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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 潘子明 | |
| dc.contributor.author | Jean-You Cai | en |
| dc.contributor.author | 蔡貞幼 | zh_TW |
| dc.date.accessioned | 2021-06-08T04:22:33Z | - |
| dc.date.copyright | 2011-09-18 | |
| dc.date.issued | 2011 | |
| dc.date.submitted | 2011-08-27 | |
| dc.identifier.citation | 中華民國血脂及動脈硬化學會。2009。台灣血脂異常防治共識-血脂異常預防及診療臨床指引。 中華民國血脂及動脈硬化學會。台北。臺灣。中華民國。
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Res. 27: 378-385. Tarchevskii, I. A. 1992. Regulatory role of degradation of biopolymers and lipids. Fiziol. Rastenii, 39: 1215-1223. Tietz, N. W. 1990. Clinical Guide to Laboratory Tests, Second Edition W.B. Saunders Company, Philaderlphia, USA. 554-556. Usman, and Hosono A. 2000. Effect of administration of Lactobacillus gasseri on serum lipids and fecal steroids in hypercholesterolemic rats. J. Dairy Sci. 83: 1705-1711. Witztum, J. L., and Steinberg, D. 1991. Role of oxidized low density lipoprotein in atherogenesis. J. Clin. Invest. 88:1785-1792. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/22620 | - |
| dc.description.abstract | 近年來紅麴二次代謝物 monascin 及 ankaflavin 之相關研究日益增加，已發現具有抗發炎、抑制癌細胞生長等多種保健功效。本研究利用高膽固醇飲食倉鼠模式，進行改善脂質代謝與抗氧化之評估。結果顯示：monascin 及 ankaflavin 具有降低血中膽固醇及三酸甘油酯的功效，且 ankaflavin 功效較 monascin 顯著。在膽固醇的組成方面，可降低低密度脂蛋白膽固醇 (low density lipoprotein cholesterol, LDL-C)，並且高密度脂蛋白膽固醇 (high density lipoprotein cholesterol, HDL-C) 不致下降，因此降低 LDL-C/HDL-C 比值。此外亦可降低脂蛋白元 B (Apolipoprotein B, Apo B)，提升脂蛋白元 A1 (Apolipoprotein A-1,ApoA-1) 含量，降低罹患心血管疾病風險。Monascin 及 ankaflavin 亦可減緩高膽固醇飲食造成之非酒精性脂肪肝，調節血清胰島素及血糖。在抗氧化方面，monascin 及 ankaflavin 皆具有降低體內脂質過氧化程度能力，並增加麩胱甘肽 (glutathione, GSH) 含量，提升麩胱甘肽過氧化酶 (glutathione peroxidase, GSH Px)、麩胱甘肽還原酶 (glutathione peroxidase, GSH Px) 活性。研究結果顯示 monascin 及 ankaflavin 對於調節脂質代謝及抗氧化都有良好效果，可預防動脈粥狀硬化及脂肪肝，保健功效極具發展潛力。 | zh_TW |
| dc.description.abstract | Recently, the research of Monascus-fermented secondary metabolites, monascin and ankaflavin, was gradually popular. The function of monascin and ankaflavin were possessed of anti-inflammation, cancer prevention and hypolipidemic effect. The aim of this study is to investigate the effects of monascin and ankaflavin on lipid metabolism and antioxidant activity in a high-cholesterol diet fed hamster model. The results showed that monascin and ankaflavin with lower blood cholesterol and triglycerides in the efficacy. Ankaflavin had more effectiveness than monascin. Monascin and ankaflavin were able to maintain high density lipoprotein cholesterol (HDL-C) level and decrease low density lipoprotein cholesterol (LDL-C) level and LDL-C/HDL-C ratio. In addition, to reduce apolipoprotein B (Apolipoprotein B, Apo B), to enhance the apolipoprotein A1 (Apolipoprotein