請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/32627完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 翁祖輝 | |
| dc.contributor.author | Yi-Ya Tsai | en |
| dc.contributor.author | 蔡宜雅 | zh_TW |
| dc.date.accessioned | 2021-06-13T04:12:31Z | - |
| dc.date.available | 2008-08-03 | |
| dc.date.copyright | 2006-08-03 | |
| dc.date.issued | 2006 | |
| dc.date.submitted | 2006-07-25 | |
| dc.identifier.citation | 陳琮明. 2004. 人類第九纖維母細胞生長因子基因之啟動子及三端微衛星序列功能性分析. 國立成功大學分子醫學研究所碩士論文
Adami HO, Persson I, Hoover R, Schairer C, Bergkvist L. 1989. Risk of cancer in women receiving hormone replacement therapy. Int J Cancer 44(5):833-9 Angel P, Smeal T, Meek J, Karin M. 1989. Jun and v-jun contain multiple regions that participate in transcriptional activation in an interdependent manner. New Biol 1(1):35-43 Bain C, Feskanich D, Speizer FE, Thun M, Hertzmark E, Rosner BA, Colditz GA. 2004. Lung cancer rates in men and women with comparable histories of smoking. J Natl Cancer Inst 96(11):826-34 Buckpitt A, Chang AM, Weir A, Van Winkle L, Duan X, Philpot R, Plopper C. 1995. Relationship of cytochrome P450 activity to Clara cell cytotoxicity. IV. Metabolism of naphthalene and naphthalene oxide in microdissected airways from mice, rats, and hamsters. Mol Pharmacol 47(1):74-81 Burdick AD, Davis JW 2nd, Liu KJ, Hudson LG, Shi H, Monske ML, Burchiel SW. 2003. Benzo(a)pyrene quinones increase cell proliferation, generate reactive oxygen species, and transactivate the epidermal growth factor receptor in breast epithelial cells. Cancer Res 63(22):7825-33 Chan-Yeung M, Dimich-Ward H. 2003. Respiratory health effects of exposure to environmental tobacco smoke. Respirology 8(2):131-9 Chang CC, Shih JY, Jeng YM, Su JL, Lin BZ, Chen ST, Chau YP, Yang PC, Kuo ML. 2004. Connective tissue growth factor and its role in lung adenocarcinoma invasion and metastasis. J Natl Cancer Inst 96(5):364-75 Chen KY, Chang CH, Yu CJ, Kuo SH, Yang PC. 2005. Distribution according to histologic type and outcome by gender and age group in Taiwanese patients with lung carcinoma. Cancer 103(12):2566-74 Cheng YW, Lee WW, Li CH, Lee CC, Kang JJ. 2004. Genotoxicity of motorcycle exhaust particles in vivo and in vitro. Toxicol Sci 81(1):103-11 Chiang TA, Wu PF, Ko YC. 1999. Identification of carcinogens in cooking oil fumes. Environ Res 81(1):18-22 Chomczynski P, Sacchi N. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162(1):156-9 Cinaroglu A, Ozmen Y, Ozdemir A, Ozcan F, Ergorul C, Cayirlioglu P, Hicks D, Bugra K. 2005. Expression and possible function of fibroblast growth factor 9 (FGF9) and its cognate receptors FGFR2 and FGFR3 in postnatal and adult retina. J Neurosci Res 79(3):329-39 Colvin JS, Feldman B, Nadeau JH, Goldfarb M, Ornitz DM. 1999. Genomic organization and embryonic expression of the mouse fibroblast growth factor 9 gene. Dev Dyn 216(1):72-88 Colvin JS, Green RP, Schmahl J, Capel B, Ornitz DM. 2001. Male-to-female sex reversal in mice lacking fibroblast growth factor 9. Cell 104(6):875-89 Colvin JS, White AC, Pratt SJ, Ornitz DM. 2001. Lung hypoplasia and neonatal death in Fgf9-null mice identify this gene as an essential regulator of lung mesenchyme. Development 128(11):2095-106 Cronauer MV, Schulz WA, Seifert HH, Ackermann R, Burchardt M. 2003. Fibroblast growth factors and their receptors in urological cancers: basic research and clinical implications. Eur Urol 43(3):309-19 del Moral PM, De Langhe SP, Sala FG, Veltmaat JM, Tefft D, Wang K, Warburton D, Bellusci S. 2006. Differential role of FGF9 on epithelium and mesenchyme in mouse embryonic lung. Dev Biol 293(1):77-89 Devesa SS, Shaw GL, Blot WJ. 1991. Changing patterns of lung cancer incidence by histological type. Cancer Epidemiol Biomarkers Prev 1(1):29-34 Devesa SS, Bray F, Vizciano AP ,Parkin DM . 