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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 高全良(Chuan-Liang Kao) | |
| dc.contributor.author | Tsao-Chuen Chung | en |
| dc.contributor.author | 鍾兆春 | zh_TW |
| dc.date.accessioned | 2021-06-08T05:18:00Z | - |
| dc.date.copyright | 2005-08-04 | |
| dc.date.issued | 2005 | |
| dc.date.submitted | 2005-08-01 | |
| dc.identifier.citation | 1. Santos, F.A., et al., Brazilian propolis: physicochemical properties, plant origin and antibacterial activity on periodontopathogens. Phytother Res, 2003. 17(3): p. 285-9.
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Rapta, P., et al., Redox intermediates of flavonoids and caffeic acid esters from propolis: an EPR spectroscopy and cyclic voltammetry study. Free Radic Biol Med, 1995. 18(5): p. 901-8. 9. Okonenko, L.B., [Propolis as an inhibitor of free radical lipid oxidation in salmonellosis]. Vopr Med Khim, 1986. 32(3): p. 45-8. 10. Ozen, S., et al., Role of caffeic acid phenethyl ester, an active component of propolis, against cisplatin-induced nephrotoxicity in rats. J Appl Toxicol, 2004. 24(1): p. 27-35. 11. Nakanishi, I., et al., Efficient radical scavenging ability of artepillin C, a major component of Brazilian propolis, and the mechanism. Org Biomol Chem, 2003. 1(9): p. 1452-4. 12. Han, S., et al., Activation of murine macrophage cell line RAW 264.7 by Korean propolis. Arch Pharm Res, 2002. 25(6): p. 895-902. 13. Tatefuji, T., et al., Isolation and identification of compounds from Brazilian propolis which enhance macrophage spreading and mobility. Biol Pharm Bull, 1996. 19(7): p. 966-70. 14. Luo, J., et al., PM-3, a benzo-gamma-pyran derivative isolated from propolis, inhibits growth of MCF-7 human breast cancer cells. Anticancer Res, 2001. 21(3B): p. 1665-71. 15. Kimoto, T., et al., Pulmonary carcinogenesis induced by ferric nitrilotriacetate in mice and protection from it by Brazilian propolis and artepillin C. Virchows Arch, 2001. 438(3): p. 259-70. 16. Havsteen, B.H., The biochemistry and medical significance of the flavonoids. Pharmacol Ther, 2002. 96(2-3): p. 67-202. 17. Amoros, M., et al., Synergistic effect of flavones and flavonols against herpes simplex virus type 1 in cell culture. Comparison with the antiviral activity of propolis. J Nat Prod, 1992. 55(12): p. 1732-40. 18. Halliwell, B., J. Rafter, and A. Jenner, Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not? Am J Clin Nutr, 2005. 81(1 Suppl): p. 268S-276S. 19. Sahinler, N. and O. Kaftanoglu, Natural product propolis: chemical composition. Nat Prod Res, 2005. 19(2): p. 183-8. 20. Santos, F.A., et al., Antibacterial activity of Brazilian propolis and fractions against oral anaerobic bacteria. J Ethnopharmacol, 2002. 80(1): p. 1-7. 21. Steinberg, D., G. Kaine, and I. Gedalia, Antibacterial effect of propolis and honey on oral bacteria. Am J Dent, 1996. 9(6): p. 236-9. 22. Mirzoeva, O.K., R.N. Grishanin, and P.C. Calder, Antimicrobial action of propolis and some of its components: the effects on growth, membrane potential and motility of bacteria. Microbiol Res, 1997. 152(3): p. 239-46. 23. Koo, H., et al., In vitro antimicrobial activity of propolis and Arnica montana against oral pathogens. Arch Oral Biol, 2000. 45(2): p. 141-8. 24. Park, Y.K., et al., Antimicrobial activity of propolis on oral microorganisms. Curr Microbiol, 1998. 36(1): p. 24-8. 25. Ikeno K, Ikeno T, Miyazawa C., Effects of propolis on dental caries in rats., Caries Res. 1991;25(5):347-51. 26. Sa-Nunes A, Faccioli LH, Sforcin JM., Propolis: lymphocyte proliferation and IFN-gamma production. J Ethnopharmacol. 2003 Jul;87(1):93-7. 