請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/25408
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 林正芳(Cheng-Fang Lin) | |
dc.contributor.author | Tsung-Hsien Yu | en |
dc.contributor.author | 余宗賢 | zh_TW |
dc.date.accessioned | 2021-06-08T06:12:14Z | - |
dc.date.copyright | 2011-08-10 | |
dc.date.issued | 2011 | |
dc.date.submitted | 2011-08-04 | |
dc.identifier.citation | Abegglen, C., Joss, A., McArdell, C.S., Fink, G., Schlüsener, M.P., Ternes, T.A., Siegrist, H., 2009. The fate of selected micropollutants in a single-house MBR. Water Research 43, 2036-2046.
Alcock, R.E., Sweetman, A., Jones, K.C., 1999. Assessment of organic contaminant fate in waste water treatment plants I: Selected compounds and physicochemical properties. Chemosphere 38, 2247-2262. Alexy, R., Kumpel, T., Kummerer, K., 2004. Assessment of degradation of 18 antibiotics in the Closed Bottle Test. Chemosphere 57, 505-512. Batt, A.L., Kim, S., Aga, D.S., 2006. Enhanced biodegradation of iopromide and trimethoprim in nitrifying activated sludge. Environmental Science & Technology 40, 7367-7373. Batt, A.L., Kim, S., Aga, D.S., 2007. Comparison of the occurrence of antibiotics in four full-scale wastewater treatment plants with varying designs and operations. Chemosphere 68, 428-435. Brain, R.A., Johnson, D.J., Richards, S.M., Sanderson, H., Sibley, P.K., Solomon, K.R., 2004. Effects of 25 pharmaceutical compounds to Lemna gibba using a seven-day static-renewal test. Environmental Toxicology and Chemistry 23, 371-382. Brown, K.D., Kulis, J., Thomson, B., Chapman, T.H., Mawhinney, D.B., 2006. Occurrence of antibiotics in hospital, residential, and dairy, effluent, municipal wastewater, and the Rio Grande in New Mexico. Science of the Total Environment 366, 772-783. Calamari, D., Zuccato, E., Castiglioni, S., Bagnati, R., Fanelli, R., 2003. Strategic survey of therapeutic drugs in the rivers Po and Lambro in northern Italy. Environmental Science & Technology 37, 1241-1248. Carballa, M., Omil, F., Lema, J.M., 2007. Calculation methods to perform mass balances of micropollutants in sewage treatment plants. Application to pharmaceutical and personal care products (PPCPs). Environmental Science & Technology 41, 884-890. Carballa, M., Omil, F., Lema, J.M., Llompart, M., Garcia-Jares, C., Rodriguez, I., Gomez, M., Ternes, T., 2004. Behavior of pharmaceuticals, cosmetics and hormones in a sewage treatment plant. Water Research 38, 2918-2926. Carlsson, C., Johansson, A.K., Alvan, G., Bergman, K., Kuhler, T., 2006. Are pharmaceuticals potent environmental pollutants? Part I: Environmental risk assessments of selected active pharmaceutical ingredients. Science of the Total Environment 364, 67-87. Cho, E.S., Zhu, J., Yang, P.Y., 2007. Intermittently aerated EMMC-Blobarrel (entrapped mixed microbial cell with Bio-barrel) process for concurrent organic and nitrogen removal. Journal of Environmental Management 84, 257-265. De Gusseme, B., Vanhaecke, L., Verstraete, W., Boon, N., 2011. Degradation of acetaminophen by Delftia tsuruhatensis and Pseudomonas aeruginosa in a membrane bioreactor. Water Research 45, 1829-1837. Ding, Y.J., Zhang, W.H., Gu, C., Xagoraraki, I., Li, H., 2011. Determination of pharmaceuticals in biosolids using accelerated solvent extraction and liquid chromatography/tandem mass spectrometry. Journal of Chromatography A 1218, 10-16. Figueroa, R.A., Mackay, A.A., 2005. Sorption of oxytetracycline to