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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/30876完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 劉謙美,侯連團 | |
| dc.contributor.author | Chin-hua Li | en |
| dc.contributor.author | 李錦華 | zh_TW |
| dc.date.accessioned | 2021-06-13T02:19:09Z | - |
| dc.date.available | 2010-02-13 | |
| dc.date.copyright | 2007-02-13 | |
| dc.date.issued | 2007 | |
| dc.date.submitted | 2007-01-31 | |
| dc.identifier.citation | Aichelmann-Reidy ME, Heath CD, Reynolds MA. Clinical evaluation of calcium sulfate in combination with demineralized freeze-dried bone allograft for the treatment of human intraosseous defects. J Periodontol 2004; 75:340-7.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/30876 | - |
| dc.description.abstract | Background: Alveolar bone resorption in patients with periodontal disease is an important issue for future implant therapy, there is little information about the dimensional changes of alveolar ridge following tooth extraction. The purposes of this study are to investigate 1) the effectiveness of either calcium sulfate or collagen material for ridge preservation in extraction sockets by measuring the changes of alveolar bone height and width clinically; and 2) the histologic outcome of calcium sulfate. Methods: 21 single root tooth extraction sites were selected and randomly assigned to calcium sulfate group (7 sites), collagen plug group (7 sites), and control group (7 sites). An occlusal stent was fabricated to measure the changes of alveolar height and width (at 3 and 5 mm level below alveolar crest). The measurements, right after extraction, of the alveolar bone height and width were compared with those data at 1, 2, and 4 months postoperatively. Two representative cases with control and treated teeth were selected for histologic analysis of socket healing after ridge preservation. At each time point post-extraction, a trephine core was harvested from the extraction site for histologic analysis. Results: Clinically, sockets augmented with either calcium sulfate or collagen plug showed better hemostasis and more rapidly epithelialization than control during early period of wound healing. Calcium sulfate group exhibited less shrinkage of the alveolar bone height at 1 month postoperatively than other two groups (1.8 mm vs. 2.5 mm), especially at the mid-buccal aspect. However, there were no significant changes of bone width at 2 levels of measurements among three groups at 1, 2, and 4 months postoperatively. Histologically, new bone formation was noted in all specimens. There were still a few residual particles remained in the calcium sulfate group, while the extent of new bone formation was similar at one month’s specimens. At two month’s follow-up, the volume of new bone increased in both groups. Conclusion: Both calcium sulfate and collagen plug had good wound healing of extraction sockets. Besides, therapy with calcium sulfate seemed to have some benefit to prevent the ridge collapse after extraction at limited period of the present study. Based on histological data, calcium sulfate might be a good bone substitute for ridge preservation in extraction sockets because it was completely resorbed shortly after implantation and did not interfere with the healing of extraction sockets. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T02:19:09Z (GMT). No. of bitstreams: 1 ntu-96-R92422013-1.pdf: 1031437 bytes, checksum: 6979adb74c32e276499a089216a638eb (MD5) Previous issue date: 2007 | en |
| dc.description.tableofcontents | Contents
Abstract 1 Literature Review 3 I. Ridge Preservation Following Tooth Extraction 3 A. Dimensional change after tooth extraction 3 B. Defect classification 4 C. The natural healing of extraction socket 6 D. Ridge preservation techniques 7 E. Conclusion 20 II. Calcium Sulfate 21 A. Mechanism of calcium sulfate 23 B. Histologic analysis of calcium sulfate 26 C. Clinical applications of calcium sulfate 30 D. Conclusion 39 III. Collagen Plug 40 Experimental Purpose 42 Experimental Study 43 I. Evaluation of medical calcium sulfate in ridge preservation after extraction — clinical analysis 43 A. Introduction 43 B. Materials and Methods 45 C. Results 53 D. Discussion 60 