請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/28893
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 陳為堅(Wei J. Chen) | |
dc.contributor.author | Chi-Shin Wu | en |
dc.contributor.author | 吳其炘 | zh_TW |
dc.date.accessioned | 2021-06-13T00:28:14Z | - |
dc.date.available | 2007-08-08 | |
dc.date.copyright | 2007-08-08 | |
dc.date.issued | 2007 | |
dc.date.submitted | 2007-07-26 | |
dc.identifier.citation | References
1. Blanchard JJ, Brown SA, Horan WP, Sherwood AR. Substance use disorders in schizophrenia: review, integration, and a proposed model. Clin Psychol Rev. 2000;20:207-234. 2. Cuffel BJ. Prevalence estimates of substance abuse in schizophrenia and their correlates. J Nerv Ment Dis. 1992;180:589-592; discussion 593-586. 3. Gut-Fayand A, Dervaux A, Olie JP, Loo H, Poirier MF, Krebs MO. Substance abuse and suicidality in schizophrenia: a common risk factor linked to impulsivity. Psychiatry Res. 2001;102:65-72. 4. Chen WJ, Hsiao CK, Lin CC. Schizotypy in community samples: the three-factor structure and correlation with sustained attention. J Abnorm Psychol. 1997;106:649-654. 5. Raine A, Sheard C, Lencz T, Scerbo A, Triphon N, Kim D. Cognitive-perceptual, interpersonal, and disorganized feature of schizotypal personality. Schizophr Bull. 1994;20:191-120. 6. Gottesman, II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry. 2003;160:636-645. 7. Williams JH, Wellman NA, Allan LM, et al. Tobacco smoking correlates with schizotypal and borderline personality traits. Personality and Individual Differences. 1996;20:267-270. 8. Kolliakou A, Joseph S. Further evidence that tobacco smoking correlates with schizotypal and borderline personality traits. Personality and Individual Differences. 2000;29:191-194. 9. Larrison AL. Nicotine, caffeine, alcohol and schizotypy. Personality and Individual Differences. 1998;27:101-108. 10. Nunn JA, Rizza F, Peters ER. The incidence of schizotypy among cannabis and alcohol users. J Nerv Ment Dis. 2001;189:741-748. 11. Moeller FG, Barratt ES, Dougherty DM, Schmitz JM, Swann AC. Psychiatric aspects of impulsivity. Am J Psychiatry. 2001;158:1783-1793. 12. Rosvold HE, Mirsky AF, Sarason I, Bransome ED, Jr., Beck LH. A Continuous Performance Test of brain damage. J Consult Psychol. 1956;20:343-350. 13. Dougherty DM, Bjork JM, Harper RA, et al. Behavioral impulsivity paradigms: a comparison in hospitalized adolescents with disruptive behavior disorders. J Child Psychol Psychiatry. 2003;44:1145-1157. 14. Swann AC, Bjork JM, Moeller FG, Dougherty DM. Two models of impulsivity: relationship to personality traits and psychopathology. Biol Psychiatry. 2002;51:988-994. 15. Dougherty DM, Mathias CW, Tester ML, Marsh DM. Age at first drink relates to behavioral measures of impulsivity: the immediate and delayed memory tasks. Alcohol Clin Exp Res. 2004;28:408-414. 16. Bjork JM, Hommer DW, Grant SJ, Danube C. Impulsivity in abstinent alcohol-dependent patients: relation to control subjects and type 1-/type 2-like traits. Alcohol. 2004;34:133-150. 17. Chen WJ, Faraone SV. Sustained attention deficits as markers of genetic susceptibility to schizophrenia. American Journal of Medical Genetics (Seminars in Medical Genetics). 2000;97:52-57. 18. Cornblatt BA, Keilp JG. Impaired attention, genetics, and the pathophysiology of schizophrenia. Schizophr Bull. 1994;20:31-46. 19. Dinn WM, Harris CL, Aycicegi A, Greene P, Andover MS. Positive and negative schizotypy in a student sample: neurocognitive and clinical correlates. Schizophr Res. 2002;56:171-185. 