2005. International lung cancer trends by histologic types: male:female differences diminishing and adenocarcinoma rates rising. Int J Cancer 117:294-299 Dickson C, Spencer-Dene B, Dillon C, Fantl V. 2000. Tyrosine kinase signalling in breast cancer: fibroblast growth factors and their receptors. Breast Cancer Res 2(3):191-6 Ding J, Li J, Chen J, Chen H, Ouyang W, Zhang R, Xue C, Zhang D, Amin S, Desai D, Huang C. 2006. Effects of polycyclic aromatic hydrocarbons (PAHs) on vascular endothelial growth factor induction through phosphatidylinositol 3-kinase/AP-1-dependent, HIF-1alpha-independent pathway. J Biol Chem 281(14):9093-100 Divine KK, Pulling LC, Marron-Terada PG, Liechty KC, Kang T, Schwartz AG, Bocklage TJ, Coons TA, Gilliland FD, Belinsky SA. 2005. Multiplicity of abnormal promoter methylation in lung adenocarcinomas from smokers and never smokers. Int J Cancer 114(3):400-5 Dohr O, Vogel C, Abel J. 1995. Different response of 2,3,7,8-tetrachlorodibenzo -p-dioxin (TCDD)-sensitive genes in human breast cancer MCF-7 and MDA-MB 231 cells. Arch Biochem Biophys 321(2):405-12 Draper BW, Stock DW, Kimmel CB. 2003. Zebrafish fgf24 functions with fgf8 to promote posterior mesodermal development. Development 130(19):4639-54 Enmark E, Pelto-Huikko M, Grandien K, Lagercrantz S, Lagercrantz J, Fried G, Nordenskjold M, Gustafsson JA. 1997. Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern. J Clin Endocrinol Metab 82(12):4258-65 Fleenor DL, Pang IH, Clark AF. 2003. Involvement of AP-1 in interleukin-1alpha-stimulated MMP-3 expression in human trabecular meshwork cells. Invest Ophthalmol Vis Sci 44(8):3494-501 Fromont-Hankard G, Philippe-Chomette P, Delezoide AL, Nessmann C, Aigrain Y, Peuchmaur M. 2002. Glial cell-derived neurotrophic factor expression in normal human lung and congenital cystic adenomatoid malformation. Arch Pathol Lab Med 126(4):432-6 Garces A, Nishimune H, Philippe JM, Pettmann B, deLapeyriere O. 2000. FGF9: a motoneuron survival factor expressed by medial thoracic and sacral motoneurons. J Neurosci Res 60(1):1-9 Garnis C, Davies JJ, Buys TP, Tsao MS, MacAulay C, Lam S, Lam WL. 2005. Chromosome 5p aberrations are early events in lung cancer: implication of glial cell line-derived neurotrophic factor in disease progression. Oncogene 24(30):4806-12 Gerard N, Caillaud M, Martoriati A, Goudet G, Lalmanach AC. 2004. The interleukin-1 system and female reproduction. J Endocrinol 180(2):203-12 Giri D, Ropiquet F, Ittmann M. 1999. FGF9 is an autocrine and paracrine prostatic growth factor expressed by prostatic stromal cells. J Cell Physiol 180(1):53-60 Granerus M, Engstrom W. 2003. Effects of fibroblast growth factor 8, fibroblast growth factor 9 and keratinocyte growth factor on multiplication and locomotion in human teratocarcinoma cells in vitro. Anticancer Res 23(2B):1313-6 Hakura A, Tsutsui Y, Sonoda J, Kai J, Imade T, Shimada M, Sugihara Y, Mikami T. 1998. Comparison between in vivo mutagenicity and carcinogenicity in multiple organs by benzo[a]pyrene in the lacZ transgenic mouse (Muta Mouse). Mutat Res 398(1-2):123-30 Hecht SS. 1996. Recent studies on mechanisms of bioactivation and detoxification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific lung carcinogen. Crit Rev Toxicol 26(2):163-81 Hecht SS. 1998. Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines. Chem Res Toxicol 11(6):559-603 Hecht SS. 2003. Tobacco carcinogens, their biomarkers and tobacco-induced cancer. Nat Rev Cancer 3(10):733-44 Hecht SS, Isaacs S, Trushin N. 1994. Lung tumor induction in A/J mice by the tobacco smoke carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene: a potentially useful model for evaluation of chemopreventive agents. Carcinogenesis 15(12):2721-5 Hendrix ND, Wu R, Kuick R, Schwartz DR, Fearon ER, Cho KR. 2006. Fibroblast growth factor 9 has oncogenic activity and is a downstream target of Wnt signaling in ovarian endometrioid adenocarcinomas. Cancer Res 66(3):1354-62 Hippo Y, Yashiro M, Ishii M, Taniguchi