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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 龐飛(Victor Fei Pang) | |
dc.contributor.author | Yuk-Hong Li | en |
dc.contributor.author | 李育匡 | zh_TW |
dc.date.accessioned | 2021-06-08T04:37:36Z | - |
dc.date.copyright | 2011-08-20 | |
dc.date.issued | 2011 | |
dc.date.submitted | 2011-08-16 | |
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Wood, P.R., Corner, L.A., Rothel, J.S., Baldock, C., Jones, S.L., Cousins, D.B., McCormick, B.S., Francis, B.R., Creeper, J., Tweddle, N.E., 1991, Field comparison of the interferon-gamma assay and the intradermal tuberculin test for the diagnosis of bovine tuberculosis. Aust Vet J 68, 286-290. Woods, R., Cousins, D.V., Kirkwood, R., Obendorf, D.L., 1995, Tuberculosis in a wild Australian fur seal (Arctocephalus pusillus doriferus) from Tasmania. J Wildlife Dis 31, 83-86. World Health Organization. 2002. Tuberculosis. In: Fact sheet. pp. 104. World Organisation for Animal Health. 2009. In: OIE Terrestrial Manual. pp. 1. Yeager, H., Jr., Lacy, J., Smith, L.R., LeMaistre, C.A., 1967, Quantitative studies of mycobacterial populations in sputum and saliva. Am Rev Respir Dis 95, 998-1004. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/23009 | - |
dc.description.abstract | 台灣實施牛隻皮內結核菌素檢驗 (ITT) 至今已超過五十年,但每年仍有零星的結核菌素檢驗陽性病例,且仍被世界動物衛生組織 (OIE) 認定為牛結核病疫區。本研究收集台灣地區12個牧場共137頭ITT陽性撲殺乳牛組織樣本,進行分枝桿菌分離、病理學檢查、分子生物學診斷及菌株基因型別鑑定。結果顯示,共有40頭 (40/137; 29.2%) 培養出分枝桿菌,其中有29株為Mycobacterium bovis (29/137; 21.17%),另外11株則為M. bovis以外的Mycobacterium spp. (11/137; 8.03%)。有89頭 (89/137; 64.96%) 在肉眼或/及顯微檢查下有結核樣病灶,其中最常出現病變的位置為縱膈淋巴結,其次依序為咽背淋巴結、肺門淋巴結、腸繫膜淋巴結及肺臟。透過細菌分離及聚合酶鏈鎖反應 (PCR) 檢測,確認是因M.bovis感染引起ITT陽性反應的有69頭 (69/137; 50.37%),其中出現結核樣病變的有59頭 (59/137; 43.07%)。Variable number tandem repeat (VNTR) 的分析,從本研究的34個M.bovis陽性樣本中,鑑別出5種不同的基因型別,其中,I型和IV有親緣關係, III型和V型亦有親緣關係。本研究揭示了台灣地區因ITT陽性而撲殺之乳牛中,結核病的確切發病情形。台灣仍有牛結核病的疫情,且仍為乳牛ITT陽性的重要致敏原。然而,亦有其他非M. bovis及M. tuberculosis的分枝桿菌感染,也可引起ITT陽性反應。此外,結果亦顯示牛隻的M. bovis有超過一個以上的VNTR菌株存在,且同一親緣性的菌株有可能感染不同縣市牧場的乳牛。VNTR基因分型技術能分辨出不同的M. bovis菌株及其間的親緣關係,展現其在台灣牛結核病疫情之流行病學調查上的應用潛力。 | zh_TW |
dc.description.abstract | The tuberculin test-and-culling program for eradication of bovine tuberculosis has been carried out in Taiwan for more than 50 years; however, sporadic tuberculin test reactors still occur, and Taiwan is still defined as an epidemic country of bovine tuberculosis by OIE. In this study, a total of 137 dairy cattle with skin test-positive reaction, originated from 12 dairy farms, were euthanatized and sampled for mycobacterial isolation, pathological examination, molecular diagnosis, and bacterial strain genotyping. Mycobacterium spp. could be isolated in 40 cattle (40/137; 29.2%), 29 of them (29/137; 21.17%) were identified as Mycobacterium bovis, another 11 cattle (11/137; 8.03%) were other Mycobacterium spp. other than M. bovis. Tuberculous lesions were identified in 89 cattle (89/137; 64.96%) following gross and/or microscopic examination. The most frequently affected site was mediastinal lymph node, followed by retropharyngeal lymph node, hilar lymph node, mesenteric lymph node, and lung. Sixty nine cattle (69/137; 50.37%) were identified as M. bovis infection through mycobacterium isolation and PCR assay, 59 of them (59/137; 43.07%) developed tuberculous lesion. Five genotypes of M. bovis were found among 34 skin test-positive cattle from four different farms by a molecular genotyping