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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 王敏瑩(Man-Ying Wong) | |
| dc.contributor.author | Ruey-Cherng Yu | en |
| dc.contributor.author | 俞瑞成 | zh_TW |
| dc.date.accessioned | 2021-06-13T03:15:39Z | - |
| dc.date.available | 2007-08-04 | |
| dc.date.copyright | 2006-08-04 | |
| dc.date.issued | 2006 | |
| dc.date.submitted | 2006-07-31 | |
| dc.identifier.citation | Albert, M. L., Sauter, B. & Bhardwaj, N. (1998). Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature, 392, 86-89.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/31603 | - |
| dc.description.abstract | 本實驗之目的是探討慢性牙周炎與侵犯型牙周炎的牙周病患與健康受試者相較，其兩種周邊血樹突狀細胞亞群，髓系(myeloid)樹突狀細胞與淋巴系/胞漿系(lymphoid/plasmacytoid)樹突狀細胞比例的差異以及其牙齦下牙菌斑紅色複合體比例的差異。實驗方法是抽取21位慢性牙周炎與26位侵犯型牙周炎病患與22位健康受試者的周邊全血400μl，經由免疫螢光抗體染色，以流式細胞儀分析周邊血中不同樹突狀細胞亞群的比例，再採取受試者牙齦下牙菌斑樣本，以定量聚合酶連鎖反應分析其中紅色複合體的比例，並統計分析三組的差異性以及三種細菌對周邊血樹突狀細胞亞群的影響。實驗結果發現，兩種類型牙周病患與健康對照組相較，侵犯型牙周炎患者的白血球中，周邊血淋巴系樹突狀細胞的比例比慢性牙周病患高。而髓系樹突狀細胞/淋巴系樹突狀細胞的比值則以慢性牙周炎患者的比值最高，但是未達統計上的顯著差異。三種紅色複合體牙周致病菌，Tannerella forsythensis和Treponema denticola在牙齦下牙菌斑的比例，在侵犯型牙周炎組的比例比慢性牙周炎組高，在慢性牙周炎組的比例比健康控制組高， Porphyromonas gingivalis在慢性牙周炎患者與侵犯型牙周炎患者牙齦下牙菌斑的比例，都比健康控制組高，侵犯型牙周炎組和慢性牙周炎組相比較，則沒有顯著差異性。三種紅色複合體牙周致病菌比例對於周邊血樹突狀細胞比例沒有顯著影響。不同類型牙周病患周邊血樹突狀細胞亞群比例的差異，顯示牙周組織遭遇外來致病菌入侵時，除了局部組織的反應外，周邊血與深部淋巴結也可能參與免疫反應對抗外來抗原。 | zh_TW |
| dc.description.abstract | The present study was to evaluate the proportion of peripheral blood dendritic cell (DC) subsets and subgingival red complex in patients with different types of periodontitis. 400μl peripheral blood and subgingival plaque sample was obtained from 22 healthy volunteer, 21 patients with chronic periodontitis and 26 patients with aggressive periodontitis. The proportion of myeloid DC and lymphoid DC was analyzed by flow cytometry. The proportion of red complex was analyzed by Quantitative PCR. The results showed that the lymphoid DC proportion of aggressive periodontitis group was significantly higher than the chronic periodontitis group. The ratio of DC1/DC2 in chronic periodontitis group was higher than other two group. The proportion of Tannerella forsythensis (Bacteroides forsythus) and Treponema denticola in the aggressive periodontitis group was significantly higher than in the chronic periodontitis group. The proportion of these two pathogen in the chronic periodontitis group was significantly higher than the healthy control. The proportion of Porphyromonas gingivalis in both periodontitis group was significantly higher than the healthy control. The present study implicated that the different proportion of the peripheral blood DC in patients with different types of periodontitis reveal peripheral blood and lymphoid tissue may be involved in the immune response to periodontal pathogens challenge. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T03:15:39Z (GMT). No. of bitstreams: 1 ntu-95-R92422012-1.pdf: 861099 bytes, checksum: db5c48ba4b21242cc045dbb379156bac (MD5) Previous issue date: 2006 | en |