iron oxides and iron oxide-rich soils. Environmental Science & Technology 39, 6664-6671. Göbel, A., Thomsen, A., McArdell, C.S., Alder, A.C., Giger, W., Thei, N., Löffler, D., Ternes, T.A., 2005. Extraction and determination of sulfonamides, macrolides, and trimethoprim in sewage sludge. Journal of Chromatography A 1085, 179-189. Gómez, M.J., Petrovic, M., Fernandez-Alba, A.R., Barcelo, D., 2006. Determination of pharmaceuticals of various therapeutic classes by solid-phase extraction and liquid chromatography-tandem mass spectrometry analysis in hospital effluent wastewaters. Journal of Chromatography A 1114, 224-233. Gauthier, H., Yargeau, V., Cooper, D.G., 2010. Biodegradation of pharmaceuticals by Rhodococcus rhodochrous and Aspergillus niger by co-metabolism. Science of the Total Environment 408, 1701-1706. Ghosh, G.C., Okuda, T., Yamashita, N., Tanaka, H., 2009. Occurrence and elimination of antibiotics at four sewage treatment plants in Japan and their effects on bacterial ammonia oxidation. Water Science and Technology 59, 779-786. Gobel, A., Thomsen, A., McArdell, C.S., Joss, A., Giger, W., 2005. Occurrence and sorption behavior of sulfonamides, macrolides, and trimethoprim in activated sludge treatment. Environmental Science & Technology 39, 3981-3989. Grady, C.P.L., Daigger, G.T., Lim, H.C., 1999. Biological wastewater treatment. Marcel Dekker, New York. Gross, B., Montgomery-Brown, J., Naumann, A., Reinhard, M., 2004. Occurrence and fate of pharmaceuticals and alkylphenol ethoxylate metabolites in an effluent-dominated river and wetland. Environmental Toxicology and Chemistry 23, 2074-2083. Halling-Sørensen, B., Nors Nielsen, S., Lanzky, P.F., Ingerslev, F., Holten Lützhøt, H.C., Jørgensen, S.E., 1998. Occurrence, fate and effects of pharmaceutical substances in the environment- A review. Chemosphere 36, 357-393. Halling-Sorensen, B., 2001. Inhibition of aerobic growth and nitrification of bacteria in sewage sludge by antibacterial agents. Archives of Environmental Contamination and Toxicology 40, 451-460. Halling-Sorensen, B., Lutzhoft, H.C.H., Andersen, H.R., Ingerslev, F., 2000. Environmental risk assessment of antibiotics: comparison of mecillinam, trimethoprim and ciprofloxacin. J. Antimicrob. Chemother. 46, 53-58. Hardman, D.J., 1991. Biotranformation of halogenated compounds. Critical Reviews in Biotechnology 11, 1-40. Hashimoto, T., Onda, K., Nakamura, Y., Tada, K., Miya, A., Murakami, T., 2007. Comparison of natural estrogen removal efficiency in the conventional activated sludge process and the oxidation ditch process. Water Research 41, 2117-2126. Hernando, M.D., Heath, E., Petrovic, M., Barcelo, D., 2006. Trace-level determination of pharmaceutical residues by LC-MS/MS in natural and treated waters. A pilot-survey study. Analytical and Bioanalytical Chemistry 385, 985-991. Ingerslev, F., Halling-Sørensen, B., 2000. Biodegradability properties of sulfonamides in activated sludge. Environmental Toxicology and Chemistry 19, 2467-2473. Jenkins, D., Richard, M.G., Daigger, G.T., 1993. Manual on the causes and control of activated sludge bulking and foaming. Lewis, Boca Raton. Karthikeyan, K.G., Meyer, M.T., 2006. Occurrence of antibiotics in wastewater treatment facilities in Wisconsin, USA. Science of the Total Environment 361, 196-207. Kim, S., Aga, D.S., Jensen, J.N., Weber, A.S., 2007. Effect of sequencing batch reactor operation on presence and concentration of