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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/26483完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 許翠瑛(Tsuey-Ying Hsu) | |
| dc.contributor.author | Chu-Ying Chen | en |
| dc.contributor.author | 陳楚穎 | zh_TW |
| dc.date.accessioned | 2021-06-08T07:12:00Z | - |
| dc.date.copyright | 2008-09-11 | |
| dc.date.issued | 2008 | |
| dc.date.submitted | 2008-07-29 | |
| dc.identifier.citation | Adamson, A. L., Darr, D., Holley-Guthrie, E., Johnson, R. A., Mauser, A., Swenson, J. and Kenney, S. (2000). Epstein-Barr virus immediate-early proteins BZLF1 and BRLF1 activate the ATF2 transcription factor by increasing the levels of phosphorylated p38 and c-Jun N-terminal kinases. J Virol 74, 1224-33.
Aguilera, A. and Gomez-Gonzalez, B. (2008). Genome instability: a mechanistic view of its causes and consequences. Nat Rev Genet 9, 204-17. Ahn, N. G., Seger, R., Bratlien, R. L., Diltz, C. D., Tonks, N. K. and Krebs, E. G. (1991). Multiple components in an epidermal growth factor-stimulated protein kinase cascade. In vitro activation of a myelin basic protein/microtubule-associated protein 2 kinase. J Biol Chem 266, 4220-7. Albanese, C., Johnson, J., Watanabe, G., Eklund, N., Vu, D., Arnold, A. and Pestell, R. G. (1995). Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions. J Biol Chem 270, 23589-97. Amador, V., Ge, S., Santamaria, P. G., Guardavaccaro, D. and Pagano, M. (2007). APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase. Mol Cell 27, 462-73. Baer, R., Bankier, A. T., Biggin, M. D., Deininger, P. L., Farrell, P. J., Gibson, T. J., Hatfull, G., Hudson, G. S., Satchwell, S. C., Seguin, C. et al. (1984). DNA sequence and expression of the B95-8 Epstein-Barr virus genome. Nature 310, 207-11. Bagui, T. K., Mohapatra, S., Haura, E. and Pledger, W. J. (2003). P27Kip1 and p21Cip1 are not required for the formation of active D cyclin-cdk4 complexes. Mol Cell Biol 23, 7285-90. Balmanno, K. and Cook, S. J. (1999). Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells. Oncogene 18, 3085-97. Bates, S., Ryan, K. M., Phillips, A. C. and Vousden, K. H. (1998). Cell cycle arrest and DNA endoreduplication following p21Waf1/Cip1 expression. Oncogene 17, 1691-703. Bischoff, J. R., Anderson, L., Zhu, Y., Mossie, K., Ng, L., Souza, B., Schryver, B., Flanagan, P., Clairvoyant, F., Ginther, C. et al. (1998). A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. Embo J 17, 3052-65. Bracken, A. P., Ciro, M., Cocito, A. and Helin, K. (2004). E2F target genes: unraveling the biology. Trends Biochem Sci 29, 409-17. Brooks, L., Yao, Q. Y., Rickinson, A. B. and Young, L. S. (1992). Epstein-Barr virus latent gene transcription in nasopharyngeal carcinoma cells: coexpression of EBNA1, LMP1, and LMP2 transcripts. J Virol 66, 2689-97. Burke, A. P., Yen, T. S., Shekitka, K. M. and Sobin, L. H. (1990). Lymphoepithelial carcinoma of the stomach with Epstein-Barr virus demonstrated by polymerase chain reaction. Mod Pathol 3, 377-80. Burkitt, D. (1958). A sarcoma involving the jaws in African children. Br J Surg 46, 218-23. Chang, B. D., Broude, E. V., Fang, J., Kalinichenko, T. V., Abdryashitov, R., Poole, J. C. and Roninson, I. B. (2000). p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells. Oncogene 19, 2165-70. Chang, L. K., Chung, J. Y., Hong, Y. R., Ichimura, T., Nakao, M. and Liu, S. T. (2005). Activation of Sp1-mediated transcription by Rta of Epstein-Barr virus via an interaction with MCAF1. Nucleic Acids Res 33, 6528-39. Chang, P. J., Chang, Y. S. and Liu, S. T. (1998). Role of Rta in the translation of bicistronic BZLF1 of Epstein-Barr virus. J Virol 72, 5128-36. Chang, P. J. and Liu, S. T. (2001). Function of the intercistronic region of BRLF1-BZLF1 bicistronic mRNA in translating the zta protein of Epstein-Barr virus. J Virol 75, 1142-51. Chang, Y., Cheng, S. D. and Tsai, C. H. (2002). Chromosomal integration of Epstein-Barr virus genomes in nasopharyngeal carcinoma cells. Head Neck 24, 143-50. Chang, Y., Tung, C. H., Huang, Y. T., Lu, J., Chen, J. Y. and Tsai, C. H. (1999). Requirement for cell-to-cell contact in Epstein-Barr virus infection of nasopharyngeal carcinoma cells and keratinocytes. J Virol 73, 8857-66. Chen, J. Y., Chen, C. J., Liu, M. Y., Cho, S. M., Hsu, M. M., Lynn, T. C., Shieh, T., Tu, S. M., Beasley, R. P., Hwang, L. Y. et al. (1989). Antibody to Epstein-Barr virus-specific DNase as a marker for field survey of patients with nasopharyngeal carcinoma in Taiwan. J Med Virol 27, 269-73. Chen, J. Y., Liu, M. Y., Chen, C. J., Hsu, M. M., Tu, S. M., Lee, H. H., Kuo, S. L. and Yang, C. S. (1985). Antibody to Epstein-Barr virus-specific DNase as a marker for the early detection of nasopharyngeal carcinoma. J Med Virol 17, 47-9. Chen, J. Y., Liu, M. Y., Lynn, T. C. and Yang, C. S. (1982). Antibody to Epstein-Barr virus-specific DNase in patients with nasopharyngeal carcinoma. Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi 15, 255-61. Chen, M. R., Liu, M. Y., Hsu, S. M., Fong, C. C., Chen, C. J., Chen, I. H., Hsu, M. M., Yang, C. S. and Chen, J. Y. (2001). Use of bacterially expressed EBNA-1 protein cloned from a nasopharyngeal carcinoma (NPC) biopsy as a screening test for NPC patients. J Med Virol 64, 51-7. Chen, Y. R., Liu, M. T., Chang, Y. T., Wu, C. C., Hu, C. Y., and Chen, J. Y. (2008). Epstein-Barr virus latent membrane protein 1 represses DNA repair through the PI3K/Akt/FOXO3a pathway in human epithelial cells. J Virol 82, 8124-37. Chen, R. H., Abate, C. and Blenis, J. (1993). Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase. Proc Natl Acad Sci U S A 90, 10952-6. Chen, R. H., Sarnecki, C. and Blenis, J. (1992). Nuclear localization and regulation of erk- and rsk-encoded protein kinases. Mol Cell Biol 12, 915-27. Cheng, M., Olivier, P., Diehl, J. A., Fero, M., Roussel, M. F., Roberts, J. M. and Sherr, C. J. (1999). The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. Embo J 18, 1571-83. Cheng, Y., Poulos, N. E., Lung, M. L., Hampton, G., Ou, B., Lerman, M. I. and Stanbridge, E. J. (1998). Functional evidence for a nasopharyngeal carcinoma tumor suppressor gene that maps at chromosome 3p21.3. Proc Natl Acad Sci U S A 95, 3042-7. Cheng, Y. C., Chen, J. Y., Glaser, R. and Henle, W. (1980). Frequency and levels of antibodies to Epstein-Barr virus-specific DNase are elevated in patients with nasopharyngeal carcinoma. Proc Natl Acad Sci U S A 77, 6162-5. Chevallier-Greco, A., Manet, E., Chavrier, P., Mosnier, C., Daillie, J. and Sergeant, A. (1986). Both Epstein-Barr virus (EBV)-encoded trans-acting factors, EB1 and EB2, are required to activate transcription from an EBV early promoter. EMBO J 5, 3243-9. Chien, Y. C., Chen, J. Y., Liu, M. Y., Yang, H. I., Hsu, M. M., Chen, C. J. and Yang, C. S. (2001). Serologic markers of Epstein-Barr virus infection and nasopharyngeal carcinoma in Taiwanese men. N Engl J Med 345, 1877-82. Cho, M. S., Milman, G. and Hayward, S. D. (1985). A second Epstein-Barr virus early antigen gene in BamHI fragment M encodes a 48- to 50-kilodalton nuclear protein. J Virol 56, 860-6. Chung, E. and Chen, R. H. (2003). Phosphorylation of Cdc20 is required for its inhibition by the spindle checkpoint. Nat Cell Biol 5, 748-53. Clough, W. (1979). Deoxyribonuclease activity found in Epstein--Barr virus producing lymphoblastoid cells. Biochemistry 18, 4517-21. Cochet, C., Martel-Renoir, D., Grunewald, V., Bosq, J., Cochet, G., Schwaab, G., Bernaudin, J. F. and Joab, I. (1993). Expression of the Epstein-Barr virus immediate early gene, BZLF1, in nasopharyngeal carcinoma tumor cells. Virology 197, 358-65. Cooper, J. A., Sefton, B. M. and Hunter, T. (1984). Diverse mitogenic agents induce the phosphorylation of two related 42,000-dalton proteins on tyrosine in quiescent chick cells. Mol Cell Biol 4, 30-7. Countryman, J., Jenson, H., Seibl, R., Wolf, H. and Miller, G. (1987). Polymorphic proteins encoded within BZLF1 of defective and standard Epstein-Barr viruses disrupt latency. J Virol 61, 3672-9. Countryman, J. and Miller, G. (1985). Activation of expression of latent Epstein-Barr herpesvirus after gene transfer with a small cloned subfragment of heterogeneous viral DNA. Proc Natl Acad Sci U S A 82, 4085-9. Cox, M. A., Leahy, J. and Hardwick, J. M. (1990). An enhancer within the divergent promoter of Epstein-Barr virus responds synergistically to the R and Z transactivators. J Virol 64, 313-21. Culjkovic, B., Topisirovic, I., Skrabanek, L., Ruiz-Gutierrez, M. and Borden, K. L. (2005). eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3'UTR. J Cell Biol 169, 245-56. Dangi, S., Chen, F. M. and