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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.advisor | 鍾孝文(Hsiao-Wen Chung) | |
dc.contributor.author | Ming-Long Wu | en |
dc.contributor.author | 吳明龍 | zh_TW |
dc.date.accessioned | 2021-06-13T06:05:31Z | - |
dc.date.available | 2007-07-31 | |
dc.date.copyright | 2006-07-31 | |
dc.date.issued | 2006 | |
dc.date.submitted | 2006-06-15 | |
dc.identifier.citation | Ardekani, S. and U. Sinha (2005). 'Geometric distortion correction of high-resolution 3 T diffusion tensor brain images.' Magn Reson Med 54(5): 1163-71.
Bangerter, N. K., B. A. Hargreaves, et al. (2004). 'Analysis of multiple-acquisition SSFP.' Magn Reson Med 51(5): 1038-47. Chen, N. K. and A. M. Wyrwicz (2001). 'Optimized distortion correction technique for echo planar imaging.' Magn Reson Med 45(3): 525-8. Cheng, K., R. A. Waggoner, et al. (2001). 'Human ocular dominance columns as revealed by high-field functional magnetic resonance imaging.' Neuron 32(2): 359-74. Duerk, J. L., J. S. Lewin, et al. (1998). 'Remember true FISP? A high SNR, near 1-second imaging method for T2-like contrast in interventional MRI at.2 T.' J Magn Reson Imaging 8(1): 203-8. Durand, E., P. F. van de Moortele, et al. (2001). 'Artifact due to B(0) fluctuations in fMRI: correction using the k-space central line.' Magn Reson Med 46(1): 198-201. Ebel, A. and A. A. Maudsley (2005). 'Detection and correction of frequency instabilities for volumetric 1H echo-planar spectroscopic imaging.' Magn Reson Med 53(2): 465-9. Foerster, B. U., D. Tomasi, et al. (2005). 'Magnetic field shift due to mechanical vibration in functional magnetic resonance imaging.' Magn Reson Med 54(5): 1261-7. Frahm, J., K. D. Merboldt, et al. (1993). 'Functional MRI of human brain activation at high spatial resolution.' Magn Reson Med 29(1): 139-44. Friston, K. J. (1995). 'Commentary and opinion: II. Statistical parametric mapping: ontology and current issues.' J Cereb Blood Flow Metab 15(3): 361-70. Friston, K. J., A. W. Toga, et al. (1996). Brain Mapping: The Methods. San Diego, USA, Academic Press. Goodyear, B. G. and R. S. Menon (2001). 'Brief visual stimulation allows mapping of ocular dominance in visual cortex using fMRI.' Hum Brain Mapp 14(4): 210-7. Goodyear, B. G., D. A. Nicolle, et al. (2002). 'High resolution fMRI of ocular dominance columns within the visual cortex of human amblyopes.' Strabismus 10(2): 129-36. Haacke, E. M., P. A. Wielopolski, et al. (1990). 'Steady-state free precession imaging in the presence of motion: application for improved visualization of the cerebrospinal fluid.' Radiology 175(2): 545-52. Hanicke, W. and H. U. Vogel (2003). 'An analytical solution for the SSFP signal in MRI.' Magn Reson Med 49(4): 771-5. Haykin, S. S. (2002). Adaptive filter theory, Prentice Hall. Hennig, J., O. Speck, et al. (2003). 'Functional magnetic resonance imaging: a review of methodological aspects and clinical applications.' J Magn Reson Imaging 18(1): 1-15. Henry, P. G., P. F. van de Moortele, et al. (1999). 'Field-frequency locked in vivo proton MRS on a whole-body spectrometer.' Magn Reson Med 42(4): 636-42. Hoogenraad, F. G., M. B. Hofman, et al. (1999). 