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  1. NTU Theses and Dissertations Repository
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  3. 獸醫專業學院
  4. 獸醫學系
請用此 Handle URI 來引用此文件: http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/22903
完整後設資料紀錄
DC 欄位值語言
dc.contributor.advisor葉力森
dc.contributor.authorHan-Ting Chuangen
dc.contributor.author莊涵婷zh_TW
dc.date.accessioned2021-06-08T04:32:51Z-
dc.date.copyright2009-08-21
dc.date.issued2009
dc.date.submitted2009-08-20
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Lomniczi, A., C. Mohn, et al. (2001). 'Inhibition of salivary secretion by lipopolysaccharide: possible role of prostaglandins.' Am J Physiol Endocrinol Metab 281(2): E405-11.
Lung, M. A. (1993). 'An investigation of the vascular organisation of the canine submandibular gland.' J Anat 183 ( Pt 3): 619-30.
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Morse, Z., K. Sano, et al. (2001). 'Decreased intraoral secretions during sedation-analgesia with propofol-ketamine and midazolam-ketamine combinations.' J Anesth 15(4): 197-200.
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Tsujii, H. (1985). 'Quantitative dose-response analysis of salivary function following radiotherapy using sequential RI-sialography.' Int J Radiat Oncol Biol Phys 11(9): 1603-12.
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Vincent, I. C. and A. R. Michell (1992). 'Comparison of cortisol concentrations in saliva and plasma of dogs.' Res Vet Sci 53(3): 342-5.
Watkins, P. E. (1993). 'Surgical anatomy of the dog.' Br J Surg 80(8): 1077.
Watkins, S. B., L. W. Hall, et al. (1987). 'Propofol as an intravenous anaesthetic agent in dogs.' Vet Rec 120(14): 326-9.
Wilkie, T. F. (1967). 'The problem of drooling in cerebral palsy: a surgical approach.' Can J Surg 10(1): 60-7.
Wong, A. M., C. J. Chang, et al. (1997). 'Laser intraductal photocoagulation of bilateral parotid ducts for reducing drooling of cerebral palsied children: a preliminary report.' J Clin Laser Med Surg 15(2): 65-9.
Wong, V., J. G. Sun, et al. (2001). 'Traditional Chinese medicine (tongue acupuncture) in children with drooling problems.' Pediatr Neurol 25(1): 47-54.
Zeppetella, G. (1999). 'Nebulized scopolamine in the management of oral dribbling: three case reports.' J Pain Symptom Manage 17(4): 293-5.
Brown, C. M., C. F. Snowdon, et al. (1995). 'Effect of topical oesophageal
acidification on human salivary and oesophageal alkali secretion.' Gut 36(5):
649-53.
Conrad, B., R. Larsen, et al. (1990). '[Propofol infusion for sedation in regional
anesthesia. A comparison with midazolam].' Anasth Intensivther Notfallmed
25(3): 186-92.
De Grood, P. M., L. G. Coenen, et al. (1987). 'Propofol emulsion for induction and
maintenance of anaesthesia. A combined technique of general and regional
anaesthesia.' Acta Anaesthesiol Scand 31(3): 219-23.
Engelhardt, G., D. Homma, et al. (1995). 'Anti-inflammatory, analgesic, antipyretic
and related properties of meloxicam, a new non-steroidal anti-inflammatory
agent with favourable gastrointestinal tolerance.' Inflamm Res 44(10):
423-33.
Galatos, A. D. and D. Raptopoulos (1995). 'Gastro-oesophageal reflux during
anaesthesia in the dog: the effect of age, positioning and type of surgical
procedure.' Vet Rec 137(20): 513-6.
Galatos, A. D. and D. Raptopoulos (1995). 'Gastro-oesophageal reflux during
anaesthesia in the dog: the effect of preoperative fasting and premedication.'
Vet Rec 137(19): 479-83.
Holton, L., J. Reid, et al. (2001). 'Development of a behaviour-based scale to measure
acute pain in dogs.' Vet Rec 148(17): 525-31.
Holton, L. L., E. M. Scott, et al. (1998). 'Comparison of three methods used for
assessment of pain in dogs.' J Am Vet Med Assoc 212(1): 61-6.
