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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳保中 | |
| dc.contributor.author | Li-Yao Wu | en |
| dc.contributor.author | 吳禮堯 | zh_TW |
| dc.date.accessioned | 2021-06-08T04:49:38Z | - |
| dc.date.copyright | 2009-09-16 | |
| dc.date.issued | 2009 | |
| dc.date.submitted | 2009-07-28 | |
| dc.identifier.citation | 一.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/23247 | - |
| dc.description.abstract | 1. ABTRACT
Purpose: The objective of this study is to investigate the association between husbands’ alcohol drinking and wives’ HRQOL in the postpartum period. Methods: We used multistage stratified systematic sampling to recruit 24,200 pairs, postpartum women and newborns, from the Taiwan national birth register in 2005. A structured questionnaire was successfully administered to 87.8% of the sampled population. Subjects undertook a home interview 6 months after their deliveries between June 2005 and July 2006. The Medical Outcomes Study 36-item Short-Form (SF-36) was used to measure the quality of life of the women with their husbands’ alcohol drinking behavior. Results: After controlling for the potential confounders, there were significantly gradual decreases in wives’ scores of SF-36 scales other than physical functioning along with the increase in frequency of husbands’ alcohol drinking. There were significantly gradual decreases in wives’ scores of SF-36 scales other than physical functioning and role-physical along with the increase in frequency of husbands’ alcohol drinking either in primiparous or multiparous women Conclusions: Our study adds evidence supporting the adverse effect of husbands’ alcohol drinking on women’s health as measured by the SF-36 HRQOL. 2. ABTRACT Purpose: The aim of this study was to develop a sensitive, convenient and accurate method by using UPLC-MS/MS for a broad range of PFCs for studies involving large sample series. Methods: We analyze the perfluorinated compounds by using ultra performance liquid chromatography－tandem mass spectrometry with protein precipitation and matrix-matched calibration method. And seven samples of plasma from TBPS were analyzed to investigate the applicability of this validated method. Results: Perfluorinated compounds were detected in all seven plasma samples. The average concentration of PFOS and PFOA were 31.25 ng/mL and 3.52 ng/mL. Moreover, UPLC provides significantly reduced analysis time and improved chromatographic behavior for PFCs compared with traditional LC. Conclusions: The low sample volume needed, the limited time consuming and the broad range of analytes which are included, make this method advantageous for large-scale epidemiological studies. Besides, this sample preparation technique and matrix-matched calibration method can easily be set up on standard LC-MS/MS instruments and is thus available to a wide range of laboratories. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-08T04:49:38Z (GMT). No. of bitstreams: 1 ntu-98-R96841010-1.pdf: 778686 bytes, checksum: 80dfd7e3dfefda5547c076c325570953 (MD5) Previous issue date: 2009 | en |
| dc.description.tableofcontents | Contents
Husbands’ drinking behavior as a risk factor of wives’ health-related quality of life in the postpartum period 1 中文摘要 2 ABTRACT 3 Abbreviations 4 Introduction 5 Materials and Methods 7 Study population and sampling strategy 7 Data collection 7 Husbands’ drinking behavior 8 Health-related Quality of Life measures 9 Potential confounding variables 9 Statistical analysis 10 Results 11 Discussion 19 Acknowledgements 23 References 24 Appendix 28 Figure 1. Adjusted SF-36 scores of study subjects by the frequency of their husbands’ alcohol drinking during the 6-month postpartum period as well as stratified by parity. 18 Table 1. Characteristics of study subjects by their husbands’ alcohol drinking 12 Table 2. Crude and adjusted SF-36 scores of study subjects by their husbands’ alcohol drinking 15 Table 3. Adjusted SF-36 scores of study subjects by their husbands’ alcohol drinking stratified by parity 17 Determination of Perfluorinated Compounds in Human Plasma Using Ultra Performance Liquid Chromatography–Tandem Mass Spectrometry – preliminary study 39 中文摘要 40 ABTRACT 41 Abbreviations 42 Introduction 43 Experimental 45 Materials and reagents 45 Standard solution and sample preparation 45 Ultra performance liquid chromatography–tandem mass spectrometry 48 Results and discussion 52 Method development 52 Sensitivity 53 Linearity 54 Determination of PFCs in human plasma 56 Conclusions 59 References 60 Appendix 64 Figure 1. The flow chart of sample preparation. 47 Figure 2. The matrix-matched calibration curves of PFCs. 55 Figure 3. Typical UPLC-MS/MS chromatogram of a 100-µL plasma extract spiked with PFCs (2.5 ng/mL) (left) and a blank, nonspiked plasma (right) 58 Table 1. UPLC configuration for plasma analyses 49 Table 2. UPLC mobile phase gradient for plasma analyses 49 Table 3. Mass spectrometric parameters for the analysis of polyfluorochemicals in plasma 51 Table 4. Estimate instrument detection limit (IDL) for PFCs in plasma as well as correlation coefficients (R) and ranges for calibration curves. 54 Table 5. Concentrations (ng/mL) of PFOS and PFOA in human serum collected from volunteers in TBPS cohort. 56 | |
| dc.language.iso | en | |
| dc.subject | 健康相關的生活品質 | zh_TW |
| dc.subject | 血漿 | zh_TW |
| dc.subject | 全氟辛酸 | zh_TW |
| dc.subject | 全氟辛烷磺酸 | zh_TW |
| dc.subject | 極致液相層析/質譜/質譜儀 | zh_TW |
| dc.subject | 先生的飲酒行為 | zh_TW |
| dc.subject | 全氟碳化合物 | zh_TW |
| dc.subject | 產後婦女 | zh_TW |
| dc.subject | Plasma | en |
| dc.subject | husbands’ drinking behavior | en |
| dc.subject | postpartum women | en |
| dc.subject | Perfluorinated compounds | en |
| dc.subject | PFOS | en |
| dc.subject | PFOA | en |
| dc.subject | UPLC/MS/MS | en |
| dc.subject | health-related quality of life | en |
| dc.title | 1.先生的飲酒行為是產後婦女生活品質的危險因子
2.應用極致液相層析/串聯式質譜儀分析人體血漿中之全氟碳化合物 – 初步研究 | zh_TW |
| dc.title | 1.Husbands’ drinking behavior as a risk factor of wives’ health-related quality of life in the postpartum period
2.Determination of perfluorinated compounds in human plasma using ultra performance liquid chromatography–tandem mass spectrometry – preliminary study | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 97-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 陳怡君,陳家揚 | |
| dc.subject.keyword | 健康相關的生活品質,先生的飲酒行為,產後婦女,全氟碳化合物,極致液相層析/質譜/質譜儀,全氟辛烷磺酸,全氟辛酸,血漿, | zh_TW |
| dc.subject.keyword | health-related quality of life,husbands’ drinking behavior,postpartum women,Perfluorinated compounds,PFOS,PFOA,UPLC/MS/MS,Plasma, | en |
| dc.relation.page | 71 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2009-07-28 | |
| dc.contributor.author-college | 公共衛生學院 | zh_TW |
| dc.contributor.author-dept | 職業醫學與工業衛生研究所 | zh_TW |
| 顯示於系所單位： | 職業醫學與工業衛生研究所 | |
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