'Sub-millimeter fMRI at 1.5 Tesla: correlation of high resolution with low resolution measurements.' J Magn Reson Imaging 9(3): 475-82. Hoogenraad, F. G., P. J. Pouwels, et al. (2000). 'High-resolution segmented EPI in a motor task fMRI study.' Magn Reson Imaging 18(4): 405-9. Hoogenraad, F. G., J. R. Reichenbach, et al. (1998). 'In vivo measurement of changes in venous blood-oxygenation with high resolution functional MRI at 0.95 tesla by measuring changes in susceptibility and velocity.' Magn Reson Med 39(1): 97-107. Huang, T. Y., I. J. Huang, et al. (2002). 'Are TrueFISP images T2/T1-weighted?' Magn Reson Med 48(4): 684-8. Jesmanowicz, A., P. A. Bandettini, et al. (1998). 'Single-shot half k-space high-resolution gradient-recalled EPI for fMRI at 3 Tesla.' Magn Reson Med 40(5): 754-62. Jezzard, P. and S. Clare (1999). 'Sources of distortion in functional MRI data.' Hum Brain Mapp 8(2-3): 80-5. Kalatsky, V. A., D. B. Polley, et al. (2005). 'Fine functional organization of auditory cortex revealed by Fourier optical imaging.' Proc Natl Acad Sci U S A 102(37): 13325-30. Kwong, K. K., J. W. Belliveau, et al. (1992). 'Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation.' Proc Natl Acad Sci U S A 89(12): 5675-9. Lee, J., B. A. Hargreaves, et al. (2005). High resolutin 3D spiral trajectory BOSS fMRI. Proc Intl Soc Magn Reson Med, Miami, USA. Li, Z., G. Wu, et al. (2002). 'Multiecho segmented EPI with z-shimmed background gradient compensation (MESBAC) pulse sequence for fMRI.' Magn Reson Med 48(2): 312-21. Mansfield, P. (1977). 'Multi-planar image formation using NMR spin echoes.' J Physics C Solid State Phys 10: L55-L58. McKeown, M. J., S. Makeig, et al. (1998). 'Analysis of fMRI data by blind separation into independent spatial components.' Hum Brain Mapp 6(3): 160-88. Menon, R. S. and B. G. Goodyear (1999). 'Submillimeter functional localization in human striate cortex using BOLD contrast at 4 Tesla: implications for the vascular point-spread function.' Magn Reson Med 41(2): 230-5. Menon, R. S., S. Ogawa, et al. (1997). 'Ocular dominance in human V1 demonstrated by functional magnetic resonance imaging.' J Neurophysiol 77(5): 2780-7. Miller, K. L., R. C. DeCharms, et al. (2004). High resolution BOSS fMRI at 1.5T. Proc Intl Soc Magn Reson Med, Kyoto, Japan. Miller, K. L., B. A. Hargreaves, et al. (2003). 'Functional brain imaging using a blood oxygenation sensitive steady state.' Magn Reson Med 50(4): 675-83. Miller, K. L., S. M. Smith, et al. (2005). High-resolution FMRI at 1.5T Using 3D BOSS. Proc Intl Soc Magn Reson Med, Miami, USA. Miller, K. L., S. M. Smith, et al. (2006). 'High-resolution FMRI at 1.5T using balanced SSFP.' Magn Reson Med 55(1): 161-70. Nolte, J. (2002). The Human Brain: An Introduction to Its Functional Anatomy, C.V. Mosby. Ogawa, S., D. W. Tank, et al. (1992). 'Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging.' Proc Natl Acad Sci U S A 89(13): 5951-5. Pfeuffer, J., P. F. Van de Moortele, et al. (2002). 'Correction of physiologically induced global off-resonance effects in dynamic echo-planar and spiral functional imaging.' Magn Reson Med 47(2): 344-53. Pruessmann, K. P., M. Weiger, et al. (1999). 'SENSE: sensitivity encoding for fast MRI.' Magn Reson Med 42(5): 952-62. Scheffler, K. and S. Lehnhardt (2003). 'Principles and applications of balanced SSFP techniques.' Eur Radiol 13(11): 2409-18. Scheffler, K., E. Seifritz, et al. (2001). 