Shapiro, P. (2006). Activation of extracellular signal-regulated kinase (ERK) in G2 phase delays mitotic entry through p21CIP1. Cell Prolif 39, 261-79. Darr, C. D., Mauser, A. and Kenney, S. (2001). Epstein-Barr virus immediate-early protein BRLF1 induces the lytic form of viral replication through a mechanism involving phosphatidylinositol-3 kinase activation. J Virol 75, 6135-42. Degrassi, F. and Tanzarella, C. (1988). Immunofluorescent staining of kinetochores in micronuclei: a new assay for the detection of aneuploidy. Mutat Res 203, 339-45. Delecluse, H. J., Bartnizke, S., Hammerschmidt, W., Bullerdiek, J. and Bornkamm, G. W. (1993). Episomal and integrated copies of Epstein-Barr virus coexist in Burkitt lymphoma cell lines. J Virol 67, 1292-9. Delmas, C., Manenti, S., Boudjelal, A., Peyssonnaux, C., Eychene, A. and Darbon, J. M. (2001). The p42/p44 mitogen-activated protein kinase activation triggers p27Kip1 degradation independently of CDK2/cyclin E in NIH 3T3 cells. J Biol Chem 276, 34958-65. Dhillon, A. S., Hagan, S., Rath, O. and Kolch, W. (2007). MAP kinase signalling pathways in cancer. Oncogene 26, 3279-90. Diehl, J. A., Yang, W., Rimerman, R. A., Xiao, H. and Emili, A. (2003). Hsc70 regulates accumulation of cyclin D1 and cyclin D1-dependent protein kinase. Mol Cell Biol 23, 1764-74. Ditchfield, C., Johnson, V. L., Tighe, A., Ellston, R., Haworth, C., Johnson, T., Mortlock, A., Keen, N. and Taylor, S. S. (2003). Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J Cell Biol 161, 267-80. Dolyniuk, M., Pritchett, R. and Kieff, E. (1976). Proteins of Epstein-Barr virus. I. Analysis of the polypeptides of purified enveloped Epstein-Barr virus. J Virol 17, 935-49. Downward, J. (1996). Control of ras activation. Cancer Surv 27, 87-100. Downward, J. (2003). Role of receptor tyrosine kinases in G-protein-coupled receptor regulation of Ras: transactivation or parallel pathways? Biochem J 376, e9-10. Draviam, V. M., Xie, S. and Sorger, P. K. (2004). Chromosome segregation and genomic stability. Curr Opin Genet Dev 14, 120-5. Duensing, S. and Munger, K. (2004). Mechanisms of genomic instability in human cancer: insights from studies with human papillomavirus oncoproteins. Int J Cancer 109, 157-62. Epstein, M. A., Achong, B. G. and Barr, Y. M. (1964). Virus Particles in Cultured Lymphoblasts from Burkitt's Lymphoma. Lancet 1, 702-3. Eves, E. M., Shapiro, P., Naik, K., Klein, U. R., Trakul, N. and Rosner, M. R. (2006). Raf kinase inhibitory protein regulates aurora B kinase and the spindle checkpoint. Mol Cell 23, 561-74. Feederle, R., Kost, M., Baumann, M., Janz, A., Drouet, E., Hammerschmidt, W. and Delecluse, H. J. (2000). The Epstein-Barr virus lytic program is controlled by the co-operative functions of two transactivators. EMBO J 19, 3080-9. Fenech, M. (2000). The in vitro micronucleus technique. Mutat Res 455, 81-95. Fenech, M. (2002). Chromosomal biomarkers of genomic instability relevant to cancer. Drug Discov Today 7, 1128-37. Fenech, M. and Morley, A. A. (1989). Kinetochore detection in micronuclei: an alternative method for measuring chromosome loss. Mutagenesis 4, 98-104. Feng, P., Ren, E. C., Liu, D., Chan, S. H. and Hu, H. (2000). Expression of Epstein-Barr virus lytic gene BRLF1 in nasopharyngeal carcinoma: potential use in diagnosis. J Gen Virol 81, 2417-23. Fenton, M. and Sinclair, A. J. (1999). Divergent requirements for the MAPK(ERK) signal transduction pathway during initial virus infection of quiescent primary B cells and disruption of Epstein-Barr virus latency by phorbol esters. J Virol 73, 8913-6. Fingeroth, J. D., Weis, J. J., Tedder, T. F., Strominger, J. L., Biro, P. A. and Fearon, D. T. (1984). Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2. Proc Natl Acad Sci U S A 81, 4510-4. Foghsgaard, L. and Jaattela, M. (1997). The ability of BHRF1 to inhibit apoptosis is dependent on stimulus and cell type. J Virol 71, 7509-17. Friedberg, E. C. et al., (2006). DNA Repair and Mutagenesis. pp. 461-750. American Society For Microbiology Press, Washinton DC Gao, Z., Krithivas, A., Finan, J. E., Semmes, O. J., Zhou, S., Wang, Y. and Hayward, S. D. (1998). The Epstein-Barr virus lytic transactivator Zta interacts with the helicase-primase replication proteins. J Virol 72, 8559-67. Given, D. and Kieff, E. (1979). DNA of Epstein-Barr virus. VI. Mapping