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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 郭光雄(Guang-Hsiung Kou) | |
dc.contributor.author | Han-Ching Wang | en |
dc.contributor.author | 王涵青 | zh_TW |
dc.date.accessioned | 2021-06-08T06:18:50Z | - |
dc.date.copyright | 2007-01-24 | |
dc.date.issued | 2006 | |
dc.date.submitted | 2007-01-04 | |
dc.identifier.citation | Chang PS, Lo CF, Wang YC and Kou GH (1996) Identification of white spot syndrome associated baculovirus (WSBV) target organs in shrimp, Penaeus monodon by in situ hybridization. Dis Aquat Org 27: 131-139
Chen LL, Leu JH, Huang CJ, Chou CM, Chen SM, Wang CH, Lo CF, GH Kou (2002a) Identification of a nucleocapsid protein (VP35) gene of shrimp white spot syndrome virus and characterization of the motif important for targeting VP35 to the nuclei of transfected insect cells. Virology 293: 44-53 Chen LL, Wang HC, Huang CJ, Peng SE, Chen YG, Lin SJ, Chen WY, Dai CF, Yu HT, Wang CH, Lo CF, Kou GH (2002b) Transcriptional analysis of the DNA polymerase gene of shrimp white spot syndrome virus. Virology 301: 136-147 Chou HY, Huang CY, Wang CH, Chiang HC , Lo CF (1995) Pathogenicity of a baculovirus infection causing white spot syndrome in cultured penaeid shrimp in Taiwan. Dis Aquat Org 23: 165-173 Chou HY, Huang CY, Lo CF, Kou GH (1998) Studies on the transmission of white spot syndrome associated baculovirus (WSBV) in Penaeus monodon and P japonicus via waterborne contact and oral ingestion. Aquaculture 164: 263-276 Flegel TW (1997) Special topic review: major viral diseases of the black tiger prawn (Penaeus monodon) in Thailand. World J Microbiol Biotechnol 13: 433-442 Flegel TW, Pasharawipas T (1998) Active viral accommodation: A new concept for crustacean response to viral pathogens, In Advances in Shrimp Biotechnology, eds T W Flegel (National Center for Genetic Engineering and Biotechnology, Bangkok), pp 245-250 Han F, Zhang X (2005) Internal initiation of mRNA translation in insect cell mediated by an internal ribosome entry site (IRES) from shrimp white spot syndrome virus (WSSV). Biochem Biophys Res Commun 344: 893-899 Huang J, Yu J, Song XL, Kong J, Yang CH (1995) Studies on fine structure, nucleic acid, polypeptide and serology of hypodermal and hematopoietic necrosis baculovirus of penaeid shrimp. Mar Fish Res 16: 11-23 Huang C, Zang X, Lin Q, Xu X, Hew CL (2002a) Characterization of a novel envelope protein (VP281) of shrimp white spot syndrome virus by mass spectrometry. J Gen Virol 83: 2385-2392 Huang C, Zang X, Lin Q, Xu X, Hu Z, Hew CL (2002b) Proteomic analysis of white spot syndrome viral proteins and characterization of a novel protein VP466. Mol Cell Proteomics 1: 223-231 Hossain MS, Khadijah S, Kwang J (2004) Characterization of ORF89--a latency-related gene of white spot syndrome virus. Virology 325: 106-115 Hsu HC, Lo CF, Lin SC, Liu KF, Peng SE, Chang YS, Chen LL, Liu WJ, Kou GH (1999) Studies on effective PCR screening strategies for white spot syndrome virus (WSSV) detection in Penaeus monodon brooders. Dis Aquat Org 39: 13-19 Inouye K, Miwa S, Oseko N, Nakano H, Kimura T (1994) Mass mortalities of cultured kuruma shrimp, Penaeus japonicus, in Japan in 1993: Electron microscopic evidence of the causative virus. Fish Pathol. 