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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 陳昭岑(Chao-Tsen Chen) | |
dc.contributor.author | Charng-Sheng Tsai | en |
dc.contributor.author | 蔡長昇 | zh_TW |
dc.date.accessioned | 2021-06-13T05:46:51Z | - |
dc.date.available | 2011-07-13 | |
dc.date.copyright | 2006-07-13 | |
dc.date.issued | 2006 | |
dc.date.submitted | 2006-07-12 | |
dc.identifier.citation | 參考文獻
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/33823 | - |
dc.description.abstract | 摘要
本論文主要分成兩部分,第一部份是在金奈米粒子表面分別修飾醣配基、活性標示分子及進行Staudinger Ligation與1,3-Dipolar Cycloaddition所需的Phosphine與Propargyl ether。 我們所合成的一系列醣修飾金奈米粒子,不但可以用來測試醣受體蛋白與何種醣配基作用,也可以用來偵測蛋白質間的作用力。我們結合醣修飾金奈米粒子及其相對應的凝集素來偵測凝集素與其他蛋白質間之作用力。此方法具有很高的偵測極限 (5 nM),且實驗時間短無需修飾蛋白質等優點,再者肉眼即可輕易判斷實驗結果。此外,此方法不只可用來定性分析,也可用來定量測量蛋白質間的的結合常數。由於此方法非常簡單、快速,所以適合用來做為大量篩選 (High-Throughput Screening) 蛋白質間作用力的工具,用於蛋白質體學上的分析應該有相當的濳力,甚至可用來篩選影響醣受體蛋白與細胞之間作用力的藥物。 醣修飾金奈米粒子也可用於純化醣受體蛋白。藉由表面電漿帶是否有紅位移的現象,來判斷細胞萃取液中是否含有可與醣修飾金奈米粒子作用的醣受體蛋白,若表面電漿帶有紅位移的現象,可進一步利用離心的方式純化醣受體蛋白,並藉由SDS-PAGE及MALDI-TOF來鑑定醣受體蛋白。與傳統的方式比較,我們可縮減偵測及分離所需的時間,也可藉由結合MALDI-TOF,提高偵測醣受體蛋白的靈敏度,其偵測極限約為0.05-0.10 | zh_TW |
dc.description.abstract | Abstract
This thesis is divided into two parts. The first part used substrate-capped gold nanoparticles to detect protein-protein interactions and to purify specific protein. We designed and synthesized a series of sugar-capped gold nanoparticles (Sugar-GNPs) used in competition colorimetric assay for studying protein-protein interactions, particularly lectins. The competition assay uses the ensemble of lectin and Sugar-GNPs, which display blue color due to multivalent interactions between lectin and Sugar-GNPs, to identify the binding partners for lectin. Protein-Protein interaction can be evaluated qualitatively as well as quantitatively by using this competition assay. By using this methodology, a broad range of proteins can be rapidly evaluated for their abilities to interact with the protein of interest in real time, rendering high throughput screening possible. Sugar-GNPs can be used not only in detection of protein-protein interaction but also in purification of carbohydrate-binding protein. If the surface plasmon resonance band is red-shifted, it indicates that the binding occurs between Sugar-GNPs and the protein in the solution. By centrifuging the colloid, the