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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 邱文英 | |
| dc.contributor.author | Chia-Cheng Lin | en |
| dc.contributor.author | 林家正 | zh_TW |
| dc.date.accessioned | 2021-06-13T05:45:18Z | - |
| dc.date.available | 2006-07-18 | |
| dc.date.copyright | 2006-07-18 | |
| dc.date.issued | 2006 | |
| dc.date.submitted | 2006-07-12 | |
| dc.identifier.citation | 1.陳威倩，「以γ→α相變機制製作alpha-Fe2O3微粒」國立成功大學碩士論文(2001)
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/33737 | - |
| dc.description.abstract | 本論文以氮-異丙基丙烯醯胺(N-isopropylacrylamide，NIPAAM)和丙烯酸(acrylic acid，AA)的乳膠顆粒，在改變AA/NIPAAM比例及交聯劑濃度下進行各項測試。
接著進行磁性乳膠顆粒的製備實驗，與傳統“氧化鐵/高分子'合成方法有所不同，本實驗先將高分子乳膠顆粒合成，利用乳膠顆粒的AA鏈段官能基(-COOH)與鐵離子先鍵結成-COOFe2+及-COOFe3+，當氨水參與反應時，Fe3O4會以in-situ的方式形成，於是磁性乳膠顆粒形成。 以下為各項測試簡述： TEM圖形下觀察粒徑大小及型態，AA/NIPAAM比例越高，與乳膠顆粒鍵結的磁性粒子會越多；而交聯劑濃度越高，在含磁流與不含磁流的狀態下粒徑是完全相反的趨勢，未含磁流的粒徑變小，而含有磁流的組別粒徑變大。 利用紫外光-可見光分光光度計在改變溫度下測量450nm下的吸收值變化，得出LCST變化AA/NIPAAM比例越高，LCST在測試溫度下會越來越不明顯；而交聯劑濃度越高，疏水性增加，LCST會稍微下降；在含有磁流組別與未含磁流組別可以看出，在交聯度較大時，含有磁流的LCST較未含磁流組別來的大。 利用紫外光-可見光分光光度計在272nm，於不同時間下取樣測試咖啡因濃度－藥物包覆釋放實驗，主要可以看出磁性粒子對藥物釋放結果有著不同的結果，磁性粒子影響乳膠顆粒孔隙路徑的大小及結構，造成藥物釋放結果呈現0%>4%>2%(Fe3O4含量比例)。 利用紫外光-可見光分光光度計在280nm測試不同組別的BSA濃度，可反推鍵結上的BSA含量。AA/NIPAAM比例越高，接枝率越高；溫度升高，鍵結活性升高，接枝率升高，但乳膠顆粒因有溫度敏感性，體積表面積均會縮小，接枝率降低。 | zh_TW |
| dc.description.abstract | In our study, we discuss the copolymer of NIPAAM (N-isopropylacrylamide) and AA (acrylic acid) in different ratio of AA/NIPAAM and in different concentration of crosslinking agent. We test this copolymer in some experiments incluiding TEM, LCST, drug release and protein (BSA) bonding.
Then synthesizing the magnetic hydrogel, we use different method to synthesize “iron oxide/polymer” form the traditional method. In our work, we firstly synthesize the hydrogel. Second, using the functional group(-COOH) on the hyrogel surface to bond with Fe2+ and Fe3+. Finally, we put ammonia into the latex, and we can get magnetic hydrogel. According to each test about poly(NIPAAM-co-AA), we choose suitable group to synthesize magnetic hydrogel. Then we test all events described in the first paragraph. From all testing experiments, we can realize the properties of the (magnetic) hydrogel and the effect on experimental results from each parameter. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T05:45:18Z (GMT). No. of bitstreams: 1 ntu-95-R93524050-1.pdf: 11937593 bytes, checksum: 2e256c930518ce7c01ad2f688cf11346 (MD5) Previous issue date: 2006 | en |
| dc.description.tableofcontents | 摘要 I
