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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 廖永豐(Yung-Feng Liao) | |
dc.contributor.author | Lan-Hsin Kuo | en |
dc.contributor.author | 郭嵐忻 | zh_TW |
dc.date.accessioned | 2021-06-13T03:18:45Z | - |
dc.date.available | 2008-08-01 | |
dc.date.copyright | 2006-08-01 | |
dc.date.issued | 2006 | |
dc.date.submitted | 2006-07-28 | |
dc.identifier.citation | Aggarwal, B. B. (2003). Signalling pathways of the TNF superfamily: a double-edged sword. Nat Rev Immunol 3, 745-756.
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Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease. J Neurochem 76, 435-441. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/31733 | - |
dc.description.abstract | Amyloid-β precursor protein (APP)經過β-secretase和γ-secretase相繼作用後產生Amyloid-β (Aβ),是阿茲海默症致病機制中非常重要的一步。γ-secretase是負責在APP的transmembrane domain執行最後一步的蛋白水解反應,許多研究都認為這是阿茲海默症致病機制中最關鍵的ㄧ步。近來已有證據顯示γ-secretase為一個由presenilin (PS)、nicastrin (NCT)、Aph-1和Pen-2所組成的多蛋白複合體,且此四種蛋白的完善組合為其酵素活性的充要條件。先前的證據已指出一些cytokines能夠刺激γ-secretase的活性,其中又以tumer necrosis factor-α (TNF-α)最為有效。在最初的研究中,我們發現TNF-α透過JNK-dependent MAPK pathway活化γ-secretase,我們接著想看看cytokines對於γ-secretase的調控是否來自於JNK對於此蛋白水解酶的磷酸化所做的改變。為了提高對於γ-secretase磷酸化改變的解析度,我們建立了一細胞株大量表現有His-tag的NCT,以及正常的PS1、Aph-1、Pen-2和APP,因此可以用HIS-SelectedTM Cobalt Affinity Gel有效地純化整個γ-secretase複合體。在此,我們提出一些證據顯示TNF-α透過JNK促進PS1和NCT上的serine/threonine的磷酸化程度,同時活化γ-secretase;若用JNK的抑制劑─SP600125抑制JNK的活性,則會減低TNF-α對於PS1和NCT所引起的磷酸化。再者,活化的JNK能夠與γ-secretase一起被純化出來,並且活化的JNK可以在體外實驗中促進PS1和NCT的磷酸化。我們接著在PS1上找到一可能由JNK所調控的磷酸化位置,擁有此PS1突變的細胞表現出降低的γ-secretase活性。由我們的發現可以推論在TNF-α所引起γ-secretase的磷酸化中,JNK為其細胞中一重要的調停者,可能藉由直接與γ-secreatase相互作用來達到調控其鄰酸化程度與活性的目的。 | zh_TW |
dc.description.abstract | Amyloid-β (Aβ), which is generated through β- and γ-secretase-mediated proteolysis of amyloid precursor protein (APP), plays a critical role in the pathogenesis of Alzheimer’s disease (AD). γ-Secretase which cleaves Amyloid-β precursor protein (APP) in its transmembrane domain catalyzes the final proteolytic step in the generation of Aβ. Recent evidence has demonstrated that γ-secretase is a multiprotein complex composed of presenilin (PS), nicastrin (NCT), Aph-1 and Pen-2 and that all four proteins are essential and sufficient for the proteolytic activity of γ-secretase. Previous evidence has shown that several cytokines can stimulate γ-secretase activity, and tumor necrosis factor-α (TNF-α) is the most potent one. In this study, we initially show that TNF-α activates γ-secretase via a JNK-dependent MAPK pathway. We then seek to determine whether this cytokine-elicited regulation of γ-secretase is due to alteration in the JNK-dependent phosphorylation of this protease. To improve the efficiency on visualizing the alteration in phosphorylation of γ-secretase, we have generated a CHO-derived cell line (γNCT-36) that stably co-expresses a His-tagged NCT along with PS1, Aph-1, Pen-2 and APP. The complexes of γ-secretase can then be efficiently pulled down by HIS-SelectedTM Cobalt Affinity Gel through the affinity of His-tagged NCT. Here, we present evidence that TNF-α elicits JNK-dependent serine/threonine phosphorylation of PS1 and NCT in γNCT-36 cells, concomitant with the stimulation of γ-secretase activity. Blocking JNK activity with a potent JNK inhibitor (SP600125) can reduce TNF-α-triggered phosphorylation of PS1 and NCT. Consistently, the activated JNK can be co-purified with γ-secretase complexes, and promotes the phosphorylation of PS1 and NCT in an in vitro kinase assay. A putative JNK-induced phosphorylation site of PS1 has been identified, and cells harboring this PS1 mutant exhibit decreased γ-secretase activity. Our findings suggest that JNK is an intracellular mediator of TNF-α-elicited phosphorylation of γ-secretase and may directly interact with γ-secretase to modulate its phosphorylation levels and hence its activity. | en |
dc.description.provenance | Made available in DSpace on 2021-06-13T03:18:45Z (GMT). No. of bitstreams: 1 ntu-95-R93b41004-1.pdf: 1639290 bytes, checksum: c0ed29ce1b2462a7a8154647e20bdf09 (MD5) Previous issue date: 2006 | en |
dc.description.tableofcontents | 摘要 1
ABSTRACT 2 CONTENTS 4 APPENDIX OF TABLE 6 APPENDIX OF FIGURE 6 INTRODUCTION 7 MATERIAL AND METHODS 14 RESULT 22 DISCUSSION 30 REFERENCE 38 TABLE 51 FIGURE 52 | |
dc.language.iso | en | |
dc.title | TNF-α經由活化JNK MAPK pathway增強γ-secretase活性分子機制之研究 | zh_TW |
dc.title | TNF-α enhances serine/threonine phosphorylation of γ-secretase via a JNK-dependent MAPK pathway | en |
dc.type | Thesis | |
dc.date.schoolyear | 94-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 陳俊宏(Jiun-Hong Chen),黃偉邦(Wei-Pang Huang) | |
dc.subject.keyword | 阿茲海默氏症,老年癡呆症, | zh_TW |
dc.subject.keyword | gamma-secretase,JNK,TNF-alpha, | en |
dc.relation.page | 65 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2006-07-30 | |
dc.contributor.author-college | 生命科學院 | zh_TW |
dc.contributor.author-dept | 動物學研究研究所 | zh_TW |
顯示於系所單位: | 動物學研究所 |
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