complex can be isolated and purified. The identity of the isolated carbohydrate-binding protein can be further confirmed by SDS-PAGE and MALDI-TOF-MS. The feasibility of Sugar-GNPs for the simultaneous enrichment and isolation of ConA from protein mixture is demonstrated. Furthermore, very few quantity of agglutinin can be purified from a small amount of dry weight of algae and the biological activity still remains after recovering the protein from the complex. In addition, activity-based probe was designed and synthesized to form a covalent bond between the specific protein and substrate-capped gold nanoparticles through “click” reaction. Our experimental results indicate that labeled enzymes are easily separated from the unlabeled ones by centrifuge. SDS-PAGE and MALDI-TOF-MS are applied to analyze the purified samples. In second part, two methods were employed to synthesize fluorescent silica nanoparticles, which were then modified by mannose derivatives on the surface, namely Man-F-SNP and Man-R-SNP. Both types of particles were used to stain Salmonella typhimurium for bacteria imaging and the results showed that photostability of Man-R-SNP is better than Man-F-SNP. | en |
dc.description.provenance | Made available in DSpace on 2021-06-13T05:46:51Z (GMT). No. of bitstreams: 1 ntu-95-D91223006-1.pdf: 42688591 bytes, checksum: 551ba1846ec8851ef16171bc6c118482 (MD5) Previous issue date: 2006 | en |
dc.description.tableofcontents | 目錄
目錄 i 圖目錄 vi 表目錄 xiv 簡稱用語對照表 xv 中文摘要 xvii 英文摘要 xix 第一章 醣修飾金奈米粒子應用於分離醣受體蛋白 1 1.1 醣類重要性之簡介 1 1.1.1 醣類與生物體之間的關係 1 1.1.2 多價性醣配基與醣受體結合的探討 3 1.2 金奈米粒子及其應用於分子辨識的介紹 7 1.2.1 金奈米粒子之介紹 7 1.2.2 金奈米粒子應用於分子辨識的介紹 8 1.3外源凝集素 (Lectin) 之介紹 13 1.3.1 外源凝集素 (lectin) 的源由 13 1.3.2 外源凝結素的構造及作用機制 15 1.3.3 外源凝結素的生物活性及功能 17 1.4純化蛋白質的方法 21 1.5利用醣修飾金奈米粒子偵測及純化醣受體蛋白之原理 24 1.6 In Gel Digestion及MALDI-TOF應用於蛋白質分析之簡介 24 1.7 感測分子的組成與原理 27 1.8 用於修飾金奈米粒子的醣分子設計 29 1.9 醣配基衍生物的合成策略 30 1.9.1 醣配基衍生物合成方法 (1) 30 1.9.2 醣配基衍生物合成方法 (2) 32 1.10 醣配基衍生物的合成策略 34 1.10.1 醣配基衍生物合成方法 (1) 34 1.10.2 醣配基衍生物合成方法 (2) 40 1.11 大小不同的醣修飾金奈米粒子的合成方法及初步測試 44 1.12結論一 53 1.13 五種醣修飾金奈米粒子的合成條件 54 1.14利用醣修飾金奈米粒子分離醣受體蛋白的測試情形 55 1.15 結論二 68 第二章 利用醣修飾金奈米粒子偵測蛋白質間作用力 69 2.1 研究蛋白質間作用力之方法 69 2.2 利用醣修飾金奈米粒子偵測蛋白質之間作用力設計原理 79 2.3 利用醣修飾金奈米粒子測試蛋白質間作用力的測試情形 80 2.4 結論 109 第三章 將活性標示分子修飾於金奈米粒子以便用於純化具有活性之蛋白質 110 3.1 前言 110 3.2 利用化學方法來研究蛋白質體學的相關研究 112 3.3 利用修飾於金奈米粒子上的活性探針來對特定酵素之原理 