H, Tsutsumi S, Hirakawa K, Kodama T, Aburatani H. 2001. Differential gene expression profiles of scirrhous gastric cancer cells with high metastatic potential to peritoneum or lymph nodes. Cancer Res 61(3):889-95 Husgafvel-Pursiainen K, Boffetta P, Kannio A, Nyberg F, Pershagen G, Mukeria A, Constantinescu V, Fortes C, Benhamou S. 2000. p53 mutations and exposure to environmental tobacco smoke in a multicenter study on lung cancer. Cancer Res 60(11):2906-11 Jin C, Wang F, Wu X, Yu C, Luo Y, McKeehan WL. 2004. Directionally specific paracrine communication mediated by epithelial FGF9 to stromal FGFR3 in two-compartment premalignant prostate tumors. Cancer Res 64(13):4555-62 Kanda T, Iwasaki T, Nakamura S, Kurokawa T, Ikeda K, Mizusawa H. 2000. Self-secretion of fibroblast growth factor-9 supports basal forebrain cholinergic neurons in an autocrine/paracrine manner. Brain Res 876(1-2):22-30 Kanda T, Iwasaki T, Nakamura S, Ueki A, Kurokawa T, Ikeda K, Mizusawa H. 1999. FGF-9 is an autocrine/paracrine neurotrophic substance for spinal motoneurons. Int J Dev Neurosci 17(3):191-200 Kassie F, Sundermann VM, Edenharder R, Platt KL, Darroudi F, Lhoste E, Humbolt C, Muckel E, Uhl M, Kundi M, Knasmuller S. 2003. Development and application of test methods for the detection of dietary constituents which protect against heterocyclic aromatic amines. Mutat Res 523-524:183-92 Kathpalia VP, Mussak EN, Chow SS, Lam PH, Skelley N, Time M, Markelewicz RJ Jr, Kanduc D, Lomas L, Xiang Z, Sinha AA. 2006. Genome-wide transcriptional profiling in human squamous cell carcinoma of the skin identifies unique tumor-associated signatures. J Dermatol 33(5):309-18 Klein RD, Maliner-Jongewaard MS, Udayakumar TS, Boyd JL, Nagle RB, Bowden GT. 1999. Promatrilysin expression is induced by fibroblast growth factors in the prostatic carcinoma cell line LNCaP but not in normal primary prostate epithelial cells. Prostate 41(4):215-23 Ko YC, Lee CH, Chen MJ, Huang CC, Chang WY, Lin HJ, Wang HZ, Chang PY. 1997. Risk factors for primary lung cancer among non-smoking women in Taiwan. Int J Epidemiol 26(1):24-31 Koo LC, Ho JH. 1990. Worldwide epidemiological patterns of lung cancer in nonsmokers. Int J Epidemiol 19 Suppl 1:S14-23 Kuo ML, Jee SH, Chou MH, Ueng TH. 1998. Involvement of oxidative stress in motorcycle exhaust particle-induced DNA damage and inhibition of intercellular communication. Mutat Res 413(2):143-50 Laemmli UK. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227(5259):680-5 Lam WK. 2005. Lung cancer in Asian women—the environment and genes. Respirology 10: 408–417 Lee CC, Liao JW, Kang JJ. 2004. Motorcycle exhaust particles induce airway inflammation and airway hyperresponsiveness in BALB/C mice. Toxicol Sci 79(2):326-34 Li S, Pan D, Wang G. 1994. Analysis of polycyclic aromatic hydrocarbons in cooking oil fumes. Arch Environ Health 49(2):119-22 Lin P, Chang H, Tsai WT, Wu MH, Liao YS, Chen JT, Su JM. 2003. Overexpression of aryl hydrocarbon receptor in human lung carcinomas. Toxicol Pathol 31(1):22-30 Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the Folin phenol reagent. J Biol Chem 193(1):265-75 Luch A. 2005. Nature and nurture - lessons from chemical carcinogenesis. Nat Rev Cancer 5(2):113-25 Mastrangelo G, Fadda E, Marzia V. 1996. Polycyclic aromatic hydrocarbons and cancer in man. Environ Health Perspect 104(11):1166-70 Matsumoto-Yoshitomi S, Habashita J, Nomura C, Kuroshima K, Kurokawa T. 1997 Autocrine transformation by fibroblast growth factor 9 (FGF-9) and its possible participation in human oncogenesis. Int J Cancer 71(3):442-50 Matsumoto-Yoshitomi S, Kuroshima K, Nomura C, Habashita J, Kurokawa T. 1996. Construction of a sensitive enzyme immunoassay for human fibroblast growth factor 9. Hybridoma 15(4):299-305 Melchiori A, Colacci A, Lollini PL, De Giovanni C, Carlone S, Grilli S, Parodi S, Albini A. 1992. Induction of invasive and