J. Sanford, R. E., V.Molony, W.D. Tavernor, O.uvarov (1986). 'Guidelines for the
recognition and assessment of pain in animals. Prepared by a working party of
the Association of Veterinary Teachers and Research Workers.' Vet Rec
118(12): 334-8.
Kang, J. G., J. K. Kim, et al. (2008). 'A prospective, randomized comparison of the
effects of inhaled sevoflurane anesthesia and propofol/remifentanil
intravenous anesthesia on salivary excretion during laryngeal microsurgery.'
Anesth Analg 106(6): 1723-7.
Ko, J. C., R. E. Mandsager, et al. (2000). 'Cardiorespiratory responses and plasma
cortisol concentrations in dogs treated with medetomidine before undergoing
ovariohysterectomy.' J Am Vet Med Assoc 217(4): 509-14.
Kreis, M. E. (2006). 'Postoperative nausea and vomiting.' Auton Neurosci 129(1-2):
86-91.
Lahteenmaki, M., M. Salo, et al. (1998). 'Mucosal host defence response to
hysterectomy assessed by saliva analyses: a comparison of propofol and
58
isoflurane anaesthesia.' Anaesthesia 53(11): 1067-73.
Lomniczi, A., C. Mohn, et al. (2001). 'Inhibition of salivary secretion by
lipopolysaccharide: possible role of prostaglandins.' Am J Physiol Endocrinol
Metab 281(2): E405-11.
Monteiro, E. R., A. R. Junior, et al. (2009). 'Comparative study on the sedative effects
of morphine, methadone, butorphanol or tramadol, in combination with
acepromazine, in dogs.' Vet Anaesth Analg 36(1): 25-33.
Morse, Z., K. Sano, et al. (2001). 'Decreased intraoral secretions during
sedation-analgesia with propofol-ketamine and midazolam-ketamine
combinations.' J Anesth 15(4): 197-200.
Morton, D. B. and P. H. Griffiths (1985). 'Guidelines on the recognition of pain,
distress and discomfort in experimental animals and an hypothesis for
assessment.' Vet Rec 116(16): 431-6.
Murphy, M. J., V. D. Hooper, et al. (2006). 'Identification of risk factors for
postoperative nausea and vomiting in the perianesthesia adult patient.' J
Perianesth Nurs 21(6): 377-84.
Padda, G. S., C. Kishioka, et al. (2001). 'Propofol and methohexital have no
significant effect on mucus secretion or clearance in the anesthetized dog.'
Crit Care Med 29(5): 1045-8.
Schaer, H. (1988). '[Propofol infusion for the maintenance of short-term anesthesia].'
Anaesthesist 37(3): 187-92.
Shafik, A., O. El-Sibai, et al. (2005). 'Effect of topical esophageal acidification on
salivary secretion: identification of the mechanism of action.' J Gastroenterol
Hepatol 20(12): 1935-9.
Tsai, Y. C., L. Y. Wang, et al. (2007). 'Clinical comparison of recovery from total
intravenous anesthesia with propofol and inhalation anesthesia with isoflurane
in dogs.' J Vet Med Sci 69(11): 1179-82.
Watkins, S. B., L. W. Hall, et al. (1987). 'Propofol as an intravenous anaesthetic agent
in dogs.' Vet Rec 120(14): 326-9.