118 3.4 含硫醇醣水解酵素活性探針的合成策略 121 3.5 含硫醇醣水解酵素活性探針45的合成方法 122 3.6 以化合物45修飾32 nm金奈米粒子 125 3.7 β-葡萄糖水解酵素與Glc-ABPP-GNP的測試情形 126 3.7 結論 134 第四章 金奈米粒子結合兩步標示用以純化特定蛋白質 135 4.1 前言 135 4.2 目標酵素的介紹 135 4.2.1碳酸酐酶 (Carbonic Anhydrase) 及其相對應活性探針之介 紹 135 4.2.2 針對碳酸酐酶的活性探針介紹 137 4.2.3 Penicillin-Binding Proteins (PBPs)及其相對應活性探針之介紹 138 4.2.4 針對Penicillin-Binding Protein的活性探針介紹 141 4.3 Staudinger Ligation及1,3-Dipolar Cycloaddition的簡介 141 4.3.1 Staudinger Ligation的反應機構 141 4.3.2 1,3-Dipolar Cycloaddition的反應機構 142 4.4 利用兩步標示來純化特定蛋白質之策略 144 4.5 用於兩步標示策略的分子設計 145 4.6 化合物50的合成策略 146 4.7 化合物50合成方法的探討 147 4.8 化合物57的合成策略 149 4.9 化合物57合成方法的探討 150 4.10 化合物62的合成策略 154 4.11 化合物62合成方法的探討 155 4.12 化合物65及化合物66的合成策略 157 4.13 化合物65及化合物66合成方法的探討 158 4.14 以化合物62、65及66修飾32 nm金奈米粒子 160 4.15 碳酸酐酶與化合物50及PPh3-GNP的作用情形測試 160 4.16 Penicillin-Binding Protein與化合物56及PPh3-GNP的作用情形測試 167 4.17 結論二 173 第五章 螢光二氧化矽奈米粒子應用於生物系統的標示 174 5.1 前言 174 5.1.1 量子點 (Quantum Dots) 174 5.1.2 染料摻雜的奈米粒子 (Dye-Doped Nanoparticles) 177 5.2 利用醣修飾螢光奈米粒子標示生物系統的研究 181 5.3 醣修飾螢光二氧化矽奈米粒子的原理 183 5.4醣修飾螢光二氧化矽奈米粒子的組成單元 183 5.4.1 修正Blaaderen教授的方法所合成的醣修飾螢光二氧化矽奈米粒子 183 5.4.2 修正Rosenzweig教授的方法所合成的醣修飾螢光二氧化矽奈米粒子 184 5.4.3 醣配基的組成單元 185 5.5 化合物72及化合物73的合成策略 186 5.6 化合物73、74合成方法的探討 187 5.7 醣修飾螢光二氧化矽奈米粒子的製備 190 5.7.1 第一種醣修飾螢光二氧化矽奈米粒子的製備 190 5.7.2 第二種醣修飾螢光二氧化矽奈米粒子的製備 192 5.8 Man-F-SNP及Man-R-SNP的標示效果 195 5.9 結論 202 實驗部分 203 壹 ㄧ般敘述 203 貳 實驗步驟及光譜數據 205 參 生物活性測試方法 268 參考文獻 280 附錄 298 | |
dc.language.iso | zh-TW | |
dc.title | 1. 金奈米粒子應用於偵測蛋白質間作用力與純化特定蛋白質
2. 螢光二氧化矽奈米粒子應用於鼠傷寒沙門氏桿菌的顯像 | zh_TW |
dc.title | 1. Detection of Protein-Protein Interactions and Purification of Specific Proteins with Substrate-Capped Gold Nanoparticles
2. Application of Fluorescent Silica Nanoparticles to image Salmonella typhimurium | en |
dc.type | Thesis | |
dc.date.schoolyear | 94-2 | |
dc.description.degree | 博士 | |
dc.contributor.oralexamcommittee | 牟中原(Chung-Yuan),劉緒宗(Shiuh-Tzung Liu),羅禮強(Lee-Chiang Lo),張富雄(Fu-Hsiung Chang),賴信志(Hsin-Chih Lai) | |
dc.subject.keyword | 金奈米粒子,螢光二氧化矽奈米粒子, | zh_TW |
dc.subject.keyword | Gold Nanoparticles,Fluorescent Silica Nanoparticles, | en |
dc.relation.page | 362 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2006-07-12 | |
dc.contributor.author-college | 理學院 | zh_TW |
dc.contributor.author-dept | 化學研究所 | zh_TW |
顯示於系所單位: | 化學系 |
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