experimental metastasis potential in BALB/c 3T3 cells by benzo(a)pyrene transformation. Invasion Metastasis 12(1):1-11. Miller ME, Holloway AC, Foster WG. 2005. Benzo-[a]-pyrene increases invasion in MDA-MB-231 breast cancer cells via increased COX-II expression and prostaglandin E2 (PGE2) output. Clin Exp Metastasis 22(2):149-56 Miyagi N, Kato S, Terasaki M, Shigemori M, Morimatsu M. 1998. Fibroblast growth factor-2 and -9 regulate proliferation and production of matrix metalloproteinases in human gliomas. Int J Oncol 12(5):1085-90 Miyakawa K, Hatsuzawa K, Kurokawa T, Asada M, Kuroiwa T, Imamura T. 1999. A hydrophobic region locating at the center of fibroblast growth factor-9 is crucial for its secretion. J Biol Chem 274(41):29352-7 Miyamoto M, Naruo K, Seko C, Matsumoto S, Kondo T, Kurokawa T. 1993. Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property. Mol Cell Biol 13(7):4251-9 Mosmann T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65(1-2):55-63 Mountain CF. 1997. Revisions in the International System for Staging Lung Cancer. Chest 111:1710–1717 Nakamura S, Todo T, Haga S, Aizawa T, Motoi Y, Ueki A, Kurokawa T, Ikeda K. 1997. Motor neurons in human and rat spinal cord synthesize fibroblast growth factor-9. Neurosci Lett 221(2-3):181-4 Nakamura S, Todo T, Motoi Y, Haga S, Aizawa T, Ueki A, Ikeda K. 1999. Glial expression of fibroblast growth factor-9 in rat central nervous system. Glia 28(1):53-65 Naruo K, Seko C, Kuroshima K, Matsutani E, Sasada R, Kondo T, Kurokawa T. 1993. Novel secretory heparin-binding factors from human glioma cells (glia-activating factors) involved in glial cell growth. Purification and biological properties. J Biol Chem 268(4):2857-64 Nash MA, Ferrandina G, Gordinier M, Loercher A, Freedman RS. 1999. The role of cytokines in both the normal and malignant ovary. Endocr Relat Cancer 6(1):93-107 Omoto Y, Kobayashi Y, Nishida K, Tsuchiya E, Eguchi H, Nakagawa K, Ishikawa Y, Yamori T, Iwase H, Fujii Y, Warner M, Gustafsson JA, Hayashi SI. 2001. Expression, function, and clinical implications of the estrogen receptor beta in human lung cancers. Biochem Biophys Res Commun 285(2):340-7 Ornitz DM, Itoh N. 2001. Fibroblast growth factors. Genome Biol 2(3):REVIEWS 3005,1-12 Patten Hitt E, DeLong MJ, Merrill AH Jr. 2002. Benzo(a)pyrene activates extracellular signal-related and p38 mitogen-activated protein kinases in HT29 colon adenocarcinoma cells: involvement in NAD(P)H:quinone reductase activity and cell proliferation. Toxicol Appl Pharmacol 183(3):160-7 Pfeifer GP, Denissenko MF, Olivier M, Tretyakova N, Hecht SS, Hainaut P. 2002. Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers. Oncogene 21(48):7435-51 Pillai MC, Vines CA, Wikramanayake AH, Cherr GN. 2003. Polycyclic aromatic hydrocarbons disrupt axial development in sea urchin embryos through a beta-catenin dependent pathway. Toxicology 186(1-2):93-108 Plowright EE, Li Z, Bergsagel PL, Chesi M, Barber DL, Branch DR, Hawley RG, and Stewart AK. 2000. Ectopic expression of fibroblast growth factor receptor 3 promotes myeloma cell proliferation and prevents apoptosis. Blood 95, 992–998 Qu YH, Xu GX, Zhou JZ, Chen TD, Zhu LF, Shields PG, Wang HW, Gao YT. 1992. Genotoxicity of heated cooking oil vapors. Mutat Res 298(2):105-11 Reiners JJ Jr, Lee JY, Clift RE, Dudley DT, Myrand SP. 1998. PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase. Mol Pharmacol 53(3):438-45 Revest JM, DeMoerlooze L, Dickson C. 2000. Fibroblast growth factor 9 secretion is mediated by a non-cleaved amino-terminal signal sequence. J Biol Chem 275(11):8083-90 Rosen EM, Zitnik RJ, Elias JA, Bhargava MM, Wines J, Goldberg ID. 1993. The interaction of HGF-SF with other cytokines in tumor invasion and angiogenesis. EXS 65:301-10 Safe S. 2001. Molecular biology of the Ah receptor and its role in carcinogenesis. Toxicol Lett 120(1-3):1-7 Sallenave JM, Silva A, Marsden ME, Ryle AP. 1993. Secretion of mucus proteinase inhibitor and elafin by Clara cell and type II pneumocyte cell lines. Am J Respir Cell Mol Biol 8(2):126-33 Schaefer KL, Wai DH, Poremba C, Korsching E, van Valen F, Ozaki T, Boecker W, Dockhorn-Dworniczak B. 2002. Characterization of the malignant melanoma of soft-parts cell line GG-62 by expression analysis using DNA microarrays. Virchows Arch 440(5):476-84 Sheehan D, Meade G, Foley VM, Dowd CA. 2001. Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily. Biochem J 360(Pt 1):1-16 Shibazaki M, Takeuchi T, Ahmed S, Kikuchi H. 2004. Suppression by p38 MAP kinase inhibitors (pyridinyl imidazole compounds) of Ah receptor target gene activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin and the possible mechanism. J Biol Chem 279(5):3869-76 Shields PG, Xu GX, Blot WJ, Fraumeni JF Jr, Trivers GE, Pellizzari ED, Qu YH, Gao YT, Harris CC. 1995. Mutagens from heated Chinese and U.S. cooking oils. J Natl Cancer Inst 87(11):836-41 Shimizu Y, Nakatsuru Y, Ichinose M, Takahashi Y, Kume H, Mimura J, Fujii-Kuriyama Y, Ishikawa T. 2000. Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor. Proc Natl Acad Sci 97(2):779-82 Simpson FG, Belfield PW, Cooke NJ. 1985. Chronic airflow limitation after inhalation of overheated cooking oil fumes. Postgrad Med J 61(721):1001-2 Song J, Slack JM. 1996. XFGF-9: a new fibroblast growth factor from Xenopus embryos. Dev Dyn 206(4):427-36 Stabile LP, Davis AL, Gubish CT, Hopkins TM, Luketich JD, Christie N, Finkelstein S, Siegfried JM. 2002. Human non-small cell lung tumors and cells derived from normal lung express both estrogen receptor alpha and beta and show biological responses to estrogen. Cancer Res 62(7):2141-50 Tagashira S, Ozaki K, Ohta M, Itoh N. 1995. Localization of fibroblast growth factor-9 mRNA in the rat brain. Brain Res Mol Brain Res 30(2):233-41 Taioli E, Wynder EL. 1994. Re: Endocrine factors and adenocarcinoma of the lung in women. J Natl Cancer Inst 86(11):869-70 The World Health Organization histological typing of lung tumors. 2nd ed. 1982. Am J Clin Pathol 77:123–136 Thiery JP. 2002. Epithelial mesenchymal transitions in tumor progression. Nat Rev Cancer 2(6):442-454 Tsai SJ, Wu MH, Chen HM, Chuang PC, Wing LY. 2002. Fibroblast growth factor-9 is an endometrial stromal growth factor. Endocrinology 143(7):2715-21 Todo T, Kondo T, Kirino T, Asai A, Adams EF, Nakamura S, Ikeda K, Kurokawa T. 1998. Expression and growth stimulatory effect of fibroblast growth factor 9 in human brain tumors. Neurosurgery 43(2):337-46 Ueng TH, Hu SH, Chen RM, Wang HW, Kuo ML. 2000. Induction of cytochrome P-450 1A1 in human hepatoma HepG2 and lung carcinoma NCI-H322 cells by motorcycle exhaust particulate. J Toxicol Environ Health A 60(2):101-19 Ueng TH, Hung CC, Kuo ML, Chan PK, Hu SH, Yang PC, Chang LW. 2005. Induction of fibroblast growth factor-9 and interleukin-1alpha gene expression by motorcycle exhaust particulate extracts and benzo(a)pyrene in human lung adenocarcinoma cells. Toxicol Sci 87(2):483-96 Ueng TH, Hwang WP, Chen RM, Wang HW, Kuo ML, Park SS, Guengerich FP. 1998. Effects of motorcycle exhaust on cytochrome P-450-dependent monooxygenases and glutathione S-transferase in rat tissues. J Toxicol Environ Health A 54(7):509-27 Ueng TH, Ueng YF, Chen TL, Park SS, Iwasaki M, Guengerich FP. 1993. Induction of cytochrome P450-dependent monooxygenases in hamster tissues by fasting. Toxicol Appl Pharmacol 119(1):66-73 Ueng TH, Wang HW, Huang YP, Hung CC. 2004. Antiestrogenic effects of motorcycle exhaust particulate in MCF-7 human breast cancer cells and immature female rats. Arch Environ Contam Toxicol 46(4):454-62 Ueng TH, Wang HW, Hung CC, Chang HL. 2004. Effects of motorcycle exhaust inhalation exposure on cytochrome P-450 2B1, antioxidant enzymes, and lipid peroxidation in rat liver and lung. J Toxicol Environ Health A 67(11):875-88 US Environmental