method based on variable number tandem repeat (VNTR) analysis, and the phylogenetic relationships between genotype I, IV and genotype III, V were also noted. The findings uncovered the actual incident status of bovine tuberculosis in the cattle under routine tuberculin test survey, indicating that M. bovis still is the major cause of bovine tuberculosis and is also an important allergen for the positive reaction of tuberculin test in Taiwan. However, there are Mycobacterium spp. other than M. bovis and M. tuberculosis that may trigger the tuberculin test reaction of dairy cattle in Taiwan. Based on the data obtained from the 12 dairy farms, there are more than one VNTR strains of M. bovis present in Taiwan, and the same VNTR strain may infect cattle from different counties. The present study further supports that VNTR genotyping can be used to differentiate different strains of M. bovis and can be a powerful tool for epidemiological investigation of bovine tuberculosis in Taiwan. | en |
dc.description.provenance | Made available in DSpace on 2021-06-08T04:37:36Z (GMT). No. of bitstreams: 1 ntu-100-R98629001-1.pdf: 2665127 bytes, checksum: 196e2205f3c6826a0a8738277ad6f590 (MD5) Previous issue date: 2011 | en |
dc.description.tableofcontents | 中文摘要 i
英文摘要 ii 目錄 iv 表次 viii 圖次 viii 第一章、前言 1 第二章、文獻探討 3 第一節 結核病歷史與引響 3 第二節 分枝桿菌的分類 4 2.1 結核分枝桿菌群(Mycobacterium tuberculosis complex) 6 2.2 非結核分枝桿菌群(Nontuberculosis mycobacteria) 6 第三節 分枝桿菌之生物特性及致病機轉 7 3.1 形態學、細胞壁構造及染色特性 8 3.2 培養特性 9 3.3 抵抗性 9 3.4 致病機轉 10 3.5 免疫反應 12 第四節 結核病的診斷 13 4.1 放射線學檢查 13 4.2 細菌分離及培養 13 4.3 病理學檢查 14 4.3.1 肉眼及組織病理學檢查 14 4.3.2抗酸染色法 14 4.4 結核菌素試驗 15 4.5 分子學診斷 16 4.5.1迦傌干擾素檢驗(gamma interferon assay, IFN-γ assay)16 4.5.2血清抗體檢驗 16 4.5.3聚合酶鏈鎖反應(PCR) 17 第五節 結核病之流行病學 18 5.1傳播途徑 18 5.2分子流行病學 19 5.2.1 分子流行病學在結核病上的應用 20 5.2.2 親源性分析法 20 第三章、材料與方法 23 第一節實驗設計 23 第二節樣本採集 24 第三節分枝桿菌分離及培養 24 第四節病理學檢查 24 4.1肉眼解剖檢查 24 4.2組織病理學檢查 24 4.3抗酸桿菌檢查 25 第五節分子生物學診斷 25 5.1組織樣本核酸萃取 25 5.2核酸檢測 26 5.2.1引子對之選擇 26 5.2.2聚合酶鏈鎖反應(PCR) 27 5.2.2.1 16S rRNA PCR 27 5.2.2.2 TbD1 nested PCR 29 5.2.2.3 RD8 nested PCR 31 第六節分子流行病學調查 34 6.1異數重複序列分析(Variable Number Tandem Repeat, VNTR)引子對之選擇 34 6.2 VNTR之聚合酶鏈鎖反應 36 6.3 VNTR結果分析 37 6.3.1序列重複數及VNTR分型 37 6.3.2等位基因多樣性 (Allele diversity) 37 6.3.3親緣性分析 38 第四章、結果 39 第一節組織樣材蒐集 39 第二節分枝桿菌分離 39 第三節病理學檢查 39 3.1病變分佈 39 3.2抗酸桿菌檢查 41 第四節分子生物學診斷 41 4.116S rRNA PCR 41 4.2 TbD1 nested PCR 42 4.3 RD8 nested PCR 42 4.4 16S rRNA PCR核酸產物基因定序 43 第五節分子流行病學調查 43 5.1 VNTR基因分型之VNTR位點之選擇 43 5.2 VNTR基因分型 44 5.3 等位基因多樣性 (Allele diversity) 及VNTR基因分型效力(discriminatory) 44 5.4 VNTR基因分型親緣性分析 45 第五章、討論 76 第六章、參考文獻 85 | |
dc.language.iso | zh-TW | |
dc.title | 乳牛結核病田間調查及親緣性分析 | zh_TW |
dc.title | Field Investigation and Phylogenetic Analysis of Bovine Tuberculosis in Dairy Cattle | en |
dc.type | Thesis | |
dc.date.schoolyear | 99-2 | |
dc.description.degree | 碩士 | |
dc.contributor.coadvisor | 鄭謙仁(Chian-Ren Jeng),蕭士烜(Shih-Hsan Hsiao) | |
dc.contributor.oralexamcommittee | 劉涓(Jiuan Judy Liu),張志成(Chih-Cheng Chang) | |
dc.subject.keyword | 病理學檢查,分子生物學診斷,台灣,牛結核病,異數重複序列分析基, | zh_TW |
dc.subject.keyword | VNTR genotyping,molecular diagnostic,pathologic investigation,Taiwan,bovine tuberculosis, | en |
dc.relation.page | 103 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2011-08-17 | |
dc.contributor.author-college | 獸醫專業學院 | zh_TW |
dc.contributor.author-dept | 獸醫學研究所 | zh_TW |
顯示於系所單位: | 獸醫學系 |
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