of the internal tandem reiteration. J Virol 31, 315-24. Given, D., Yee, D., Griem, K. and Kieff, E. (1979). DNA of Epstein-Barr virus. V. Direct repeats of the ends of Epstein-Barr virus DNA. J Virol 30, 852-62. Greulich, H. and Erikson, R. L. (1998). An analysis of Mek1 signaling in cell proliferation and transformation. J Biol Chem 273, 13280-8. Gruffat, H., Duran, N., Buisson, M., Wild, F., Buckland, R. and Sergeant, A. (1992). Characterization of an R-binding site mediating the R-induced activation of the Epstein-Barr virus BMLF1 promoter. J Virol 66, 46-52. Gruffat, H., Manet, E., Rigolet, A. and Sergeant, A. (1990). The enhancer factor R of Epstein-Barr virus (EBV) is a sequence-specific DNA binding protein. Nucleic Acids Res 18, 6835-43. Gruffat, H., Moreno, N. and Sergeant, A. (1990). The Epstein-Barr virus (EBV) ORI1yt enhancer is not B-cell specific and does not respond synergistically to the EBV transcription factors R and Z. J Virol 64, 2810-8. Gudi, R., Sandhu, S. S. and Athwal, R. S. (1990). Kinetochore identification in micronuclei in mouse bone-marrow erythrocytes: an assay for the detection of aneuploidy-inducing agents. Mutat Res 234, 263-8. Gutsch, D. E., Marcu, K. B. and Kenney, S. C. (1994). The Epstein-Barr virus BRLF1 gene product transactivates the murine and human c-myc promoters. Cell Mol Biol (Noisy-le-grand) 40, 747-60. Gysin, S., Lee, S. H., Dean, N. M. and McMahon, M. (2005). Pharmacologic inhibition of RAF-->MEK-->ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1. Cancer Res 65, 4870-80. Hammerschmidt, W. and Sugden, B. (1988). Identification and characterization of oriLyt, a lytic origin of DNA replication of Epstein-Barr virus. Cell 55, 427-33. Hampar, B., Derge, J. G., Martos, L. M. and Walker, J. L. (1971). Persistence of a repressed Epstein-Barr virus genome in Burkitt lymphoma cells made resistant to 5-bromodeoxyuridine. Proc Natl Acad Sci U S A 68, 3185-9. Hanahan, D. and Weinberg, R. A. (2000). The hallmarks of cancer. Cell 100, 57-70. Harbour, J. W. and Dean, D. C. (2000). The Rb/E2F pathway: expanding roles and emerging paradigms. Genes Dev 14, 2393-409. Hardwick, J. M., Lieberman, P. M. and Hayward, S. D. (1988). A new Epstein-Barr virus transactivator, R, induces expression of a cytoplasmic early antigen. J Virol 62, 2274-84. Hardwick, J. M., Tse, L., Applegren, N., Nicholas, J. and Veliuona, M. A. (1992). The Epstein-Barr virus R transactivator (Rta) contains a complex, potent activation domain with properties different from those of VP16. J Virol 66, 5500-8. Hatfull, G., Bankier, A. T., Barrell, B. G. and Farrell, P. J. (1988). Sequence analysis of Raji Epstein-Barr virus DNA. Virology 164, 334-40. Hayne, C., Tzivion, G. and Luo, Z. (2000). Raf-1/MEK/MAPK pathway is necessary for the G2/M transition induced by nocodazole. J Biol Chem 275, 31876-82. Henle, G. and Henle, W. (1966). Immunofluorescence in cells derived from Burkitt's lymphoma. J Bacteriol 91, 1248-56. Henle, G. and Henle, W. (1976). Epstein-Barr virus-specific IgA serum antibodies as an outstanding feature of nasopharyngeal carcinoma. Int J Cancer 17, 1-7. Henle, G., Henle, W. and Diehl, V. (1968). Relation of Burkitt's tumor-associated herpes-ytpe virus to infectious mononucleosis. Proc Natl Acad Sci U S A 59, 94-101. Hennig, U. G., Rudd, N. L. and Hoar, D. I. (1988). Kinetochore immunofluorescence in micronuclei: a rapid method for the in situ detection of aneuploidy and chromosome breakage in human fibroblasts. Mutat Res 203, 405-14. Hoeijmakers, J. H. (2001). Genome maintenance mechanisms for preventing cancer. Nature 411, 366-74. Holley-Guthrie, E. A., Quinlivan, E. B., Mar, E. C. and Kenney, S. (1990). The Epstein-Barr virus (EBV) BMRF1 promoter for early antigen (EA-D) is regulated by the EBV transactivators, BRLF1 and BZLF1, in a cell-specific manner. J Virol 64, 3753-9. Hoshikawa, Y., Satoh, Y., Murakami, M., Maeta, M., Kaibara, N., Ito, H., Kurata, T. and Sairenji, T. (2002). Evidence of lytic infection of Epstein-Barr virus (EBV) in EBV-positive gastric carcinoma. J Med Virol 66, 351-9. Hsu, T. Y., Chang, Y., Wang, P. W., Liu, M. Y., Chen, M. R., Chen, J. Y. and Tsai, C. H. (2005). Reactivation of Epstein-Barr virus can be triggered by an Rta protein mutated at the nuclear localization signal. J Gen Virol 86, 