Protection Agency. Respiratory Health Effects of Passive Smoking: Lung Cancer and Other Disorders. Environmental Protection Agency, Office of Air and Radiation, Washington, DC, 1992. Van Wagoner NJ, Benveniste EN. 1999. Interleukin-6 expression and regulation in astrocytes. J Neuroimmunol 100(1-2):124-39 Vondracek J, Kozubik A, Machala M. 2002. Modulation of estrogen receptor-dependent reporter construct activation and G0/G1-S-phase transition by polycyclic aromatic hydrocarbons in human breast carcinoma MCF-7 cells. Toxicol Sci 70(2):193-201 Wang HW, Chen TL, Yang PC, Ma YC, Yu CC, Ueng TH. 2002. Induction of cytochromes P450 1A1 and 1B1 in human lung adenocarcinoma CL5 cells by frying-meat emission particulate. Food Chem Toxicol 40(5):653-61 Wang HW, Chen TL, Yang PC, Ueng TH. 2001. Induction of cytochromes P450 1A1 and 1B1 by emodin in human lung adenocarcinoma cell line CL5. Drug Metab Dispos 29(9):1229-35 Wang HW, Chen FW, Ueng TH. 2002. Induction of cytochromes P-450 1A1 and 1B1 by motorcycle exhaust particulate in human breast cancer MCF-7 cells. J Toxicol Environ Health A 65(19):1401-17 Wang HW, Ueng TH, Chen TL, Yang PC. 2003. Effect of frying-meat emission particulate on 17beta-estradiol 2- and 4-hydroxylation in human lung adenocarcinoma CL5 cells. J Toxicol Environ Health A 66(12):1175-88. Weaver M, Batts L, Hogan BL. 2003. Tissue interactions pattern the mesenchyme of the embryonic mouse lung. Dev Biol 258(1):169-84 Wen Cheng Y, Lee H. 2003. Environmental exposure and lung cancer among nonsmokers: an example of Taiwanese female lung cancer. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 21(1):1-28 White AC, Xu J, Yin Y, Smith C, Schmid G, Ornitz DM. 2006. FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains. Development 133(8):1507-17 Wing LY, Chen HM, Chuang PC, Wu MH, Tsai SJ. 2005. The mammalian target of rapamycin-p70 ribosomal S6 kinase but not phosphatidylinositol 3-kinase-Akt signaling is responsible for fibroblast growth factor-9-induced cell proliferation. J Biol Chem 280(20):19937-47 Wing LY, Chuang PC, Wu MH, Chen HM, Tsai SJ. 2003. Expression and mitogenic effect of fibroblast growth factor-9 in human endometriotic implant is regulated by aberrant production of estrogen. J Clin Endocrinol Metab 88(11):5547-54 Witschi H, Espiritu I, Peake JL, Wu K, Maronpot RR, Pinkerton KE. 1997. The carcinogenicity of environmental tobacco smoke. Carcinogenesis18(3):575-86 Wu SC, Yen GC, Sheu F. 2001. Mutagenicity and identification of mutagenic compounds of fumes obtained from heating peanut oil. J Food Prot 64(2):240-5 Wu SC, Yen GC. 2004. Effects of cooking oil fumes on the genotoxicity and oxidative stress in human lung carcinoma (A-549) cells. Toxicol In Vitro 18, 571–580 Wu X, Jin C, Wang F, Yu C, McKeehan WL. 2003. Stromal cell heterogeneity in fibroblast growth factor-mediated stromal-epithelial cell cross-talk in premalignant prostate tumors. Cancer Res 63:4936–44 Yang PC, Luh KT, Wu R, Wu CW. 1992. Characterization of the mucin differentiation in human lung adenocarcinoma cell lines. Am J Respir Cell Mol Biol 7(2):161-71 Yasuda M, Ohzeki Y, Shimizu S, Naito S, Ohtsuru A, Yamamoto T, Kuroiwa Y. 1999. Stimulation of in vitro angiogenesis by hydrogen peroxide and the relation with ETS-1 in endothelial cells. Life Sci 64(4):249-58 Yim S, Oh M, Choi SM, Park H. 2004. Inhibition of the MEK-1/p42 MAP kinase reduces aryl hydrocarbon receptor-DNA interactions. Biochem Biophys Res Commun 322(1):9-16 Yoon JH, Smith LE, Feng Z, Tang M, Lee CS, Pfeifer GP. 2001. Methylated CpG dinucleotides are the preferential targets for G-to-T transversion mutations induced by benzo[a]pyrene diol epoxide in mammalian cells: similarities with the p53 mutation spectrum in smoking-associated lung cancers. Cancer Res 61(19):7110-7 Yoshimura A. 2006. Signal transduction of inflammatory cytokines and tumor development. Cancer Sci 97(6):439-47 Zhang X, Stappenbeck TS, White AC, Lavine KJ, Gordon JI, Ornitz DM. 2006 Reciprocal epithelial-mesenchymal FGF signaling is required for cecal development. Development 133(1):173-80 | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/32627 | - |