'Detection of BOLD changes by means of a frequency-sensitive trueFISP technique: preliminary results.' NMR Biomed 14(7-8): 490-6. Scheffler, K., E. Seifritz, et al. (1999). 'Titration of the BOLD effect: separation and quantitation of blood volume and oxygenation changes in the human cerebral cortex during neuronal activation and ferumoxide infusion.' Magn Reson Med 42(5): 829-36. Schmidt, O., S. Widmaier, et al. (2000). 'Artifacts in CSI-measurements caused by the drift of the static magnetic field.' Magma 10(3): 167-70. Schmitt, P., M. A. Griswold, et al. (2006). 'A simple geometrical description of the TrueFISP ideal transient and steady-state signal.' Magn Reson Med 55(1): 177-86. Scott, A. H., W. S. Allen, et al. (2004). Functional Magnetic Resonance Imaging, Sinauer Associates. Slotnick, S. D. and S. Yantis (2003). 'Efficient acquisition of human retinotopic maps.' Hum Brain Mapp 18(1): 22-9. Springer, C. S. and Y. Xu (1991). Aspects of bulk magnetic susceptibility in in-vivo MRI and MRS. European Magnetic Resonance Forum, Bolnay, Switzerland. Thulborn, K. R., S. Y. Chang, et al. (1997). 'High-resolution echo-planar fMRI of human visual cortex at 3.0 tesla.' NMR Biomed 10(4-5): 183-90. Ward, H. A., S. J. Riederer, et al. (2002). 'Real-time autoshimming for echo planar timecourse imaging.' Magn Reson Med 48(5): 771-80. Warnking, J., M. Dojat, et al. (2002). 'fMRI retinotopic mapping--step by step.' Neuroimage 17(4): 1665-83. Weisskoff, R. M. and S. Kiihne (1992). 'MRI susceptometry: image-based measurement of absolute susceptibility of MR contrast agents and human blood.' Magn Reson Med 24(2): 375-83. Wu, P. H., M. L. Wu, et al. (2006). Transient state BOSS fMRI for a further increase in sensitivity. Proc Intl Soc Magn Reson Med, Seattle, USA. Yang, Q. X., J. Wang, et al. (2004). 'Reduction of magnetic field inhomogeneity artifacts in echo planar imaging with SENSE and GESEPI at high field.' Magn Reson Med 52(6): 1418-23. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/34376 | - |
dc.description.abstract | 利用穩定態脈衝程序來達成功能性磁振造影是近年來發展出的一項新技術。本文主要的目的是探討穩定態功能性磁振造影技術的原理,以及在高場磁振造影系統上的應用。相較於已被廣泛使用的面回訊功能性磁振造影,穩定態功能性磁振造影具有較少的假影,更高的功能性靈敏度,以及達成高解析度功能性磁振造影的潛力。然而,由於穩定態功能性磁振造影的敏感區集中於極窄的頻帶,進行功能性磁振造影實驗過程中,若系統頻率偏移,將會失去功能性對比,而無法偵測到血氧濃度因腦部活動的改變。在本文當中我們提出一個改善頻率穩定度的方法,增進此技術在高磁場 3 Tesla系統上的可行性。在擷取每張影像之前,利用一個小角度射頻波得到頻率隨時間偏移的資訊,並即時更新系統頻率。我們更進一部採用無限脈衝響應濾波 (IIR filtering) 的方式,對小角度射頻波方法估計的頻率偏移做低通濾波,以減少更新頻率之震盪,增進信號之穩定度。實驗結果顯示利用 IIR filtering 的方式更新頻率,頻率震盪維持在 0.5 赫茲以內;在穩定態功能性磁振造影實驗過程當中,信號變異維持在 5% 以下。我們並進行高解析度功能性磁振造影實驗(單位像素長寬在一釐米以下),在給予視覺刺激的實驗當中,因血氧濃度改變產生之信號變化達到 10-17%,偵測到的活化區域和視覺區灰質有良好的對應。因此,穩定態功能性磁振造影具有低假影及高解析力的特性;採用適當的穩定頻率的方法,則使得此一新技術,更適於高磁場磁振系統,達到更高的靈敏度。 | zh_TW |
dc.description.abstract | One major challenge of Blood Oxygenation Sensitive Steady-state (BOSS) fMRI is that the frequency band corresponding to highest functional sensitivity is extremely narrow, leading to substantial loss of functional contrast in the presence of magnetic field drifts. In this thesis, a frequency stabilization scheme was proposed for BOSS fMRI at 3T, where an radio-frequency (RF) pulse with very small flip angle was applied before each image scan, with the initial phase of the excited free induction