27. Lin, S.C., et al., Hepatoprotective effects of Arctium lappa on carbon tetrachloride- and acetaminophen-induced liver damage. Am J Chin Med, 2000. 28(2): p. 163-73. 28. Lin, S.C., et al., The hepatoprotective effects of Solanum alatum Moench. on acetaminophen-induced hepatotoxicity in mice. Am J Chin Med, 2000. 28(1): p. 105-14. 29. Lin, S.C., et al., The hepatoprotective and therapeutic effects of propolis ethanol extract on chronic alcohol-induced liver injuries. Am J Chin Med, 1997. 25(3-4): p. 325-32. 30. Lin, S.C., et al., The influence of propolis ethanol extract on liver microsomal enzymes and glutathione after chronic alcohol administration. Am J Chin Med, 1999. 27(1): p. 83-93. 31. Choi, Y.H., et al., Apoptosis induced by propolis in human hepatocellular carcinoma cell line. Int J Mol Med, 1999. 4(1): p. 29-32. 32. Kimoto, T., et al., [Cell cycle and apoptosis in cancer induced by the artepillin C extracted from Brazilian propolis]. Gan To Kagaku Ryoho, 1996. 23(13): p. 1855-9. 33. Lu, L.C., Y.W. Chen, and C.C. Chou, Antibacterial activity of propolis against Staphylococcus aureus. Int J Food Microbiol, 2005. 102(2): p. 213-20. 34. Miorin, P.L., et al., Antibacterial activity of honey and propolis from Apis mellifera and Tetragonisca angustula against Staphylococcus aureus. J Appl Microbiol, 2003. 95(5): p. 913-20. 35. Krol, W., et al., Synergistic effect of ethanolic extract of propolis and antibiotics on the growth of staphylococcus aureus. Arzneimittelforschung, 1993. 43(5): p. 607-9. 36. Shub, T.A., et al., [Effect of propolis on Staphylococcus aureus strains resistant to antibiotics]. Antibiotiki, 1981. 26(4): p. 268-71. 37. Koo, H., et al., Effects of compounds found in propolis on Streptococcus mutans growth and on glucosyltransferase activity. Antimicrob Agents Chemother, 2002. 46(5): p. 1302-9. 38. Bosio, K., et al., In vitro activity of propolis against Streptococcus pyogenes. Lett Appl Microbiol, 2000. 31(2): p. 174-7. 39. Keskin, N., et al., Antibacterial activity and chemical composition of Turkish propolis. Z Naturforsch [C], 2001. 56(11-12): p. 1112-5. 40. Yildirim, Z., et al., Effect of water extract of Turkish propolis on tuberculosis infection in guinea-pigs. Pharmacol Res, 2004. 49(3): p. 287-92. 41. Scheller, S., et al., Synergism between ethanolic extract of propolis (EEP) and anti-tuberculosis drugs on growth of mycobacteria. Z Naturforsch [C], 1999. 54(7-8): p. 549-53. 42. Hegazi, A.G. and F.K. El Hady, Egyptian propolis: 1-antimicrobial activity and chemical composition of Upper Egypt propolis. Z Naturforsch [C], 2001. 56(1-2): p. 82-8. 43. Orsi, R.O., et al., Effects of Brazilian and Bulgarian propolis on bactericidal activity of macrophages against Salmonella Typhimurium. Int Immunopharmacol, 2005. 5(2): p. 359-68. 44. Ota, C., et al., Antifungal activity of propolis on different species of Candida. Mycoses, 2001. 44(9-10): p. 375-8. 45. Koc, A.N., et al., Comparison of in vitro activities of antifungal drugs and ethanolic extract of propolis against Trichophyton rubrum and T. mentagrophytes by using a microdilution assay. Mycoses, 2005. 48(3): p. 205-10. 46. Huleihel, M. and V. Ishano, Effect of propolis extract on malignant cell transformation by moloney murine sarcoma virus. Arch Virol, 2001. 146(8): p. 1517-26. 47. Amoros, M., et al., Comparison of the anti-herpes simplex virus activities of propolis and 3-methyl-but-2-enyl caffeate. J Nat Prod, 1994. 57(5): p. 644-7. 48. Serkedjieva, J., N. Manolova, and V. Bankova, Anti-influenza virus effect of some propolis constituents and their analogues (esters of substituted cinnamic acids). J Nat Prod, 1992. 55(3): p. 294-302. 49. Debiaggi, M., et al., Effects of propolis flavonoids on virus infectivity and replication. Microbiologica, 1990. 