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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 王立民(Li-Min Wang) | |
| dc.contributor.author | Liang-Yu Hsiung | en |
| dc.contributor.author | 熊良瑜 | zh_TW |
| dc.date.accessioned | 2021-06-08T03:58:35Z | - |
| dc.date.copyright | 2018-08-16 | |
| dc.date.issued | 2018 | |
| dc.date.submitted | 2018-08-13 | |
| dc.identifier.citation | [1] M. A. Bouchiat, T. R. Carver, and C. M. Varnum, Nuclear Polarization in 3He Gas Induced by Optical Pumping and Dipolar Exchange, Phys. Rev. Lett. 5,373(1960).
[2] R.L. Gamblin and T. R. Carver, Polarization and Relaxation Processes in 3He Gas Phys. Rev. 138, A946 (1965). [3] X. Zeng, E. Miron, W. A. van Wijngaarden, D. Schreiber, and W.Happer, Polarization of the nuclear spins of noble-gas atoms by spin exchange with optically pumped alkali-metal atoms, Phys. Lett. 96A,191 (1983). [4] B. Chann, E. Babcock, L.W. Anderson, T.G. Walker, W.C. Chen, T.B.Smith, A.K. Thomson, and T.B. Gentile, Gas cells for 3He hyperpolarized via spin-exchange optical pumping, J. Appl. Phys. 94, 6908 (2003) [5] T. G. Walker and W. Happer, Spin-Rotation Interaction of Noble-Gas Alkali-Metal Atom Pairs, Rev. Mod. Phys. 44, 169 (1972). [6] R. D. Black, H.L . Middleton, G.D. Cates, G.P. Cofer, B. Driehuys, W.Happer, L.W. Hedlund, G.A. Johnson, M.D. Shattuck and J.C. Swartz, In vivo He-3 MR images of guinea pig lungs. Radiology. 199, 867 (1996). [7] D. Raftery, H. Long, T. Meersmann, P. J. Grandinetti, L. Raven, and A. Pines, High-field NMR of adsorbed xenon polarized by laser pumping. Phys. Rev. Lett. 66, 584 (1991). [8] E. J. R. van Beek, A. M. Dahmen, T. Stavngaard, K. K. Gast, C. P. Heussel, F. Krummenauer, J. Schmiedeskamp, J. M. Wild, L. V. Søgaard, A. E. Morbach, L. M. Schreiber, H-U. Kauczor. Hyperpolarized 3He MRI versus HRCT in COPD and normal volunteers: PHIL trial. European Respiratory Journal (2009). [9] Samee S, Altes T, Powers P, et al. Imaging the lungs in asthmatic patients by using hyperpolarized helium-3 magnetic resonance: assessment of response to methacholine and exercise challenge. J Allergy Clin Immunol 2003;111:1205–1211. [10] Woodhouse N, Wild JM, Paley MN, et al. Combined helium-3/proton magnetic resonance imaging measurement of ventilated lung volumes in smokers compared to never-smokers. J Magn Reson Imaging 2005;2 1:365–369. [11] van Beek EJ, Dahmen AM, Stavngaard T, et al. Hyperpolarized 3He MRI versus HRCT in COPD and normal volunteers: PHIL trial. Eur Respir J 2009;34:1311–1321. [12] Marcus J. Couch, Iain K. Ball, Tao Lib, Matthew S. Fox, Alexei V. Ouriadov, Birubi Biman and Mitchell S. Albert. Inert fluorinated gas MRI: a new pulmonary imaging modality. (2014) [13] Bommerich U, Trantzschel T, Mulla-Osman S, Buntkowsky G, Bargon J, Bernarding J. Hyperpolarized 19F-MRI: parahydrogen-induced polarization and field variation enable 19F-MRI at low spin density. Phys.Chem. Chem. Phys. 2010; 12: 10309–10312. [14] M A Bernstein, K F King and X J Zhou. Handbook of MRI Pulse Sequences. Elsevier Academic Press, 960 (2004) [15] R. E. Jacob, S. W. Morgan, B. Saam, J. 3He spin exchange cells for magnetic resonance imagingAppl. Phys., 92, 1588 (2002). [16] Earl D. Babcock, Spin-Exchange Optical Pumping with Alkali-Metal Vapors. (2005) | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/22026 | - |
| dc.description.abstract | 本研究架設「光激發超極化氣體與低場核磁共振系統」，主要是經由數據擷取卡(DAQ)整合雷射系統、加熱系統和磁場等裝置，穩定的將3He或129Xe極化並測量核磁共振訊號。實驗經由電源供應器輸出穩定電流於主磁場線圈以產生穩定約10高斯的低磁場，並經由數據截取卡（DAQ）輸出所需要脈衝電壓、梯度電壓。並透過更換電容的方式，視所要量測的樣品調整系統共振頻率。經由數據擷取卡量測水(共振頻率為42800 Hz)、SF6氣體(共振頻率為42800 Hz)和光激發3He(共振頻率為32320 Hz)、129Xe(共振頻率為10400 Hz)氣體的核磁共振訊號頻譜。結合梯度補償的方式使得3He的核磁共振訊號的訊雜比從16提升到62、線寬從29 Hz降低到10 Hz，並利用gradient echo的方式成功地完成了光激發3He氣體的核磁共振造影。 | zh_TW |
