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| ???org.dspace.app.webui.jsptag.ItemTag.dcfield??? | Value | Language |
|---|---|---|
| dc.contributor.advisor | 江伯倫 | |
| dc.contributor.author | Chih-Kang Chen | en |
| dc.contributor.author | 陳志剛 | zh_TW |
| dc.date.accessioned | 2021-06-08T06:29:03Z | - |
| dc.date.copyright | 2006-08-02 | |
| dc.date.issued | 2006 | |
| dc.date.submitted | 2006-07-26 | |
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The role of IFN-gamma in systemic lupus erythematosus: a challenge to the Th1/Th2 paradigm in autoimmunity. Arthritis Res 2001;3(3):136-41. 64. Wadhwa M, Seghatchian MJ, Dilger P, Contreras M, Thorpe R. Cytokine accumulation in stored red cell concentrates: effect of buffy-coat removal and leucoreduction. Transfus Sci 2000;23(1):7-16. 65. Wells TN, Power CA, Shaw JP, Proudfoot AE. Chemokine blockers--therapeutics in the making? Trends Pharmacol Sci 2006;27(1):41-7. 66. Winkler O, Hadnagy W, Idel H. Cytokines detectable in saliva of children as appropriate markers of local immunity of the oral cavity--an approach for the use in air pollution studies. Int J Hyg Environ Health 2001;204(2-3):181-4. 67. Wrone-Smith T, Nickoloff BJ. Dermal injection of immunocytes induces psoriasis. J Clin Invest 1996;98(8):1878-87. 68. Yamashita T, Akamatsu H, Tomitaka A, Ogawa Y, Sugawara N, Matsunaga K. IP-10 in atopic dermatitis. Allergy 2003;58(3):261. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/25768 | - |
| dc.description.abstract | 背景：浸潤到表皮的嗜中性球在乾癬的生成上扮演最重要角色。化學激素則負責嗜中性球移動的工作，並與疾病的嚴重度有關。本實驗是想要研究疾病嚴重度與化學激素的相關性。目的：研究可利用的化學激素指標，是否用來評估乾癬的嚴重度。方法：於本院收集16位乾癬病患，測量血液、尿液、及唾液中化學激素IP-10 (interferon inducible protein 10), MCP-1 (monocyte chemoattractant protein-1), MIG (monokine induced by IFNγ), RANTES (regulated upon activation normal T cell expressed and secreted), IL-8 (interleukin 8)的濃度，並於一個月後重複採集標本；同時收集50名健康成人體液標本為對照組，利用免疫螢光流式細胞儀測定。結果：乾癬病患血清中化學激素IP-10, MIG 濃度較正常對照組高出許多(p<0.0001)，並與PASI 呈現正相關 (Spearman’s γ=0.91)。而乾癬病患血清中化學激素RANTES, IL-8卻較對照組為低(p<0.05)。尿液及唾液化學激素則在各組之間則沒有太大差異。結論：血清中IP-10濃度與乾癬病患PASI分數呈現良好正相關，可考慮作為臨床研究上替代PASI評估乾癬疾病嚴重度的工具。 | zh_TW |
| dc.description.abstract | Background: Infiltrating neutrophils play a key role in pathogenesis of psoriasis. Chemokines are involved in leukocyte homing and contribute to inflammatory process in psoriatic skin lesions. Objective: To investigate the possible chemokine index for the assessment of the disease severity. Methods: Serum concentrations of chemokines IP-10, MCP-1, MIG, RANTES, and IL-8 were assayed in 16 psoriasis patients with serial sampling and 50 healthy controls by immunofluorescence flow cytometry with beads array. Results: Serum IP-10, MIG concentrations in psoriasis patients were higher than in controls (p<0.0001), and correlated significantly with PASI score. While serum RANTES, IL-8 in psoriasis patients were lower than in controls (p<0.05). No significant differences in urine and saliva chemokines concentrations among all groups. Conclusions: Serum IP-10 levels fits well with PASI score in psoriasis patients, even under different treatment regimen. It may be used as parallel parameter for PASI score in researching of psoriasis. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-08T06:29:03Z (GMT). No. of bitstreams: 1 ntu-95-P93421004-1.pdf: 847938 bytes, checksum: 9a46c32bb1777dd3de836baba7bc2f97 (MD5) Previous issue date: 2006 | en |
| dc.description.tableofcontents | 中文摘要------------------------------------- 5
緒論----------------------------------------- 7 研究方法與材料-------------------------------22 結果-----------------------------------------26 討論-----------------------------------------28 展望-----------------------------------------33 論文英文簡述---------------------------------35 參考文獻-------------------------------------39 圖表-----------------------------------------45 | |
| dc.language.iso | zh-TW | |
| dc.subject | 化學激素 | zh_TW |
| dc.subject | 乾癬 | zh_TW |
| dc.subject | T細胞 | zh_TW |
| dc.subject | psoriasis | en |
| dc.subject | chemokine | en |
| dc.subject | Th1 | en |
| dc.title | 乾癬病患之化學激素濃度與疾病嚴重度相關性 | zh_TW |
| dc.title | Correlation between chemokine level and severity of psoriasis | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 94-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 張雲亭,邱顯清 | |
| dc.subject.keyword | 乾癬,化學激素,T細胞, | zh_TW |
| dc.subject.keyword | psoriasis,chemokine,Th1, | en |
| dc.relation.page | 59 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2006-07-26 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 臨床醫學研究所 | zh_TW |
| Appears in Collections: | 臨床醫學研究所 | |
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