tetracycline-resistant organisms. Water Environmental Research 79, 2287-2297. Kim, S., Eichhorn, P., Jensen, J.N., Weber, A.S., Aga, D.S., 2005. Removal of antibiotics in wastewater: Effect of hydraulic and solid retention times on the fate of tetracycline in the activated sludge process. Environmental Science & Technology 39, 5816-5823. Kolpin, D.W., Furlong, E.T., Meyer, M.T., Thurman, E.M., Zaugg, S.D., Barber, L.B., Buxton, H.T., 2002. Pharmaceuticals, hormones, and other organic wastewater contaminants in US streams, 1999-2000: A national reconnaissance. Environmental Science & Technology 36, 1202-1211. Kreuzinger, N., Clara, M., Strenn, B., Kroiss, H., 2004. Relevance of the sludge retention time (SRT) as design criteria for wastewater treatment plants for the removal of endocrine disruptors and pharmaceuticals from wastewater. Water Science and Technology 50, 149-156. Kulshrestha, P., Giese, R.F., Jr., Aga, D.S., 2004. Investigating the molecular interactions of oxytetracycline in clay and organic matter: Insights on factors affecting its mobility in soil. Abstracts of Papers American Chemical Society 228, U629. Kummerer, K., 2009a. Antibiotics in the aquatic environment - A review - Part I. Chemosphere 75, 417-434. Kummerer, K., 2009b. Antibiotics in the aquatic environment - A review - Part II. Chemosphere 75, 435-441. Ladenburger, S.J., Drewes, J.E., Hemming, J., Schauer, J., Sonzongi, W., 2005. Endocrine disrupting activity changes in water reclamation systems. Proceedings of the 20th Annual Water Reuse Symposium: Water Reuse and Desalination: mile high opportunities, Denver, Colorado. Leahy, J.G., Colwell, R.R., 1990. Microbial-degradation of hydrocarbons in the environment. Microbiological Reviews 54, 305-315. Leclercq, M., Mathieu, O., Gomez, E., Casellas, C., Fenet, H., Hillaire-Buys, D., 2009. Presence and Fate of Carbamazepine, Oxcarbazepine, and Seven of Their Metabolites at Wastewater Treatment Plants. Archives of Environmental Contamination and Toxicology 56, 408-415. Li, B., Zhang, T., 2010. Biodegradation and Adsorption of Antibiotics in the Activated Sludge Process. Environmental Science & Technology 44, 3468-3473. Lin, A.Y.-C., Yu, T.-H., Lateef, S.K., 2009. Removal of pharmaceuticals in secondary wastewater treatment processes in Taiwan. Journal of Hazardous Materials 167, 1163-1169. Lin, A.Y.-C., Yu, T.-H., Lin, C.-F., 2008. Pharmaceutical contamination in residential, industrial, and agricultural waste streams: Risk to aqueous environments in Taiwan. Chemosphere 74, 131-141. Loke, M.-L., Ingerslev, F., Halling-Sørensen, B., Tjørnelund, J., 2000. Stability of Tylosin A in manure containing test systems determined by high performance liquid chromatography. Chemosphere 40, 759-765. Maoz, A., Chefetz, B., 2010. Sorption of the pharmaceuticals carbamazepine and naproxen to dissolved organic matter: Role of structural fractions. Water Research 44, 981-989. Metcalfe, C.D., Koenig, B.G., Bennie, D.T., Servos, M., Ternes, T.A., Hirsch, R., 2003. Occurrence of neutral and acidic drugs in the effluents of Canadian sewage treatment plants. Environmental Toxicology and Chemistry 22, 2872-2880. Miege, C., Choubert, J.M., Ribeiro, L., Eusebe, M., Coquery, M., 2008. Removal efficiency of pharmaceuticals and personal care products with varying wastewater treatment processes and operating conditions - conception of a database and first results. Water Science and Technology 57, 