317-22. Hsu, T. Y., Pai, C. Y., Shieh, S. M., Cho, S. M., Liu, M. Y., Chen, J. Y. and Yang, C. S. (1992). Use of antigen expressed in bacteria for detection of EBV-specific thymidine kinase antibodies in sera from patients with nasopharyngeal carcinoma. J Med Virol 38, 214-9. Huang, D. P., Ho, J. H., Chan, W. K., Lau, W. H. and Lui, M. (1989). Cytogenetics of undifferentiated nasopharyngeal carcinoma xenografts from southern Chinese. Int J Cancer 43, 936-9. Huang, D. P., Lo, K. W., Choi, P. H., Ng, A. Y., Tsao, S. Y., Yiu, G. K. and Lee, J. C. (1991). Loss of heterozygosity on the short arm of chromosome 3 in nasopharyngeal carcinoma. Cancer Genet Cytogenet 54, 91-9. Huang, J., Chen, H., Hutt-Fletcher, L., Ambinder, R. F. and Hayward, S. D. (2003). Lytic viral replication as a contributor to the detection of Epstein-Barr virus in breast cancer. J Virol 77, 13267-74. Hung, C. H. and Liu, S. T. (1999). Characterization of the Epstein-Barr virus BALF2 promoter. J Gen Virol 80 ( Pt 10), 2747-50. Jefford, C. E. and Irminger-Finger, I. (2006). Mechanisms of chromosome instability in cancers. Crit Rev Oncol Hematol 59, 1-14. Johnson, G. L., Dohlman, H. G. and Graves, L. M. (2005). MAPK kinase kinases (MKKKs) as a target class for small-molecule inhibition to modulate signaling networks and gene expression. Curr Opin Chem Biol 9, 325-31. Jones, J. F., Shurin, S., Abramowsky, C., Tubbs, R. R., Sciotto, C. G., Wahl, R., Sands, J., Gottman, D., Katz, B. Z. and Sklar, J. (1988). T-cell lymphomas containing Epstein-Barr viral DNA in patients with chronic Epstein-Barr virus infections. N Engl J Med 318, 733-41. Jones, S. M. and Kazlauskas, A. (2001). Growth-factor-dependent mitogenesis requires two distinct phases of signalling. Nat Cell Biol 3, 165-72. Kahan, C., Seuwen, K., Meloche, S. and Pouyssegur, J. (1992). Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition. J Biol Chem 267, 13369-75. Kanda, T., Kamiya, M., Maruo, S., Iwakiri, D. and Takada, K. (2007). Symmetrical localization of extrachromosomally replicating viral genomes on sister chromatids. J Cell Sci 120, 1529-39. Kao, S. Y. and Marriott, S. J. (1999). Disruption of nucleotide excision repair by the human T-cell leukemia virus type 1 Tax protein. J Virol 73, 4299-304. Kenney, S., Holley-Guthrie, E., Mar, E. C. and Smith, M. (1989). The Epstein-Barr virus BMLF1 promoter contains an enhancer element that is responsive to the BZLF1 and BRLF1 transactivators. J Virol 63, 3878-83. Kerkhoff, E. and Rapp, U. R. (1997). Induction of cell proliferation in quiescent NIH 3T3 cells by oncogenic c-Raf-1. Mol Cell Biol 17, 2576-86. Kikuta, H., Taguchi, Y., Tomizawa, K., Kojima, K., Kawamura, N., Ishizaka, A., Sakiyama, Y., Matsumoto, S., Imai, S., Kinoshita, T. et al. (1988). Epstein-Barr virus genome-positive T lymphocytes in a boy with chronic active EBV infection associated with Kawasaki-like disease. Nature 333, 455-7. Klein, E., Kis, L. L. and Klein, G. (2007). Epstein-Barr virus infection in humans: from harmless to life endangering virus-lymphocyte interactions. Oncogene 26, 1297-305. Klein, G., Clifford, P., Klein, E. and Stjernsward, J. (1966). Search for tumor-specific immune reactions in Burkitt lymphoma patients by the membrane immunofluorescence reaction. Proc Natl Acad Sci U S A 55, 1628-35. Knauf, J. A., Ouyang, B., Knudsen, E. S., Fukasawa, K., Babcock, G. and Fagin, J. A. (2006). Oncogenic RAS induces accelerated transition through G2/M and promotes defects in the G2 DNA damage and mitotic spindle checkpoints. J Biol Chem 281, 3800-9. Kohno, M. (1985). Diverse mitogenic agents induce rapid phosphorylation of a common set of cellular proteins at tyrosine in quiescent mammalian cells. J Biol Chem 260, 1771-9. Kohno, M. and Pouyssegur, J. (1986). Alpha-thrombin-induced tyrosine phosphorylation of 43,000- and 41,000-Mr proteins is independent of cytoplasmic alkalinization in quiescent fibroblasts. Biochem J 238, 451-7. Kyriakis, J. M., App, H., Zhang, X. F., Banerjee, P., Brautigan, D. L., Rapp, U. R. and Avruch, J. (1992). Raf-1 activates MAP kinase-kinase. Nature 358, 417-21. LaBaer, J., Garrett, M. D., Stevenson, L. F., Slingerland, J. M., Sandhu, C., Chou, H. S., Fattaey, A. and Harlow, E. (1997). New functional activities for the p21 family of CDK inhibitors. Genes Dev 11, 847-62. Lai, H. K. and Borden, K. L. (2000). The promyelocytic leukemia (PML) protein suppresses cyclin D1 protein production by altering the nuclear cytoplasmic distribution of cyclin D1 mRNA. Oncogene 19, 1623-34. Lavoie, J. N., L'Allemain, G., Brunet, A., Muller, R. and Pouyssegur, J. (1996). Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J Biol Chem 271, 20608-16. Lengauer, C., Kinzler, K. W. and Vogelstein, B. (1998). Genetic instabilities in human cancers. Nature 396, 643-9. Lenormand, P., Sardet, C., Pages, G., L'Allemain, G., Brunet, A. and Pouyssegur, J. (1993). Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts. J Cell Biol 122, 1079-88. Li, J. J. and Li, S. A. (2006). Mitotic kinases: the key to duplication, segregation, and cytokinesis errors, chromosomal instability, and oncogenesis. Pharmacol Ther 111, 974-84. Li, Y., Jenkins, C. W., Nichols, M. A. and Xiong, Y. (1994). Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21. Oncogene 9, 2261-8. Lin, C. T., Chan, W. Y., Chen, W., Huang, H. M., Wu, H. C., Hsu, M. M., Chuang, S. M. and Wang, C. C. (1993). Characterization of seven newly established nasopharyngeal carcinoma cell lines. Lab Invest 68, 716-27. Littler, E. and Arrand, J. R. (1988). Characterization of the Epstein-Barr virus-encoded thymidine kinase expressed in heterologous eucaryotic and procaryotic systems. J Virol 62, 3892-5. Liu, C., Sista, N. D. and Pagano, J. S. (1996). Activation of the Epstein-Barr virus DNA polymerase promoter by the BRLF1 immediate-early protein is mediated through USF and E2F. J Virol 70, 2545-55. Liu, M. T., Chang, Y. T., Chen, S. C., Chuang, Y. C., Chen, Y. R., Lin, C. S. and Chen, J. Y. (2005). Epstein-Barr virus latent membrane protein 1 represses p53-mediated DNA repair and transcriptional activity. Oncogene 24, 2635-46. Liu, M. T., Chen, Y. R., Chen, S. C., Hu, C. Y., Lin, C. S., Chang, Y. T., Wang, W. B. and Chen, J. Y. (2004). Epstein-Barr virus latent membrane protein 1 induces micronucleus formation, represses DNA repair and enhances sensitivity to DNA-damaging agents in human epithelial cells. Oncogene 23, 2531-9. Liu, M. Y., Chang, Y. L., Ma, J., Yang, H. L., Hsu, M. M., Chen, C. J., Chen, J. Y. and Yang, C. S. (1997). Evaluation of multiple antibodies to Epstein-Barr virus as markers for detecting patients with nasopharyngeal carcinoma. J Med Virol 52, 262-9. Liu, M. Y., Chou, W. H., Nutter, L., Hsu, M. M., Chen, J. Y. and Yang, C. S. (1989). Antibody against Epstein-Barr virus DNA polymerase activity in sera of patients with nasopharyngeal carcinoma. J Med Virol 28, 101-5. Liu, M. Y., Shih, Y. Y., Chou, S. P., Chen, C. J., Sheen, T. S., Yang, C. S. and Chen, J. Y. (1998). Antibody against the Epstein-Barr virus BHRF1 protein, a homologue of Bcl-2, in patients with nasopharyngeal carcinoma. J Med Virol 56, 179-85. Liu, X., Yan, S., Zhou, T., Terada, Y. and Erikson, R. L. (2004). The MAP kinase pathway is required for entry into mitosis and cell survival. Oncogene 23, 763-76. Liu, Y., Martindale, J. L., Gorospe, M. and Holbrook, N. J. (1996). Regulation of p21WAF1/CIP1 expression through mitogen-activated protein kinase signaling pathway. Cancer Res 56, 31-5. Lo, K. W., Teo, P. M., Hui, A. B., To, K. F., Tsang, Y. S., Chan, S. Y., Mak, K. F., Lee, J. C. and Huang, D. P. (2000). High resolution allelotype of microdissected primary nasopharyngeal carcinoma. Cancer Res 60, 3348-53. Macleod, K. F., Sherry, N., Hannon, G., Beach, D., Tokino, T., Kinzler, K., Vogelstein, B. and Jacks, T. (1995). p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev 9, 935-44. Majone, F., Semmes, O. J. and Jeang, K. T. (1993). Induction of micronuclei by HTLV-I Tax: a cellular assay for function. Virology 193, 456-9. Manet, E., Allera, C., Gruffat, H., Mikaelian, I., Rigolet, A. and Sergeant, A. (1993). The acidic activation domain of the Epstein-Barr virus transcription factor R interacts in vitro with both TBP and TFIIB and is cell-specifically potentiated by a proline-rich region. Gene Expr 3, 49-59. Manet, E., Rigolet, A., Gruffat, H., Giot, J. F. and Sergeant, A. (1991). Domains of the Epstein-Barr virus (EBV) transcription factor R required for dimerization, DNA binding and activation. Nucleic Acids Res 19, 2661-7. Marschall, M., Leser, U., Seibl, R. and Wolf, H. (1989). Identification of proteins encoded by Epstein-Barr virus trans-activator