29: 149-158 Inouye K, Yamano K, Ikeda N, Kimura T, Nakano H, Momoyama K, Kobayashi J, Miyajima S (1996) The penaeid rod-shaped DNA virus (PRDV), which caused penaeid acute viremia (PAV). Fish Pathol 31: 39-45 Karunasagar I, Otta SK, Karunasagar I (1998) Disease problems affecting cultured penaeid shrimp in India: Fish Pathol 33: 413-419 Keith IR, Paterson WD, Airdrie D, Boston LD (1992) Defence mechanisms of the American lobster (Homarus americanus): Vaccination provided protection against gaffkemia infections in laboratory and field trials. Fish Shellfish Immunol 2: 109-119 Kou GH, Chang YS, Peng SE, Lo CF (2001) Viral infection of cultured shrimp in Taiwan In Proceedings of the JSPS-NRCT International Symposium on Sustainable Shrimp Culture and Health Management Diseases and Environment, (Japan), vol 221, pp15-27 Leu JH, Tsai JM, Wang HC, Wang AH, Kou GH, Lo CF (2005) The Unique Stacked Rings in the Nucleocapsid of the White Spot Syndrome Virus Virion Are Formed by the Major Structural Protein VP664, the Largest Viral Structural Protein Ever Found. J Virol 79: 140-149 Li L, Lin S, Yanga F (2005) Functional identification of the non-specific nuclease from white spot syndrome virus. Virology 337: 399-406 Lightner DV (1996) A handbook of shrimp pathology and diagnostic procedures for diseases of penaeid shrimp (World Aquaculture Society, Baton Rouge, Louisiana) Lightner DV, Redman RM, Poulos BT, Nunan LM, Mari JL, Hasson KW, JR Bonami (1997) Taura syndrome: Etiology, pathology, hosts and geographic distribution, and detection methods In New approaches to viral diseases of aquatic animals (National Research Institute of Aquaculture, Nansei, Mie, Japan) pp 190-205 Lin ST, Chang YS, Wang HC, Tzeng HF, Chang TZ, Lin JY, Wang CH, Lo CF, Kou GH (2002) Ribonucleotide reductase of shrimp white spot syndrome virus (WSSV): Expression and enzymatic activity in a baculovirus/insect cell system and WSSV-infected shrimp. Virology 304: 282-290 Liu WJ, Yu HT, Peng SE, Chang YS, Pien HW, Lin CJ, Huang CJ, Tsai MF, Huang CJ, Wang CH, Lin JY, Lo CF, Kou GH (2001) Cloning, characterization and phylogenetic analysis of a shrimp white spot syndrome virus (WSSV) gene that encodes a protein kinase Virology 289: 362-377 Liu WJ, Chang YS, Wang CH, Kou GH, Lo CF (2005) Microarray and RT-PCR screening for white spot syndrome virus immediate early genes in cycloheximide-treated shrimp. Virology 334: 327-341 Liu WJ, Chang YS, Wang AH, Kou GH, Lo CF. WSSV has Successfully Annexed a Shrimp STAT To Enhance the Expression of the Immediate Early Gene (ie1). J Virol (accepted) Liu X, Yang F (2005) Identification and function of a shrimp white spot syndrome virus (WSSV) gene that encodes a dUTPase. Virus Res 110: 21-30 Lo CF, Leu JH, Ho CH, Chen CH, Peng SE, Chen YT, Chou CM, Yeh PY, Huang CJ, Chou HY, Wang CH, Kou GH (1996) Detection of baculovirus associated with white spot syndrome (WSBV) in penaeid shrimps using polymerase chain reaction. Dis Aquat Org 25: 133-141 Lo CF, Ho CH, Chen CH, Liu KF, Chiu