49-56. Nakada, N., Shinohara, H., Murata, A., Kiri, K., Managaki, S., Sato, N., Takada, H., 2007. Removal of selected pharmaceuticals and personal care products (PPCPs) and endocrine-disrupting chemicals (EDCs) during sand filtration and ozonation at a municipal sewage treatment plant. Water Research 41, 4373-4382. Nakada, N., Tanishima, T., Shinohara, H., Kiri, K., Takada, H., 2006. Pharmaceutical chemicals and endocrine disrupters in municipal wastewater in Tokyo and their removal during activated sludge treatment. Water Research 40, 3297-3303. Nitisoravut, S., Yang, P.Y., 1992. Denitrification of nitrate-rich water using entrapped-mixed-microbial cells immobilization technique. Water Science and Technology 26, 923-931. Okuda, T., Yamashita, N., Tanaka, H., Matsukawa, H., Tanabe, K., 2009. Development of extraction method of pharmaceuticals and their occurrences found in Japanese wastewater treatment plants. Environment International 35, 815-820. Pérez, S., Eichhorn, P., Aga, D.S., 2005. Evaluating the biodegradability of sulfamethazine, sulfamethoxazole, sulfathiazole, and trimethoprim at different stages of sewage treatment. Environmental Toxicology and Chemistry 24, 1361-1367. Prado, N., Ochoa, J., Amrane, A., 2009. Biodegradation by activated sludge and toxicity of tetracycline into a semi-industrial membrane bioreactor. Bioresource Technology 100, 3769-3774. Qian, X., Yang, P.Y., Maekawa, T., 2001. Evaluation of Direct Removal of Nitrate with Entrapped Mixed Microbial Cell Technology Using Ethanol as the Carbon Source. Water Environmental Research 73, 584-589. Quintana, J.B., Weiss, S., Reemtsma, T., 2005. Pathway's and metabolites of microbial degradation of selected acidic pharmaceutical and their occurrence in municipal wastewater treated by a membrane bioreactor. Water Research 39, 2654-2664. Radjenovic, J., Petrovic, M., Barcelo, D., 2009. Fate and distribution of pharmaceuticals in wastewater and sewage sludge of the conventional activated sludge (CAS) and advanced membrane bioreactor (MBR) treatment. Water Research 43, 831-841. Sanderson, H., Johnson, D.J., Wilson, C.J., Brain, R.A., Solomon, K.R., 2003. Probabilistic hazard assessment of environmentally occurring pharmaceuticals toxicity to fish, daphnids and algae by ECOSAR screening. Toxicology Letters 144, 383-395. Santos, J.L., Aparicio, I., Alonso, E., 2007. Occurrence and risk assessment of pharmaceutically active compounds in wastewater treatment plants. A case study: Seville city (Spain). Environment International 33, 596-601. Sarmah, A.K., Meyer, M.T., Boxall, A.B.A., 2006. A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment. Chemosphere 65, 725-759. Sassman, S.A., Lee, L.S., 2005. Sorption of three tetracyclines by several soils: Assessing the role of pH and cation exchange. Environmental Science & Technology 39, 7452-7459. Sim, W.J., Lee, J.W., Lee, E.S., Shin, S.K., Hwang, S.R., Oh, J.E., 2011. Occurrence and distribution of pharmaceuticals in wastewater from households, livestock farms, hospitals and pharmaceutical manufactures. Chemosphere 82, 179-186. Song, C.Y., Cho, E., Wang, Z., Yang, P.Y., 2006. Removal of organic and nitrogen and molecular weight distribution of residual soluble organic from entrapped mixed microbial cells and activated sludge processes. Water Environmental Research 78, 2501-2507. Stasinakis, A.S., Kordoutis, C.I., Tsiouma, V.C., Gatidou, G., Thomaidis, N.S., 2010. Removal of selected endocrine