genes. J Virol 63, 938-42. Marshall, C. J. (1996). Ras effectors. Curr Opin Cell Biol 8, 197-204. Martel-Renoir, D., Grunewald, V., Touitou, R., Schwaab, G. and Joab, I. (1995). Qualitative analysis of the expression of Epstein-Barr virus lytic genes in nasopharyngeal carcinoma biopsies. J Gen Virol 76 ( Pt 6), 1401-8. Matsuda, S., Kosako, H., Takenaka, K., Moriyama, K., Sakai, H., Akiyama, T., Gotoh, Y. and Nishida, E. (1992). Xenopus MAP kinase activator: identification and function as a key intermediate in the phosphorylation cascade. Embo J 11, 973-82. Matsuoka, A., Yamazaki, N., Suzuki, T., Hayashi, M. and Sofuni, T. (1992). Evaluation of the micronucleus test using a Chinese hamster cell line as an alternative to the conventional in vitro chromosomal aberration test. Mutat Res 272, 223-36. McKay, M. M. and Morrison, D. K. (2007). Integrating signals from RTKs to ERK/MAPK. Oncogene 26, 3113-21. Meloche, S. (1995). Cell cycle reentry of mammalian fibroblasts is accompanied by the sustained activation of p44mapk and p42mapk isoforms in the G1 phase and their inactivation at the G1/S transition. J Cell Physiol 163, 577-88. Meloche, S. and Pouyssegur, J. (2007). The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition. Oncogene 26, 3227-39. Meloche, S., Seuwen, K., Pages, G. and Pouyssegur, J. (1992). Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity. Mol Endocrinol 6, 845-54. Michieli, P., Chedid, M., Lin, D., Pierce, J. H., Mercer, W. E. and Givol, D. (1994). Induction of WAF1/CIP1 by a p53-independent pathway. Cancer Res 54, 3391-5. Miller, B. M. and Adler, I. D. (1990). Application of antikinetochore antibody staining (CREST staining) to micronuclei in erythrocytes induced in vivo. Mutagenesis 5, 411-5. Miller, B. M., Zitzelsberger, H. F., Weier, H. U. and Adler, I. D. (1991). Classification of micronuclei in murine erythrocytes: immunofluorescent staining using CREST antibodies compared to in situ hybridization with biotinylated gamma satellite DNA. Mutagenesis 6, 297-302. Mirza, A. M., Gysin, S., Malek, N., Nakayama, K., Roberts, J. M. and McMahon, M. (2004). Cooperative regulation of the cell division cycle by the protein kinases RAF and AKT. Mol Cell Biol 24, 10868-81. Moore, A. E., Sabachewsky, L. and Toolan, H. W. (1955). Culture characteristics of four permanent lines of human cancer cells. Cancer Res 15, 598-602. Morrow, C. J., Tighe, A., Johnson, V. L., Scott, M. I., Ditchfield, C. and Taylor, S. S. (2005). Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20. J Cell Sci 118, 3639-52. Musacchio, A. and Hardwick, K. G. (2002). The spindle checkpoint: structural insights into dynamic signalling. Nat Rev Mol Cell Biol 3, 731-41. Nakamura, K. D., Martinez, R. and Weber, M. J. (1983). Tyrosine phosphorylation of specific proteins after mitogen stimulation of chicken embryo fibroblasts. Mol Cell Biol 3, 380-90. Noda, A., Ning, Y., Venable, S. F., Pereira-Smith, O. M. and Smith, J. R. (1994). Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res 211, 90-8. Old, L. J., Boyse, E. A., Oettgen, H. F., Harven, E. D., Geering, G., Williamson, B. and Clifford, P. (1966). Precipitating Antibody in Human Serum to an Antigen Present in Cultured Burkitt's Lymphoma Cells. Proc Natl Acad Sci U S A 56, 1699-1704. Oudejans, J. J., van den Brule, A. J., Jiwa, N. M., de Bruin, P. C., Ossenkoppele, G. J., van der Valk, P., Walboomers, J. M. and Meijer, C. J. (1995). BHRF1, the Epstein-Barr virus (EBV) homologue of the BCL-2 protooncogene, is transcribed in EBV-associated B-cell lymphomas and in reactive lymphocytes. Blood 86, 1893-902. Pawson, T. (2002). Regulation and targets of receptor tyrosine kinases. Eur J Cancer 38 Suppl 5, S3-10. Pelengaris, S., Khan, M. and Evan, G. (2002). c-MYC: more than just a matter of life and death. Nat Rev Cancer 2, 764-76. Philpott, S. M. and Buehring, G. C. (1999). Defective DNA repair in cells with human T-cell leukemia/bovine leukemia viruses: role of tax gene. J Natl Cancer Inst 91, 933-42. Quilliam, L. A., Khosravi-Far, R., Huff, S. Y. and Der, C. J. (1995). Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins. Bioessays 17, 395-404. Quinlivan, E. B., Holley-Guthrie, E. A., Norris, M., Gutsch, D., Bachenheimer, S. L. and Kenney, S. C. (1993). Direct BRLF1 binding is required for cooperative BZLF1/BRLF1 activation of the Epstein-Barr virus early promoter, BMRF1. Nucleic Acids Res 21, 1999-2007. Raab-Traub, N. and Flynn, K. (1986). The structure of the termini of the Epstein-Barr virus as a marker of clonal cellular proliferation. Cell 47, 883-9. Ragoczy, T., Heston, L. and Miller, G. (1998). The Epstein-Barr virus Rta protein activates lytic cycle genes and can disrupt latency in B lymphocytes. J | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/26483 | - |
