請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/33518完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳振中 | |
| dc.contributor.author | Hsin-Kuan Lee | en |
| dc.contributor.author | 李信寬 | zh_TW |
| dc.date.accessioned | 2021-06-13T04:44:59Z | - |
| dc.date.available | 2011-07-29 | |
| dc.date.copyright | 2011-07-29 | |
| dc.date.issued | 2011 | |
| dc.date.submitted | 2011-07-27 | |
| dc.identifier.citation | Chapter 1
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C., Efficient Spin-Spin Scalar Coupling Mediated C-13 Homonuclear Polarization Transfer in Biological Solids without Proton Decoupling. Solid State Nucl. Magn. Reson. 2006, 29 (4), 278-282. 19. Takegoshi, K.; Terao, T., C-13-H-1 Dipolar Recoupling under Very Fast Magic-Angle Spinning Using Virtual Pulses. Solid State Nucl. Magn. Reson. 1999, 13 (4), 203-212. 20. Chen, L.; Wang, Q. A.; Hu, B. W.; Lafon, O.; Trebosc, J.; Deng, F.; Amoureux, J. P., Measurement of Hetero-Nuclear Distances Using a Symmetry-Based Pulse Sequence in Solid-State NMR. Phys. Chem. Chem. Phys. 2010, 12 (32), 9395-9405. 21. Mo | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/33518 | - |
| dc.description.abstract | 本研究工作是以磁偶極作用力為基礎進行生物固態核磁共振的研發及測量生物分子的二面角(dihedral angles)。論文的第一章將回顧固態核磁共振技術於生物分子結構的測定，第二章則簡單介紹固態核磁共振的理論背景。而本論文的主要內容包含三個研究主題，其一是脈衝序列的內部對稱性(internal symmetry)及其相對應的選擇律(selection rules)。我們利用所推導出來的內部對稱性理論來討論C-REDOR序列抑制同核偶極作用(homonuclear dipole-dipole interaction)的能力，進一步我們再利用脈衝內部對稱性的概念來提升該序列於實驗中的表現。另一研究主題是設計一脈衝序列並將其應用於同核偶極作用回耦(homonuclear dipolar recoupling)。最後我們藉由13C(alpha)-1H(alpha)及13C(alpha)-14N兩個異核偶極張量(heteronuclear dipolar tensors)之間的相互關係來進行生物分子的psi角測量。 | zh_TW |
| dc.description.abstract | This work contains the development of pulse sequences in solid-state NMR and dihedral angle determination of biological solids based on magnetic dipole-dipole interaction. Chapter 1 gives a review of using solid-state NMR to obtain the structural information for biological solids. Chapter 2 introduces the theoretical background for solid-state NMR. The main thesis contains three topics. First, we show by a detailed analysis that a set of internal selection rules does exist for many basic elements of pulse sequences. And we have derived the symmetry arguments to rationalize the observation that the C-REDOR pulse sequence can suppress homonuclear dipole-dipole interaction (Chapter 3). The concept of the internal symmetry has further applied to increase the efficiency of C-REDOR (Chapter 4). Second, we design a constant-time sequence composed of DRAMA-based pulses for homonuclear dipolar dephasing (Chapter 5 and 6). Third, we introduce an approach for the dihedral angle determination of biological samples. In this part, we discuss the psi angle determination by correlation of the 13C(alpha)-1H(alpha) and the 13C(alpha)-14N dipolar tensors within a single labeled residue (Chapter 7). | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T04:44:59Z (GMT). No. of bitstreams: 1 ntu-100-R98223145-1.pdf: 1226692 bytes, checksum: 0a4e210cdcbae98c7af74e1928fabaff (MD5) Previous issue date: 2011 | en |
| dc.description.tableofcontents | 口試委員會審定書 II