YL, Yeh PY, Peng SE, Hsu HE, Liu HC, Chang CF, Su MS, Wang CH, Kou GH (1997) Detection and tissue tropism of white spot syndrome baculovirus (WSBV) in captured brooders of Penaeus monodon with a special emphasis on reproductive organs. Dis Aquat Org 30: 53-72 Lo CF, Kou GH (1998) Virus-associated white spot syndrome of shrimp in Taiwan: a review. Fish Pathol 33: 365-371 Lo CF, Chang YS, Cheng CT, Kou GH (1998) PCR monitoring cultured shrimp for white spot syndrome virus (WSSV) in growout ponds In Advances in Shrimp Biotechnology, eds T W Flegel (National Center for Genetic Engineering and Biotechnology, Bangkok), pp 281-286 Lotz JM, Browdy CL, Carr WH, Frelier PF, Lightner DV (1995) Swimming Trough Troubled Water. Special session on shrimp farming. Aquaculture ‘95’ : 66-75. World Aquaculture Society, LA, USA. Lu CP, Zhu S, Guo FS, Wu SY (1997) Electron microscopic observation on a non-occluded baculo-like virus in shrimps. Arch Virol 142: 2073-2078 Magbanua FO, Natividad KT, Migo VP, Alfafara CG, de la Pena FO, Miranda RO, Albaladejo JD, Jr Nadala EC, Loh PC, Mahilum-TapayL (2002) White spot syndrome virus (WSSV) in cultured Penaeus monodon in the Philippines. Dis Aquat Org 42: 77-82 Marks H, Ren XY, Sandbrink H, van Hulten MC, Vlak JM (2006) In silico identification of putative promoter motifs of White Spot Syndrome Virus. BMC Bioinformatics 7: 309 Mohan CV, Shankar KM, Kulkarni S, Sudha PM (1998) Histopathology of cultured shrimp showing gross signs of yellow head syndrome and white spot syndrome during 1994 Indian epizootics. Dis Aquat Org 34: 9-12 Owens L, Haqshenas G, McElnea C, Coelen R (1998) Putative spawner-isolated mortality virus associated with mid-crop mortality syndrome in farmed Penaeus monodon from northern Australia. Dis Aquat Org 34: 177-185 Park JH, Lee YS, Lee S, Lee Y (1998) An infectious viral disease of penaeid shrimp newly found in Korea. Dis Aquat Org 34: 71-75 Peng SE, Lo CF, Lin SC, Chen LL, Chang YS, Liu KF, Su MS, Kou GH (2001) Performance of WSSV-infected and WSSV-negative Penaeus monodon postlarvae in culture ponds. Dis Aquat Org 46: 165-172 Poulos BT, Pantoja CR, Bradley-Dunlop D, Aguilar J, DV Lightner (2001) Development and application of monoclonal antibodies for the detection of white spot syndrome virus of penaeid shrimp. Dis Aquat Org 47: 13-23 Rajendran KV, Vijayan KK, Krol RM (1999) Experimental host range and histopathology of white spot syndrome virus (WSSV) infection in shrimp, prawns, crabs and lobsters from India. Dis Aquat Org 22: 183-191 Rosenberry B. (1995) World shrimp Farming 1995. Shrimp News International 9. Sritunyalucksana K, Wannapapho W, Lo CF, Flegel TW (2006) PmRab7 is a VP28-binding protein involved in white spot syndrome virus infection in shrimp. J Virol 80: 10734-10742 Soto MA, Lotz JM (2000) Epidemiological parameters of White Spot Syndrome Virus infections in Litopenaeus vannamei and L setiferus. J Invertebr Pathol 78: 9-15 Tsai MF, Kou GH, Liu HC, Liu, KF Chang CF, Peng SE, Hsu HC, Wang CH , Lo CF (1999) Long-term presence of white spot syndrome virus (WSSV) in a cultivated shrimp population without disease outbreaks. Dis Aquat