20. Chambers RA, Taylor JR, Potenza MN. Developmental neurocircuitry of motivation in adolescence: a critical period of addiction vulnerability. Am J Psychiatry. 2003;160:1041-1052. 21. Lin CC, Chen WJ, Yang HJ, Hsiao CK, Tien AY. Performance on the Wisconsin Card Sorting Test among adolescents in Taiwan: norms, factorial structure, and relation to schizotypy. J Clin Exp Neuropsychol. 2000;22:69-79. 22. Yang HJ, Soong WT, Chiang CN, Chen WJ. Competence and behavioral/emotional problems among Taiwanese adolescents as reported by parents and teachers. J Am Acad Child Adolesc Psychiatry. 2000;39:232-239. 23. Kuo P-H, Yang H-J, Soong W-T, Chen WJ. Substance use in Taiwanese adolescents: Associated personality traits, incompetence and behavioral/emotional problems. Drug Alcohol Depend. 2002;67:27-39. 24. Cochrane J, Chen H, Conigrave KM, Hao W. Alcohol use in China. Alcohol Alcohol. 2003;38:537-542. 25. Chapman LJ, Chapman JP, Raulin ML. Body-image aberration in schizophrenia. J Abnorm Psychol. 1978;87:399-407. 26. Raine A. The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophr Bull. 1991;17:555-564. 27. Chen WJ, Hsiao CK, Hsiao LL, Hwu HG. Performance of the Continuous Performance Test among community samples. Schizophr Bull. 1998;24:163-174. 28. Lin HF, Liu Y-L, Liu C-M, Hung S-I, Hwu H-G, Chen WJ. Neuregulin 1 gene and variations in perceptual aberration of schizotypal personality in adolescents. Psychol Med. 2005;35:1589-1598. 29. Lin CCH, Su CH, Kuo PH, Hsiao CK, Soong WT, Chen WJ. Genetic and environmental influences on schizotypy among adolescents in Taiwan: a multivariate twin/sibling analysis. Behav Genet. 2006. 30. Cheung AM, Mitsis EM, Halperin JM. The relationship of behavioral inhibition to executive functions in young adults. J Clin Exp Neuropsychol. 2004;26:393-404. 31. Dougherty DM, Bjork JM, Marsh DM, Moeller FG. A comparison between adults with conduct disorder and normal controls on a Continuous Performance Test: Differences in impulsive response characteristics. Psychological Record. 2000;50:203-219. 32. Baron RM, Kenny DA. The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol. 1986;51:1173-1182. 33. Kwapil TR. A longitudinal study of drug and alcohol use by psychosis-prone and impulsive-nonconforming individuals. J Abnorm Psychol. 1996;105:114-123. 34. Dinn WM, Aycicegi A, Harris CL. Cigarette smoking in a student sample: neurocognitive and clinical correlates. Addict Behav. 2004;29:107-126. 35. Doran N, Spring B, McChargue D, Pergadia M, Richmond M. Impulsivity and smoking relapse. Nicotine & Tobacco Research. 2004;6:641-647. 36. Mitchell SH. Measures of impulsivity in cigarette smokers and non-smokers. Psychopharmacology (Berl). 1999;146:455-464. 37. Spinella M. Correlations between orbitofrontal dysfunction and tobacco smoking. Addictive Biology. 2002;7:381-384. 38. Aytaclar S, Tarter RE, Kirisci L, Lu S. Association between hyperactivity and executive cognitive functioning in childhood and substance use in early adolescence. J Am Acad Child Adolesc Psychiatry. 1999;38:172-178. 39. Patton JH, Stanford MS, Barratt ES. Factor structure of the Barratt impulsiveness scale. J Clin Psychol. 1995;51:768-774. 40. Skinner MD, Aubin HJ, Berlin I. Impulsivity in smoking, nonsmoking, and ex-smoking alcoholics. Addict Behav. 2004;29:973-978. 41. Swann AC, Bjork JM, Moeller FG, Dougherty DM. Two models of impulsivity: relationship to personality traits and psychopathology. Biol Psychiatry. 2002;51:988-994. 42. Swann AC, Dougherty DM, Pazzaglia PJ, Pham M, Steinberg JL, Moeller FG. Increased impulsivity associated with severity of suicide attempt history in patients with bipolar disorder. Am J Psychiatry. 