disrupters in activated sludge systems: Effect of sludge retention time on their sorption and biodegradation. Bioresource Technology 101, 2090-2095. Sui, Q., Huang, J., Deng, S., Yu, G., Fan, Q., 2010. Occurrence and removal of pharmaceuticals, caffeine and DEET in wastewater treatment plants of Beijing, China. Water Research 44, 417-426. Takigami, H., Taniguchi, N., Matsuda, T., Yamada, M., Shimizu, Y., Matsui, S., 2000. The fate and behaviour of human estrogens in a night soil treatment process. Water Science and Technology 42, 45-51. Vieno, N., Tuhkanen, T., Kronberg, L., 2007. Elimination of pharmaceuticals in sewage treatment plants in Finland. Water Research 41, 1001-1012. Wang, S., Holzem, R.M., Gunsch, C.K., 2008. Effects of pharmaceutically active compounds on a mixed microbial community originating from a municipal wastewater treatment plant. Environmental Science & Technology 42, 1091-1095. Winkler, G., Fischer, R., Krebs, P., Thompson, A., Cartmell, E., 2007. Mass flow balances of triclosan in rural wastewater treatment plants and the impact of biomass parameters on the removal. Engineering in Life Sciences 7, 42-51. Wu, C.X., Spongberg, A.L., Witter, J.D., 2009. Sorption and biodegradation of selected antibiotics in biosolids. Journal of Environmental Science and Health Part a-Toxic/Hazardous Substances & Environmental Engineering 44, 454-461. Xue, W., Wu, C., Xiao, K., Huang, X., Zhou, H., Tsuno, H., Tanaka, H., 2010. Elimination and fate of selected micro-organic pollutants in a full-scale anaerobic/anoxic/aerobic process combined with membrane bioreactor for municipal wastewater reclamation. Water Research 44, 5999-6010. Yang, P.Y., Cao, K., Kim, S.J., 2002. Entrapped mixed microbial cell process for combined secondary and tertiary wastewater treatment. Water Environmental Research 74, 226-234. Yang, P.Y., Chen, H.J., Kim, S.J., 2003. Integrating entrapped mixed microbial cell (EMMC) process for biological removal of carbon and nitrogen from dilute swine wastewater. Bioresource Technology 86, 245-252. Yang, P.Y., See, T.S., 1991. Packed entrapped mixed microbial cell process for removal of phenol and its compounds. Journal of Environmental Science & Health, Part A: Environmental Science & Engineering A26, 1491-1512. Yasojima, M., Nakada, N., Komori, K., Suzuki, Y., Tanaka, H., 2006. Occurrence of levofloxacin, clarithromycin and azithromycin in wastewater treatment plant in Japan. Water Science and Technology 53, 227-233. Yi, T.W., Harper, W.F., Holbrook, R.D., Love, N.G., 2006. Role of particle size and ammonium oxidation in removal of 17 alpha-ethinyl estradiol in bioreactors. Journal of Environmental Engineering-ASCE 132, 1527-1529. Yu, J.T., Bouwer, E.J., Coelhan, M., 2006. Occurrence and biodegradability studies of selected pharmaceuticals and personal care products in sewage effluent. Agricultural Water Management 86, 72-80. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/25408 | - |
dc.description.abstract | 藥物和個人保健用品(pharmaceuticals and personal care products)不僅用以治療人類及動物的疾病,另亦用於畜牧養殖業及水產養殖業等,但藥物經食用後仍會以原型態及代謝型態隨著尿液及糞便排出,導致廢污水殘留藥物。目前廢污水需經由污水處理廠處理後才可排放,但傳統污水處理廠之設計並非針對藥物去除,故傳統污水處理廠無法有效地去除污水中之殘留藥物,且去除效能變異非常大(無去除~幾乎完全去除)。一般而言,藥物去除效率隨污泥停留時間(solid retention time)增加而提升,而固定化生物技術(immobilized cell bio-process)具有長污泥停留時間,且兼具好氧及厭氧程序可有效去除碳和氮。因此,共選定4種抗生素(sulfadimethoxine、sulfamethazine、sulfamethoxazole、trimethoprim)及4種非類醇類消炎止痛藥(acetaminophen、ibuprofen、naproxen、ketoprofen)等8種藥物為目標抗生素與止痛藥,並探討上流式固定化生物技術反應槽對於目標抗生素與止痛藥之處理效能,再藉由批次式實驗評估目標抗生素與止痛藥之主要去除機制及去除動力,及評估各目標抗生素與止痛藥之吸附及脫附特性。