dc.identifier.urihttp://tdr.lib.ntu.edu.tw/jspui/handle/123456789/22903-
dc.description.abstract一、 研究目的
本研究之目的為調查犬隻在全身麻醉下進行各是外科手術後,恢復時過度流涎的發生率,並分析影響過度流涎發生的危險因子。
二、 研究方法
於台灣大學生農學院附設動物醫院外科,隨機收集進行全身麻醉隻犬隻的恢復流涎與否紀錄。術前給藥皆由各麻醉之根據犬隻的生理狀況及手術程序設計之。所有犬隻皆用propofol作為導入麻醉,以氣體麻醉藥isoflurane或是propofol全靜脈低量注射的方式維持麻醉深度。所有的犬隻在麻醉中皆有完善的生理監控及記錄,術後記錄有無過度流涎、恢復平順度或其他併發症發生。將所收集的資料用統計方法分析評估影響過度流涎的相關風險因子。
三、 結果
本實驗共隨機收集了548隻歷經全身麻醉犬隻。麻醉後發生過度流涎的比率為23.5%。術前鎮靜給藥、止痛藥物的給予、母犬及開腹探查在統計上對於過度流涎的發生有顯著差異(p<0.05)。年齡、體重、品種、誘導藥物劑量、麻醉維持藥物種類、麻醉時間長短、麻醉藥物種類與過度流涎在統計上沒有顯著的關係。即使在過度流涎的狀況下,術後恢復大多呈現平順。
四、 結論
性別、術前鎮靜給藥、止痛藥物、術式皆可能是影響犬隻術後過度流涎發生的因子,犬隻臨床並無明顯危害,也驗證並非疼痛之表現,但影響機制與確切臨床意義尚不清楚,需要更多研究。
zh_TW
dc.description.abstractTo investigate the incidence and risk factors of excess salivation in post-anaesthetized dogs undergoing various surgical procedures. Five hundred and forty-eight client-owned dogs admitted to the National Taiwan University Veterinary Hospital requiring general anesthesia for a variety of surgical or diagnostic procedures were included in this study. The premedication and analgesia protocols were designed by individual anaesthetists according to the physical status and the nature of procedures. All dogs were induced with propofol and maintained with isoflurane in oxygen or with propofol in total intravenous anesthesia. Excess salivation status were recorded during recovery. Univariate analyses were conducted to observe the potential risk factors of drooling/hypersalivation. The overall incidence of excess salivation was 23.5%. Premedication agents and using of analgesia showed significant effect (p<0.05) on excess salivation. Females with laparotomy had potential effect on excess salivation. Ages, body weights, breeds, propofol dosages, maintained agents , anesthesia time, and analgesia agents had no impact on excess salivation. The general recovery qualities were good despite of excess salivation. These results indicate the excess salivation in dogs after general anesthesia are not associated with pain and the potential risk factors are variable.en
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en
dc.description.tableofcontents目錄 ii
圖次…………………………………………………………………...iii
表次.....................................................iii
中文摘要 iv
英文摘要 v
第一章 前言.........................................1
第二章 文獻探討.....................................2
第一節 流涎之定義 2
第二節 唾液之病理生理學 2
一、唾液之功用 2
二、唾液腺之組織解剖構造及生理學 5
三、唾液分泌之神經調控 12
四、影響唾液分泌之因子 18
4-1 增加唾液分泌之因子 18
4-2 降低唾液分泌之因子 20
五、唾液分泌量之評估方式 23
5-1 主觀方式 23
5-2 客觀方式 23
第三節 過度流涎的影響與病理生理學 26
第四節 過度流涎之評估與治療 28
一、不治療 29
二、行為治療 29
三、藥物治療 29
四、低侵入性治療......................................30
五、放射治療..........................................30
六、外科治療..........................................31
參考文獻..............................................37
第三章 犬隻麻醉後過度流涎之發生率與因子調查...........43
附錄..................................................61
dc.language.isozh-TW
dc.subject過度流涎zh_TW
dc.subject疼痛zh_TW
dc.subject流涎zh_TW
dc.subject犬zh_TW
dc.subjectpainen
dc.subjectdogen
dc.subjectsalivationen
dc.subjectdroolingen
dc.subjecthypersalivationen
dc.subjectanalgesiaen
dc.title犬隻麻醉後過度流涎之發生率與因子調查zh_TW
dc.titleThe Prevalence and Risk Factors of Drooling/hypersalivation in Post- anaesthetized Dogsen
dc.typeThesis
dc.date.schoolyear97-2
dc.description.degree碩士
dc.contributor.oralexamcommittee林中天,張紹光
dc.subject.keyword犬,流涎,過度流涎,疼痛,zh_TW
dc.subject.keyworddog,salivation,drooling,hypersalivation,analgesia,pain,en
dc.relation.page71
dc.rights.note未授權
dc.date.accepted2009-08-20
dc.contributor.author-college獸醫專業學院zh_TW
dc.contributor.author-dept獸醫學研究所zh_TW
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