2005;162:1680-1687. 43. Tibbo P, Warneke L. Obsessive-compulsive disorder in schizophrenia: epidemiologic and biologic overlap. J Psychiatry Neurosci. 1999;24:15-24. 44. Poyurovsky M, Koran LM. Obsessive-compulsive disorder (OCD) with schizotypy vs. schizophrenia with OCD: diagnostic dilemmas and therapeutic implications. J Psychiatr Res. 2005;39:399-408. 45. Goldstein RZ, Volkow ND. Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. Am J Psychiatry. 2002;159:1642-1652. 46. Ridderinkhof KR, van den Wildenberg WP, Segalowitz SJ, Carter CS. Neurocognitive mechanisms of cognitive control: the role of prefrontal cortex in action selection, response inhibition, performance monitoring, and reward-based learning. Brain Cogn. 2004;56:129-140. 47. Koob GF. Neural mechanisms of drug reinforcement. Ann N Y Acad Sci. 1992;654:171-191. 48. Adinoff B. Neurobiologic processes in drug reward and addiction. Harv Rev Psychiatry. 2004;12:305-320. 49. Abi-Dargham A, Kegeles LS, Zea-Ponce Y, et al. Striatal amphetamine-induced dopamine release in patients with schizotypal personality disorder studied with single photon emission computed tomography and [123I]iodobenzamide. Biol Psychiatry. 2004;55:1001-1006. 50. Braver TS, Barch DM, Cohen JD. Cognition and control in schizophrenia: a computational model of dopamine and prefrontal function. Biol Psychiatry. 1999;46:312-328. 51. Mohanty A, Herrington JD, Koven NS, et al. Neural mechanisms of affective interference in schizotypy. J Abnorm Psychol. 2005;114:16-27. 52. Toga AW, Thompson PM, Sowell ER. Mapping brain maturation. Trends Neurosci. 2006;29:148-159. 53. Eisenberg J, Mei-Tal G, Steinberg A, et al. Haplotype relative risk study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD): association of the high-enzyme activity Val allele with ADHD impulsive-hyperactive phenotype. Am J Med Genet. 1999;88:497-502. 54. Avramopoulos D, Stefanis NC, Hantoumi I, Smyrnis N, Evdokimidis I, Stefanis CN. Higher scores of self reported schizotypy in healthy young males carrying the COMT high activity allele. Mol Psychiatry. 2002;7:706-711. 55. Li T, Chen CK, Hu X, et al. Association analysis of the DRD4 and COMT genes in methamphetamine abuse. Am J Med Genet B Neuropsychiatr Genet. 2004;129:120-124. 56. Hollander E, Swann AC, Coccaro EF, Jiang P, Smith TB. Impact of trait impulsivity and state aggression on divalproex versus placebo response in borderline personality disorder. Am J Psychiatry. 2005;162:621-624. 57. Anthony JC, Petronis KP. Early-onset drug use and risk of later drug problems. Drug Alcohol Depend. 1995;40:9-15. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/28893 | - |
dc.description.abstract | 中文摘要
目的:本研究的目的是評估衝動性(impulsivity)在精神分裂病質(schizotypy)與物質濫用的關係中所扮演的角色,以社區青少年為樣本。 方法:從台北市國民中學分層隨機取樣後,共有905名國中學生,完成施測量表,包含物質使用經驗、知覺偏差量表,與精神分裂性人格量表。其中六分之一的學生,經由系統化選取後,進行連續注意力測驗。精神分裂病質的指標包含知覺偏差,以及精神分裂性人格與其三個因子(認知知覺因子,人際因子,以及失序因子)。而衝動指標包含連續注意力測驗中的漏判率(omission error rate),誤判率 (commission error rate)、快速反應次數(total number of very fast response),及平均反應時間(mean reaction time)。 結果:結果顯示物質使用(包含香煙或酒精)與較高的正性精神病質相關,特別是知覺偏差,但與負性精神分裂病質或失序病質(disorganization)無關。而連續注意力測驗中,較高的誤判率不只與物質使用相關,也與較高的知覺偏差相關。再者,當控制了連續注意力測驗中的誤判率之後,知覺偏差對物質使用的回歸係數下降了55.8%,並且變得不再顯著。 結論:我們的結果顯示衝動性在正性精神病質與物質使用之間,可能扮演了一個中介因子的角色,也可能成為預防精神分裂病質或精神分裂症病患使用物質的治療目標。 | zh_TW |
dc.description.abstract | Abstract
