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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 賈景山(Jean-San Chia) | |
dc.contributor.author | Min-Jie Tsai | en |
dc.contributor.author | 蔡旻潔 | zh_TW |
dc.date.accessioned | 2021-06-08T04:19:29Z | - |
dc.date.copyright | 2010-09-09 | |
dc.date.issued | 2010 | |
dc.date.submitted | 2010-07-22 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/22508 | - |
dc.description.abstract | In the particular microenvironment of oral squamous cell carcinoma (OSCC), the orchestra of cancer cells, infiltrating immune cells, certain bacteria (such as Streptococcus anginosus), and stromal fibroblasts (cancer-associated fibroblasts, CAFs) play a symphony of cancer-related inflammation. In oral cancer, the role of CAFs in modulating the cancer-assoicated inflammation remains poorly understood. The CAFs isolated and cultured from oral cancer tissues are characterized with human fibroblast markers. Recombinant human IL-1β activates CAFs in a dose-dependent manner, and the production of IL-6, IL-8 and MCP-1 in supernatant accumulates as the stimulation time increases. Recombinant IL-1β-activated CAFs express increased levels of proinflammtory cytokines (such as IL-6), and chemokines which are associated with cancer progression, and recruitment of monocytes/macrophages (including IL-8, MCP-1, MCP-3, and GM-CSF). Stimulation of OSCC cells and peripheral blood mononuclear cells with S. anginosus induces the factors which activate CAFs in an IL-1-dependent manner. Conditioned media of CAF promote migration of human monocytes, and IL-1β activation enhances the chemotactic effect. Taken together, both the interaction with invaded streptococci as the exogenous stimuli for immune cells and the endogenous property of OSCC cells lead to IL-1 production. Activation of stromal fibroblasts by IL-1 may give rise to tumor-promoting inflammation in oral cancer microenvironment. | en |
dc.description.provenance | Made available in DSpace on 2021-06-08T04:19:29Z (GMT). No. of bitstreams: 1 ntu-99-R97445127-1.pdf: 4940067 bytes, checksum: 8df30e3e31413997c388a784358309bc (MD5) Previous issue date: 2010 | en |
dc.description.tableofcontents | 授權書 I
口試委員會審定書 II Acknowledgement III Table of Contents IV List of Figures / Tables VI Abstract in Chinese 1 Abstract in English 2 Abbreviations List 3 Chapter 1: Introduction 5 1.1 Oral Cancers 5 1.2 Cancer Microenvironment 7 1.3 Cancer and Inflammation 11 1.4 Relationship of Bacteria and Cancer 16 Chapter 2: Purposes and Aims 19 Chapter 3: Materials and Methods 20 3.1 Cell culture 20 3.2 Characterization of CAFs 21 3.3 Interaction of Bacteria and Cells 22 3.4 Activation of CAFs 24 3.5 Enzyme-Linked Immunosorbent Assay (ELISA) 25 3.6 RNA Extraction 25 3.7 Reverse Transcription 26 3.8 Polymerase Chain Reaction (PCR) and Real-time PCR 27 3.9 Statistic Analysis 27 Chapter 4: Results 29 Chapter 5: Discussion 36 Chapter 6: References 41 Chapter 7: Tables 58 Chapter 8: Figures 60 | |
dc.language.iso | en | |
dc.title | 口腔鏈球菌與人類口腔癌細胞,白血球,及癌症相關纖維母細胞之交互作用 | zh_TW |
dc.title | Interactions of Oral Streptococci with Human Oral Cancer Cells, Leukocytes and Cancer-Associated Fibroblasts | en |
dc.type | Thesis | |
dc.date.schoolyear | 98-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 陳振陽(Jen-Yang Chen),林琬琬(Wan-Wan Lin),蔡錦華(Ching-Hwa Tsai) | |
dc.subject.keyword | 口腔癌,口腔共生鏈球菌,單核球,癌症相關纖維母細胞,發炎反應, | zh_TW |
dc.subject.keyword | oral cancer,oral commensal streptococci,monocyte,cancer-associated fibroblast,inflammation, | en |
dc.relation.page | 70 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2010-07-22 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 微生物學研究所 | zh_TW |
顯示於系所單位: | 微生物學科所 |
文件中的檔案:
檔案 | 大小 | 格式 | |
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ntu-99-1.pdf 目前未授權公開取用 | 4.82 MB | Adobe PDF |
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