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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 潘永寧(Yung-Ning Pan) | |
dc.contributor.author | Guo-Jr Feng | en |
dc.contributor.author | 馮國治 | zh_TW |
dc.date.accessioned | 2021-06-13T05:44:03Z | - |
dc.date.available | 2006-07-18 | |
dc.date.copyright | 2006-07-18 | |
dc.date.issued | 2006 | |
dc.date.submitted | 2006-07-14 | |
dc.identifier.citation | http://www.stat.gov.tw/ct.asp?xItem=15408&CtNode=3623 中華民國統計資訊網,上網日期:2006.05.25
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/33635 | - |
dc.description.abstract | 本研究針對先前所開發之高強度、低楊氏係數與含低毒性元素之Ti-Nb合金-Ti-30Nb-1Fe-1Hf與Ti-40Nb-1Hf,以鹼性溶液與熱處理進行表面改質,再以體外骨母細胞培養實驗來評估其生物相容性,並與商用純鈦及Ti-6Al-4V合金作一比較。藉由鹼性溶液及熱處理可於商用純鈦及Ti-6Al-4V表面成長多孔性的表面組織,而對於Ti-30Nb-1Fe-1Hf及Ti-40Nb-1Hf之表面則會形成不規則裂痕的形貌。又,利用鹼性溶液及熱處理可增加鈦合金表層氧及氫氧根的含量,有效改善表面潤濕性。對於表層化學組成而言,經鹼性溶液及熱處理可促使純鈦及Ti- 6Al-4V的表層生成TiO2,而促使Ti-30Nb-1Fe-1Hf及Ti-40Nb- 1Hf的表層生成TiO2與Nb2O5。對於Ti-30Nb-1Fe-1Hf及Ti-40Nb- 1Hf合金而言,以鹼性溶液及熱處理法作表面改質之後,表面所形成之不規則狀裂痕形貌、表層氧及氫氧根的含量增加,而提升表面潤濕性,以及在表層所生成之TiO2與Nb2O5等,均有利於骨母細胞的貼附及增殖。體外生物相容性實驗結果顯示,Ti-30Nb-1Fe-1Hf及Ti-40Nb- 1Hf之細胞貼附形貌、細胞總數與MTT吸光值分析皆與商用純鈦及Ti- 6Al-4V合金相近。綜上所述,本研究以鹼性溶液及熱處理法對於Ti-30Nb-1Fe- 1Hf及Ti-40Nb-1Hf合金進行表面改質之後,可增進該合金之生物相容性。 | zh_TW |
dc.description.abstract | The previously developed titanium-niobium alloys – Ti-40Nb-1Hf and Ti-30Nb-1Fe-1Hf alloys – exhibit relatively high strength and low elastic modulus and are considered quite suitable for implants application. This study employed alkali solution treatment and heat treatment to modify the surfaces of Ti-40Nb-1Hf and Ti-30Nb-1Fe-1Hf alloys together with the commercially pure Ti and Ti-6Al-4V alloy, and then the biocompatibility of the treated alloys was analyzed by means of osteoblast cell culture in vitro. The results indicate that porous surfaces were obtained for pure Ti and Ti-Al-4V, while surfaces with irregular cracks were obtained for Ti-40Nb-1Hf and Ti-30Nb-1Fe-1Hf alloys, after surface modification. Also, the surface wettability was improved after alkali solution treatment and heat treatment due to the increase of oxygen and hydroxyl on the surface layer. In addition, both alkali and heat treatments enhanced the growth of TiO2 on the surface layer of the commercially pure Ti and Ti-6Al-4V, and TiO2 and Nb2O5 for Ti-40Nb-1Hf and Ti-30Nb-1Fe-1Hf alloys. The formation of irregular cracks on the treated surfaces together with the increase in oxygen and hydroxyl, and TiO2 and Nb2O5 on the surface layer had been found to improve surface wettability and also the osteoblast attachment and proliferation of the surface-treated alloys. This has also been confirmed in vitro study, where the cell morphology, cell number and MTT optical assay of Ti-40Nb-1Hf and Ti-30Nb-1Fe-1Hf alloys are similar to those of pure Ti and Ti-6Al-4V alloy. | en |
dc.description.provenance | Made available in DSpace on 2021-06-13T05:44:03Z (GMT). No. of bitstreams: 1 ntu-95-R93522717-1.pdf: 12724189 bytes, checksum: 1b4bebefe297edc86c74de3ffe29ea05 (MD5) Previous issue date: 2006 | en |
dc.description.tableofcontents | 目 錄
中文摘要……………………………………………………………………………….Ⅰ 英文摘要……………………………………………………………………………….Ⅱ 目錄…………………………………………………………………………………….Ⅲ 表目錄………………………………………………………………………………….Ⅳ 圖目錄………………………………………………………………………………….Ⅴ 第一章 諸論 1 1.1前言 1 1.2研究動機 3 第二章 文獻探討 7 2.1 生醫材料 7 2.1.1 生醫材料的簡介 7 2.1.2 生醫植入材的種類 7 2.1.3 鈦及鈦合金 9 2.1.4 生醫植入材的性質與應用 10 2.2 金屬離子釋出 11 2.3 鈦及鈦合金生醫植入材表面處理 13 2.3.1 表面處理 13 2.3.2 表面處理-物理方法 14 2.3.3 表面處理-化學方法 16 2.3.4 表面處理-機械方法 18 2.4 鹼與熱處理 19 2.5 骨組織與骨細胞 21 2.5.1 骨細胞與骨生成 21 2.5.2 骨細胞的貼附與生醫材料表面性質的關係 23 第三章 實驗步驟及方法 34 3.1 試片準備及前處理 34 3.2 試片表面處理 34 3.3 試片分析 35 3.3.1 基材組成元素分析 35 3.3.2 試片表面形貌及元素分析 35 3.3.3 試片表面性質分析 36 3.3.4 生物相容性分析 36 第四章 結果與討論 42 4.1 表面形貌及元素成分分析 42 4.2 表面物理及化學性質分析 43 4.2.1 維克氏硬度與液滴法實驗結果與討論 43 4.2.2 XRPD與ESCA實驗結果與討論 44 4.3 生物相容性 49 4.4 綜合討論 50 第五章 總結 95 參考文獻……………………………………………………………………………….98 | |
dc.language.iso | zh-TW | |
dc.title | 以鹼性溶液與熱處理法進行鈦合金表面改質之研究 | zh_TW |
dc.title | Study on surface modification by alkali and heat treatment in Ti alloys | en |
dc.type | Thesis | |
dc.date.schoolyear | 94-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 歐耿良,呂炫? | |
dc.subject.keyword | 鈦鈮合金,鹼性溶液及熱處理法,生物相容性, | zh_TW |
dc.subject.keyword | Titanium-niobium alloys,Alkali solution and heat treatment,Biocompatibility, | en |
dc.relation.page | 104 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2006-07-17 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 機械工程學研究所 | zh_TW |
顯示於系所單位: | 機械工程學系 |
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