decay signals extracted to reflect the temporal field drifts. A simple infinite impulse response (IIR) filter was further employed to obtain a low-pass filtered estimate of the central reference frequency for the upcoming scan. Experimental results suggest that the proposed scheme was able to stabilize the central reference frequency settings in accordance with the magnetic drifts, with oscillation amplitudes less than 0.5Hz. Phantom studies show that both the slow drifts and the fast fluctuations were prominently reduced for the dynamic BOSS scans, resulting in less than 5% signal variations. Visual fMRI at sub-millimeter in-plane resolution further demonstrated 10-17% activation signals nicely registered in the microvessels within the sulci. It is concluded that the IIR-filtered frequency stabilization is effective for reliable BOSS fMRI at high fields. | en |
dc.description.provenance | Made available in DSpace on 2021-06-13T06:05:31Z (GMT). No. of bitstreams: 1 ntu-95-D90921014-1.pdf: 2988401 bytes, checksum: df3fb0695e72b064f78dc296505b85ce (MD5) Previous issue date: 2006 | en |
dc.description.tableofcontents | 中文摘要 1
Abstract 2 Chapter 1 Background 5 1.1 Functional MRI utilizing EPI-BOLD technique 5 1.1.1 Functional contrast of BOLD fMRI 5 1.1.2 Echo planar imaging 6 1.2 bSSFP pulse sequence 11 1.2.1 bSSFP sequence characteristics 11 1.2.2 Steady-state imaging 12 Chapter 2 Introduction 15 Chapter 3 Principles of BOSS technique 19 3.1 Mathematical simulation of bSSFP signal 19 3.1.1 Steady-state signal and SSFP angle 19 3.1.2 Banding artifact and field homogeneity 23 3.2 fMRI using Blood Oxygenation Sensitive Steady-state 25 3.2.1 Pulse sequence variants 25 3.2.2 BOSS sequence simulation 28 3.2.2 BOSS functional contrast 32 3.3 Combining trials at multiple reference frequencies 41 Chapter 4 BOSS fMRI at high field and frequency stabilization 43 4.1 Frequency stabilization utilizing tiny RF pre-pulses 43 4.2 Frequency stabilization with infinite impulse response filtering 45 4.3 Experiment material and method 48 4.4 Experiment results 51 4.5 Discussion 60 Chapter 5 Application: high resolution fMRI 64 5.1 High resolution fMRI with BOSS 65 5.2 Experiment material and method 67 5.3 Experiment results 72 5.4 Discussion 91 Chapter 6 Conclusion 97 Reference 100 | |
dc.language.iso | en | |
dc.title | 利用穩定態影像達成之功能性磁振造影:在高磁場系統上的技術與應用 | zh_TW |
dc.title | FMRI Utilizing Blood Oxygenation Sensitive Steady-state Imaging: Techniques and Applications at High Field | en |
dc.type | Thesis | |
dc.date.schoolyear | 94-2 | |
dc.description.degree | 博士 | |
dc.contributor.oralexamcommittee | 陳震宇(Cheng-Yu Chen),高怡宣(Yi-Hsuan Kao),劉鶴齡(Ho-Ling Liu),吳銘庭(Ming-Ting Wu),柯正雯(Cheng-Wen Ko),劉益瑞(Yi-Jui Liu),林益如(Yi-Ru Lin) | |
dc.subject.keyword | 血氧濃度敏感穩定態,功能性磁振造影,穩定態造影術,頻率穩定技術,無限脈衝響應濾波, | zh_TW |
dc.subject.keyword | blood oxygenation sensitive steady-state,functional magnetic resonance imaging,balanced steady-state free precession,frequency stabilization,infinite impulse response filter, | en |
dc.relation.page | 104 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2006-06-15 | |
dc.contributor.author-college | 電機資訊學院 | zh_TW |
dc.contributor.author-dept | 電機工程學研究所 | zh_TW |
顯示於系所單位: | 電機工程學系 |
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