Org 38: 107-114 Tsai MF, Lo CF, van Hulten MCW, Tzeng HF, Chou CM, Huang CJ, Wang CH, Lin JY, Valk JM, Kou GH (2000a)Transcriptional analysis of the ribonucleotide reductase genes of shrimp white spot syndrome virus. Virology 277: 92-99 Tsai MF, Yu HT, Tzeng HF, Leu JH, Chou CM, Huang CJ, Wang CH, Lin JY, Kou GH, Lo CF (2000b) Identification and characterization of a shrimp white spot syndrome virus (WSSV) gene that encodes a novel chimeric polypeptide of cellular-type thymidine kinase and thymidylate kinase. Virology 277: 100-110 Tsai JM, Wang HC, Leu JH, Hsiao HH, Wang AH, Kou GH, Lo CF (2004) Genomic and proteomic analysis of thirty-nine structural proteins of shrimp white spot syndrome virus. J Virol 78: 11360-11370 Tsai JM, Wang HC, Leu JH, Wang AH, Zhuang Y, Walker PJ, Kou GH, Lo CF (2006) Identification of the nucleocapsid, tegument, and envelope proteins of the shrimp white spot syndrome virus virion. J Virol 80: 3021-3029 Tzeng HF, Chang ZF, Peng SE, Wang CH, Lin JY, Kou GH, Lo CF (2002) Chimeric polypeptide of thymidine kinase and thymidylate kinase of shrimp white spot syndrome virus: thymidine kinase activity of the recombinant protein expressed in a baculovirus/insect cell system. Virology 299: 248-255 van Hulten MCW, Westenberg M, Goodall SD, Vlak JM (2000) Identification of two major virion protein genes of white spot syndrome virus of shrimp. Virology 266: 227-236 van Hulten MCW, Witteveldt J, Snippe M, Vlak JM (2001a) White spot syndrome virus envelope protein VP28 is involved in the systemic infection of shrimp. Virology 285: 228-233 van Hulten MCW, Witteveldt J, Peters S, Kloosterboer N, Tarchini R, Fiers M, Sandbrink H, Lankhorst RK, Vlak JM (2001b) The white spot syndrome virus DNA genome sequence. 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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/25562 | - |
dc.description.abstract | 蝦類水產養殖是亞洲地區之重要產業之一,而此產業持續地受到幾種蝦類病毒性疾病的危害,尤為白點症病毒 (white spot syndrome virus, WSSV)所造成的白點症(white spot syndrome)。本研究係探討白點症病毒在兩種蝦類—草蝦 (Penaeus monodon) 及白蝦 (Litopenaeus vannamei) —寄主細胞內病毒基因表現的層次。藉由微陣列分析及草蝦蝦苗EST資料庫,分析WSSV感染之草蝦體內之病毒基因表現圖譜,從中鑑定出WSSV icp11 (infective cytosolic protein 11) 係為具有最高表現量的病毒基因 (其基因表現量為WSSV主要結構性蛋白質基因vp28的三倍)。而WSSV感染之白蝦之蛋白質表現上,依感染後之白蝦鰓組織之蛋白質二維電泳及液相層析串聯式質譜儀進行蛋白質鑑定所得結果,顯示ICP11同樣在轉譯層次上具有高度表現性。然而屬於白點症病毒非結構性蛋白質的ICP11之胺基酸序列與現在任何已知蛋白質序列不具有同源性,而認為ICP11為一個新穎蛋白質。我們利用蛋白質結構和功能分析,成功地鑑定出ICP11多重生物性功能。ICP11具有形成多聚體特性,且可同時存在於感染病毒之草蝦血細胞及轉染ICP11之昆蟲細胞 (Sf9) 的細胞質與細胞核中。而經由Far-Western blot反應顯示ICP11可與histone 相結合。除此之外,ICP11亦具有鎂離子依存之DNA水解酵素的特性,而只要存在有Mg2+及足夠量的ICP11下,這兩種功能皆可以同時存在的。因此,我們假設ICP11與寄主DNA競爭與histone結合,使表現或複製中的寄主DNA持續裸露外,亦因此結合而使寄主無法形成完整的核小體構造,而其餘的ICP11則可利用DNase活性以切割寄主DNA,此種作用機制或許就是導致寄主細胞死亡的主要原因。 | zh_TW |
