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標題: | 面迴訊氫原子核磁振頻譜影像技術之發展及應用 Proton-Echo-Planar-Spectroscopy-Imaging (PEPSI): Developments and Applications |
作者: | Shang-Yueh Tsai 蔡尚岳 |
指導教授: | 鍾孝文(Hsiao-Wen Chung) |
關鍵字: | 磁核共振頻譜,面迴訊氫原子核頻譜影像,平行影像,高單位陣列線圈,自旋自旋遲緩時間, MRS,PEPSI,Parallel imaging,large-N array coils,T2 relaxation time., |
出版年 : | 2007 |
學位: | 博士 |
摘要: | 利用氫原子核磁振頻譜來量測腦部代謝物可以幫助臨床預先及診斷。面回訊頻譜影像技術是一種快速磁振頻譜影像技術,相較於傳統的頻譜影像技術,取像時間可以縮短到一分鐘左右,因此大大的改善了頻譜影像技術於臨床使用上的限制。在這篇論文中,我們在不同磁場強度的臨床機器上實現了這個面回訊頻譜技術,同時將此技術和多線圈平行影像的技術結合,使頻譜影像的擷取時間可以更加縮短;實驗結果證明,這兩種技術的結合,可以讓取像時間更加縮短到數十秒鐘的時間解析度;同時,使用目前最新發展的高單位陣列線圈,可以達到更高的時間解析度。由於面回訊技術可以大大的減低取像時間,我們利用這個技術去量測代謝物的自旋自旋遲緩時間的影像,結果顯示我們提出的程序可以在臨床使用許可的時間內,量測到相當準確及可信的數據,具有臨床使用的可能性。 Magnetic Resonance Spectroscopy (MRS) has been used for almost three decades to investigate the living tissue for prognostic or diagnostic markers. Fast magnetic resonance spectroscopy imaging technique, PEPSI, can reduce the long scan time of conventional SI to a single minute, which significantly raise the clinical potential of SI. In this thesis, a PEPSI sequence suitable for general clinical application has been implemented on the clinical machine at various field strengths. We investigate the possibility to combine PEPSI with parallel imaging techniques to further improve the temporal resolution of SI. The experiments showed that the parallel acceleration on PEPSI is feasible with the enrollment of multiple array coils to achieve sub-minute measurement. With the current developed large-N array coils, the temporal resolution of SI can be further reduce. Beneficial from the fast property of PEPSI technique, spatial distributed metabolite T2 relaxation time can be derived in clinical acceptable time. Consistent and reliable results were observed using the proposed protocol based on PEPSI sequence. The acquisition of less than 30 minutes is potentially applicable in clinical practice. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/30780 |
全文授權: | 有償授權 |
顯示於系所單位: | 電機工程學系 |
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