| dc.description.tableofcontents | 中文摘要 7
Abstract 9 文獻回顧 11 細菌在牙周病扮演的角色 12 紅色複合體與牙周病的相關性 13 樹突狀細胞與免疫反應 18 樹突狀細胞的種類 23 周邊血中的樹突狀細胞 25 周邊血樹突狀細胞與T細胞反應 28 兩種周邊血樹突狀細胞的功能 29 牙周病與樹突狀細胞的關係 30 牙周致病菌對樹突狀細胞的影響 33 侵犯型牙周炎 36 樹突狀細胞在牙周病所扮演的角色的模型 44 實驗目的 47 實驗材料與方法 48 1. 受試者的選取 48 2. 受試者血液樣本與牙菌斑樣本的選取 48 3. 牙菌斑樣本的處理 49 4. 流式細胞儀測定周邊血樹突狀細胞的數量與比例 50 5. 聚合酶連鎖反應 51 6. 同步定量聚合酶連鎖反應 56 7. 免疫組織化學染色 58 8. 血清中IL-10與IL-12p40細胞激素的測定 59 9. 統計分析 59 實驗結果Results 61 周邊血樹突狀細胞的比例 61 紅色複合體牙周致病菌的盛行率 62 紅色複合體牙周致病菌在牙齦下牙菌斑中所佔的百分比 62 紅色複合體牙周致病菌與周邊血樹突狀細胞的相關性 64 慢性牙周炎病患牙齦下牙菌斑細菌量與周邊血樹突狀細胞的相關性 64 周邊血樹突狀細胞在牙周組織的表現 65 血清中IL-10與IL-12p40細胞激素 66 討論Discussion 67 紅色複合體牙周致病菌的盛行率與牙齦下牙菌斑紅色複合體比例的差異 67 周邊血樹突狀細胞比例和比值的差異 70 紅色複合體致病菌對周邊血樹突狀細胞的影響 75 牙齦組織中周邊血樹突狀細胞的表現 77 血清中IL-10與IL-12p40細胞激素 78 周邊血樹突狀細胞在牙周致病原理的模型之檢討 78 結論 Conclusion 81 圖表 83 圖一：細胞體積大小 (FSC)與細胞顆粒度 (SSC)分布圖。 84 圖二：lin 1與HLA-DR表型分布圖。 84 圖三：CD11c與HLA-DR表型分布圖。 85 圖四：CD123與HLA-DR表型分布圖。 85 圖五：健康受試者、慢性牙周炎與侵犯型牙周炎病患的髓系樹突狀細胞百分比箱型圖 86 圖六：健康受試者、慢性牙周炎與侵犯型牙周炎病患的淋巴系樹突狀細胞百分比的箱型圖 86 圖七：健康受試者、慢性牙周炎與侵犯型牙周炎病患三個組別周邊血髓系比淋巴系樹突狀細胞的比值的箱型圖 87 圖八：T.forsythensis在健康受試者、慢性牙周炎與侵犯型牙周炎病患盛行率 87 圖九：P.gingivalis在健康受試者、慢性牙周炎與侵犯型牙周炎病患的盛行率 88 圖十：T.denticola在健康受試者、慢性牙周炎與侵犯型牙周炎病患的盛行率 88 圖十一：T.forsythensis在健康受試者、慢性牙周炎與侵犯型牙周炎病患牙齦下牙菌斑所的百分比 89 圖十二：P.gingivalis在健康受試者、慢性牙周炎與侵犯型牙周炎病患牙齦下牙菌斑所的百分比 89 圖十三：T.denticola在健康受試者、慢性牙周炎與侵犯型牙周炎病患牙齦下牙菌斑所的百分比 90 圖十四：紅色複合體三種牙周致病菌比例分別與周邊血髓系樹突狀細胞的比例的相關分佈圖 91 圖十五：紅色複合體三種致病菌分別與周邊血淋巴系樹突狀細胞的的相關分佈圖 92 圖十六：三種紅色複合體致病菌比例與周邊血髓系/淋巴系樹突狀細胞的比值的相關分析 93 圖十七：慢性牙周炎病患牙齦下牙菌斑總細菌量與周邊血髓系/淋巴系樹突狀細胞的比例的相關分佈圖 94 圖十八：慢性牙周病患牙齦組織的H&E染色。 95 圖十九：慢性牙周病患#37、#45牙齒牙齦組織的CD11c 及CD234免疫螢光染色 96 圖二十：慢性牙周病患#46牙齦組織CD11c與CD123的免疫螢光染色 97 圖二十一：慢性牙周病患#47牙齦組織CD11c與CD123的免疫螢光染色 98 表一：不同類型牙周炎病患之周邊血髓系及淋巴系樹突狀細胞佔所有白血球的百分比與兩種周邊血樹突狀細胞的比值 99 表二：紅色複合體牙周致病菌在不同類型牙周炎病患的牙齦下牙菌斑中所佔的百分比 99 表三：紅色複合體及慢性牙周炎病患牙齦下牙菌斑細菌總量與周邊血樹突狀細胞的相關性 100 表四：採取牙齦樣本病患之周邊血樹突狀細胞分析 100 參考文獻References 101 | |
| dc.language.iso | zh-TW | |
| dc.subject | 侵犯型牙周炎 | zh_TW |
| dc.subject | 周邊血 | zh_TW |
| dc.subject | 紅色複合體 | zh_TW |
| dc.subject | 樹突狀細胞 | zh_TW |
| dc.subject | dendritic cell | en |
| dc.subject | peripheral blood | en |
| dc.subject | red complex | en |
| dc.subject | aggressive periodontitis | en |
| dc.title | 不同類型牙周病患周邊血樹突狀細胞亞群比例與
其紅色複合體數量的差異 | zh_TW |
| dc.title | Proportion of peripheral blood dendritic cell subsets and
red complex in patients with different types of periodontitis | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 94-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.coadvisor | 江伯倫(Bor-Luen Chiang) | |
| dc.contributor.oralexamcommittee | 周幸華 | |
| dc.subject.keyword | 樹突狀細胞,周邊血,紅色複合體,侵犯型牙周炎, | zh_TW |
| dc.subject.keyword | dendritic cell,peripheral blood,red complex,aggressive periodontitis, | en |
| dc.relation.page | 109 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2006-07-31 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 臨床牙醫學研究所 | zh_TW |
| 顯示於系所單位： | 臨床牙醫學研究所 | |
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