dc.description.abstract | This study investigates white spot syndrome virus (WSSV) gene expression levels in the cells of two hosts (Penaeus monodon and Litopenaeus vannamei). Microarray and EST analysis of the mRNA profiles in WSSV-infected P. monodon cells were used to identify WSSV genes that were very highly expressed. Results showed that the mRNA of the WSSV icp11 gene consistently had the highest copy number of all other viral transcripts (eg. 3x higher than the transcripts of the major envelope protein, VP28). At the protein level in WSSV-infected L. vannamei, 2-DE gel analysis and MS/MS protein identification also showed that this WSSV non-structural protein has the highest expression levels so far reported in WSSV-infected cells. However, this novel protein has no sequence homology to any other known protein, and its function remains unknown. Therefore, by using structural and functional analysis, we successfully characterized its multiple biological roles. ICP11 is capable of homo-oligomerization and localizing in both the cytoplasm and nucleus of the host cell and transfected insect cell. A Far-Western blot confirmed ICP11 can interact with the histone protein. We also found that ICP11 exhibits Mg2+ dependent nuclease activity. Additional competitive binding assays further suggested that in the presence of Mg2+ and sufficient ICP11, both of these functions are fulfilled. We therefore hypothesize that ICP11 competes with host DNA to bind to histone protein, and when all of the eligible DNA binding sites are filled, any excess ICP11 will remain unbound and act as a DNase to digest host DNA. These functions could easily result in nucleosome disorder and lead to cell death. | en |
dc.description.provenance | Made available in DSpace on 2021-06-08T06:18:50Z (GMT). No. of bitstreams: 1 ntu-95-D91225001-1.pdf: 3450991 bytes, checksum: b3f3c93b9e9ac443a2c278f60374b47a (MD5) Previous issue date: 2006 | en |
dc.description.tableofcontents | 中文摘要………………………………………………………………………………1
英文摘要………………………………………………………………………………3 第一章 蝦白點症及其病原體-蝦白點症病毒相關文獻回顧……….……………...4 蝦白點症及其病原體 -蝦白點症病毒..………………………………………...5 參考文獻.…………………...………………………………….………………16 第二章 蝦白點症病毒極高表現新穎蛋白質ICP11 之鑑定、功能分析與應用..26 前言 …………………………………………………………………………….27 材料與方法 …………………………………………………………………….33 結果 …………………………………………………………………………….44 討論 …………………………………………………………………………….57 總結 …………………………………………………………………………….68 參考文獻.……………………………………………………………………….69 Table 1.………………………………………………………………………....78 Table 2………………………………………………………………………….79 Figures …………………………………………………………………………81 附錄 …………………………………………………………………………….94 參與發表文章 ……………………………………………………………………….96 期刊論文 ……………………………………………………………………….97 研討會論文 ...…………………………………………………………………..99 專利及專書論文....……………………………………………………………100 | |
dc.language.iso | zh-TW | |
dc.title | 蝦白點症病毒極高表現新穎蛋白質ICP11之鑑定、功能分析與應用 | zh_TW |
dc.title | Identification, functional assay and application of ICP11,
the most highly expressed novel protein of shrimp white spot syndrome virus (WSSV) | en |
dc.type | Thesis | |
dc.date.schoolyear | 95-1 | |
dc.description.degree | 博士 | |
dc.contributor.coadvisor | 黃偉邦(Wei-Pang Huang) | |
dc.contributor.oralexamcommittee | 廖一久(I-Chiu,Liao),周信佑(Hsin-Yiu,Chuo),趙裕展(Yu-Chan, Chao) | |
dc.subject.keyword | 白點症病毒,ICP11,最高表現量,DNA水解酵素, | zh_TW |
dc.subject.keyword | WSSV,ICP11,the highest expression level,DNase, | en |
dc.relation.page | 100 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2007-01-05 | |
dc.contributor.author-college | 生命科學院 | zh_TW |
dc.contributor.author-dept | 動物學研究研究所 | zh_TW |
顯示於系所單位: | 動物學研究所 |
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