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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 張惠婷(Hui-Ting Chang) | |
| dc.contributor.author | Yen-Ting Chen | en |
| dc.contributor.author | 陳彥廷 | zh_TW |
| dc.date.accessioned | 2021-06-08T03:45:47Z | - |
| dc.date.copyright | 2019-02-15 | |
| dc.date.issued | 2019 | |
| dc.date.submitted | 2019-02-13 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/21764 | - |
| dc.description.abstract | 本研究主要進行伽羅木醇型土肉桂葉子精油的化學組成分析與生物活性評估，經由 GC-MS 分析確定伽羅木醇型土肉桂葉子精油的主要成分為 Linalool，佔了總成分的 93.2%。在小鼠的強迫游泳試驗中，顯示伽羅木醇型土肉桂葉子精油在 400 mg/kg 時具有良好之抗憂鬱活性的效果。在 GMC101 基因轉殖秀麗隱桿線蟲的麻痺試驗中，線蟲在 25℃ 環境中 48 hr 後，可以觀察到伽羅木醇型土肉桂葉子精油在濃度 100 μg/mL、200 μg/mL與 400 μg/mL時能夠有效降低線蟲的麻痺率，而在72 hr 後，伽羅木醇型土肉桂葉子精油濃度在 200 μg /mL與 400 μg /mL亦有降低線蟲麻痺率的效果。綜合上述結果顯示，伽羅木醇型土肉桂葉子精油具有抗憂鬱活性與抗阿茲海默症效果，值得後續進一步的研究與開發應用。 | zh_TW |
| dc.description.abstract | The purposes of the study were to analysize the chemical composition of the leaf essential oil of Cinnamomum osmophloeum ct. linalool, and evaluate the bioactivities of leaf essential oil. The main component of the leaf essential oil of C. osmophloeum ct. linalool was confirmed by GC-MS analysis; the leaf essential oil is rich in linalool (93.2%). Results revealed that the leaf essential oil of C. osmophloeum ct. linalool had the good antidepressant activity in the forced swimming test in mice at the concentration of 400 μg/ml. In the paralysis assay, the leaf essential oil can reduce the paralysis rate of Caenorhabditis elegans transgenic strain GMC101 at the concentrations of 100 μg/ml, 200 μg/ml and 400 μg/ml after 25℃ and 48 hr of paralysis test. The leaf essential oil can also reduce the paralysis rate of C. elegans transgenic strain GMC101 at the concentrations of 200 μg/ml and 400 μg/ml after 72-hr paralysis test. According to the results, the leaf essential oil of C. osmophloeum ct. linalool has the antidepressant activity and the anti-Alzheimer's effect, and it is worthy of further research and exploitation. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-08T03:45:47Z (GMT). No. of bitstreams: 1 ntu-108-R05625034-1.pdf: 3122923 bytes, checksum: cb99c66cd0c374c8b8b402f2a812ed6c (MD5) Previous issue date: 2019 | en |
| dc.description.tableofcontents | 摘 要 I