Publications III 摘要 i Abstract ii Contents iii Figure Contents vi Table Contents x Chapter 1 Introduction 1 1.1 Introduction 1 1.2 Pulse Sequences for Structural Determination 2 1.2.1 Homonuclear dipolar recoupling 2 1.2.2 Heteronuclear dipolar recoupling 4 1.2.3 Angular constraint 5 1.3 Summary 8 1.4 References 9 Chapter 2 Theoretical Background 15 2.1 Spin Hamiltonians in Solid-State NMR 15 2.2 Pulse Sequence in Static Solid-State NMR 16 2.3 Magic Angle Spinning (MAS) 18 2.4 Pulse Sequence under MAS 20 2.5 References 21 Chapter 3 Internal Symmetry of Basic Elements in Pulse Sequences under MAS 22 3.1 Introduction 22 3.2 Theory 23 3.2.1 Internal symmetry of basic elements 23 3.2.2 Internal symmetry of selected basic elements 30 3.2.3 Active rotor synchronization of C-REDOR 35 3.3 Numerical Simulations 36 3.4 Experimental Conditions 38 3.5 Results and Discussion 40 3.6 Conclusions 43 3.7 References 44 Chapter 4 Windowed C-REDOR with a Large Scaling Factor 47 4.1 Introduction 47 4.2 Pulse sequences 48 4.3 Numerical Simulations 50 4.4 Experimental Conditions 52 4.5 Results and Discussion 54 4.6 Conclusions 56 4.7 References 57 Chapter 5 DRAMA-CT: A New Dipolar Dephasing Experiment 58 5.1 Introduction 58 5.2 Theory 59 5.3 Numerical Simulations 62 5.4 Experiments 65 5.4.1 Samples 65 5.4.2 Solid-state NMR 66 5.5 Results and Discussion 67 5.6 Conclusions 71 5.7 References 71 Chapter 6 DRAMA-Based Recoupling Sequence without Proton Decoupling 74 6.1 Introduction 74 6.2 Theory 75 6.3 Experiments and Numerical Simulations 77 6.4 Results and Discussion 79 6.5 References 81 Chapter 7 Angle Determination by Tensor Correlation with 1H-13C-14N-13C Scheme 84 7.1 Introduction 84 7.2 Spin System 86 7.3 Pulse sequence 87 7.3.1 Zero quantum excitation 87 7.3.2 14N-13C and 1H-13C dipolar recoupling 90 7.4 Results and Discussion 90 7.5 References 93 Chapter 8 Conclusions and Outlook 96 | |
| dc.language.iso | en | |
| dc.subject | psi角測量 | zh_TW |
| dc.subject | 固態核磁共振 | zh_TW |
| dc.subject | 脈衝序列 | zh_TW |
| dc.subject | 偶極作用力 | zh_TW |
| dc.subject | 同核偶極作用力回耦 | zh_TW |
| dc.subject | 異核偶極作用力回耦 | zh_TW |
| dc.subject | 核間距離測量 | zh_TW |
| dc.subject | pulse sequence | en |
| dc.subject | solid-state NMR | en |
| dc.subject | psi angle measurement | en |
| dc.subject | distance measurement | en |
| dc.subject | heteronuclear dipolar recoupling | en |
| dc.subject | homonuclear dipolar recoupling | en |
| dc.subject | dipole-dipole interaction | en |
| dc.title | 以磁偶極作用力為基礎發展生物固態核磁共振之脈衝序列 | zh_TW |
| dc.title | Development of Pulse Sequences for Biological Solid-State NMR Based on Magnetic Dipole-Dipole Interaction | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 99-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 劉尚斌,鄭原中 | |
| dc.subject.keyword | 固態核磁共振,脈衝序列,偶極作用力,同核偶極作用力回耦,異核偶極作用力回耦,核間距離測量,psi角測量, | zh_TW |
| dc.subject.keyword | solid-state NMR,pulse sequence,dipole-dipole interaction,homonuclear dipolar recoupling,heteronuclear dipolar recoupling,distance measurement,psi angle measurement, | en |
| dc.relation.page | 98 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2011-07-27 | |
| dc.contributor.author-college | 理學院 | zh_TW |
| dc.contributor.author-dept | 化學研究所 | zh_TW |
| 顯示於系所單位： | 化學系 | |
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