上流式固定化生物反應槽對acetaminophen及ibuprofen之單位污泥吸附降解量介於0.5 ~ 12.3 µg/g-sludge/day (1 ~ 100 µg/L進流濃度);ketoprofen及naproxen則為0.6 ~ 1.6 µg/g-sludge/day (5 ~ 15 µg/L進流濃度);sulfadimethoxine、sulfamethazine及sulfamethoxazole為0.2 ~ 0.9 µg/g-sludge/day (2 ~ 10 µg/L進流濃度);trimethoprim為0.1 µg/g-sludge/day (1 µg/L進流濃度)。 由批次實驗結果得知,目標抗生素與止痛藥之主要去除機制為生物降解作用(bio-degradation)及生物吸附作用(bio-sorption),而揮發作用(volatilization)及水解作用(hydrolysis)均可忽略。依據生物降解及生物吸附可分成以下類型:acetaminophen可被歸類為易生物降解/易生物吸附之物質;sulfamethoxazole、sulfadimethoxine、ibuprofen及naproxen則被歸類為難生物吸附/易生物降解;sulfamethazine及ketoprofen則歸類為難生物吸附/難生物降解之物質;trimethoprim則為中等生物吸附/難生物降解之物質。 依據擬一階生物吸附降解反應速率常數(pseudo-first order bio-sorption-degradation rate constant),acetaminophen及ibuprofen可歸類為容易生物吸附降解之物質,其次為sulfamethoxazole、sulfadimethoxine、naproxen及trimethoprim,而sulfamethazine及ketoprofen則為較難被生物吸附降解作用去除之物質。就90%去除時間(time required for 90% removal, t90)而言,以acetaminophen及ibuprofen之t90為最短,分別為2.1及2.6日;其次為sulfamethoxazole、sulfadimethoxine、trimethoprim及naproxen (7.2 ~ 14.3日);而sulfamethazine及ketoprofen為最長,分別為39.7及44.0日。 由吸附脫附試驗結果,acetaminophen、sulfamethoxazole及sulfadimethoxine屬於易吸附/不易脫附物質;sulfamethazine、trimethoprim及naproxen歸類為中等吸附/易脫附物質;ibuprofen及naproxen屬於不易吸附/易脫附物質。 | zh_TW |
dc.description.abstract | Pharmaceuticals are widely used not only for curing human and animal diseases, but also in farming and aquaculture. Depending on the nature of the pharmaceuticals, parent compounds and metabolites of pharmaceuticals are excreted via urine and feces. Most of wastewater is typically treated by wastewater treatment plants (WWTPs). Since the existing domestic WWTPs are not specially designed for pharmaceuticals removal, their removal in WWTPs is often incomplete, and the degree of removal varied broadly from nearly complete to very little. In general, the removal of pharmaceuticals increases with the increase of solid retention time. Immobilized cell biological process is one of the biological treatment technologies with longer sludge retention time and combination of aerobic and anaerobic process that has excellent potential for carbon and nitrogen removal.
The aims of this study were to: 1) investigate treatability of eight selected pharmaceuticals (four antibiotics: sulfamethoxazole, sulfadimethoxine, sulfamethazine and trimethoprim and four non-steroidal anti-inflammatory drugs (NSAIDs): acetaminophen, ibuprofen, naproxen and ketoprofen) with various influent concentrations by up-flow immobilized cell bio-process at a constant operation, 2) evaluate potential elimination mechanism (bio-degradation, bio-sorption, hydrolysis and volatilization) and their kinetics using batch experiment, and 3) study sorption/desorption capacity and solid-liquid partitioning coefficient by batch experiment. These removal efficiencies are good and steady even at high initial concentrations, removal rate ranging from 0.5 µg/g-sludge/day (at 5 µg/L) to 12.3 µg/g-sludge/day (at 100 µg/L) for acetaminophen and ibuprofen, 0.6 ~ 1.6 µg/g-sludge/day (at 5 ~ 15 µg/L) for ketoprofen and naproxen, 0.2 ~ 0.9 µg/g-sludge/day (at 2 ~ 10 µg/L) for sulfonamide antibiotics, and 0.1 µg/g-sludge/day (at 1 µg/L) for trimethoprim. In the batch experiment, bio-degradation and bio-sorption were found to be the dominant elimination routes, while volatilization and hydrolysis can be ignored for all target pharmaceuticals. Based on