Abstract II 表目錄 VII 圖目錄 X 壹、前言 1 貳、文獻回顧 3 一、土肉桂植物 3 (一) 簡介 3 (二) 土肉桂植物之生物活性 4 1. 抗氧化活性 4 2. 抗發炎活性 5 3. 抗真菌活性 7 4. 抗高血脂活性 7 二、植物抽出物抗憂鬱活性之相關研究 8 (一) 憂鬱症之簡介 8 (二) 憂鬱症病因 8 1. 生物學因素 9 2. 心理學因素 9 3. 社會學因素 9 (三) 常見的憂鬱試驗評估模式 9 1. 強迫游泳試驗 9 2. 尾部懸吊試驗 10 (四) 植物抽出物治療憂鬱症之研究 10 1. 西洋接骨木 10 2. 斐濟果 12 3. 迷迭香 12 三、植物抽出物治療阿茲海默症之相關研究 13 (一) 阿茲海默症之簡介 13 (二) 阿茲海默症的病因 14 1. 膽鹼性假說 15 2. β類澱粉胜肽 15 3. Tau蛋白假說 15 4. 其他病因 16 (三) 植物抽出物治療阿茲海默症之研究 16 1. 山葛抽出物與韓國紅蔘抽出物 16 2. 玫瑰精油 21 3. EGCG 22 參、材料與方法 28 一、試驗材料 28 (一) 試材 28 (二) 實驗小鼠 28 (三) 秀麗隱桿線線蟲與菌種 28 1. 秀麗隱桿線線蟲 28 2. 大腸桿菌 28 (四) 試驗藥品與溶劑 28 1. 藥品 28 2. 溶劑 29 二、試驗方法 29 (一) 精油成分分析 29 (二) 強迫游泳試驗 (憂鬱動物模型) 30 (三) 熱刺激甩尾法試驗 (鎮痛動物模型) 30 (四) 巴比妥誘導催眠小鼠睡眠試驗 30 (五) 抑制酪胺酸酶活性之試驗 30 (六) 斑馬魚試驗 31 (七) 線蟲培養 31 1. E.coli OP50製備 31 2. NGM agar plate製備 31 3. E.coli OP50的NGM agar plate製備 31 4. 線蟲培養 32 5. 線蟲同齡化 32 6. 試驗樣品之NGM agar plate製備 32 (八) 基因轉殖線蟲GMC101麻痺試驗 32 (九) 秀麗隱桿線蟲之耐熱性試驗 33 (十) 統計分析 33 肆、結果與討論 34 一、伽羅木醇型土肉桂葉子精油成分與含量分析 34 二、伽羅木醇型土肉桂葉子精油之質譜分析 36 (一) Linalool 36 (二) Camphor 37 (三) trans-Cinnamaldehyde 38 (四) β-Caryophyllene 39 (五) Coumarin 40 (六) Caryophyllene oxide 41 二、以小鼠模式評估伽羅木醇型土肉桂葉子精油之抗憂鬱與其他活性 42 (一) 伽羅木醇型土肉桂葉子精油對小鼠體重變化之影響 42 (二) 伽羅木醇型土肉桂葉子精油之抗憂鬱活性評估 44 (三) 伽羅木醇型土肉桂葉子精油對小鼠熱刺激甩尾法試驗之影響 51 (四) 伽羅木醇型土肉桂葉子精油對小鼠睡眠時間之影響 53 三、伽羅木醇型土肉桂葉子精油抑制黑色素生成之活性評估 55 (一) 伽羅木醇型土肉桂葉子精油對蕈類酪胺酸酶的抑制效果 55 (二) 伽羅木醇型土肉桂葉子精油對斑馬魚黑色素的抑制效果 58 四、以秀麗隱桿線蟲模式評估伽羅木醇型土肉桂葉子精油對生物耐熱性與抗阿茲海默症活性的影響 60 (一) 伽羅木醇型土肉桂葉子精油對秀麗隱桿線蟲之耐熱性影響 60 (二) 伽羅木醇型土肉桂葉子精油對基因轉殖線蟲GMC101之麻痺率影響 61 伍、結論 65 陸、參考文獻 66 | |
| dc.language.iso | zh-TW | |
| dc.title | 伽羅木醇型土肉桂葉精油成分及生物活性探討 | zh_TW |
| dc.title | Chemical Composition and Bioactivities of Leaf Essential Oil of Cinnamomum osmophloeum ct. Linalool | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 107-1 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 葉汀峰(Ting-Feng Yeh),許富蘭(Fu-Lan Hsu) | |
| dc.subject.keyword | 土肉桂,抗憂鬱活性,伽羅木醇,秀麗隱桿線蟲,阿茲海默症, | zh_TW |
| dc.subject.keyword | Antidepressant activity,Caenorhabditis elegans,Cinnamomum osmophloeum,Linalool, | en |
| dc.relation.page | 75 | |
| dc.identifier.doi | 10.6342/NTU201900484 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2019-02-13 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 森林環境暨資源學研究所 | zh_TW |
| 顯示於系所單位： | 森林環境暨資源學系 | |
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