| dc.description.abstract | Epstein-Barr virus (EBV)為感染性單核球增多症 (infectious mononucleosis)與口黏膜白斑症 (oral hairy leukoplakia)的病原，並且發現與許多人類癌症，例如巴氏淋巴癌 (Burkitt's lymphoma)、何杰金氏淋巴癌 (Hodgin's lymphoma)及鼻咽癌 (nasopharyngeal carcinoma, NPC)等有關。鼻咽癌為發源於鼻咽部上皮細胞的腫瘤，以細胞遺傳學方法分析發現鼻咽癌細胞有基因體不穩定現象，而基因體不穩定與癌症的發生過程息息相關。在NPC活組織切片檢體中發現的EBV相關基因產物主要為潛伏期表現的基因產物，但在這些檢體中亦發現有EBV溶裂期基因的產物。此外，NPC病人的血清中能偵測到較高效價的抗EBV溶裂期基因產物抗體，這些發現提供了EBV溶裂期的進行與NPC發生有關的線索。依據我們實驗室之前的研究，EBV特早期基因BRLF1基因產物Rta會干擾細胞周期行進並造成基因體不穩定，在這篇研究中，更進一步發現Rta可以透過ERK (extracellular signal-regulated kinase)訊息傳遞路徑造成微核生成。細胞經MEK1/2抑制劑U0126處理即能抑制微核生成。同時亦發現表現Rta的細胞中ERK活化程度較高，且細胞中執行絲裂期檢查點的Aurora B kinase活性較低，造成細胞絲裂期較早結束。 | zh_TW |
| dc.description.abstract | Epstein-Barr virus (EBV) is the etiologic agent of infectious mononucleosis and oral hairy leukoplakia. It is also associated with several human malignancies, such as Burkitt’s lymphoma, Hodgkin’s lymphoma and nasopharyngeal carcinoma (NPC), etc. NPC is a tumor derived from the epithelial cells of nasal-pharynx. Chromosomal instability has been demonstrated in the tumor cells by cytogenetic analysis. Chromosomal instability is highly associated with the development of cancer cells. Although the major viral products demonstrated in the NPC biopsy samples are derived from latent genes, many lytic gene products are also found in these samples. High antibody titers against viral lytic proteins can be detected in the serum samples obtained from NPC patients. These observations have led to the hypothesis that viral lytic replication is highly associated with the development of NPC. From our previous observation, the viral immediate-early protein Rta, the gene product of BRLF1 is able to interfere with the cell cycle progression and induce chromosomal instability. In this study we further demonstrate that Rta-induced micronucleus formation is mediated through the extracellular signal-regulated kinase (ERK) signaling pathway. In the presence of MEK1/2 inhibitor, U0126, the micronucleus formation ability is blocked. Enhanced ERK phosphorylation can be detected in cells expressing Rta protein. The kinase activity of the mitotic checkpoint protein, Aurora B kinase, is decreased and consequently leading to an early exist from the mitotic phase is demonstrated in Rta expressed cells. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-08T07:12:00Z (GMT). No. of bitstreams: 1 ntu-97-R95445127-1.pdf: 5113119 bytes, checksum: a43d88e26e620aae1c51610f0b0cfbb4 (MD5) Previous issue date: 2008 | en |
| dc.description.tableofcontents | 序論 ……………………………………………………… 1
材料與方法 ……………………………………………………… 16 實驗結果 ……………………………………………………… 28 討論 ……………………………………………………… 33 圖表 ……………………………………………………… 38 參考文獻 ……………………………………………………… 52 | |
| dc.language.iso | zh-TW | |
| dc.subject | 絲裂原活化蛋白激酶 | zh_TW |
| dc.subject | EBV | zh_TW |
| dc.subject | 溶裂期 | zh_TW |
| dc.subject | 微核生成 | zh_TW |
| dc.subject | Aurora B kinase | zh_TW |
| dc.subject | 訊息傳遞路徑 | zh_TW |
| dc.subject | Aurora B kinase | en |
| dc.subject | micronuclei formation | en |
| dc.subject | ERK | en |
| dc.subject | EBV | en |
| dc.subject | Rta | en |
| dc.title | EB病毒特早期蛋白質Rta促使人類上皮細胞微核生成之研究 | zh_TW |
| dc.title | Enhancement of micronuclei formation by Epstein-Barr virus immediate-early protein, Rta in human epithelial cells | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 96-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 陳振陽(Jen-Yang Chen),陳美如(Mei-Ru Chen),林素芳(Su-Fang Lin),許晉銓(Jinn-Chyuan Sheu) | |
| dc.subject.keyword | EBV,溶裂期,微核生成,絲裂原活化蛋白激酶,訊息傳遞路徑,Aurora B kinase, | zh_TW |
| dc.subject.keyword | EBV,Rta,ERK,Aurora B kinase,micronuclei formation, | en |
| dc.relation.page | 65 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2008-07-31 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 微生物學研究所 | zh_TW |
| 顯示於系所單位： | 微生物學科所 | |
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