Abstract III 目 錄 IV 表 目 錄 VI 圖 目 錄 VII 第一章 序論 1 第二章 文獻回顧 3 2-1. 氧化鐵 3 2-2 磁性材料 4 2-3 磁性流體的製造 5 2-4 乳化聚合 8 2-4-1 簡介 8 2-4-2 無乳化劑乳化聚合 9 2-5 藥物控制釋放技術 11 2-6 免疫乳膠顆粒的製備 12 2-7 聚（氮-異丙基丙烯醯胺）[Poly（N-isopropyl acrylamide）] 13 2-7-1 環境敏感型高分子 13 2-7-2 溫度敏感型高分子 15 2-7-3 LCST的形成原因 16 2-7-4 膨潤理論 17 2-7-5 具LCST之溫度敏感型高分子在藥物釋放上的應用 17 第三章 實驗方法 18 3-1 實驗藥品與儀器 18 3-1-1 實驗藥品 18 3-1-2 實驗儀器 21 3-2 實驗流程 25 3-2-1 溫度敏感型乳膠微粒的合成 25 3-2-2 磁性溫度敏感型乳膠微粒的製備 26 3-2-3 實驗流程圖 27 3-3 合成方法 28 3-3-1溫度敏感型乳膠微粒的合成方法 28 3-3-2磁性溫度敏感型乳膠微粒的製備 29 3-3-3 溫度敏感型乳膠微粒的透析 30 3-4 性質測定 31 3-4-1元素分析(EA) 31 3-4-2型態之觀察-TEM 31 3-4-3 LCST測試實驗 31 3-4-4 模擬測試 (LCST及TEM觀察) 31 3-4-5 藥物包覆釋放測試及膨潤性測試 32 3-4-6 蛋白質的化學鍵結 34 第四章 結果與討論 36 4-1磁性溫度敏感型乳膠微粒之合成 36 4-1-1 合成PNIPAAM-co-PAA之乳膠微粒 36 4-1-2 合成P(NIPAAM-co-AA)/Fe3O4磁性乳膠顆粒 36 4-1-3 以APS(陰離子型)為起始劑進行聚合 39 4-2乳膠微粒/磁性乳膠微粒的性質測定 40 4-2-1 元素分析(EA) 40 4-2-2 TEM的觀察 41 4-2-2-1 未含磁流的乳膠顆粒 41 4-2-2-2 含磁流的乳膠顆粒 42 4-2-2-3 不含磁流乳膠顆粒與含磁流乳膠顆粒的比較 43 4-2-4 LCST測試實驗 44 4-2-2-1 未含磁流的乳膠顆粒 44 4-2-2-2 含磁流的乳膠顆粒 45 4-2-2-3 不含磁流乳膠顆粒與含磁流乳膠顆粒的比較 45 4-3-5 模擬測試 (LCST及TEM觀察) 48 4-3-5-1 TEM 48 4-3-5-2 LCST 49 4-3-6 藥物包覆釋放測試及膨潤性測試 50 4-3-6-1 Caffeine calibration curve之建立 50 4-3-6-2 乳膠顆粒之藥物包覆釋放測試 50 4-3-6-3 磁性乳膠顆粒之藥物包覆釋放測試 52 4-3-6-4 乳膠顆粒之膨潤度測試 54 4-3-6-5磁性乳膠顆粒之膨潤性測試 55 4-3-7 蛋白質的化學鍵結 55 4-3-7-1 BSA(牛血清白蛋白) calibration curve之建立 55 4-3-7-2 化學鍵結結果 55 第五章 結論 57 參考文獻 59 | |
| dc.language.iso | zh-TW | |
| dc.subject | 丙烯酸 | zh_TW |
| dc.subject | 氮-異丙基丙烯醯胺 | zh_TW |
| dc.subject | 藥物釋放 | zh_TW |
| dc.subject | 溫度敏感性 | zh_TW |
| dc.subject | 磁性 | zh_TW |
| dc.subject | 蛋白質接枝 | zh_TW |
| dc.subject | acrylic acid | en |
| dc.subject | protein bonding | en |
| dc.subject | magnetic | en |
| dc.subject | thermo-sensitive | en |
| dc.subject | N-isopropylacrylamide | en |
| dc.subject | drug release | en |
| dc.title | 磁性溫感型乳膠顆粒之製造與研究 | zh_TW |
| dc.title | Synthesis and Research of Thermosensitive Magnetic Latex Particle | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 94-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.coadvisor | 李佳芬 | |
| dc.contributor.oralexamcommittee | 陳文章,林江珍 | |
| dc.subject.keyword | 氮-異丙基丙烯醯胺,丙烯酸,藥物釋放,溫度敏感性,磁性,蛋白質接枝, | zh_TW |
| dc.subject.keyword | N-isopropylacrylamide,acrylic acid,drug release,thermo-sensitive,magnetic,protein bonding, | en |
| dc.relation.page | 108 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2006-07-14 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 化學工程學研究所 | zh_TW |
| 顯示於系所單位： | 化學工程學系 | |
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