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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/25665
標題: | 甲襞微循環之血液動力學與皮膚微循環生理關係之探討:溫度、藥物及低能量雷射等參數影響下之紅血球流速變化 Capillary hemodynamics on nailfold under physiological variation:temperature.centella & low intensity laser |
作者: | Chiun-Yuan Cheng 鄭鈞元 |
指導教授: | 邵耀華 |
關鍵字: | 微循環,紅血球流速,低能量雷射,甲襞, hemodynamics,nailfold,LLLI,rbcv, |
出版年 : | 2006 |
學位: | 碩士 |
摘要: | 微循環系統與整個血液的循環系統緊密關連,包含了微動脈、微血管、微靜脈等結構,是一個功能性的循環系統,人體中血液與組織細胞代謝物質的交換,主要就發生在微血管部分。許多疾病的徵狀也都容易在微循環中顯現。
本研究利用capillaroscope及顯微影像,來探討皮膚微循環生理學上與血液流動力學之間關係的研究,改變可能影響血流的參數,觀察其血液流變異常、微循環障礙,並且在量測藥物對於微循環的反應上,發現除了流速會隨著藥物的吸收而上升(0.38±0.29mms-1 to 0.37±0.22 mms-1)之外,影像也會隨之變得更加清晰;實驗數據的分析結果,流速也隨著溫度的上升約由0.35±0.27mms-1 t至0.67±0.20mms-1,與文獻探討中的數據大致相符合;也同時證實了低能量雷射對於微循環的功效(紅血球流速由0.37±0.24mms-1 上升至 0.45±0.30 mms-1)。本研究試圖提出合理的定量臨床參數,來作為將來醫師臨床上的應用。 本實驗的研究方法,使用價錢較為低廉的系統設備,能夠觀察平行於皮膚表面的單一條微血管在一個階段的時間變域內,幫助我們在實驗中得到不同於LDP流量儀的資訊,並且能夠成功的應用於活體的紅血球流速量測,提供臨床上實質的應用。 Great finger nail matrix capillaries were continuously examined in 35 normal volunteers with the Lippolis capillaroscope . Under the increasing of body temperature red blood cell velocities(RBCV) were raised from 0.35±0.27mms-1 to 0.67±0.20mms-1 in 80.2% amounts of flowing cappilaries and 61.0% amounts of total capillaries. All subjects were treated with total triterpenic fraction of Centella asiatica (TTFCA) (0.1g on 1cm2 of nail finger), a drug active on microcirculation and capillary permeability. With the absorption of TTFCA, real-time images monitored on which the amounts of capillaries could be observed were raised were clearer and RBCVs were raised from 0.38±0.29mms-1 to 0.37±0.22 mms-1 in 24.7% amounts of flowing capillaries and 18.8% amounts of total capillaries. Under the Diode laser (low level laser irradiation) scanning, RBCVs were raised from 0.37±0.24mms-1 to 0.45±0.30 mms-1 in 95.1% amounts of flowing capillaries and 72.3% amounts of total capillaries. Both TTFCA and Diode laser were useful on nail fold by improving microcirculation. . The present method provided a less expensive system with which capillaries were measured relatively parallel to the skin for some period, the RBC particle traces and the corresponding velocity gave a better view of the vessel wall interaction, path irregularity, and upstream influence of pulsation. The present apparatus can be used for the capillaries on the nail fold of fingers, thus its clinical applications to any kind of microcirculation study is feasible. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/25665 |
全文授權: | 未授權 |
顯示於系所單位: | 應用力學研究所 |
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