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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/29823完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 蔡睿哲 | |
| dc.contributor.author | Chun-Ming Wu | en |
| dc.contributor.author | 吳峻名 | zh_TW |
| dc.date.accessioned | 2021-06-13T01:20:21Z | - |
| dc.date.available | 2007-07-20 | |
| dc.date.copyright | 2007-07-20 | |
| dc.date.issued | 2007 | |
| dc.date.submitted | 2007-07-19 | |
| dc.identifier.citation | [1] C. -W. Sun, Probing Biological Tissues and Phantoms with Quasi-coherent Polarized Light Based on Ultrafast Lasers, Ph.D thesis, National Taiwan University, R.O.C., 2003
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Beuthan, Near-infrared diffuse optical tomography, Disease Markers, Vol. 18, p. 313–337, 2002, IOS Press [13] http://www.hitachimed.com/contentindex.asp?ID=221 [14] Daqing Piao, Brian W. Pogue, Rapid near-infrared diffuse tomography for 50 hemodynamic imaging using a low-coherence wideband light source, Journal of Biomedical Optics, Vol. 12(1), 014016 (January/February 2007) [15] Daqing Piao, Hao Xie, Weili Zhang, Jerzy S. Krasinski, Guolong Zhang, Hamid Dehghani, and Brian W. Pogue, Endoscopic, rapid near-infrared optical tomography, OPTICS LETTERS, Vol. 31, No. 19, p. 2876, October 1, 2006 [16] Claudia Casavola Lelia, Adelina Paunescu, Sergio Fantini, Enrico Gratton, Blood flow and oxygen consumption with near-infrared spectroscopy and venous occlusion: spatial maps and the effect of time and pressure of inflation, Journal of Biomedical Optics, Vol. 5(3), 269–276 (July 2000) [17] Danny K. Joseph, Theodore J. Huppert, Maria Angela Franceschini, and David A. Boas, Diffuse optical tomography system to image brain activation with improved spatial resolution and validation with functional magnetic resonance imaging, APPLIED OPTICS, Vol. 45, No. 31, p. 8142, 1 November 2006 [18] Brian W. Pogue, Shudong Jiang, Hamid Dehghani, Christine Kogel, Sandra Soho, Subhadra Srinivasan, Xiaomei Song, Tor D. Tosteson, Steven P. Poplack, Keith D. Paulsen, Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes, Journal of Biomedical Optics, Vol. 9(3), 541–552 (May/June 2004) [19] Troy O. McBride, Brian W. Pogue, Steven Poplack, Sandra Soho, Wendy A. Wells, Shudong Jiang, Ulf L. O ぴ sterberg, Keith D. 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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/29823 | - |
| dc.description.abstract | 本篇論文中設計了一套擴散光學斷層掃瞄術的系統，擴散光學斷層掃瞄術是利用近紅外光來觀測生物體內吸收係數、散射係數分佈的一套技術，能精確地描繪出生物組織中含氧血紅素、缺氧血紅素濃度以及血氧飽和度的變化狀態。
以軟性電路板作為主要的底材，將光源與光偵測器以棋盤式的幾何位置安置於其上，利用時間多工的方式使光源輪流發亮，再擷取光檢測器上的光強度作為影像重建的資料來源。 文中對健康的案例及一些加護病房中的病患做了一些生理量測實驗，主要是在靜脈束縛的觀察上，得到的實驗數據與真實的生理資訊有相當程度的對應性，且在特定病例上能看出與常人的差異性。 | zh_TW |
| dc.description.abstract | Diffuse optical tomography (DOT) is the technique that probes and images spatial variations in absorption and scattering properties of the biological tissues. DOT can accurately measure simultaneous changes in concentrations of oxy-hemoglobin and deoxy-hemoglobin. The oxygenation images have been reconstructed by the measured hemodynamics signals with nearest-neighbor pairs of sources and detectors. In our study, a portable DOT system is built with optode design on flexible print circuit board (PCB). The DAQ card is used to PC connection for multiplex driving of laser diodes and detected signal process form photodiodes on optode in DOT system.
