125, but not PI3K inhibitor LY294002, ERK inhibitor PD98059, p38 MAPK inhibitor SB203580, significantly reduced thrombin induced CTGF synthesis. Furthermore, epigallocatechin-3-gallate completely inhibited thrombin-induced CTGF synthesis. These results suggested that thrombin-induced CTGF synthesis could be mediated by reactive oxygen species, ASK1 and JNK pathways in BMFs and EGCG may serve as a useful agent in controlling OSF. | en |
dc.description.provenance | Made available in DSpace on 2021-06-13T06:21:48Z (GMT). No. of bitstreams: 1 ntu-100-R98450018-1.pdf: 1849078 bytes, checksum: 9cea18a965bb9c3a33635b051bff7739 (MD5) Previous issue date: 2011 | en |
dc.description.tableofcontents | 口試委員審定書 Ⅰ
致謝 Ⅱ 中文摘要 Ⅲ Abstract Ⅳ 導論 1 第一節 口腔黏膜下纖維化 1 1-1 口腔黏膜下纖維化 1 1-2 口腔黏膜下纖維化的流行病學 1 1-3 口腔黏膜下纖維化的致病機制 2 1-4 口腔黏膜下纖維化的治療 4 第二節 凝血酶 ( Thrombin ) 5 2-1 Thrombin的簡介 5 2-2 Thrombin的訊息傳遞路徑 5 2-3 Thrombin與纖維化 6 第三節 結締組織生長因子 ( Connective tissue growth factor ) 8 3-1 CTGF的介紹 8 3-2 CTGF的訊息傳遞路徑 9 3-3 CTGF與纖維化 10 第四節 茶多酚 ( EGCG ) 11 實驗目的 12 材料與方法 13 第一節 細胞株與細胞培養 13 第二節 藥物處理 13 第三節 西方墨點法 14 結果 17 凝血酶Thrombin可以誘導口腔頰黏膜細胞中CTGF的表現 17 凝血酶Thrombin可經由PAR1誘導CTGF表現 17 ROS抑制劑、JNK抑制劑、ASK-1抑制劑會抑制Thrombin對於CTGF的誘導 17 茶多酚EGCG可以降低正常口腔頰黏膜細胞內由Thrombin誘導的CTGF表現量 18 討論 19 結論 23 圖與表 23 References 30 附錄1 41 | |
dc.language.iso | zh-TW | |
dc.title | Thrombin 誘導頰黏膜纖維母細胞 CTGF 表現機轉及以EGCG 治療口腔黏膜下纖維化症潛力之研究 | zh_TW |
dc.title | Thrombin-stimulated connective tissue growth factor (CTGF/CCN2) production in human buccal mucosal fibroblast: inhibition by epigallocatechin-3-gallate | en |
dc.type | Thesis | |
dc.date.schoolyear | 99-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 蕭宏昇,張正琪 | |
dc.subject.keyword | 口腔黏膜下纖維化症,Thrombin,CTGF,EGCG, | zh_TW |
dc.subject.keyword | OSF,Thrombin,CTGF,EGCG, | en |
dc.relation.page | 46 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2011-07-26 | |
dc.contributor.author-college | 牙醫專業學院 | zh_TW |
dc.contributor.author-dept | 口腔生物科學研究所 | zh_TW |
顯示於系所單位: | 口腔生物科學研究所 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-100-1.pdf 目前未授權公開取用 | 1.81 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。