E. Conclusion 69 II. Evaluation of medical calcium sulfate in ridge preservation after extraction — histological analysis 71 A. Introduction 71 B. Materials and Methods 71 C. Results 77 D. Discussion 79 E. Conclusion 80 Tables and Illustrations List of tables Literature Review Table 1 Time sequence of extraction socket healing 81 Table 2 Bone score 82 Experimental Study I Table 1 Selection criteria of graft materials 83 Table 2-1. Changes of alveolar bone width of extraction site at 1 month post-extraction 84 Table 2-2. Changes of alveolar bone width of extraction site at 2 month post-extraction 85 Table 2-3. Changes of alveolar bone width of extraction site at 4 month post-extraction 86 Table 3. ANOVA test 87 Table 4-1. Accumulated loss of alveolar bone height at 1 month post-extraction 88 Table 4-2. Accumulated loss of alveolar bone height at 1 month post-extraction 89 Table 4-3. Accumulated loss of alveolar bone height at 1 month post-extraction 90 Table 5. Multiple regression (analysis of variables related to bone height loss after tooth extraction) 87 Table 6-1. Pearson correlation coefficients of Bone height loss and Bone thickness 91 Table 6-2. Pearson correlation coefficients of Bone height loss and Soft tissue thickness-3mm 91 Table 7-1. Pearson correlation coefficients of Bone height loss and Bone thickness (only buccal aspect) 92 Table 7-2. Pearson correlation coefficients of Bone height loss and Soft tissue thickness-3mm (only buccal aspect) 92 Table 8-1. Comparison of extraction alone studies resorpting horizontal ridge changes 93 Table 8-2. Comparison of extraction alone studies resorpting vertical ridge changes 94 Table 8-3. Comparison of ridge preservation studies resorpting horizontal and vertical ridge changes 95 Experimental Study II Table 1. Patient’s data and study design 96 Table 2. Histomorphometric analysis 96 List of figures Experimental Study I Fig. 1 Stent design 97 Fig. 2 Illustration of six reference points 97 Fig. 3 Measurement of soft tissue dimension 98 Fig. 4 Measurement of height of alveolar bone 98 Fig. 5 Measurement of width of alveolar bone 99 Fig. 6 Illustration of measurement of alveolar bone width 99 Fig. 7 Illustration of measurement of alveolar bone width 100 Fig. 8-1 Clinical appearance. (CS and TER) 100 Fig. 8-2 Clinical appearance. (Control) 101 Fig. 9-1 Radiographic examination. (CS and TER) 101 Fig. 9-2 Radiographic examination. (Control) 102 Fig. 10-1 Accumulative loss of alveolar bone height at 2 mm mesial to mid-buccal point (BM2). 102 Fig. 10-2 Accumulative loss of alveolar bone height at mid-buccal point (BM). 103 Fig. 10-3 Accumulative loss of alveolar bone height at 2 mm distal to mid-buccal point (BD2). 103 Fig. 11 More pronounced resorption at the middle point (BM) than the adjacent two points (B2M and B2D) at one month post-extraction. 104 Fig. 12 Calcium sulfate (CS) group have significant less loss of alveolar bone height only during the first month at the middle point of buccal aspect (BM). 104 Experimental Study II Fig. 1 Periapical X-ray of patient A. 105 Fig. 2 Periapical X-ray of patient B. 105 Fig. 3 Overview of the bone biopsy (central portion) of patient A. H&E stain 106 Fig 3-d 106 Fig. 4 Overview of the bone biopsy (central portion) of patient B. H&E stain. 107 Fig. 5 Overview of the bone biopsy (central portion) of patient A. Goldner’s Masson trichrome stain 107 Fig. 6 Overview of the bone biopsy (central portion) of patient B. Goldner’s Masson trichrome stain 108 References 109 | |
| dc.language.iso | en | |
| dc.title | 評估醫用硫酸鈣在拔牙後齒槽嵴保存之效果—臨床比較與組織分析 | zh_TW |
| dc.title | Evaluation of medical calcium sulfate in ridge preservation after extraction— clinical and histologic analysis | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 95-1 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 傅鍔 | |
| dc.subject.keyword | 硫酸鈣,齒槽嵴,保存,骨粉,拔牙槽, | zh_TW |
| dc.subject.keyword | calcium sulfate,ridge preservation,tooth extraction,bone substitutes,extraction socket, | en |
| dc.relation.page | 119 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2007-01-31 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 臨床牙醫學研究所 | zh_TW |
| 顯示於系所單位： | 臨床牙醫學研究所 | |
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