In this thesis, the principles and systematic designs of DOT are demonstrated. In experiments, the excise and vessel occlusion hemodynamics are observed with in vivo measurements form normal subjects and some patients in intensive care unit. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T01:20:21Z (GMT). No. of bitstreams: 1 ntu-96-R94941067-1.pdf: 3966330 bytes, checksum: 903d230baee3044dec0c215c0eda2b25 (MD5) Previous issue date: 2007 | en |
| dc.description.tableofcontents | 誌謝……………………………………………………………….i
摘要………………………………………………………………ii Abstract………………………………………………………….iii 目錄……………………………………………………………...iv 圖目錄…………………………………………………………..vii 表目錄…………………………………………………………...ix 第一章 緒論……………………………………………………1 1.1 生醫影像技術………………………………………………..….1 1.1.1 X射線輻射造影技術……………………………………...1 1.1.2 磁振斷層掃瞄術…………………………………………...2 1.1.3 電腦斷層掃瞄術…………………………………………...2 1.1.4 超音波造影技術…………………………………………...3 1.1.5 正子放射斷層掃瞄術……………………………………...3 1.1.6 光學同調斷層掃瞄術……………………………………...4 1.1.7 擴散光學斷層掃瞄術……………………………………...4 1.1.8 小結………………………………………………………...5 1.2 文獻回顧…………………………………………………………7 1.3 研究動機………………………………………………………..12 第二章 擴散光學斷層掃瞄術………………………………..13 2.1 光子遷移………………………………………………………..13 2.2 近紅外光光譜學………………………………………………..15 2.3 擴散光學斷層掃瞄術…………………………………………..16 2.3.1 擴散方程式………………………………………………...16 2.3.2 Modified Beer-Lambert Law………………………………..17 2.4 擴散光學斷層掃瞄術的系統分類……………………………..19 2.4.1 時域式擴散光學斷層掃瞄術………………………….…19 2.4.2 頻域式擴散光學斷層掃瞄術………………………….…20 2.4.3 連續波擴散光學斷層掃瞄術………………………….…21 2.4.4 三類系統的比較………………………………………….21 第三章 系統架構………………………………………………23 3.1 儀器設備………………………………………………………..23 3.2 探測器…………………………………………………………..23 3.2.1 雷射二極體……………………………………………….24 3.2.2 光檢測器………………………………………………….24 3.3 探測器與電腦間的連接介面…………………………………..26 3.3.1 資料擷取卡……………………………………………….26 3.3.2 訊號產生器、電源供應器及排線………………………..27 3.3.3 雷射二極體驅動電路…………………………………….27 3.4 訊號擷取的設定………………………………………………..28 3.5 二維影像重建…………………………………………………..29 3.6 LabVIEW程式介面……………………………………………30 3.7 系統可改進空間………………………………………………..32 3.7.1 雷射二極體間的距離差………………………………….33 3.7.2 軟性電路板的材質……………………………………….33 3.7.3 排線長短對訊號造成的影響…………………………….34 3.7.4 光檢測器的放大增益…………………………………….34 第四章 實驗結果與討論………………………………………36 4.1 系統效能量測…………………………………………………..36 4.2 實驗方法………………………………………………………..36 4.3 運動狀態………………………………………………………..37 4.4 血管束縛………………………………………………………..39 4.5 病例……………………………………………………………..44 4.6 討論……………………………………………………………..46 4.6.1 系統的可重複性………………………………………….47 4.6.2 實驗誤差的原因………………………………………….47 第五章 結論……………………………………………………49 參考文獻………………………………………………………..50 | |
| dc.language.iso | zh-TW | |
| dc.subject | 造影系統 | zh_TW |
| dc.subject | 擴散光學斷層掃瞄術 | zh_TW |
| dc.subject | 近紅外光光譜學 | zh_TW |
| dc.subject | 醫學造影 | zh_TW |
| dc.subject | Diffuse optical tomography | en |
| dc.subject | Imaging system | en |
| dc.subject | Medical imaging | en |
| dc.subject | Near-infrared spectroscopy | en |
| dc.title | 擴散光學斷層掃瞄術：系統設計以及臨床量測研究 | zh_TW |
| dc.title | Diffuse Optical Tomography: Optode Design and Clinical Study | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 95-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.coadvisor | 孫家偉 | |
| dc.contributor.oralexamcommittee | 莊銘隆,林保宏,李柏磊 | |
| dc.subject.keyword | 擴散光學斷層掃瞄術,近紅外光光譜學,醫學造影,造影系統, | zh_TW |
| dc.subject.keyword | Diffuse optical tomography,Near-infrared spectroscopy,Medical imaging,Imaging system, | en |
| dc.relation.page | 53 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2007-07-19 | |
| dc.contributor.author-college | 電機資訊學院 | zh_TW |
| dc.contributor.author-dept | 光電工程學研究所 | zh_TW |
| 顯示於系所單位： | 光電工程學研究所 | |
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