13(3): p. 207-13. 50. Esanu, V., et al., The effect of an aqueous propolis extract, of rutin and of a rutin-quercetin mixture on experimental influenza virus infection in mice. Virologie, 1981. 32(3): p. 213-5. 51. Maichuk Iu, F., L.E. Orlovskaia, and V.P. Andreev, [The use of ocular drug films of propolis in the sequelae of ophthalmic herpes]. Voen Med Zh, 1995(12): p. 36-9, 80. 52. Drogovoz, S.M., et al., [The liver-protective properties of the pediatric drug form of propolis in animals of different age groups]. Eksp Klin Farmakol, 1994. 57(4): p. 39-42. 53. Garbuzova, V.M., [Drug forms of propolis prepared at home]. Med Sestra, 1988. 47(12): p. 48-51. 54. Tykhonov, O.I., [Ophthalmic drug films from the lyophilic phenolic substance of propolis]. Farm Zh, 1978(6): p. 56-8. 55. Kravchuk, P.O. and K.P. Rafal'skii, [Propolis as a drug]. Farm Zh, 1969. 24(5): p. 87-9. 56. Vynograd, N., I. Vynograd, and Z. Sosnowski, A comparative multi-centre study of the efficacy of propolis, acyclovir and placebo in the treatment of genital herpes (HSV). Phytomedicine, 2000. 7(1): p. 1-6. 57. Martins, R.S., et al., Effect of commercial ethanol propolis extract on the in vitro growth of Candida albicans collected from HIV-seropositive and HIV-seronegative Brazilian patients with oral candidiasis. J Oral Sci, 2002. 44(1): p. 41-8. 58. Ito, J., et al., Anti-AIDS agents. 48.(1) Anti-HIV activity of moronic acid derivatives and the new melliferone-related triterpenoid isolated from Brazilian propolis. J Nat Prod, 2001. 64(10): p. 1278-81. 59. Harish, Z., et al., Suppression of HIV-1 replication by propolis and its immunoregulatory effect. Drugs Exp Clin Res, 1997. 23(2): p. 89-96. 60. Semeja, Z., et al., Therapeutic value of flavonoids in Rhinovirus infections. Otolaryngologia Polska, 1989. 43(3): p. 180-4. 61. Spencer, J.V., et al., Structure of the herpes simplex virus capsid: peptide A862-H880 of the major capsid protein is displayed on the rim of the capsomer protrusions. Virology, 1997. 228(2): p. 229-35. 62. Mah, I., et al., Screening for acyclovir-resistant herpes simplex virus isolates from clinical samples. Chinese J Microbiol Immunal, 1997. 30: p. 51-4. 63. Sibrack, C.D., et al., Barry pathogenicity of acyclovir-resistant herpes siplex virus type 1 form an immuno-deficient child. Journal of infectious disease, 1982. 146(5): p. 673-682. 64. Kujumgiev, A., et al., Antibacterial, antifungal and antiviral activity of propolis of different geographic origin. J Ethnopharmacol, 1999. 64(3): p. 235-40. 65. Bernard Roizman and Patricia L. Ward , Herpesviridae, Alphaherpesvirinae, Simplexvirus, p.399-p.407 , In C. A. Tidona, and G.Darai(ed.), The Springer Index of Viruses. Springer 66. Nora M. Chapman and Steven M. Tracy, Picornaviridae, Enterovirus, Poliovirus, p.755-p.764 , In C. A. Tidona, and G.Darai(ed.), The Springer Index of Viruses. Springer 67. Wade JC, M.C., Mayers JD, Frequency and significance of acyclovir-resistant herpes simplex virus isolated from marrow transplant patients receiving multiple ciurses of treatment with acyclovir. J Inffect Dis, 1983. 148: p. 1077-1082. 68. Dumitrescu M, Crisan I, Esanu V., The mechanism of the antiherpetic action of an aqueous propolis extract. II. [Article in French] The action of the lectins of an aqueous propolis extract Rev Roum Virol. 1993 Jan-Jun;44(1-2):49-54. 69. Dumitrescu M, Esanu V, Crisan I., The mechanisms of the antiherpetic action of aqueous propolis extracts. I. The antioxidant action on human fibroblast cultures][Article in French] Spencer, Rev Roum Virol. 1992 Jul-Dec;43(3-4):165-73. 70. Esanu V., Recent advances in the chemotherapy of herpes virus infections. Virologie. 1981 Jan –Mar;32(1):57-77 | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/24188 | - |