the batch experiment results, acetaminophen was characterized by significant biodegradability and sorption, resulting in 100% removal in 8 days via sorption and > 25% removal by bio-degradation within 2 days. Sulfamethoxazole, sulfadimethoxine, ibuprofen and naproxen were fairly well biodegraded (> 40% removal) and hardly sorbed (< 40% removal) to the bio-carriers. Sulfamethazine and ketoprofen were slowly biodegraded and weakly sorbed, resulting in removal of 23% and 28% by bio-degradation and 20% and 18% by sorption. The fate of trimethoprim was characterized by low biodegradability (27%) and medium sorption (47%). Based on pseudo-first bio-sorption-degradation kinetic rate constants of target pharmaceuticals, acetaminophen and ibuprofen are readily bio-sorption-degradable substances, followed by sulfamethoxazole, sulfadimethoxine, naproxen and trimethoprim are slowly, while sulfamethazine and ketoprofen are hardly bio-sorption-degradable pharmaceuticals. Moreover, the time required for 90% removal (t90) via bio-sorption-degradation for acetaminophen and ibuprofen were 2.1 and 2.6 days, followed by sulfamethoxazole, sulfadimethoxine, trimethoprim and naproxen (7.2 ~ 14.3 days), while sulfamethazine and ketoprofen were persistent in immobilized cell system due to their longer t90 of 2.2 ~ 13.3 days. In the sorption/desorption experiment, acetaminophen, sulfamethoxazole and sulfadimethoxine were characterized by strong sorption and weak desorption. A phenomenon of moderate sorption and well desorption was observed for sulfamethazine, trimethoprim and naproxen. Both ibuprofen and ketoprofen were weakly sorbed and strongly desorbed. | en |
dc.description.provenance | Made available in DSpace on 2021-06-08T06:12:14Z (GMT). No. of bitstreams: 1 ntu-100-D95541004-1.pdf: 790041 bytes, checksum: 4eb18ba9bfd4d8c71509b9070337b778 (MD5) Previous issue date: 2011 | en |
dc.description.tableofcontents | 論文口試委員審定書 I
誌 謝 II 摘 要 III ABSTRACT V 目 錄 VIII 表 目 錄 X 圖 目 錄 XI 第一章 前 言 1 1.1 研究背景 1 1.2 研究目的與項目 2 第二章 文獻回顧 4 2.1 抗生素與止痛藥之特性 4 2.1.1 物化特性及污染來源 4 2.1.2 生物毒性資料 7 2.2 PPCPS之生物處理程序效能 8 2.3 處理效能影響因子 11 2.4 生物處理機制及動力 13 2.4.1 生物吸附作用 13 2.4.2 生物降解作用 16 2.5 固定化生物處理技術 20 第三章 研究方法 21 3.1 實驗設計與操作條件 21 3.1.1 連續流固定化上流式生物反應槽 21 3.1.2 動力實驗 23 3.1.3 吸脫附實驗 25 3.2 分析方法 26 3.2.1 一般水質分析方法 26 3.2.2 目標抗生素與止痛藥分析方法 26 3.3 數據分析 32 第四章 結果與討論 34 4.1 連續流固定化上流式生物反應槽 34 4.2 生物降解及生物吸附 42 4.3 吸脫附試驗 54 第五章 結論及建議 62 5.1 結論 62 5.2 建議 63 參考文獻 64 | |
dc.language.iso | zh-TW | |
dc.title | 固定化生物技術對抗生素及非類固醇類消炎止痛藥之生物降解與生物吸附研究 | zh_TW |
dc.title | Bio-Degradation and Bio-Sorption of Antibiotics and Non-Steroidal Anti-Inflammatory Drugs by Immobilized Cell Bio-Process | en |
dc.type | Thesis | |
dc.date.schoolyear | 99-2 | |
dc.description.degree | 博士 | |
dc.contributor.coadvisor | 林郁真(Angela Yu-Chen Lin) | |
dc.contributor.oralexamcommittee | 李俊福(Jiunn-Fwu Lee),康佩群(Pui-Kwan Andy Hong),童心欣(Hsin-Hsin Tung),劉志成(Jhy-Chern Liu) | |
dc.subject.keyword | 固定化生物處理,抗生素,非類固醇類消炎止痛藥,生物降解,生物吸附, | zh_TW |
dc.subject.keyword | Immobilized cell biological process,Antibiotics,Non-steroidal anti-inflammatory drugs,Bio-degradation,Bio-sorption, | en |
dc.relation.page | 72 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2011-08-04 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 環境工程學研究所 | zh_TW |
顯示於系所單位: | 環境工程學研究所 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-100-1.pdf 目前未授權公開取用 | 771.52 kB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。