| dc.description.abstract | In this study, we set up an 'optical pumped hyperpolarized gas and low-field magnetic resonance imaging (MRI) system ', in which the laser systems, the heating systems and magnetic devices are integrated by the data acquisition card (DAQ) . Using this system, we polarize 3He and 129Xe stably and measure the magnetic resonance signals. The experiment outputs a steady current through the power supply, generates a stable low magnetic field (about 10 Gauss) via the coil. We use the DAQ to output the required pulse voltage and gradient voltage. By replacing the capacitor, the system resonance frequency (fr) can be adjusted according to optical-pumped gas or water measured. We measure the NMR signals of water (fr = 42800 Hz), SF6 gas (fr = 42800 Hz), hyperpolarized 3He (fr = 32320 Hz), and 129Xe gas (fr = 10400 Hz) by the DAQ. With the gradient compensation method, the signal-to-noise ratio of the 3He NMR signal is increased from 16 to 62, and the line width is reduced from 29 Hz to 10 Hz. Finally, we successfully use the gradient echo method to create the nuclear magnetic resonance image of the hyperpolarized 3He gas. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-08T03:58:35Z (GMT). No. of bitstreams: 1 ntu-107-R04222003-1.pdf: 3757723 bytes, checksum: fc49c403adf3e99db709481eb93be21e (MD5) Previous issue date: 2018 | en |
| dc.description.tableofcontents | 致謝 ii
摘要 iii Abstract iv 目錄 v 圖目錄 vii 表目錄 x 第一章 緒論 1 1-1 光激發極化氣體的重要性 1 1-2 文獻探討 1 1-2-1 極化氣體 1 1-2-2 19F氣體 2 1-3 實驗動機 3 第二章 理論背景與原理簡介 4 2-1 核磁共振原理 4 2-1-1 Larmor 頻率 4 2-1-2 波茲曼分布理論與磁矩強度 6 2-1-3 B1脈衝 6 2-1-4 自由感應衰減(Free Induction Decay) 7 2-1-5 縱向鬆弛與橫向鬆弛 7 2-2 磁振造影原理 9 2-3 光激發銣原子之自旋交換原理 12 2-3-1 銣原子的光譜 12 2-3-2 光激發（Optical Pumping）銣電子 12 2-3-3 Rb 與3He 之自旋交換作用 13 2-4 極化量計算原理 14 2-5 3He、129Xe、19F、水（1H）的核磁共振特性比較 17 第三章 實驗架構與實驗流程 18 3-1 實驗用光學腔體 18 3-1-1 3He光學腔體 18 3-1-2 129Xe、19F、水腔體 18 3-2 光激發3He、129Xe與低場核磁共振系統架構介紹 19 3-2-1 雷射系統 20 3-2-2 加熱系統 20 3-2-3 磁場系統 21 3-2-4 核磁共振訊號量測系統 24 3-3 實驗流程 25 第四章 實驗結果與數據討論 27 4-1 核磁共振系統實驗前測 27 4-2 精確的電流磁場關係 30 4-3 環境中均勻磁場最佳化後對核磁共振訊號影響之比較 31 4-4 水的核磁共振訊號量測 33 4-4-1 核磁共振訊號量測 33 4-4-2 脈衝角度量測 34 4-5 3He極化率計算以及T1量測 35 4-6 129Xe極化率計算 37 4-7 19F（SF6）核磁訊號量測 38 4-8 核磁共振造影 39 第五章 結論 41 Reference 42 | |
| dc.language.iso | zh-TW | |
| dc.subject | 低磁場核磁共振造影 | zh_TW |
| dc.subject | 光激發 | zh_TW |
| dc.subject | 極化惰性氣體 | zh_TW |
| dc.subject | 核磁共振 | zh_TW |
| dc.subject | hyperpolarized gas | en |
| dc.subject | Nuclear Magnetic Resonance | en |
| dc.subject | optical pumping | en |
| dc.subject | low-field magnetic resonance imaging | en |
| dc.title | 光激發超極化氣體在低場磁振造影之特性研究 | zh_TW |
| dc.title | Low-Field Magnetic Resonance Imaging by Optical-Pumped Hyperpolarized Gas | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 106-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 廖書賢(Shu-Hsien Liao),陳昭翰(Jau-Han Chen) | |
| dc.subject.keyword | 光激發,極化惰性氣體,核磁共振,低磁場核磁共振造影, | zh_TW |
| dc.subject.keyword | optical pumping,hyperpolarized gas,Nuclear Magnetic Resonance,low-field magnetic resonance imaging, | en |
| dc.relation.page | 43 | |
| dc.identifier.doi | 10.6342/NTU201803158 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2018-08-13 | |
| dc.contributor.author-college | 理學院 | zh_TW |
| dc.contributor.author-dept | 物理學研究所 | zh_TW |
| 顯示於系所單位： | 物理學系 | |
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