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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 戴政 | |
| dc.contributor.author | Pei-Fen Kuo | en |
| dc.contributor.author | 郭沛棻 | zh_TW |
| dc.date.accessioned | 2021-06-08T05:56:27Z | - |
| dc.date.copyright | 2008-02-20 | |
| dc.date.issued | 2008 | |
| dc.date.submitted | 2008-01-30 | |
| dc.identifier.citation | 中文文獻：
戴政 (2002). '遺傳流行病學－基因定位之遺傳設計與分析方法.' 台北, 藝軒圖書出版社. 吳性慧 (2006). '利用親子二元體資料建立尋找疾病基因的相關分析方法.' 台灣大學流行病學研究所碩士論文. 張敦程 (2006). '非完整訊息染病同胞對資料之統計分析－應用熵測度為權數的加權檢定方法.' 台灣大學流行病學研究所碩士論文. 彭國倫 (2001). 'FORTRAN 95程式設計.' 台北, 碁峰資訊. 廖啟泰編譯 (1991). 'Minitab使用手冊.' 台北, 儒林出版社. 劉妍甄 (2006). '以相似度為基礎之多基因疾病相關檢定.' 台灣大學流行病學研究所碩士論文. 英文文獻： Barrios, E. (2007). Useful Functions for Box, Hunter and Hunter II. Bourgain, C.Genin, E.Holopainen, P.Mustalahti, K.Maki, M.Partanen, J.Clerget-Darpoux, F. (2001). 'Use of closely related affected individuals for the genetic study of complex diseases in founder populations.' Am J Hum Genet 68: 154-159. Bourgain, C.Genin, E.Ober, C.Clerget-Darpoux, F.(2002). 'Missing data in haplotype analysis: a study on the MILC method.' Ann Hum Genet 66: 99-108. Bourgain, C.Genin, E.Quesneville, H.Clerget-Darpoux, F. (2000). 'Search for multifactorial disease susceptibility genes in founder populations.' Ann Hum Genet 64: 255-265. Braun, J. M. a. J. (2003). Data Analysis and Graphics Using R - An Example-Based Approach. New York, Cambridge University Press. Camp, N. J. (1997). 'Genomewide transmission/disequilibrium testing--consideration of the genotypic relative risks at disease loci.' Am J Hum Genet 61: 1424-1430. Clayton, D. (1999). 'A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission.' Am J Hum Genet 65: 1170-1177. Clayton, D. and H. Jones (1999). 'Transmission/disequilibrium tests for extended marker haplotypes.' Am J Hum Genet 65: 1161-1169. Falk, C. T. and P. Rubinstein (1987). 'haplotype relative risks: an easy reliable way to construct a proper control sample for risk calculations.' Ann Hum Genet 51: 227-233. Good, P. (2005). Permutation, parametric and bootstrap tests of hypotheses. New York, Springer. Higgins, J. J. (2004). Introduction to Modern Nonparametric Statistics. USA, Thomson. Hornik, T. H. a. K. (2006). Exact Distributions for Rank and Permutation Tests. Lange, E. M. and M. Boehnke (2004). 'The haplotype runs test: the parent-parent-affected offspring trio design.' Genet Epidemiol 27: 118-130. Ott, J. (1989). 'Statistical properties of the haplotype relative risk.' Genet Epidemiol 6: 127-30. Spielman, R. S.McGinnis, R. E.Ewens, W. J. (1993). 'Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).' Am J Hum Genet 52: 506-516. Tai, J. J. and W. H. Song (1991). 'Linkage disequilibrium and linkage information from one-child families.' Hum Hered 41: 316-323. Higgins, J. J. (2004). Introduction to Modern Nonparametric Statistics. USA, Thomson Torsten Hothorn, K. H., Mark A. van de Wiel and Achim Zeileis (2007). Conditional Inference Procedures in a Permutation Test Framework. Tzeng, J. Y.Devlin, B.Wasserman, L.Roeder, K. (2003). 'On the identification of disease mutations by the analysis of haplotype similarity and goodness of fit.' Am J Hum Genet 72: 891-902. Van der Meulen, M. A. and G. J. te Meerman (1997). 'haplotype sharing analysis in affected individuals from nuclear families with at least one affected offspring.' Genet Epidemiol 14: 915-920. Yu, K.Gu, C. C.Province, M.Xiong, C. J.Rao, D. C. (2004b). 'Genetic association mapping under founder heterogeneity via weighted haplotype similarity analysis in candidate genes.' Genet Epidemiol 27: 182-191. Yu, K.Gu, C. C.Xiong, C.An, P.Province, M. A. (2005a). 'Global transmission/disequilibrium tests based on haplotype sharing in multiple candidate genes.' Genet Epidemiol 29: 323-335. Yu, K.Martin, R. B.Whittemore, A. S. (2004a). 'Classifying disease chromosomes arising from multiple founders, with application to fine-scale haplotype mapping.' Genet Epidemiol 27: 173-181. Yu, K.Xu, J.Rao, D. C.Province, M. (2005b). 