A-1, ApoA-1) levels, reduce the risk of cardiovascular disease risk. Monascin and ankaflavin can reduce the non-alcoholic fatty liver caused by high-cholesterol diet, and regulate serum insulin concentration and blood glucose. It also indicates that monascin and ankaflavin would perform a potent effect on hypolipidemic via the reduce of lipid peroxidation and the increase of glutathione (GSH), glutathione peroxidase (GSH Px) and glutathione reductase (GSH Rd) activity. These results indicated that monascin and ankaflavin exerted hypolipidemic effect and antioxidant activity to prevent atherosclerosis and fatty liver, may serve as a potential development functional compound. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-08T04:22:33Z (GMT). No. of bitstreams: 1 ntu-100-R93b47110-1.pdf: 1558830 bytes, checksum: e7e57e427faec7c900b1de27344c6afc (MD5) Previous issue date: 2011 | en |
| dc.description.tableofcontents | 目錄
縮寫表 I 中文摘要 III Abstract IV 目錄 V 表目錄 VII 圖目錄 VIII 第壹章 文獻回顧 1 一、脂質代謝 1 二、抗氧化反應 6 三、動脈粥狀硬化 7 四、紅麴 12 五、研究動機與目的 14 六、研究大綱 15 第貳章 材料與方法 16 一、實驗材料 16 二、實驗方法 17 第参章 結果與討論 25 一、試驗動物之心臟、肝臟和腎臟相對重量 25 二、試驗動物之血液中總膽固醇與三酸甘油酯濃度變化 25 三、試驗動物之血液中 HDL-C 與 LDL-C 濃度變化 28 四、試驗動物血液中ApoA-1與 Apo B濃度變化 30 五、試驗動物禁食血糖及血清胰島素之變化 30 六、試驗動物之血液中脂質過氧化程度 33 七、試驗動物之心臟主動脈脂質堆積程度 33 八、試驗動物肝臟之脂質過氧化程度 33 九、肝臟中抗氧化物質麩胱甘肽含量 38 十、肝臟抗氧化與解毒代謝酵素活性 38 十 一、試驗動物肝功能指數之影響 38 十二、試驗動物腎功能指數之影響 39 十三、組織病理鏡檢 43 第肆章 綜合討論 47 一、Monascin與ankaflavin降血脂之評估 47 二、Monascin與ankaflavin 對脂蛋白元之影響 47 三、Monascin與ankaflavin 對脂肪肝、血清胰島素及血糖之影響 47 四、Monascin與ankaflavin 抗氧化之功效 49 五、總結 49 參考文獻 50 | |
| dc.language.iso | zh-TW | |
| dc.subject | 脂肪肝 | zh_TW |
| dc.subject | 紅麴 | zh_TW |
| dc.subject | 脂質代謝 | zh_TW |
| dc.subject | 抗氧化 | zh_TW |
| dc.subject | 降血脂 | zh_TW |
| dc.subject | 動脈粥狀硬化 | zh_TW |
| dc.subject | Monascus | en |
| dc.subject | fatty liver | en |
| dc.subject | atherosclerosis | en |
| dc.subject | hypolipidemic | en |
| dc.subject | antioxidant | en |
| dc.subject | lipid metabolism | en |
| dc.title | 紅麴二次代謝物 monascin 與 ankaflavin 對脂質代謝與抗氧化活性之影響 | zh_TW |
| dc.title | The effect of Monascus-fermented secondary metabolites monascin and ankaflavin on lipid metabolism and antioxidant enzyme activity | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 99-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 蘇遠志,黃健雄,李俊霖,蔡宗佑 | |
| dc.subject.keyword | 紅麴,脂質代謝,抗氧化,降血脂,動脈粥狀硬化,脂肪肝, | zh_TW |
| dc.subject.keyword | Monascus,lipid metabolism,antioxidant,hypolipidemic,atherosclerosis,fatty liver, | en |
| dc.relation.page | 54 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2011-08-29 | |
| dc.contributor.author-college | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 生化科技學系 | zh_TW |
| 顯示於系所單位： | 生化科技學系 | |
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