| dc.description.abstract | 近幾年來，肺癌比例在全球有增加的趨勢。在台灣肺癌為女性癌症死亡的主要原因，流病調查資料顯示廚房油煙(cooking oil fumes, COF)、機車廢氣微粒(motorcycle exhaust particulate, MEP)、環境菸草煙(environmental tobacco smoke)皆為肺癌致病之可能環境因子，而這些因子皆具有的多環芳香烴(polycyclic aromatic hydrocarbons, PAHs)為目前已知環境中最大量具致癌性之單一物質；其中benzo[a]pyrene(BaP)具有強致癌性及強突變性，可作為致癌指標。Fibroblast growth factor 9 (FGF9) 為 FGF家族一員，可調控細胞增生、分化及移動。本研究主要目標在探討 FGF9 與這些環境因子交互作用後，增加肺腺癌的轉移與侵襲能力及其機制。首先利用組織免疫染色觀察肺腺癌病人中(65例) FGF9的表現與分布，結果顯示FGF9只表現於肺腺癌細胞之細胞質中，而正常肺泡細胞則無FGF9表現，並且FGF9表現與淋巴轉移程度具有正相關性。以50 μg/ml COF, 100 μg/ml MEP, 10 μg/ml cigarette smoke extract (CSE), 10 μM BaP, 10 μM trans-trans-2,4- decadienal (DDE)與10 μM 4-(methylnitrosamino)-1-(3- pyridyl)-1-butanone (NNK)處理肺腺癌CL5細胞，分別在6小時後收集RNA及24小時後收集細胞微粒體蛋白觀察FGF9表現。實驗結果顯示，COF、MEP、CSE與BaP可誘導FGF9 mRNA及蛋白表現，但是DDE及NNK則否，可見BaP是環境因子中引起FGF9上升原因之一。而進一步利用mitogen-activated protein kinase抑制劑PD98059與SB202190探討可能誘導機轉，發現BaP及MEP所誘導的FGF9、CYP1A1、IL-1α、IL-6及IL-11可被MEK抑制劑PD98059抑制；而p38 MAP kinase抑制劑SB202190則對被誘導的CYP1A1、CYP1B1、IL-1α、IL-6及IL-11發生抑制作用。在肺腺癌細胞CL5, CL1-0及CL1-5中皆有FGF receptor (FGFR)3IIIc, FGFR2IIIc, FGFR3IIIb及FGFR1IIIc分布。以10 μM BaP處理CL5細胞6小時後則可增加FGFR2IIIc及FGFR3IIIb mRNA的表現。由本研究結果顯示環境汙染物中的PAH類物質BaP是誘發肺腺癌細胞株中FGF9表現的原因之一，而FGF9在肺腺癌中的表現與腫瘤轉移的程度有關，推測環境汙染物可能透由PAHs誘導FGF9而促進肺腺癌侵襲及轉移，藉由本實驗可進一步了解基因與環境因子交互作用在肺癌轉移扮演的可能角色。 | zh_TW |
| dc.description.abstract | Lung cancer is occurring in epidemic proportions worldwide. In recent years, it has been the leading cause of cancer-related mortality in women. Epidemiological studies have indicated that exposures to cooking oil fumes (COF), motorcycle exhaust particulates (MEP), and environmental tobacco smoke (ETS) are environmental factors possibly associated with lung adenocarcinoma in Taiwan. Polycyclic aromatic hydrocarbons (PAHs) are present in these environmental factors. Among these PAHs, benzo[a]pyrene (BaP) is one of the most potent mutagen and carcinogen. Fibroblast growth factor (FGF) 9 belongs to the FGF superfamily which regulates cell differentiation, proliferation and motility. The main hypothesis of this study is that FGF9 gene and environment interaction promotes tumor progression and metastasis in lung adenocarcinoma. The results of immunohistochemistry studies of 65 human lung adenocarcinoma specimens indicated that FGF9 protein expression was moderate to high in lung adenocarcinoma cells but was not detectable in normal lung epithelium and that high FGF9 expression had positive correlation with patients who had advanced lymph node metastasis. Lung adenocarcinoma CL5 cells were treated with 50 μg/ml COF, 100 μg/ml MEP, 10 μg/ml cigarette smoke extract (CSE), 10 μM BaP ,10 μM trans-trans-2,4-decadienal (DDE) and 10 μM 4-(methylnitrosamino)-1-(3- pyridyl)-1-butanone (NNK). After 6 hr, FGF9 mRNA expression was induced by COF, MEP, CSE and BaP. Induction of FGF9 protein was observed after 24 hr. DDE and NNK had no marked effects on FGF9 mRNA or protein expression. To investigate the induction mechanism of FGF9, mitogen-activated protein kinase signaling pathway inhibitors PD98059 and SB202190 were used. Induction of FGF9, CYP1A1, IL-1α, IL-6 and IL-11 by BaP or MEP was suppressed by PD98059. Induction of CYP1A1, CYP1B1, IL-1α, IL-6 and IL-11 by BaP or MEP was suppressed by SB202190. Fgf receptor (FGFR)3IIIc, FGFR2IIIc, FGFR3IIIb and FGFR1IIIc mRNA were detected in lung adenocarcinoma cells CL5, CL1-0 and CL1-5. Treatment of CL5 cells with 10 μM BaP for 6hr increased FGFR2IIIc and FGFR3IIIb mRNA expression. These studies show that BaP of environmental factors is a chemical responsible for FGF9 induction in lung adenocarcinoma cells. Furthermore, FGF9 expression is correlated with advanced lymph node metastasis in lung adenocarcinoma patients. These results indicate that PAH may possibly mediate female lung adenocarcinoma invasion and metastasis through FGF9 induction and also reveal the possible role of gene and environment interaction in lung cancer metastasis. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T04:12:31Z (GMT). No. of bitstreams: 1 ntu-95-R93447002-1.pdf: 1689459 bytes, checksum: ef24ccf7e408fff382dfccd84cbed129 (MD5) Previous issue date: 2006 | en |
