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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 尹相姝 | |
dc.contributor.author | Meng-Lin Liao | en |
dc.contributor.author | 廖孟琳 | zh_TW |
dc.date.accessioned | 2021-06-08T04:15:40Z | - |
dc.date.copyright | 2010-09-09 | |
dc.date.issued | 2010 | |
dc.date.submitted | 2010-08-06 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/22330 | - |
dc.description.abstract | Neuregulin1(NRG1,神經調節素1)的功能為調節神經細胞發育及細胞遷移,且nrg1 基因是精神分裂症(schizophrenia)的易感性基因之一。此疾病成因可能因為基因、發育、神經傳導物質發生異常所造成。NRG1基因變異老鼠的過動和認知行為異常和精神經分裂症病人症狀類似,因此可用來做研究精神分裂症病因的動物模式。目前已知精神分裂症病人前額葉皮質麩胺酸鹽脫羧酶-67(GAD67)mRNA和蛋白質表現都比正常人少,且在齒狀迴的neural stem cells(ki-67)也是顯著較正常人少。本篇研究利用免疫化學染色比較八週NRG1變異小鼠(△TM+/-)及野生型小鼠的桶狀皮質(barrel cortex)及海馬結構(hippocampal formation) 區域內蛋白質的表現及神經細胞生成情形,以探討NRG1變異小鼠行為異常背後的可能機制。
我們發現 1.桶狀皮質 (i) 桶狀皮質第二/三層:與野生型小鼠比較,NRG1變異小鼠GAD67神經末梢密度顯著下降。 (ii) 桶狀皮質第四層:與野生型小鼠比較,NRG1變異小鼠GAD67神經末梢密度顯著下降,小白蛋白(Parvalbumin,PV)細胞體個數亦顯著減少。 (iii) 桶狀皮質第五層:與野生型小鼠比較,NRG1變異小鼠GAD67 神經元細胞體個數顯著上升,而PV細胞體個數顯著減少。 (iv) 桶狀皮質第六層:與野生型小鼠比較,NRG1變異小鼠PV細胞體個數和神經末梢密度顯著減少。 2.背側海馬結構 (i) CA1錐狀細胞層: 與野生型小鼠比較,NRG1變異小鼠γ-胺基丁酸A受體α1(GABAARα1)神經末梢密度顯著上升 (ii) CA3錐狀細胞層: 與野生型小鼠比較,NRG1變異小鼠GAD67神經末梢顯著上升,酪胺酸羥化酶(tyrosine hydroxylase,TH)神經末梢亦顯著上升。 (iii) 齒狀迴顆粒細胞層:與野生型小鼠比較,NRG1變異小鼠GAD67神經末梢顯著上升。在顆粒細胞下區(Subgranular zone, SGZ),NRG1變異小鼠在第四天犧牲的SGZ BrdU細胞數顯著減少。 3.腹側海馬結構 (i) CA1錐狀細胞層:與野生型小鼠比較,NRG1變異小鼠GABAARα1神經末梢的密度顯著上升。 (ii) CA3錐狀細胞層:與野生型小鼠比較,NRG1變異小鼠酪胺酸羥化酶(tyrosine Hydroxylase,TH)神經末梢顯著增加。 (iii) 齒狀迴顆粒細胞層:與野生型小鼠比較,NRG1變異小鼠GABAARα1神經末梢的密度顯著上升。 4.Posterior periventricle (pPV): 與野生型小鼠比較,在第四天、第十天犧牲的BrdU細胞數,NRG1變異小鼠細胞數顯著減少。 5.胼胝體(corpus callosum): 與野生型小鼠比較,在第十天犧牲的BrdU細胞數,NRG1變異小鼠細胞數顯著增加。 綜合以上所述,NRG1變異可能會影響桶狀皮質和海馬結構的伽瑪胺基丁酸(GABA)系統、海馬結構的多巴胺系統、齒狀迴及pPV的神經新生,這可能為NRG1變異小鼠行為異常的原因之一。 | zh_TW |
dc.description.provenance | Made available in DSpace on 2021-06-08T04:15:40Z (GMT). No. of bitstreams: 1 ntu-99-R97446008-1.pdf: 23424426 bytes, checksum: b065bd37a166e08da7dd5be4a14f8215 (MD5) Previous issue date: 2010 | en |
dc.description.tableofcontents | 論文口試委員審定書……………………………………………… i
目錄………………………………………………………………… ii 致謝………………………………………………………………… iii 中文摘要…………………………………………………………… iv 英文摘要…………………………………………………………… vi 緒論………………………………………………………………… 1 材料與方法………………………………………………………… 26 結果………………………………………………………………… 37 討論………………………………………………………………… 55 結論………………………………………………………………… 66 參考文獻…………………………………………………………… 67 表格與說明………………………………………………………… 74 圖表與說明………………………………………………………… 81 附表…………………………………………………………………127 | |
dc.language.iso | zh-TW | |
dc.title | 神經生長素1基因變異對桶狀皮質及海馬形成的
γ-胺基丁酸系統和神經新生的影響 | zh_TW |
dc.title | Effects of NRG1 gene mutation on GABA system and neurogenesis in barrel cortex and hippocampal formation | en |
dc.type | Thesis | |
dc.date.schoolyear | 98-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 錢宗良,呂俊宏,李旺祚,李立仁 | |
dc.subject.keyword | 神經調節素1,多巴胺,伽瑪胺基丁酸,神經新生, | zh_TW |
dc.subject.keyword | Neuregulin 1,dopamine,GABA,neurogenesis, | en |
dc.relation.page | 140 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2010-08-06 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 解剖學暨生物細胞學研究所 | zh_TW |
顯示於系所單位: | 解剖學暨細胞生物學科所 |
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