'Using tree-based recursive partitioning methods to group haplotypes for increased power in association studies.' Ann Hum Genet 69: 577-589. Yu, K.Zhang, S.Borecki, I.Kraja, A.Xiong, C.Myers, R.Province, M. (2005c). 'A haplotype similarity based transmission/disequilibrium test under founder heterogeneity.' Ann Hum Genet 69: 455-467. Zhang, S.Sha, Q.Chen, H. S.Dong, J.Jiang, R. (2003). 'Transmission/disequilibrium test based on haplotype sharing for tightly linked markers.' Am J Hum Genet 73: 566-579. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/24788 | - |
| dc.description.abstract | 近年來遺傳分析中傳遞連鎖不平衡檢定的發展特別著重於如何從多緊密連鎖的標識基因中有效地擷取單套型間相似訊息，單套基因共享概念是擷取這種相似訊息的主要方法。本研究主要考慮在親子四元體的資料結構下，以Tzeng et al.(2003)所定義之相似度為基礎，延續Yu et al(2005)方法，從改造相似度的想法著手，探討如何利用串連統計量來定義出單套型下傳組及單套型未下傳組相似度，並利用排列檢定進行檢定。模擬結果與Yu et al.(2005)比較，顯示本研究之結果所提方法之檢定力在許多情形下表現優越。 | zh_TW |
| dc.description.abstract | In recent years the development of transmission /disequilibrium test (TDT) in linkage analysis has been focused on how to extract haplotype similarity information from multiple closely linked marker. Haplotype sharing idea is the major method to extract such a type of information. In this thesis, following the methods of Tzeng et al.(2003) and Yu et al.(2005), we propose to use the run statistic to extract similarity information in transmitted haplotypes and non-transmitted haplotypes of case–parent tetrad families. Permutation test is used for test of association between the disease and the markers.The simulation results show that our method has higher power performaces than those of Yu et al.(2005) in some situations. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-08T05:56:27Z (GMT). No. of bitstreams: 1 ntu-97-R94842005-1.pdf: 620694 bytes, checksum: 0c21560c256bbb9ffaf318c05d064e6a (MD5) Previous issue date: 2008 | en |
| dc.description.tableofcontents | 誌謝 i
中文摘要 iii Abstract iv 第一章 緒論 1 1.1前言 2 第二章 文獻回顧 11 2.1文獻回顧－連鎖不平衡檢定 12 2.1.1 HRRFR—Falk and Rubinstein (1987) 12 2.1.2 HRROtt－Ott (1989) 15 2.1.3 TDT－Spielman et al. (1993) 18 2.2文獻回顧－單套基因共享 20 2.2.1 HSS－van der Meulen and te Meerman (1997) 21 2.2.2 Clayton(1999) 23 2.2.3 MILC－Bourgain et al.(2000，2001，2002) 24 2.2.4 HS-TDT－Zhang et al.(2003) 26 2.2.5 Global TDT based on HS－Yu et al. (2005a) 29 2.2.6 U statistic－Tzeng et al.(2003) 39 2.2.7 Weighted haplotype similarity－Yu et al.(2004) 41 第三章 研究方法 46 3.1研究動機: 46 3.2研究目的: 46 3.3資料結構: 47 3.4統計方法: 48 3.4.1符號定義 48 3.4.2相似度定義(similarity) 49 3.4.3 檢定統計量 61 3.4.4排列檢定 62 第四章 模擬研究 66 4.1參數設定 66 4.2模擬結果 69 第五章 結論與討論 72 5.1結論 72 5.2討論 73 參考文獻 75 附錄 80 I. 不同標識基因座之統計量型一誤差及檢定力比較表 80 II. 不同樣本數之統計量檢定力比較圖 90 III. 不同樣本數不同標識基因座之統計量檢定力比較圖 98 IV. 不同相似度計算在不同標識基因座之統計量檢定力比較表 102 V. 不同相似度計算在不同標識基因座之統計量檢定力比較圖 107 VI. 模擬文獻 111 | |
| dc.language.iso | zh-TW | |
| dc.subject | 親子四元體資料 | zh_TW |
| dc.subject | 單套基因共享 | zh_TW |
| dc.subject | 排列檢定 | zh_TW |
| dc.subject | U 統計量 | zh_TW |
| dc.subject | 串連統計量 | zh_TW |
| dc.subject | Permutation test | en |
| dc.subject | case -parent tetrad families | en |
| dc.subject | haplotype sharig | en |
| dc.subject | Ustatistic | en |
| dc.title | 應用串連統計量建立擷取親子四元體單套基因共享訊息於多基因之傳遞連鎖不平衡檢定 | zh_TW |
| dc.title | Using Run Statistic to Extract Haplotype Sharing Information from case–parent tetrad families for Transmission/Disequilibrium Test in Multiple Candidate Genes | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 96-1 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 張淑惠,黃崑明,嚴明芳,曾信嘉 | |
| dc.subject.keyword | 親子四元體資料,單套基因共享,U 統計量,串連統計量,排列檢定, | zh_TW |
| dc.subject.keyword | case -parent tetrad families,haplotype sharig,Ustatistic,Permutation test, | en |
| dc.relation.page | 111 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2008-01-30 | |
| dc.contributor.author-college | 公共衛生學院 | zh_TW |
| dc.contributor.author-dept | 流行病學研究所 | zh_TW |
| 顯示於系所單位： | 流行病學與預防醫學研究所 | |
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