| dc.description.tableofcontents | 中文摘要 ------------------------------------------------------------------------------------- 1
英文摘要 ------------------------------------------------------------------------------------- 3 縮寫表 ---------------------------------------------------------------------------------------- 5 第一章、 前言 第一節、 台灣肺癌流行病學之相關研究---------------------------------------------- 6 第二節、 環境因子與肺癌關係 ----------------------------------------------------------- 7 第三節、 Polycyclic aromatic hydrocarbons (PAHs)的毒性---------------------------12 第四節、 Fibroblast growth factor (FGF) 9介紹 --------------------------------------- 13 第五節、 Fibroblast growth factor (FGF) 9與癌症之相關性 ------------------------ 17 第六節、 研究目的-------------------------------------------------------------------------- 20 第二章、 研究方法與步驟 第一節、 實驗材料-------------------------------------------------------------------------- 22 第二節、 實驗方法-------------------------------------------------------------------------- 26 第三章、 結果 第一節、 台灣肺腺癌組織FGF9蛋白表現--------------------------------------------- 37 第二節、 COF、MEP、CSE、BaP對婦女肺腺癌CL5細胞FGF9 mRNA表現之影響-------------------------------------------------------------------------------- 39 第三節、 COF、MEP、CSE、BaP對婦女肺腺癌CL5細胞FGF9蛋白層次表現之影響----------------------------------------------------------------------------- 40 第四節、 FGF9 mRNA在肺癌、乳癌、胃癌、肝癌與前列腺癌細胞株表現情況BaP誘導現象-------------------------------------------------------------------- 42 第五節、 FGF receptor在肺癌細胞株、纖維母細胞及單核白血球表現情況------------------------------------------------------------------------------------- 43 第六節、 BaP對婦女肺腺癌CL5細胞株FGF receptor的劑量關係效應------- 45 第七節、 CSE對婦女肺腺癌CL5細胞株代謝活化酵素及細胞激素mRNA之誘導現象----------------------------------------------------------------------------- 46 第八節、 MAP kinase pathway抑制劑對婦女肺腺癌CL5細胞株細胞毒性之影響-------------------------------------------------------------------------------------- 47 第九節、 BaP、MEP對CL5細胞FGF9基因誘導作用機制之探討--- ---------- 48 第四章、 討論 第一節、 多環芳香烴對FGF9表現之影響--------------------------------------------- 51 第二節、 多環芳香烴誘導FGF9表現之機制探討------------------------------------ 56 第三節、 結論------------------------------------------------------------------------------ 65 參考文獻--------------------------------------------------------------------------------------- 67 圖表--------------------------------------------------------------------------------------------- 85 | |
| dc.language.iso | zh-TW | |
| dc.subject | 肺腺癌 | zh_TW |
| dc.subject | 纖維母細胞生長因子9 | zh_TW |
| dc.subject | 多環芳香烴 | zh_TW |
| dc.subject | polycyclic aromatic hydrocarbons | en |
| dc.subject | fibroblast growth factor 9 | en |
| dc.subject | lung adenocarcinoma | en |
| dc.title | 多環芳香烴對人類肺腺癌細胞株纖維母細胞生長因子9之誘導作用 | zh_TW |
| dc.title | Induction of fibroblast growth factor 9 by polycyclic aromatic hydrocarbons in human lung adenocarcinoma cells | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 94-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 陳大樑,陳瑞明,翁芸芳 | |
| dc.subject.keyword | 多環芳香烴,肺腺癌,纖維母細胞生長因子9, | zh_TW |
| dc.subject.keyword | polycyclic aromatic hydrocarbons,lung adenocarcinoma,fibroblast growth factor 9, | en |
| dc.relation.page | 103 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2006-07-26 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 毒理學研究所 | zh_TW |
| 顯示於系所單位： | 毒理學研究所 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-95-1.pdf 未授權公開取用 | 1.65 MB | Adobe PDF |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。