Objective: The aim of this study was to evaluate the role of impulsivity on the relationship between schizotypy and substance use in non-referred adolescents. Methods: A total of 905 middle school students randomly selected from Taipei completed a questionnaire consisting of substance use experience, the Perceptual Aberration Scale (PAS), and the Schizotypal Personality Questionnaire (SPQ), and one of every 6 students systematically selected completed the Continuous Performance Test (CPT) as well. Indexes for schizotypy included the PAS as well as the SPQ and its three factors (Cognitive-Perceptual factor, Interpersonal factor, and Disorganization factor), while indexes for impulsivity included omission error rate, commission error rate, total number of very fast response, and mean reaction time on the CPT. Results: The results revealed that substance use of either alcohol or tobacco was correlated with higher level in positive schizotypy, particularly the PAS, but not negative schizotypy or disorganization. Higher commission error rates on the CPT were associated with not only substance use but also higher scores on the PAS. Furthermore, the regression coefficient of the PAS score for substance use decreased 55.8% and became non-significant when commission error rate was controlled for. Conclusion: Our results suggest that impulsivity might act as a mediator on the relations of positive schizotypy to substance use and might be a target for the prevention for substance use in persons with schizotypy or schizophrenia. | en |
dc.description.provenance | Made available in DSpace on 2021-06-13T00:28:14Z (GMT). No. of bitstreams: 1 ntu-96-R94842011-1.pdf: 262427 bytes, checksum: 2d12a16ae1eb7605af26bec1d4c9dba0 (MD5) Previous issue date: 2007 | en |
dc.description.tableofcontents | Abstract in Chinese i
Abstract ii Contents iii Introduction 1 Background 1 Study Design and Aims 2 Methods 2 Subjects 2 Measurement 3 Statistical analysis 5 Results 6 Descriptive Data 6 Schizotypal Trait and Substance Use 7 Impulsive Response and Substance Use 7 Personality Features and Impulsive Response7 Impulsive Response, Schizotypy, and Substance Use 8 Discussion 8 Major findings 8 Limitation 11 Conclusion 12 Reference 13 Tables Table 1. Descriptive data of the adolescent participants19 Table 2. Schizotypal Personality Features in Adolescents of Different Experience in Substance Use 21 Table 3. CPT Performance Index Scores in Adolescents of Different Experience in Substance Use 22 Table 4. Partial Correlation Between CPT Performance Index Scores and Schizotypy Personality with Controlling of Age and Sex 23 Table 5. Logistic Regression of Substance Use on Perceptual Aberration Scale (PAS) Score and the Commission Error Rate on the CPT, with Adjustment for Age and Sex 24 Appendix Supplement table 1. Descriptive data of the adolescent participants by sex 25 Supplement table 2. Descriptive data of the adolescent participants by grade 26 Perceptual Aberration Scale 27 Schizotypal Personality Questionnaire 30 | |
dc.language.iso | en | |
dc.title | 青少年之精神分裂病質、衝動性、與物質使用的相關 | zh_TW |
dc.title | Schizotypy, Impulsivity, and Substance Use in Non-Referred Adolescents | en |
dc.type | Thesis | |
dc.date.schoolyear | 95-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 高淑芬,劉絮愷 | |
dc.subject.keyword | 精神分裂病質,連續注意力測驗,誤判率,酒精,香煙,中介因子, | zh_TW |
dc.subject.keyword | Schizotypy,Continuous Performance Test,Commission Error Rate,Alcohol,Tobacco,Mediator, | en |
dc.relation.page | 33 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2007-07-26 | |
dc.contributor.author-college | 公共衛生學院 | zh_TW |
dc.contributor.author-dept | 流行病學研究所 | zh_TW |
顯示於系所單位: | 流行病學與預防醫學研究所 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-96-1.pdf 目前未授權公開取用 | 256.28 kB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。