| dc.description.abstract | 本研究主要針對蜂膠 (propolis)抑制病毒活性效果做一初步之探討。由以往研究知道，蜂膠對一些病毒如第一型單純疱疹病毒及鼻病毒等有抑制作用，為瞭解蜂膠對第二型單純疱疹病毒，及與鼻病毒屬同一科之腸病毒是否有抑制作用，因此進行實驗。將來自台灣與法國產地之蜂膠以水或酒精萃取後，分別以in vitro分析方式進行測試。結果顯示，0.5％水溶液萃取物及0.1％酒精溶液萃取物均可以抑制100TCID50 (Tissue Culture Infectious Dose50; 50% 培養組織受病毒感染之劑量) 劑量的第一型、第二型單純疱疹病毒；但兩者對第一型、第二型、及第三型小兒麻痺病毒均無抑制作用。以0.5％ 之水溶液萃取物分別與病毒作用1、2、4、16小時後發現，在2小時即可降低病毒活性；而不具套膜的小兒麻痺病毒即使經由最高劑量，即1% 蜂膠酒精萃取物，處理16小時後，仍無明顯的抑制效果。除台灣產的蜂膠外，本研究亦分析來自法國之蜂膠。結果顯示，法國產之0.1%蜂膠水溶液萃取物有顯著抑制單純疱疹病毒的效果；而台灣產的0.1%蜂膠水溶液萃取物則沒有明顯的抑制效果，需0.5% 才能抑制單純疱疹病毒。有關蜂膠抑制單純疱疹病毒的機制仍有待進一步探討。 | zh_TW |
| dc.description.abstract | The object of this study is focused on the inhibitory effect of proplis on viral infectivity. It has been reported that propolis possessed inhibitory effects on herpes simplex virus type 1 (HSV-1) and rhinovirus. In this report, the HSV-2 and enteroviruses which belong to the same family of picornviruses as rhinovirus were used as the subjects to evaluate the inhibitory effect of propolis. The propolis from Taiwan or France were extracted with water or ethanol and used for subsequent in vitro study. The results showed that the minimal inhibitory concentration for HSV-1 and HSV-2 were 0.5% for water extracted propolis and 0.1% for ethanol extracted propolis. No inhibitory effect on poliovirus type 1, poliovirus type 2 or poliovirus type 3 were observed. The results of timing study revealed that the maximal inhibitory effect on HSV-1 and HSV-2 were found at 2 hours after propolis application.The non-lipid-enveloped virus, enterovirus, has no response to propolis treatment even at the 1% concentration of ethanol extracted propolis. In addition, at 0.1% concentration, propolis from Frence has distinct inhibitory effect to HSV-1. Propolis from Taiwan only showed inhibitory effect at 0.5% concentration. The mechanisms of this inhibitory effect to HSV need to be further studied in the future. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-08T05:18:00Z (GMT). No. of bitstreams: 1 ntu-94-R88424009-1.pdf: 312007 bytes, checksum: e0386ab24c9e9c9d3e443d28b07c7095 (MD5) Previous issue date: 2005 | en |
| dc.description.tableofcontents | 中文摘要 4
English Abstract 5 第一章 導論 6 第一節 蜂膠: 6 第二節 蜂膠的成分 6 第三節 蜂膠在醫學上的應用 7 第四節 蜂膠的可抑制病毒作用： 9 第五節 單純疱疹病毒的簡介： 12 第六節 腸病毒群病毒 13 第二章 實驗動機與目的 15 第三章 材料與方法 16 第一節 蜂膠 16 第二節 細胞株： 17 一、細胞株： 18 三、細胞培養方法 19 第三節 病毒 19 一、病毒標準株（prototype）： 20 二、 病毒培養 20 第四節 TCID50病毒感染力價測定法 21 第五節 蜂膠對單純疱疹病毒抑制試驗 22 第六節 蜂膠對小兒麻痺病毒抑制試驗 27 第四章 結果 29 第一節 比較不同濃度之蜂膠水萃取物對病毒之抑制作用： 29 第二節 比較不同濃度之酒精萃取物對病毒之抑制作用: 29 第三節 比較不同濃度之蜂膠萃取物對第一、二、三型小兒麻痺病毒之抑制作用： 30 第四節 比較不同濃度之蜂膠萃取物對第一、二、三型小兒麻痺病毒之抑制作用： 30 第五節 比較不同產地蜂膠水萃取物對HSV-1及HSV-2之抑制作用 30 第六節 蜂膠與病毒作用不同時間之抑制結果比較 31 第五章 討論 33 第六章 參考文獻 49 | |
| dc.language.iso | zh-TW | |
| dc.subject | 小兒麻痺病毒 | zh_TW |
| dc.subject | 蜂膠 | zh_TW |
| dc.subject | 單純疱 | zh_TW |
| dc.subject | 疹病毒 | zh_TW |
| dc.subject | propolis | en |
| dc.subject | herpes simplex virus | en |
| dc.subject | poliovirus | en |
| dc.title | 蜂膠對單純疱疹病毒及小兒麻痺病毒之藥物感受性試驗 | zh_TW |
| dc.title | Propolis Susceptibility Testing of Herpes Simplex Virus and Poliovirus | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 93-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 李君男(C. N. Lee),張淑媛(S.Y. chang) | |
| dc.subject.keyword | 蜂膠,單純疱,疹病毒,小兒麻痺病毒, | zh_TW |
| dc.subject.keyword | propolis,herpes simplex virus,poliovirus, | en |
| dc.relation.page | 53 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2005-08-01 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 醫事技術學研究所 | zh_TW |
| 顯示於系所單位： | 醫學檢驗暨生物技術學系 | |
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